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Volumn 8, Issue 6, 2006, Pages 465-471

Deranged energy substrate metabolism in the failing heart

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ACETYL COENZYME A; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; FATTY ACID; FLAVINE ADENINE NUCLEOTIDE; INSULIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; OXYGEN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; TRANSCRIPTION FACTOR;

EID: 33751569364     PISSN: 15226417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11906-006-0024-9     Document Type: Review
Times cited : (12)

References (47)
  • 1
    • 3042711537 scopus 로고    scopus 로고
    • Linking gene expression to function: Metabolic flexibility in the normal and diseased heart
    • Taegtmeyer H, Golfman L, Sharma S, et al.: Linking gene expression to function: metabolic flexibility in the normal and diseased heart. Ann N Y Acad Sci 2004, 1015:202-213.
    • (2004) Ann N Y Acad Sci , vol.1015 , pp. 202-213
    • Taegtmeyer, H.1    Golfman, L.2    Sharma, S.3
  • 2
  • 3
    • 0028144326 scopus 로고
    • Total-body and myocardial substrate oxidation in congestive heart failure
    • Paolisso G, Gambardella A, Galzerano D, et al.: Total-body and myocardial substrate oxidation in congestive heart failure. Metabolism 1994, 43:174-179.
    • (1994) Metabolism , vol.43 , pp. 174-179
    • Paolisso, G.1    Gambardella, A.2    Galzerano, D.3
  • 4
    • 0035136262 scopus 로고    scopus 로고
    • An evaluation of myocardial fatty acid and glucose uptake using PET with [18F]fluoro-6-thia-heptadecanoic acid and [18F]FDG in patients with congestive heart failure
    • Taylor M, Wallhaus TR, Degrado TR, et al.: An evaluation of myocardial fatty acid and glucose uptake using PET with [18F]fluoro-6-thia-heptadecanoic acid and [18F]FDG in patients with congestive heart failure. J Nucl Med 2001, 42:55-62.
    • (2001) J Nucl Med , vol.42 , pp. 55-62
    • Taylor, M.1    Wallhaus, T.R.2    Degrado, T.R.3
  • 5
    • 0037125371 scopus 로고    scopus 로고
    • Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy
    • Davila-Roman VG, Vedala G, Herrero P, et al.: Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy. J Am Coll Cardiol 2002, 40:271-277.
    • (2002) J Am Coll Cardiol , vol.40 , pp. 271-277
    • Davila-Roman, V.G.1    Vedala, G.2    Herrero, P.3
  • 6
    • 4744373271 scopus 로고    scopus 로고
    • Moderate severity heart failure does not involve a downregulation of myocardial fatty acid oxidation
    • Chandler MP, Kerner J, Huang H, et al.: Moderate severity heart failure does not involve a downregulation of myocardial fatty acid oxidation. Am J Physiol Heart Circ Physiol 2004, 287:H1538-H1543.
    • (2004) Am J Physiol Heart Circ Physiol , vol.287
    • Chandler, M.P.1    Kerner, J.2    Huang, H.3
  • 7
    • 0029800177 scopus 로고    scopus 로고
    • Fatty acid oxidation enzyme gene expression is downregulated in the failing heart
    • Sack MN, Rader TA, Park S, et al.: Fatty acid oxidation enzyme gene expression is downregulated in the failing heart. Circulation 1996, 94:2837-2842.
    • (1996) Circulation , vol.94 , pp. 2837-2842
    • Sack, M.N.1    Rader, T.A.2    Park, S.3
  • 8
    • 0030923761 scopus 로고    scopus 로고
    • A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program
    • Sack MN, Disch DL, Rockman HA, Kelly DP: A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. Proc Natl A cad Sci U S A 1997, 94:6438-6443.
    • (1997) Proc Natl A Cad Sci U S A , vol.94 , pp. 6438-6443
    • Sack, M.N.1    Disch, D.L.2    Rockman, H.A.3    Kelly, D.P.4
  • 9
    • 0033933236 scopus 로고    scopus 로고
    • Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth
    • Barger PM, Brandt JM, Leone TC, et al.: Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth. J Clin Invest 2000, 105:1723-1730.
    • (2000) J Clin Invest , vol.105 , pp. 1723-1730
    • Barger, P.M.1    Brandt, J.M.2    Leone, T.C.3
  • 10
    • 0035846554 scopus 로고    scopus 로고
    • Metabolic gene expression in fetal and failing human heart
    • Razeghi P, Young ME, Alcorn JL, et al.: Metabolic gene expression in fetal and failing human heart. Circulation 2001, 104:2923-2931.
