Insulin sensitizer, troglitazone, directly inhibits aromatase activity in human ovarian granulosa cells

Biochemical and Biophysical Research Communications

Volumn 271, Issue 3, 2000, Pages 710-713

  Mu, Yi Ming ^a   Yanase, Toshihiko ^a   Nishi, Yoshihiro ^b   Waseda, Naoko ^b   Oda, Tanaka ^b   Tanaka, Atsushi ^c   Takayanagi, Ryoichi ^a   Nawata, Hajime ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b National Hospital Organization   (Japan)

^c St Mother's Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6 [1 (5,6,7,8 TETRAHYDRO 3,5,5,8,8 PENTAMETHYL 2 NAPHTHYL)CYCLOPROPYL]NICOTINIC ACID; AROMATASE; INSULIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; RETINOID X RECEPTOR; TROGLITAZONE;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; GENE EXPRESSION; GRANULOSA CELL; HUMAN; HUMAN CELL; INSULIN SENSITIVITY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0034685629     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.2701     Document Type: Article

References (18)

1. Spiegelman, B. M. (1998) Diabetes 47, 507-514.
2. Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., and Kliewer, S. A. (1995) J. Biol. Chem. 270, 12953-12956.
3. Dunaif, A., Sxott, D., Finegood, D., Quintana, B., and Whitcomb, R. (1996) J. Clin. Endocrinol. Metab. 81, 3299-3306.
4. Franks, S. (1995) N. Engl. J. Med. 333, 853-861.
5. Gasic, S., Bodenburg, Y., Nagamani, M., Green, A., and Urban, R. J. (1998) Endocrinology 139, 4962-4966.
6. Boehm, M. F., Zhang, L., Zhi, L., McClurg, M. R., Berger, E., Wagoner, M., Mais, D. E., Suto, C. M., Davies, J. A., and Heyman, R. A. (1995) J. Med. Chem. 38, 3146-3155.
7. Tanaka, S., Haji, M., Takayanagi, R., Tanaka, S., Sugioka, Y., and Nawata, H. (1996) Endocrinology 137, 1860-1869.
8. Yanase, T., Yashiro, T., Takitani, K., Kato, S., Taniguchi, S., Takayanagi, R., and Nawata, H. (1997) Biochem. Biophys. Res. Commun. 233, 320-324.
9. Nakajima-Iijima, S., Hamada, H., Reddy, P., and Kakunaga, T. (1985) Proc. Natl. Acad. Sci. USA 82, 6133-6137.
10. Nolan, J. J., Ludvik, B., Beerdsen, P., Joyce, M., and Olefsky, J. (1994) N. Engl. J. Med. 331, 1188-1193.
11. Nestler, J. E., Barlascini, C. O., and Matt, D. W. (1989) J. Clin. Endocrinol. Metab. 68, 1027-1032.
12. Nestler, J. E., and Straus, J. F., III (1991) Endocrinol. Metab. Clin. North. Am. 20, 807-823.
13. Dunaif, A., and Graf, M. (1989) J. Clin. Invest. 83, 23-29.
14. Amsterdam, A., and Selvarai, N. (1997) Endocr. Rev. 18, 435-461.
15. Sasano, H., and Harada, N. (1998) Endocr. Rev. 19, 593-607.
16. Mukherjee, R., Davies, P. J., Crombie, D. L., Bischoff, E. D., Cesario, R. M., Jow, L., Hamann, L. G., Boehm, M. F., Mondon, C. E., Nadzan, M., Paterniti, J. R., Jr., and Heyman, R. A. (1997) Nature 386, 407-410.
17. Tontonoz, P., Singer, S., Forman, B. M., Sarraf, P., Fletcher, J. A., Fletcher, C. D., Brun, R. P., Mueller, E., Altiok, S., Oppenheim, H., Evans, R. M., and Spiegelman, B. M. (1997) Proc. Natl. Acad. Sci. USA 94, 237-241.
18. Rubin, G. L., Kalus, A. M., and Simpson, E. R. (1999) The Endocrine Society's 81st Annual Meeting, San Diego, CA, 1999, p. 101.