-
1
-
-
3042711537
-
Linking gene expression to function: Metabolic flexibility in the normal and diseased heart
-
Taegtmeyer H, Golfman L, Sharma S, et al.: Linking gene expression to function: metabolic flexibility in the normal and diseased heart. Ann N Y Acad Sci 2004, 1015:202-213.
-
(2004)
Ann N Y Acad Sci
, vol.1015
, pp. 202-213
-
-
Taegtmeyer, H.1
Golfman, L.2
Sharma, S.3
-
3
-
-
0028144326
-
Total-body and myocardial substrate oxidation in congestive heart failure
-
Paolisso G, Gambardella A, Galzerano D, et al.: Total-body and myocardial substrate oxidation in congestive heart failure. Metabolism 1994, 43:174-179.
-
(1994)
Metabolism
, vol.43
, pp. 174-179
-
-
Paolisso, G.1
Gambardella, A.2
Galzerano, D.3
-
4
-
-
0035136262
-
An evaluation of myocardial fatty acid and glucose uptake using PET with [18F]fluoro-6-thia-heptadecanoic acid and [18F]FDG in patients with congestive heart failure
-
Taylor M, Wallhaus TR, Degrado TR, et al.: An evaluation of myocardial fatty acid and glucose uptake using PET with [18F]fluoro-6-thia-heptadecanoic acid and [18F]FDG in patients with congestive heart failure. J Nucl Med 2001, 42:55-62.
-
(2001)
J Nucl Med
, vol.42
, pp. 55-62
-
-
Taylor, M.1
Wallhaus, T.R.2
Degrado, T.R.3
-
5
-
-
0037125371
-
Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy
-
Davila-Roman VG, Vedala G, Herrero P, et al.: Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy. J Am Coll Cardiol 2002, 40:271-277.
-
(2002)
J Am Coll Cardiol
, vol.40
, pp. 271-277
-
-
Davila-Roman, V.G.1
Vedala, G.2
Herrero, P.3
-
6
-
-
4744373271
-
Moderate severity heart failure does not involve a downregulation of myocardial fatty acid oxidation
-
Chandler MP, Kerner J, Huang H, et al.: Moderate severity heart failure does not involve a downregulation of myocardial fatty acid oxidation. Am J Physiol Heart Circ Physiol 2004, 287:H1538-H1543.
-
(2004)
Am J Physiol Heart Circ Physiol
, vol.287
-
-
Chandler, M.P.1
Kerner, J.2
Huang, H.3
-
7
-
-
0029800177
-
Fatty acid oxidation enzyme gene expression is downregulated in the failing heart
-
Sack MN, Rader TA, Park S, et al.: Fatty acid oxidation enzyme gene expression is downregulated in the failing heart. Circulation 1996, 94:2837-2842.
-
(1996)
Circulation
, vol.94
, pp. 2837-2842
-
-
Sack, M.N.1
Rader, T.A.2
Park, S.3
-
8
-
-
0030923761
-
A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program
-
Sack MN, Disch DL, Rockman HA, Kelly DP: A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. Proc Natl A cad Sci U S A 1997, 94:6438-6443.
-
(1997)
Proc Natl A Cad Sci U S A
, vol.94
, pp. 6438-6443
-
-
Sack, M.N.1
Disch, D.L.2
Rockman, H.A.3
Kelly, D.P.4
-
9
-
-
0033933236
-
Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth
-
Barger PM, Brandt JM, Leone TC, et al.: Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth. J Clin Invest 2000, 105:1723-1730.
-
(2000)
J Clin Invest
, vol.105
, pp. 1723-1730
-
-
Barger, P.M.1
Brandt, J.M.2
Leone, T.C.3
-
10
-
-
0035846554
-
Metabolic gene expression in fetal and failing human heart
-
Razeghi P, Young ME, Alcorn JL, et al.: Metabolic gene expression in fetal and failing human heart. Circulation 2001, 104:2923-2931.