    • (2001) Circulation , vol.104 , pp. 2923-2931
    • Razeghi, P.1    Young, M.E.2    Alcorn, J.L.3
  • 11
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Nuclear control of metabolism
    • Desvergne B, Wahli W: Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 1999, 20:649-688.
    • (1999) Endocr Rev , vol.20 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 12
    • 0033803048 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis
    • Lehman JJ, Barger PM, Kovacs A, et al.: Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest 2000, 106:847-856.
    • (2000) J Clin Invest , vol.106 , pp. 847-856
    • Lehman, J.J.1    Barger, P.M.2    Kovacs, A.3
  • 13
    • 0032479423 scopus 로고    scopus 로고
    • Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner
    • Motojima K, Passilly P, Peters JM, et al.: Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner. J Biol Chem 1998, 273:16710-16714.
    • (1998) J Biol Chem , vol.273 , pp. 16710-16714
    • Motojima, K.1    Passilly, P.2    Peters, J.M.3
  • 14
    • 0033963182 scopus 로고    scopus 로고
    • Long-chain fatty acid-induced changes in gene expression in neonatal cardiac myocytes
    • van der Lee KA, Vork MM, De Vries JE, et al.: Long-chain fatty acid-induced changes in gene expression in neonatal cardiac myocytes. J Lipid Res 2000, 41:41-47.
    • (2000) J Lipid Res , vol.41 , pp. 41-47
    • van der Lee, K.A.1    Vork, M.M.2    De Vries, J.E.3
  • 15
    • 0032530765 scopus 로고    scopus 로고
    • A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor alpha-deficient mice
    • Djouadi F, Weinheimer CJ, Saffitz JE, et al.: A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor alpha-deficient mice. J Clin Invest 1998, 102:1083-1091.
    • (1998) J Clin Invest , vol.102 , pp. 1083-1091
    • Djouadi, F.1    Weinheimer, C.J.2    Saffitz, J.E.3
  • 16
    • 0032771096 scopus 로고    scopus 로고
    • The role of the peroxisome proliferator-activated receptor alpha (PPAR alpha) in the control of cardiac lipid metabolism
    • Djouadi F, Brandt JM, Weinheimer CJ, et al.: The role of the peroxisome proliferator-activated receptor alpha (PPAR alpha) in the control of cardiac lipid metabolism. Prostaglandins Leukot Essent Fatty Acids 1999, 60:339-343.
    • (1999) Prostaglandins Leukot Essent Fatty Acids , vol.60 , pp. 339-343
    • Djouadi, F.1    Brandt, J.M.2    Weinheimer, C.J.3
  • 17
    • 0035008901 scopus 로고    scopus 로고
    • Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids
    • Young ME, Goodwin GW, Ying J, et al.: Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids. Am J Physiol Endocrinol Metab 2001, 280: E471-E479.
    • (2001) Am J Physiol Endocrinol Metab , vol.280
    • Young, M.E.1    Goodwin, G.W.2    Ying, J.3
  • 18
    • 0037040203 scopus 로고    scopus 로고
    • A role for peroxisome proliferator-activated receptor alpha (PPARalpha) in the control of cardiac malonyl-CoA levels: Reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase
    • Campbell FM, Kozak R, Wagner A, et al.: A role for peroxisome proliferator-activated receptor alpha (PPARalpha) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase. J Biol Chem 2002, 277:4098-4103.
    • (2002) J Biol Chem , vol.277 , pp. 4098-4103
    • Campbell, F.M.1    Kozak, R.2    Wagner, A.3
  • 19
    • 0035920140 scopus 로고    scopus 로고
    • 2-dependent modulation of mitochondrial fatty acid oxidation
    • 2-dependent modulation of mitochondrial fatty acid oxidation. J Biol Chem 2001, 276:27605-27612.
    • (2001) J Biol Chem , vol.276 , pp. 27605-27612
    • Huss, J.M.1    Levy, F.H.2    Kelly, D.P.3
  • 20
    • 0035860177 scopus 로고    scopus 로고
    • Hypoxia in vivo decreases peroxisome proliferator-activated receptor alpha-regulated gene expression in rat heart
    • Razeghi P, Young ME, Abbasi S, Taegtmeyer H: Hypoxia in vivo decreases peroxisome proliferator-activated receptor alpha-regulated gene expression in rat heart. Biochem Biophys Res Commun 2001, 287:5-10.
