Biodegradable polymersomes loaded with both paclitaxel and doxorubicin permeate and shrink tumors, inducing apoptosis in proportion to accumulated drug

Journal of Controlled Release

Volumn 116, Issue 2 SPEC. ISS., 2006, Pages 150-158

  Ahmed, Fariyal ^a   Pakunlu, Refika I ^b   Brannan, Aaron ^c   Bates, Frank ^c   Minko, Tamara ^b   Discher, Dennis E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Biodegradable; Combination therapy; Drug delivery; Polymersome; Tumors

Indexed keywords

BIODEGRADATION; CONTROLLED DRUG DELIVERY; DRUG PRODUCTS; HYDROPHILICITY; HYDROPHOBICITY; TUMORS;

COMBINATION THERAPY; DRUG INJECTION; MULTI-DRUG DELIVERY; POLYMERSOME;

BIOPOLYMERS;

COPOLYMER; DOXORUBICIN; OB 18; OL 2; PACLITAXEL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIODEGRADABILITY; CANCER INHIBITION; CELL DEATH; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DELIVERY SYSTEM; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR GROWTH;

EID: 33845296078     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2006.07.012     Document Type: Article

References (35)

1. Briasoulis E., Pentheroudakis G., Karavasilis V., Tzamakou E., Rammou D., and Pavlidis N. Annals of Oncology 15 (2004) 1566-1573
2. Gustafson D.L., Merz A.L., and Long M.E. Cancer Letter 220 (2005) 161-169
3. Briasoulis E., Karavasilis V., Tzamakou E., Rammou D., Soulti K., Piperidou C., and Pavlidis N. Cancer Chemotherapy and Pharmacology 53 (2004) 452-457
4. Mavroudis D., Kouroussis C., Kakolyris S., Agelaki S., Kalbakis K., Androulakis N., Souglakos J., Samonis G., and Georgoulias V. Oncology 62 (2002) 216-222
5. Gehl J., Boesgaard M., Paaske T., Jensen B.V., and Dombernowsky. Annals of Oncology 7 (1996) 687-693
6. Bafaloukos D., Papadimitriou C., Linardou H., Aravantinos G., Papakostas P., Skarlos D., Kosmidis P., Fountzilas G., Gogas H., Kalofonos C., and Dimopoulos A.M. British Journal of Cancer 91 (2004) 1639-1644
7. Yamaguchi J., Nishimura Y., Kanada A., Kobayashi M., Mishima K., Tatsuishi T., Iwase K., and Oyama Y. Toxicology 211 (2005) 179-186
8. Dorr R.T. The Annals of Pharmacotherapy 28 (1994) 11-14
9. Park J.W. Breast Cancer Research 4 (2002) 95-99
10. Immordino M.L., Brusa P., Arpicco S., Stella B., Dosio F., and Cattel L. Journal of Controlled Release 91 (2003) 417-429
11. Omayra L., Padilla D.J., Henrik R.I., Gagne L., Frechet J.M.J., and Szoka F.C. Bioconjugate Chemistry 13 (2002) 453-461
12. Olson F., Mayhew E., Maslow D., Rustum Y., and Szoka F. European Journal of Cancer & Clinical Oncology 18 (1982) 167-176
13. Hong R.-L., Huang C.-J., Tseng Y.-L., Pang V.F., Chen S.-T., Liu J.-J., and Chang F.-H. Clinical Cancer Research 5 (1999) 3645-3652
14. Meng F., Engbers G.H.M., and Feijen J. Journal of Controlled Release 101 (2005) 187-198
15. Ahmed F., and Discher D.E. Journal of Controlled Release 96 (2004) 37-53
16. Photos P.J., Bacakova L., Discher B., Bates F.S., and Discher D.E. Journal of Controlled Release 90 (2003) 323-334
17. F. Ahmed, G. Srinivas, R.I. Pakunlu, A. Brannan, F.S. Bates, M.L. Klein, T. Minko and D.E. Discher, 3 (2006) 340-350.
18. Bermudez H., Brannan A.K., Hammer D.A., Bates F.S., and Discher D.E. Macromolecules 35 (2002) 8203-8208
19. Mayer L.D., Bally M.B., and Cullis P.R. Biochimica et Biophysica Acta 857 (1986) 123-126
20. Pakunlu R.I., Wang Y., Tsao W., Pozharov V., Cook T.J., and Minko T. Cancer Research 64 (2004) 6214-6224
21. Minko T., Kopeckova P., and Kopecek J. International Journal of Cancer 86 (2000) 108-117
22. Abraham S.A., Edwards K., Karlsson G., MacIntosh S., Mayer L.D., McKenzie C., and Bally M.B. Biochimica et Biophysica Acta 1565 (2002) 41-54
23. Santos N.D., Cox K.A., McKenzie C.A., Baarda F.V., Gallagher R.C., Karlsson G., Edwards K., Mayer L.D., Allen C., and Bally M.B. Biochimica et Biophysica Acta 1661 (2004) 47-60
24. Grayson A.C., Cima M.J., and Langer R. Biomaterials 26 (2005) 2137-2145
25. Ivanova T., Panaiotov I., Boury F., Proust J.E., Benoit J.P., and Verger R. Colloids and Surfaces. B, Biointerfaces 8 (1997) 217-225
26. Ishida O., Maruyama K., Sasaki K., and Iwatsuru M. International Journal of Pharmaceutics 190 (1999) 49-56
27. Wong P., Lee C., and Tannock F. Clinical Cancer Research 11 (2005) 3553-3557
28. Roux E., Lafleur M., Lataste E., Moreau P., and Leroux J.-C. Biomacromolecules 4 (2003) 240-248
29. Lokling K.-E., Fossheim S.L., Klaveness J., and Skurtveit R. Journal of Controlled Release 98 (2004) 87-95
30. Simoes S., Moreira J.N., Fonseca C., Duzgunes N., and Pedroso de Lima M.C. Advanced Drug Delivery Reviews 56 (2004) 947-965
31. Guo X., and Szoka F.C. Bioconjugate Chemistry 12 (2001) 291-300
32. Belguise K., Kersual N., Galtier F., and Chalbos D. Oncogene 24 (2005) 1434-1444
33. Hashizume H., Baluk P., Morikawa S., McLean J.W., Thurston G., Sylvie R., Jain R.K., and McDonald D.M. American Journal of Pathology 156 (2000) 1363-1380
34. Charrois G.J.R., and Allen T.M. Biochimica et Biophysica Acta 2003 (2003) 102-108
35. Gabizon A., Goren D., Horowitz A.T., Tzemach D., Lossos A., and Siegal T. Advanced Drug Delivery Reviews 24 (1997) 337-344