Pex13p: Docking or cargo handling protein?

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1763, Issue 12, 2006, Pages 1585-1591

  Williams, Chris ^a   Distel, Ben ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

P x x P motif; Peroxisome; Pex13p; Pex5p; Protein import; SH3 domain; W x x x F Y motif

Indexed keywords

DOCKING PROTEIN; MEMBRANE PROTEIN; PEX13P PROTEIN; PEX5P PROTEIN; PROTEIN; PROTEIN SH3;

AMINO TERMINAL SEQUENCE; BINDING SITE; MAMMAL; NONHUMAN; PEROXISOME; PICHIA PASTORIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; SACCHAROMYCES CEREVISIAE; YEAST;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; MAMMALS; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PICHIA; PROTEIN BINDING; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SRC HOMOLOGY DOMAINS;

MAMMALIA; PICHIA PASTORIS; SACCHAROMYCES CEREVISIAE;

EID: 33845321378     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2006.09.007     Document Type: Review

References (37)

1. Albertini M., Rehling P., Erdmann R., Girzalsky W., Kiel J.A., Veenhuis M., and Kunau W.H. Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways. Cell 89 (1997) 83-92
2. Brocard C., Lametschwandtner G., Koudelka R., and Hartig A. Pex14p is a member of the protein linkage map of Pex5p. EMBO J. 16 (1997) 5491-5500
3. Elgersma Y., Kwast L., Klein A., Voorn-Brouwer T., van den Berg M., Metzig B., America T., Tabak H.F., and Distel B. The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import PTS1-containing proteins. J. Cell Biol. 135 (1996) 97-109
4. Erdmann R., and Blobel G. Identification of Pex13p a peroxisomal membrane receptor for the PTS1 recognition factor. J. Cell Biol. 135 (1996) 111-121
5. Fransen M., Terlecky S.R., and Subramani S. Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 8087-8092
6. Gould S.J., Kalish J.E., Morrell J.C., Bjorkman J., Urquhart A.J., and Crane D.I. Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTS1 receptor. J. Cell Biol. 135 (1996) 85-95
7. Huhse B., Rehling P., Albertini M., Blank L., Meller K., and Kunau W.H. Pex17p of Saccharomyces cerevisiae is a novel peroxin and component of the peroxisomal protein translocation machinery. J. Cell Biol. 140 (1998) 49-60
8. Komori M., Rasmussen S.W., Kiel J.A., Baerends R.J., Cregg J.M., van der Klei I.J., and Veenhuis M. The Hansenula polymorpha PEX14 gene encodes a novel peroxisomal membrane protein essential for peroxisome biogenesis. EMBO J. 16 (1997) 44-53
9. Shimizu N., Itoh R., Hirono Y., Otera H., Ghaedi K., Tateishi K., Tamura S., Okumoto K., Harano T., Mukai S., and Fujiki Y. The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis. J. Biol. Chem. 274 (1999) 12593-12604
10. Will G.K., Soukupova M., Hong X., Erdmann K.S., Kiel J.A., Dodt G., Kunau W.H., and Erdmann R. Identification and characterization of the human orthologue of yeast Pex14p. Mol. Cell. Biol. 19 (1999) 2265-2277
11. Purdue P.E., and Lazarow P.B. Peroxisome biogenesis. Annu. Rev. Cell Dev. Biol. 17 (2001) 701-752
12. Barnett P., Bottger G., Klein A.T., Tabak H.F., and Distel B. The peroxisomal membrane protein Pex13p shows a novel mode of SH3 interaction. EMBO J. 19 (2000) 6382-6391
13. Bottger G., Barnett P., Klein A.T., Kragt A., Tabak H.F., and Distel B. Saccharomyces cerevisiae PTS1 receptor Pex5p interacts with the SH3 domain of the peroxisomal membrane protein Pex13p in an unconventional, non-PXXP-related manner. Mol. Biol. Cell 11 (2000) 3963-3976
14. Girzalsky W., Rehling P., Stein K., Kipper J., Blank L., Kunau W.H., and Erdmann R. Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes. J. Cell Biol. 144 (1999) 1151-1162
15. Otera H., Harano T., Honsho M., Ghaedi K., Mukai S., Tanaka A., Kawai A., Shimizu N., and Fujiki Y. The mammalian peroxin Pex5pL, the longer isoform of the mobile peroxisome targeting signal (PTS) type 1 transporter, translocates the Pex7p.PTS2 protein complex into peroxisomes via its initial docking site, Pex14p. J. Biol. Chem. 275 (2000) 21703-21714
16. Schliebs W., Saidowsky J., Agianian B., Dodt G., Herberg F.W., and Kunau W.H. Recombinant human peroxisomal targeting signal receptor PEX5. Structural basis for interaction of PEX5 with PEX14. J. Biol. Chem. 274 (1999) 5666-5673