-
(2001)
Circulation
, vol.104
, pp. 2923-2931
-
-
Razeghi, P.1
Young, M.E.2
Alcorn, J.L.3
-
11
-
-
0033305213
-
Peroxisome proliferator-activated receptors: Nuclear control of metabolism
-
Desvergne B, Wahli W: Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 1999, 20:649-688.
-
(1999)
Endocr Rev
, vol.20
, pp. 649-688
-
-
Desvergne, B.1
Wahli, W.2
-
12
-
-
0033803048
-
Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis
-
Lehman JJ, Barger PM, Kovacs A, et al.: Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest 2000, 106:847-856.
-
(2000)
J Clin Invest
, vol.106
, pp. 847-856
-
-
Lehman, J.J.1
Barger, P.M.2
Kovacs, A.3
-
13
-
-
0032479423
-
Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner
-
Motojima K, Passilly P, Peters JM, et al.: Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner. J Biol Chem 1998, 273:16710-16714.
-
(1998)
J Biol Chem
, vol.273
, pp. 16710-16714
-
-
Motojima, K.1
Passilly, P.2
Peters, J.M.3
-
14
-
-
0033963182
-
Long-chain fatty acid-induced changes in gene expression in neonatal cardiac myocytes
-
van der Lee KA, Vork MM, De Vries JE, et al.: Long-chain fatty acid-induced changes in gene expression in neonatal cardiac myocytes. J Lipid Res 2000, 41:41-47.
-
(2000)
J Lipid Res
, vol.41
, pp. 41-47
-
-
van der Lee, K.A.1
Vork, M.M.2
De Vries, J.E.3
-
15
-
-
0032530765
-
A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor alpha-deficient mice
-
Djouadi F, Weinheimer CJ, Saffitz JE, et al.: A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor alpha-deficient mice. J Clin Invest 1998, 102:1083-1091.
-
(1998)
J Clin Invest
, vol.102
, pp. 1083-1091
-
-
Djouadi, F.1
Weinheimer, C.J.2
Saffitz, J.E.3
-
16
-
-
0032771096
-
The role of the peroxisome proliferator-activated receptor alpha (PPAR alpha) in the control of cardiac lipid metabolism
-
Djouadi F, Brandt JM, Weinheimer CJ, et al.: The role of the peroxisome proliferator-activated receptor alpha (PPAR alpha) in the control of cardiac lipid metabolism. Prostaglandins Leukot Essent Fatty Acids 1999, 60:339-343.
-
(1999)
Prostaglandins Leukot Essent Fatty Acids
, vol.60
, pp. 339-343
-
-
Djouadi, F.1
Brandt, J.M.2
Weinheimer, C.J.3
-
17
-
-
0035008901
-
Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids
-
Young ME, Goodwin GW, Ying J, et al.: Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids. Am J Physiol Endocrinol Metab 2001, 280: E471-E479.
-
(2001)
Am J Physiol Endocrinol Metab
, vol.280
-
-
Young, M.E.1
Goodwin, G.W.2
Ying, J.3
-
18
-
-
0037040203
-
A role for peroxisome proliferator-activated receptor alpha (PPARalpha) in the control of cardiac malonyl-CoA levels: Reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase
-
Campbell FM, Kozak R, Wagner A, et al.: A role for peroxisome proliferator-activated receptor alpha (PPARalpha) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase. J Biol Chem 2002, 277:4098-4103.
-
(2002)
J Biol Chem
, vol.277
, pp. 4098-4103
-
-
Campbell, F.M.1
Kozak, R.2
Wagner, A.3
-
19
-
-
0035920140
-
2-dependent modulation of mitochondrial fatty acid oxidation
-
2-dependent modulation of mitochondrial fatty acid oxidation. J Biol Chem 2001, 276:27605-27612.
