Identification of Pex13p, a peroxisomal membrane receptor for the PTS1 recognition factor

Journal of Cell Biology

Volumn 135, Issue 1, 1996, Pages 111-121

  Erdmann, Ralf ^a   Blobel, Günter ^b  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN;

ARTICLE; INTRACELLULAR TRANSPORT; MOLECULAR RECOGNITION; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

ACETYL-COA C-ACETYLTRANSFERASE; AMINO ACID SEQUENCE; BIOLOGICAL TRANSPORT; CATALASE; CLONING, MOLECULAR; FUMARATE HYDRATASE; FUNGAL PROTEINS; GENES, FUNGAL; INTRACELLULAR MEMBRANES; MEMBRANE PROTEINS; MICROBODIES; MOLECULAR SEQUENCE DATA; OLEIC ACID; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ANALYSIS; SRC HOMOLOGY DOMAINS;

SACCHAROMYCES CEREVISIAE;

EID: 0029795490     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.135.1.111     Document Type: Article

References (63)

1. Ausubel, F.M., R. Brent, R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Smith, and K. Struhl. 1992. Short Protocols in Molecular Biology, Green Publishing Associates, New York.
2. Blobel, F., and R. Erdmann. 1996. Identification of a yeast peroxisomal member of the family of AMP binding proteins. Eur J. Biochem. 240:468-476.
3. Bradford, M.M. 1976. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
4. Bruschi, C.V., A.R. Comer, and G.A. Howe. 1987. Specifity of DNA uptake during whole cell transformation of Saccharomyces cerevisiae. Yeast. 3:131-137.
5. Chevray, P.M., and D. Nathans. 1992. Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun. Proc. Natl. Acad. Sci. USA. 89:5789-5793.
6. Clark, S.G., M.J. Stern, and H.R. Horvitz. 1992. C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains. Nature (Lond.). 356: 340-344.
7. Cohen, G.B., R. Ren, and D. Baltimore. 1995. Modular binding domains in signal transduction proteins. Cell. 80:237-248.
8. Dodt, G., N. Bravermann, C. Wong, A. Moser, H.W. Moser, P. Watkins, D. Valle, and S.J. Gould. 1995. Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders. Nature Genet. 9:115-125.
9. Drubin, D.G., J. Mulholland, Z., Zhu, and D. Botstein. 1990. Homology of a yeast actin-binding protein to signal transduction proteins and myosin-1. Nature (Lond.). 343:288-290.
10. Erdmann, R. 1994. The peroxisomal targeting signal of 3-oxoacyl CoA thiolase from Saccharomyces cerevisiae. Yeast. 10:935-944.
11. Erdmann, R., and W.H. Kunau. 1992. A genetic approach to the biogenesis of peroxisomes in the yeast Saccharomyces cerevisiae. Cell Biochem. Funct. 10: 167-174.
12. Erdmann, R., and W.H. Kunau. 1994. Purification and immunolocalization of 3-oxoacyl-CoA thiolase from Saccharomyces cerevisiae. Yeast. 10:1173-1182.
13. Erdmann, R., and G. Blobel. 1995. Giant peroxisomes in oleic acid-induced Saccharomyces cerevisiae lacking the peroxisomal membrane protein Pmp27p. J. Cell Biol. 128:509-523.
14. Erdmann, R., M. Veenhuis, D. Mertens, and W.H. Kunau. 1989. Isolation of peroxisome-deficient mutants of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA. 86:5419-5423.
15. Erdmann, R., F.F. Wiebel, A. Flessau, J. Rytka, A. Beyer, K.U. Fröhlich, and W.H. Kunau. 1991. PAS1, a yeast gene required for peroxisome biogenesis, encodes a member of a novel family of ATPases. Cell. 64:499-510.
16. Evan, G.I., G.K. Lewis, G. Ramsay, and J.M. Bishop. 1985. Isolation of monoclonal antibodies specific for human c-myc protooncogene product. Mol. Cell. Biol. 5:3610-3616.
17. Fields, S., and O.K. Song. 1989. A novel genetic system to detect protein-protein interactions. Nature (Lond.). 340:245-246.
18. Fransen, M., C. Brees, E. Baumgart, J.C.T. Vanhooren, M. Baes, G.P. Mannaerts, and P.P. Van Veldhoven. 1995. Identification and characterization of the human peroxisomal C-terminal targeting signal receptor. J. Biol. Chem. 270:7731-7736.
19. Gilmore, R., G. Blobel, and P. Walter. 1982. Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle. J. Cell Biol. 96:463-469.