    • (2001) Biochem Biophys Res Commun , vol.287 , pp. 5-10
    • Razeghi, P.1    Young, M.E.2    Abbasi, S.3    Taegtmeyer, H.4
  • 21
    • 14644429903 scopus 로고    scopus 로고
    • ERK MAPK regulation of cardiac X receptor is involved in impaired fatty acid beta-oxidation during hypertrophic growth
    • [abstract]
    • Ballal K, Sekiguchi K, Sarmishtha N, Barger P: ERK MAPK regulation of cardiac X receptor is involved in impaired fatty acid beta-oxidation during hypertrophic growth [abstract]. Circulation 2004, 110(suppl):946.
    • (2004) Circulation , vol.110 , Issue.SUPPL. , pp. 946
    • Ballal, K.1    Sekiguchi, K.2    Sarmishtha, N.3    Barger, P.4
  • 22
    • 0017408792 scopus 로고
    • Association of glycogenolysis with cardiac sarcoplasmic reticulum: II. Effect of glycogen depletion, deoxycholate solubilization and cardiac ischemia: Evidence for a phorphorylase kinase membrane complex
    • Entman ML, Bornet EP, Van Winkle WB, et al.: Association of glycogenolysis with cardiac sarcoplasmic reticulum: II. Effect of glycogen depletion, deoxycholate solubilization and cardiac ischemia: evidence for a phorphorylase kinase membrane complex. J Mol Cell Cardiol 1977, 9:515-528.
    • (1977) J Mol Cell Cardiol , vol.9 , pp. 515-528
    • Entman, M.L.1    Bornet, E.P.2    Van Winkle, W.B.3
  • 23
    • 21244492310 scopus 로고    scopus 로고
    • Myocardial substrate metabolism in the normal and failing heart
    • Stanley WC, Recchia FA, Lopaschuk GD: Myocardial substrate metabolism in the normal and failing heart. Physiol Rev 2005, 85:1093-1129.
    • (2005) Physiol Rev , vol.85 , pp. 1093-1129
    • Stanley, W.C.1    Recchia, F.A.2    Lopaschuk, G.D.3
  • 24
    • 22544438179 scopus 로고    scopus 로고
    • Downregulation of peroxisome proliferator-activated receptor-alpha gene expression in a mouse model of ischemic cardiomyopathy is dependent on reactive oxygen species and prevents lipotoxicity
    • Dewald O, Sharma S, Adrogue J, et al.: Downregulation of peroxisome proliferator-activated receptor-alpha gene expression in a mouse model of ischemic cardiomyopathy is dependent on reactive oxygen species and prevents lipotoxicity. Circulation 2005, 112:407-415.
    • (2005) Circulation , vol.112 , pp. 407-415
    • Dewald, O.1    Sharma, S.2    Adrogue, J.3
  • 25
    • 0035976932 scopus 로고    scopus 로고
    • Reactivation of peroxisome proliferator-activated receptor alpha is associated with contractile dysfunction in hypertrophied rat heart
    • Young ME, Laws FA, Goodwin GW, Taegtmeyer H: Reactivation of peroxisome proliferator-activated receptor alpha is associated with contractile dysfunction in hypertrophied rat heart. J Biol Chem 2001, 276:44390-44395.
    • (2001) J Biol Chem , vol.276 , pp. 44390-44395
    • Young, M.E.1    Laws, F.A.2    Goodwin, G.W.3    Taegtmeyer, H.4
  • 26
    • 19344362320 scopus 로고    scopus 로고
    • PPAR-alpha activation required for decreased glucose uptake and increased susceptibility to injury during ischemia
    • Panagia M, Gibbons GF, Radda GK, Clarke K: PPAR-alpha activation required for decreased glucose uptake and increased susceptibility to injury during ischemia. Am J Physiol Heart Circ Physiol 2005, 288:H2677-H2683.
    • (2005) Am J Physiol Heart Circ Physiol , vol.288
    • Panagia, M.1    Gibbons, G.F.2    Radda, G.K.3    Clarke, K.4
  • 27
    • 0036143320 scopus 로고    scopus 로고
    • The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus
    • Finck BN, Lehman JJ, Leone TC, et al.: The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. J Clin Invest 2002, 109:121-130.
    • (2002) J Clin Invest , vol.109 , pp. 121-130
    • Finck, B.N.1    Lehman, J.J.2    Leone, T.C.3
  • 28
    • 33644662725 scopus 로고    scopus 로고
    • Chronic activation of PPARalpha is detrimental to cardiac recovery after ischemia
    • Sambandam N, Morabito D, Wagg C, et al.: Chronic activation of PPARalpha is detrimental to cardiac recovery after ischemia. Am J Physiol Heart Circ Physiol 2006,290:H87-H95.
