The SCL 3′ enhancer responds to Hedgehog signaling during hemangioblast specification

Experimental Hematology

Volumn 34, Issue 12, 2006, Pages 1643.e1-1643.e9

  Hochman, Eldar ^a   Kinston, Sarah ^b   Harmelin, Alon ^c   Göttgens, Berthold ^b   Izraeli, Shai ^a  

^a Safra Children's Hospital   (Israel)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; GLI PROTEIN, MOUSE; KRUPPEL LIKE FACTOR; ONCOPROTEIN; TAL1 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; BINDING SITE; BLOOD CELL; CELL FATE; CELL LINE; CELL SPECIFICITY; CELL TYPE; CONTROLLED STUDY; EMBRYO; EMBRYO CULTURE; ENHANCER REGION; GENE CONTROL; HEMANGIOBLAST; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN INDUCTION; RECEPTOR BINDING; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE; ANIMAL; CELL CULTURE; DRUG EFFECT; EMBRYONIC STEM CELL; GENETICS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; METABOLISM; PHYSIOLOGY;

ERINACEIDAE; MUS MUSCULUS;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BINDING SITES; CELLS, CULTURED; EMBRYONIC STEM CELLS; ENHANCER ELEMENTS (GENETICS); HEDGEHOG PROTEINS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION;

EID: 33845201800     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2006.07.019     Document Type: Article

References (27)

1. Villavicencio E.H., Walterhouse D.O., and Iannaccone P.M. The sonic hedgehog-patched-gli pathway in human development and disease. Am J Hum Genet 67 (2000) 1047-1054
2. Berman D.M., Karhadkar S.S., Maitra A., et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 425 (2003) 846-851
3. Lum L., and Beachy P.A. The Hedgehog response network: sensors, switches, and routers. Science 304 (2004) 1755-1759
4. Dyer M.A., Farrington S.M., Mohn D., Munday J.R., and Baron M.H. Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo. Development 128 (2001) 1717-1730
5. Farrington S.M., Belaoussoff M., and Baron M.H. Winged-helix, Hedgehog and Bmp genes are differentially expressed in distinct cell layers of the murine yolk sac. Mech Dev 62 (1997) 197-211
6. Byrd N., Becker S., Maye P., et al. Hedgehog is required for murine yolk sac angiogenesis. Development 129 (2002) 361-372
7. Vokes S.A., Yatskievych T.A., Heimark R.L., et al. Hedgehog signaling is essential for endothelial tube formation during vasculogenesis. Development 131 (2004) 4371-4380
8. Lecuyer E., and Hoang T. SCL: from the origin of hematopoiesis to stem cells and leukemia. Exp Hematol 32 (2004) 11-24
9. Robb L., Lyons I., Li R., et al. Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci U S A 92 (1995) 7075-7079
10. Sanchez M., Gottgens B., Sinclair A.M., et al. An SCL 3′ enhancer targets developing endothelium together with embryonic and adult haematopoietic progenitors. Development 126 (1999) 3891-3904
11. Gottgens B., Nastos A., Kinston S., et al. Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors. EMBO J 21 (2002) 3039-3050
12. Rainis L., Toki T., Pimanda J.E., et al. The proto-oncogene ERG in megakaryoblastic leukemias. Cancer Res 65 (2005) 7596-7602
13. Tsai F.Y., Keller G., Kuo F.C., et al. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature 371 (1994) 221-226
14. Garrett-Sinha L.A., Dahl R., Rao S., Barton K.P., and Simon M.C. PU.1 exhibits partial functional redundancy with Spi-B, but not with Ets-1 or Elf-1. Blood 97 (2001) 2908-2912
15. Hart A., Melet F., Grossfeld P., et al. Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia. Immunity 13 (2000) 167-177
16. Ingram W.J., Wicking C.A., Grimmond S.M., Forrest A.R., and Wainwright B.J. Novel genes regulated by Sonic Hedgehog in pluripotent mesenchymal cells. Oncogene 21 (2002) 8196-8205
17. Sasaki H., Hui C., Nakafuku M., and Kondoh H. A binding site for Gli proteins is essential for HNF-3β floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development 124 (1997) 1313-1322
18. Belaoussoff M., Farrington S.M., and Baron M.H. Hematopoietic induction and respecification of A-P identity by visceral endoderm signaling in the mouse embryo. Development 125 (1998) 5009-5018
19. Cooper M.K., Porter J.A., Young K.E., and Beachy P.A. Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 280 (1998) 1603-1607
20. Kinzler K.W., and Vogelstein B. The GLI gene encodes a nuclear protein which binds specific sequences in the human genome. Mol Cell Biol 10 (1990) 634-642
21. Yoon J.W., Kita Y., Frank D.J., et al. Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation. J Biol Chem 277 (2002) 5548-5555
22. Duman-Scheel M., Weng L., Xin S., and Du W. Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E. Nature 417 (2002) 299-304
23. Hallikas O., Palin K., Sinjushina N., et al. Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity. Cell 124 (2006) 47-59
24. Kogerman P., Grimm T., Kogerman L., et al. Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1. Nat Cell Biol 1 (1999) 312-319
25. Baron M. Induction of embryonic hematopoietic and endothelial stem/progenitor cells by hedgehog-mediated signals. Differentiation 68 (2001) 175-185
26. Gottgens B., Broccardo C., Sanchez M.J., et al. The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5′ bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1. Mol Cell Biol 24 (2004) 1870-1883
27. Visvader J.E., Fujiwara Y., and Orkin S.H. Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development. Genes Dev 12 (1998) 473-479