20. Glover, J.R., D.W. Andrews, and R.A. Rachubinski. 1994. Saccharomyces cerevisiae peroxisomal thiolase is imported as a dimer. Proc. Natl. Acad. Sci. USA. 91:10541-10545.
21. Gould, S.J., G.A. Keller, and S. Subramani. 1987. Identification of a peroxisomal targeting signal at the carboxy terminus of firefly luciferase. J. Cell Biol. 105:2923-2931.
22. Hachiya, N., K. Mihara, K. Suda, M. Horst, G. Schatz, and T. Lithgow. 1995. Reconstitution of the initial steps of mitochondrial protein import. Nature (Lond.). 376:705-709.
23. Harlow, E., and D. Lane. 1988. Antibodies: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. pp. 451-511.
24. Häusler, T., Y.D. Stierhof, E. Wirtz, and C. Clayton. 1996. Import of a DHFR hybrid protein into gycosomes in vivo is not inhibited by the folate-analogue aminopterin. J. Cell Biol. 132:311-324.
25. Hiltunen, J.K., B. Wenzel, A. Beyer, R. Erdmann, A. Fossu, and W. Kunau. 1992. Peroxisomal multifunctional β-oxidation protein of Saccharomyces cerevisiae. J. Biol. Chem. 267:6646-6653.
26. Höhfeld, J., M. Veenhuis, and W.H. Kunau. 1991. PAS3, a Saccharomyces cerevisiae gene encoding a peroxisomal integral membrane protein essential for peroxisome biogenesis. J. Cell Biol. 114:1167-1178.
27. Imanaka, T., G.M. Small, and P.B. Lazarow. 1987. Translocation of acyl-CoA oxidase into peroxisomes requires ATP hydrolysis but not a membrane potential. J. Cell Biol. 105:2915-2922.
28. Lazarow, P.B. 1993. Genetic approaches to studying peroxisome biogenesis. Trends Cell Biol. 3:89-93.
29. Lazarow, P.B., and Y. Fujiki. 1985. Biogenesis of peroxisomes. Annu. Rev. Cell. Biol. 1:489-530.
30. Lazarow, P.B., and H.W. Moser. 1994. Disorders of peroxisome biogenesis. In The Metabolic and Molecular Basis of Inherited Disease. C.R. Sciver, A.L. Beaudet, W.S. Sly, and D. Valle, editors. McGraw Hill Book Co., New York. pp. 2287-2324.
31. Maeda, T., M. Takekawa, and H. Saito. 1995. Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor. Science (Wash. DC). 269:554-558.
32. Marshall, P.A., Y.I. Krimkevich, R.H. Lark, J.M. Dyer, M. Veenhuis, and J.M. Goodman. 1995. Pmp27p promotes peroxisomal proliferation. J. Cell Biol. 129:345-355.
33. Marzioch, M., R. Erdmann, M. Veenhuis, and W.H. Kunau. 1994. PAS7 encodes a novel member of the WD-40 protein family essential for import of 3-oxoacyl-CoA thiolase, a PTS2-containing protein, into peroxisomes. EMBO (Eur. Mol. Biol. Organ.) J. 13:4908-4918.
34. McCammon, M.T., J.A. McNew, P.J. Willy, and J.M. Goodman. 1994. An internal region of the peroxisomal membrane protein PMP47 is essential for sorting to peroxisomes. J. Cell Biol. 124:915-925.
35. McNew, J.A., and J.M. Goodman. 1994. An oligomeric protein is imported into peroxisomes in vivo. J. Cell Biol. 127:1245-1257.
36. Meyer, D.I., E. Krause, and B. Dobberstein. 1982. Secretory protein translocation across membranes - the role of the 'docking protein'. Nature (Lond.). 297:503-508.
37. Moreno de la Garza, M., U. Schultz-Borchardt, J.W. Crabb, and W.H. Kunau. 1985. Peroxisomal β-oxidation system of Candida tropicalis. Eur. J. Biochem. 148:285-291.
38. 1β and α2β heterodimers: α1 or α2 bind nuclear localization signal and β interacts with peptide repeat containing nucleoporins. Proc. Natl. Acad. Sci. USA. 92:6532-6536.
39. Osumi, T., T. Tsukamoto, S. Hata, S. Yokota, S. Miura, Y. Fujiki, M. Hijikata, S. Miyazawa, and T. Hashimoto. 1991. Amino-terminal presequence of the precursor of peroxisomal 3-ketoacyl-CoA thiolase is a cleavable signal peptide for peroxisomal targeting. Biochem. Biophys. Res. Commun. 181:947-954.
40. src). Oncogene. 6:2013-2018.
41. Rachubinski, R.A., and S. Subramani. 1995. How proteins penetrate peroxisomes. Cell. 83:525-528.
42. Ren, R., B.J. Mayer, P. Ciccetti, and D. Baltimore. 1993. Identification of a ten-amino acid proline-rich SH3 binding site. Science (Wash. DC). 259:1157-1161.