    • (2006) Am J Physiol Heart Circ Physiol , vol.290
    • Sambandam, N.1    Morabito, D.2    Wagg, C.3
  • 29
    • 0036670222 scopus 로고    scopus 로고
    • Stimulation of peroxisome-proliferator-activated receptor alpha (PPAR alpha) attenuates cardiac fibrosis and endothelin-1 production in pressure-overloaded rat hearts
    • Ogata T, Miyauchi T, Sakai S, et al.: Stimulation of peroxisome-proliferator-activated receptor alpha (PPAR alpha) attenuates cardiac fibrosis and endothelin-1 production in pressure-overloaded rat hearts. Clin Sci (Lond) 2002, 103(suppl 48):284S-288S
    • (2002) Clin Sci (Lond) , vol.103 , Issue.SUPPL. 48
    • Ogata, T.1    Miyauchi, T.2    Sakai, S.3
  • 30
    • 26844561663 scopus 로고    scopus 로고
    • Decreased contractile and metabolic reserve in peroxisome proliferator-activated receptor-alpha-null hearts can be rescued by increasing glucose transport and utilization
    • Luptak I, Balschi JA, Xing Y, et al.: Decreased contractile and metabolic reserve in peroxisome proliferator-activated receptor-alpha-null hearts can be rescued by increasing glucose transport and utilization. Circulation 2005, 112:2339-2346.
    • (2005) Circulation , vol.112 , pp. 2339-2346
    • Luptak, I.1    Balschi, J.A.2    Xing, Y.3
  • 31
    • 33745712686 scopus 로고    scopus 로고
    • Deletion of peroxisome proliferators-activated receptor-alpha induces an alteration of cardiac functions
    • Loichot C, Jesel L, Tesse A, et al.: Deletion of peroxisome proliferators-activated receptor-alpha induces an alteration of cardiac functions. Am J Physiol Heart Circ Physiol 2006, 291:H161-166.
    • (2006) Am J Physiol Heart Circ Physiol , vol.291
    • Loichot, C.1    Jesel, L.2    Tesse, A.3
  • 32
    • 0242525729 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-alpha protects the heart from ischemia/reperfusion injury
    • Yue TL, Bao W, Jucker BM, et al.: Activation of peroxisome proliferator-activated receptor-alpha protects the heart from ischemia/ reperfusion injury. Circulation 2003, 108:2393-2399.
    • (2003) Circulation , vol.108 , pp. 2393-2399
    • Yue, T.L.1    Bao, W.2    Jucker, B.M.3
  • 33
    • 2642581745 scopus 로고    scopus 로고
    • Activation of the peroxisome proliferator-activated receptor alpha protects against myocardial ischaemic injury and improves endothelial vasodilatation
    • Tabernero A, Schoonjans K, Jesel L, et al.: Activation of the peroxisome proliferator-activated receptor alpha protects against myocardial ischaemic injury and improves endothelial vasodilatation. BMC Pharmacol 2002, 2:10.
    • (2002) BMC Pharmacol , vol.2 , pp. 10
    • Tabernero, A.1    Schoonjans, K.2    Jesel, L.3
  • 34
    • 33645048176 scopus 로고    scopus 로고
    • Do PPARs play a role in cardiac hypertrophy and heart failure?
    • Tian Q, Barger PM: Do PPARs play a role in cardiac hypertrophy and heart failure? Drug Discov Today: Disease Mechanism 2005, 2:109-114.
    • (2005) Drug Discov Today: Disease Mechanism , vol.2 , pp. 109-114
    • Tian, Q.1    Barger, P.M.2
  • 35
    • 0345735302 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes
    • Cheng L, Ding G, Qin J, et al.: Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes. Biochem Biophys Res Commun 2004, 313:277-286.
    • (2004) Biochem Biophys Res Commun , vol.313 , pp. 277-286
    • Cheng, L.1    Ding, G.2    Qin, J.3
  • 36
    • 9144262378 scopus 로고    scopus 로고
    • Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy
    • Cheng L, Ding G, Qin Q, et al.: Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat Med 2004, 10:1245-1250.
    • (2004) Nat Med , vol.10 , pp. 1245-1250
    • Cheng, L.1    Ding, G.2    Qin, Q.3
  • 37
    • 20444450632 scopus 로고    scopus 로고
    • Thiazolidinediones, peripheral oedema and congestive heart failure: What is the evidence?
