Biodistribution of pH-responsive liposomes for MRI and a novel approach to improve the pH-responsiveness

Journal of Controlled Release

Volumn 98, Issue 1, 2004, Pages 87-95

  Løkling, Knut Egil ^a   Fossheim, Sigrid L ^b   Klaveness, Jo ^a   Skurtveit, Roald ^b  

^a UNIVERSITY OF OSLO   (Norway)

^b Amersham Health AS   (Norway)

Author keywords

Biodistribution; Contrast agents; Paramagnetic liposomes; pH sensitivity; Protein binding; Relaxivity

Indexed keywords

ACIDITY; BLOOD; IMAGE PROCESSING; MAGNETIC RESONANCE IMAGING; PARAMAGNETISM; PH EFFECTS; POLYETHYLENE GLYCOLS; SENSITIVITY ANALYSIS; TUMORS;

BIODISTRIBUTION; BLOOD CIRCULATION; BLOOD RETENTION TIME;

BIOMEDICAL ENGINEERING;

ALBUMIN; CHELATING AGENT; DIPALMITOYLGLYCEROSUCCINATE; DIPALMITOYLPHOSPHATIDYLETHANOLAMINE; LIPOSOME; MACROGOL; SUCCINIC ACID DERIVATIVE; TRISODIUM[[2 [(4,4 DIPHENYLCYCLOHEXYL)PHOSPHONOOXYMETHYL]DIETHYLENETRIAMINE PENTAACETATO]GADOLINIUM]; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BIOAVAILABILITY; CIRCULATION; CONTROLLED STUDY; DRUG RELEASE; ENCAPSULATION; INJECTION; LIVER; MALE; MOLECULAR WEIGHT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PH; PLASMA CLEARANCE; PRIORITY JOURNAL; RAT; TIME;

ANIMALS; HYDROGEN-ION CONCENTRATION; LIPOSOMES; MAGNETIC RESONANCE IMAGING; MALE; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 3042813623     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2004.04.015     Document Type: Article

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