43. Rickles, R., M.C. Bothfield, Z., Weng, J. Taylor, O.M. Green, J. Brugge, and M.J. Zoller. 1994. Identification of Src, Fyn, Lyn, P13K, and Abl SH3 domain ligands using phage display libraries. EMBO (Eur. Mol. Biol. Organ.) J. 13:5598-5604.
44. Rothstein, R. 1991. Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. Methods. Enzymol. 194:281-301.
45. Rout, M.P., and J.V. Kilmartin. 1990. Components of the yeast spindle pole body. J. Cell Biol. 111:1913-1927.
46. Santos, M., T. Imanaka, H. Shio, G.M. Small, and P.B. Lazarow. 1988. Peroxisomal membrane ghosts in Zellweger syndrome-aberrant organelle assembly. Science (Wash. DC). 239:1536-1538.
47. Semba, K., M. Nishizawa, N. Miyajima, M.C. Yoshida, J. Sukegawa, Y. Yamanashi, M. Sasaki, T. Yamamoto, and K. Toyoshima. 1986. Yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family. Proc. Natl. Acad. Sci. USA. 83:5459-5463.
48. Sikorski, R.S., and P. Hieter. 1989. A system of shuttle vectors and host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics. 122:19-27.
49. Slawecki, M.L., G. Dodt, S. Steinberg, A.B. Moser, H.W. Moser, and S.J. Gould. 1995. Identification of three distinct peroxisomal protein import defects in patients with peroxisome biogenesis disorders. J. Cell. Sci. 108:1817-1829.
50. Subramani, S. 1992. Targeting of proteins to the peroxisomal matrix. J. Membr. Biol. 125:99-106.
51. Swinkels, B.W., S.J. Gould, A.G. Bodnar, R.A. Rachubinski, and S. Subramani. 1991. A novel, cleavable peroxisomal targeting signal at the amino-terminus of the rat 3-ketoacyl-CoA thiolase. EMBO (Eur. Mol. Biol. Organ.) J. 10: 3255-3262.
52. Tabak, H.F., Y. Elgersma, E.H. Hettema, C.W.T. Roermund, M.M. Franse, A.M. Motley, R.J.A. Wanders, and B. Distel. 1995. Traffic across the impermeable peroxisomal membrane in Saccharomyces crevisiae. Cold Spring Harbor Symp. Quant. Biol. 60:272.
53. Takeya, T., and H. Hanafusa. 1983. Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus. Cell. 32:881-890.
54. Van der Klei, I., R.E. Hilbrands, G.J. Swaving, H.R. Waterham, E.G. Vrieling, V.I. Titorenko, J.M. Cregg, W. Harder, and M. Veenhuis. 1995. The Hansenula polymorpha PER3 gene is essential for the import of PTS1 proteins into the peroxisomal matrix. J. Biol. Chem. 270:17229-17236.
55. Van der Leij, I., M.M. Franse, Y. Elgersma, B. Distel, and H.F. Tabak. 1993. PEX5 is a tetratricopeptide-repeat protein that is essential for the import of most matrix proteins into peroxisomes of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA. 90:11782-11786.
56. Walton, P.A., P.E. Hill, and S. Subramani. 1995. Import of stably folded proteins into peroxisomes. Mol. Biol. Cell. 6:675-683.
57. Watanabe, M., and G. Blobel. 1989. SecB functions as a cytosolic signal recognition factor for protein export in E. coli. Cell. 58:695-705.
58. Wendland, M., and S. Subramani. 1993. Cytosol-dependent peroxisomal protein import in a permeabilized cell system. J. Cell Biol. 120:675-685.
59. Wiemer, E.A., W.M. Nuttley, B.L. Bertolaet, X. Li, U. Francke, M.J. Wheelock, U.K. Anne, K.R. Johnson, and S. Subramani. 1995. Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisome disorders. J. Cell Biol. 130:51-65.
60. Will, G.A. 1994. Localization and import of acyl-CoA oxidase from Saccharomyces cerevisiae. PhD. Thesis. Ruhr-University Bochum, Germany, pp. 34-43.
61. Yaffe, M.P., and G. Schatz. 1984. Two nuclear mutations that block mitochondrial protein import in yeast. Proc. Natl. Acad. Sci. USA. 81:4819-4823.
62. Yu, H., J.K. Chen, S. Feng, D.C. Dalgarno, A.W. Brauer, and S.L. Schreiber. 1994. Structural basis for binding of proline-rich peptides to SH3 domains. Cell. 76:933-945.
63. Zhang, J.W., and P.B. Lazarow. 1995. PEB1 (PAS7) in Saccharomyces cerevisiae encodes a hydrophilic, intra-peroxisomal protein that is a member of the WD repeat family and is essential for the import of thiolase into peroxisomes. J. Cell Biol. 129:65-80.