    • Patel C, Wyne KL, McGuire DK: Thiazolidinediones, peripheral oedema and congestive heart failure: what is the evidence? Diab Vasc Dis Res 2005, 2:61-66.
    • (2005) Diab Vasc Dis Res , vol.2 , pp. 61-66
    • Patel, C.1    Wyne, K.L.2    McGuire, D.K.3
  • 38
    • 4444358440 scopus 로고    scopus 로고
    • Beneficial and deleterious effects of rosiglitazone on hypertension development in spontaneously hypertensive rats
    • Wu L, Wang R, De Champlain J, Wilson TW: Beneficial and deleterious effects of rosiglitazone on hypertension development in spontaneously hypertensive rats. Am J Hypertens 2004, 17:749-756.
    • (2004) Am J Hypertens , vol.17 , pp. 749-756
    • Wu, L.1    Wang, R.2    De Champlain, J.3    Wilson, T.W.4
  • 39
    • 10744221479 scopus 로고    scopus 로고
    • Quantitative analysis of peroxisome proliferator-activated receptor gamma (PPARgamma) expression in arteries and hearts of patients with ischaemic or dilated cardiomyopathy
    • Mehrabi MR, Haslmayer P, Humpeler S, et al.: Quantitative analysis of peroxisome proliferator-activated receptor gamma (PPARgamma) expression in arteries and hearts of patients with ischaemic or dilated cardiomyopathy. Eur J Heart Fail 2003, 5:733-739.
    • (2003) Eur J Heart Fail , vol.5 , pp. 733-739
    • Mehrabi, M.R.1    Haslmayer, P.2    Humpeler, S.3
  • 40
    • 0035797865 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma activators inhibit cardiac hypertrophy in cardiac myocytes
    • Yamamoto K, Ohki R, Lee RT, et al.: Peroxisome proliferator-activated receptor gamma activators inhibit cardiac hypertrophy in cardiac myocytes. Circulation 2001, 104:1670-1675.
    • (2001) Circulation , vol.104 , pp. 1670-1675
    • Yamamoto, K.1    Ohki, R.2    Lee, R.T.3
  • 41
    • 0037066014 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo
    • Asakawa M, Takano H, Nagai T, et al.: Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo. Circulation 2002, 105:1240-1246.
    • (2002) Circulation , vol.105 , pp. 1240-1246
    • Asakawa, M.1    Takano, H.2    Nagai, T.3
  • 42
    • 24044476859 scopus 로고    scopus 로고
    • Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice
    • Duan SZ, Ivashchenko CY, Russell MW, et al.: Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice. Circ Res 2005, 97:372-379.
    • (2005) Circ Res , vol.97 , pp. 372-379
    • Duan, S.Z.1    Ivashchenko, C.Y.2    Russell, M.W.3
  • 43
    • 7744234747 scopus 로고    scopus 로고
    • Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart
    • Sharma S, Adrogue JV, Golfman L, et al.: Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart. FASEB J 2004, 18:1692-1700.
    • (2004) FASEB J , vol.18 , pp. 1692-1700
    • Sharma, S.1    Adrogue, J.V.2    Golfman, L.3
  • 44
    • 0037453056 scopus 로고    scopus 로고
    • Triglyceride accumulation protects against fatty acid-induced lipotoxicity
    • Listenberger LL, Han X, Lewis SE, et al.: Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci U S A 2003, 100:3077-3082.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 3077-3082
    • Listenberger, L.L.1    Han, X.2    Lewis, S.E.3
  • 45
    • 0032478314 scopus 로고    scopus 로고
    • Fatty acid-induced beta cell apoptosis: A link between obesity and diabetes
    • Shimabukuro M, Zhou YT, Levi M, Unger RH: Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci U S A 1998, 95:2498-2502.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 2498-2502
    • Shimabukuro, M.1    Zhou, Y.T.2    Levi, M.3    Unger, R.H.4
  • 46
    • 0036092239 scopus 로고    scopus 로고
    • Banting lecture 2001: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
    • McGarry JD: Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 2002,51:7-18.
    • (2002) Diabetes , vol.51 , pp. 7-18
    • McGarry, J.D.1
  • 47
    • 0033594980 scopus 로고    scopus 로고
    • A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: The PPARalpha-null mouse as a model of fatty acid oxidation disorders
    • Leone TC, Weinheimer CJ, Kelly DP: A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci USA 1999, 96:7473-7478.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7473-7478
    • Leone, T.C.1    Weinheimer, C.J.2    Kelly, D.P.3


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