17. Urquhart A.J., Kennedy D., Gould S.J., and Crane D.I. Interaction of Pex5p, the type 1 peroxisome targeting signal receptor, with the peroxisomal membrane proteins Pex14p and Pex13p. J. Biol. Chem. 275 (2000) 4127-4136
18. Elgersma Y., van den Berg M., Tabak H.F., and Distel B. An efficient positive selection procedure for the isolation of peroxisomal import and peroxisome assembly mutants of Saccharomyces cerevisiae. Genetics 135 (1993) 731-740
19. Gould S.J., McCollum D., Spong A.P., Heyman J.A., and Subramani S. Development of the yeast Pichia pastoris as a model organism for a genetic and molecular analysis of peroxisome assembly. Yeast 8 (1992) 613-628
20. Otera H., Setoguchi K., Hamasaki M., Kumashiro T., Shimizu N., and Fujiki Y. Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import. Mol. Cell. Biol. 22 (2002) 1639-1655
21. Stein K., Schell-Steven A., Erdmann R., and Rottensteiner H. Interactions of Pex7p and Pex18p/Pex21p with the peroxisomal docking machinery: Implications for the first steps in PTS2 protein import. Mol. Cell. Biol. 22 (2002) 6056-6069
22. Kay B.K., Williamson M.P., and Sudol M. The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains. FASEB J. 14 (2000) 231-241
23. Mayer B.J. SH3 domains: complexity in moderation. J. Cell Sci. 114 (2001) 1253-1263
24. Feng S., Chen J.K., Yu H., Simon J.A., and Schreiber S.L. Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions. Science 266 (1994) 1241-1247
25. Lim W.A., Richards F.M., and Fox R.O. Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains. Nature 372 (1994) 375-379
26. Kang H., Freund C., Duke-Cohan J.S., Musacchio A., Wagner G., and Rudd C.E. SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55. EMBO J. 19 (2000) 2889-2899
27. Mongiovi A.M., Romano P.R., Panni S., Mendoza M., Wong W.T., Musacchio A., Cesareni G., and Di Fiore P.P. A novel peptide-SH3 interaction. EMBO J. 18 (1999) 5300-5309
28. Douangamath A., Filipp F.V., Klein A.T., Barnett P., Zou P., Voorn-Brouwer T., Vega M.C., Mayans O.M., Sattler M., Distel B., and Wilmanns M. Topography for independent binding of alpha-helical and PPII-helical ligands to a peroxisomal SH3 domain. Mol. Cell 10 (2002) 1007-1017
29. Pires J.R., Hong X., Brockmann C., Volkmer-Engert R., Schneider-Mergener J., Oschkinat H., and Erdmann R. The ScPex13p SH3 domain exposes two distinct binding sites for Pex5p and Pex14p. J. Mol. Biol. 326 (2003) 1427-1435
30. Schell-Steven A., Stein K., Amoros M., Landgraf C., Volkmer-Engert R., Rottensteiner H., and Erdmann R. Identification of a novel, intraperoxisomal pex14-binding site in pex13: association of pex13 with the docking complex is essential for peroxisomal matrix protein import. Mol. Cell. Biol. 25 (2005) 3007-3018
31. Saidowsky J., Dodt G., Kirchberg K., Wegner A., Nastainczyk W., Kunau W.H., and Schliebs W. The di-aromatic pentapeptide repeats of the human peroxisome import receptor PEX5 are separate high affinity binding sites for the peroxisomal membrane protein PEX14. J. Biol. Chem. 276 (2001) 34524-34529
32. Kami K., Takeya R., Sumimoto H., and Kohda D. Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13p. EMBO J. 21 (2002) 4268-4276
33. Agne B., Meindl N.M., Niederhoff K., Einwachter H., Rehling P., Sickmann A., Meyer H.E., Girzalsky W., and Kunau W.H. Pex8p: an intraperoxisomal organizer of the peroxisomal import machinery. Mol. Cell 11 (2003) 635-646
34. Reguenga C., Oliveira M.E., Gouveia A.M., Sa-Miranda C., and Azevedo J.E. Characterization of the mammalian peroxisomal import machinery: Pex2p, Pex5p, Pex12p, and Pex14p are subunits of the same protein assembly. J. Biol. Chem. 276 (2001) 29935-29942
35. Salomons F.A., Kiel J.A., Faber K.N., Veenhuis M., and van der Klei I.J. Overproduction of Pex5p stimulates import of alcohol oxidase and dihydroxyacetone synthase in a Hansenula polymorpha Pex14 null mutant. J. Biol. Chem. 275 (2000) 12603-12611
36. Geuze H.J., Murk J.L., Stroobants A.K., Griffith J.M., Kleijmeer M.J., Koster A.J., Verkleij A.J., Distel B., and Tabak H.F. Involvement of the endoplasmic reticulum in peroxisome formation. Mol. Biol. Cell 14 (2003) 2900-2907
37. Tabak H.F., Hoepfner D., v.d. Zand A., Geuze H.J., Braakman I., and Huynen M.A. Formation of peroxisomes: Present and past. Mol. Cell Res. 1763 (2006) 1647-1654 10.1016/j.bbamcr.2006.08.045 (this issue)