The human peroxisomal targeting signal receptor, Pex5p, is translocated into the peroxisomal matrix and recycled to the cytosol

Cell

Volumn 105, Issue 2, 2001, Pages 187-196

  Dammai, Vincent ^a   Subramani, Suresh ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSOL RECEPTOR; MEMBRANE PROTEIN; PEROXISOMAL TARGETING SIGNAL RECEPTOR PEX5P; RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE PERMEABILITY; CELL ORGANELLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; PEROXISOME; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION;

EID: 0035917528     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(01)00310-5     Document Type: Article

References (25)

1. PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import
2. Mechanism of protein import across the chloroplast envelope
3. Multiple PEX genes are required for proper subcellular distribution and stability of Pex5p, the PTS1 receptor: Evidence that PTS1 protein import is mediated by a cycling receptor
4. Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders
5. The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import PTS1-containing proteins
6. Saccharomyces cerevisiae peroxisomal thiolase is imported as a dimer
7. Transport between the cell nucleus and the cytoplasm
8. Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTS1 receptor
9. Characterization of peroxisomal Pex5p from rat liver. Pex5p in the Pex5p-Pex14p membrane complex is a transmembrane protein
10. Structural analysis of cDNA for rat peroxisomal 3-ketoacyl-CoA thiolase
11. Pichia pastoris Pex14p, a phosphorylated peroxisomal membrane protein, is part of a PTS-receptor docking complex and interacts with many peroxins
12. Targeting of proteins to mitochondria
13. An oligomeric protein is imported into peroxisomes in vivo
14. Molecular anatomy of the peroxin Pex12p: RING finger domain is essential for the Pex12p function and interacts with the peroxisome targeting signal type 1-receptor Pex5p and a RING peroxin, Pex10p
15. The mammalian peroxin Pex5pL, the longer isoform of the mobile peroxisome targeting signal (PTS) type 1 transporter, translocates the Pex7p.PTS2 protein complex into peroxisomes via its initial docking site, Pex14p
16. Regulation of ribosome detachment from the mammalian endoplasmic reticulum membrane
17. How proteins penetrate peroxisomes
18. A novel RING finger protein complex essential for a late step in protein transport to the yeast vacuole
19. Import of peroxisomal matrix and membrane proteins
20. A novel, cleavable peroxisomal targeting signal at the amino-terminus of the rat 3-ketoacyl-CoA thiolase
21. Pay32p of the yeast Yarrowia lipolytica is an intraperoxisomal component of the matrix protein translocation machinery
22. Import of stably folded proteins into peroxisomes
23. Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders
24. Novel peroxisomal populations in subcellular fractions from rat liver. Implications for peroxisome structure and biogenesis
25. Peb1p (Pas7p) is an intraperoxisomal receptor for the NH2-terminal, type 2, peroxisomal targeting sequence of thiolase: Peb1p itself is targeted to peroxisomes by an NH2-terminal peptide