-
(2001)
J Biol Chem
, vol.276
, pp. 27605-27612
-
-
Huss, J.M.1
Levy, F.H.2
Kelly, D.P.3
-
20
-
-
0035860177
-
Hypoxia in vivo decreases peroxisome proliferator-activated receptor alpha-regulated gene expression in rat heart
-
Razeghi P, Young ME, Abbasi S, Taegtmeyer H: Hypoxia in vivo decreases peroxisome proliferator-activated receptor alpha-regulated gene expression in rat heart. Biochem Biophys Res Commun 2001, 287:5-10.
-
(2001)
Biochem Biophys Res Commun
, vol.287
, pp. 5-10
-
-
Razeghi, P.1
Young, M.E.2
Abbasi, S.3
Taegtmeyer, H.4
-
21
-
-
14644429903
-
ERK MAPK regulation of cardiac X receptor is involved in impaired fatty acid beta-oxidation during hypertrophic growth
-
[abstract]
-
Ballal K, Sekiguchi K, Sarmishtha N, Barger P: ERK MAPK regulation of cardiac X receptor is involved in impaired fatty acid beta-oxidation during hypertrophic growth [abstract]. Circulation 2004, 110(suppl):946.
-
(2004)
Circulation
, vol.110
, Issue.SUPPL.
, pp. 946
-
-
Ballal, K.1
Sekiguchi, K.2
Sarmishtha, N.3
Barger, P.4
-
22
-
-
0017408792
-
Association of glycogenolysis with cardiac sarcoplasmic reticulum: II. Effect of glycogen depletion, deoxycholate solubilization and cardiac ischemia: Evidence for a phorphorylase kinase membrane complex
-
Entman ML, Bornet EP, Van Winkle WB, et al.: Association of glycogenolysis with cardiac sarcoplasmic reticulum: II. Effect of glycogen depletion, deoxycholate solubilization and cardiac ischemia: evidence for a phorphorylase kinase membrane complex. J Mol Cell Cardiol 1977, 9:515-528.
-
(1977)
J Mol Cell Cardiol
, vol.9
, pp. 515-528
-
-
Entman, M.L.1
Bornet, E.P.2
Van Winkle, W.B.3
-
23
-
-
21244492310
-
Myocardial substrate metabolism in the normal and failing heart
-
Stanley WC, Recchia FA, Lopaschuk GD: Myocardial substrate metabolism in the normal and failing heart. Physiol Rev 2005, 85:1093-1129.
-
(2005)
Physiol Rev
, vol.85
, pp. 1093-1129
-
-
Stanley, W.C.1
Recchia, F.A.2
Lopaschuk, G.D.3
-
24
-
-
22544438179
-
Downregulation of peroxisome proliferator-activated receptor-alpha gene expression in a mouse model of ischemic cardiomyopathy is dependent on reactive oxygen species and prevents lipotoxicity
-
Dewald O, Sharma S, Adrogue J, et al.: Downregulation of peroxisome proliferator-activated receptor-alpha gene expression in a mouse model of ischemic cardiomyopathy is dependent on reactive oxygen species and prevents lipotoxicity. Circulation 2005, 112:407-415.
-
(2005)
Circulation
, vol.112
, pp. 407-415
-
-
Dewald, O.1
Sharma, S.2
Adrogue, J.3
-
25
-
-
0035976932
-
Reactivation of peroxisome proliferator-activated receptor alpha is associated with contractile dysfunction in hypertrophied rat heart
-
Young ME, Laws FA, Goodwin GW, Taegtmeyer H: Reactivation of peroxisome proliferator-activated receptor alpha is associated with contractile dysfunction in hypertrophied rat heart. J Biol Chem 2001, 276:44390-44395.
-
(2001)
J Biol Chem
, vol.276
, pp. 44390-44395
-
-
Young, M.E.1
Laws, F.A.2
Goodwin, G.W.3
Taegtmeyer, H.4
-
26
-
-
19344362320
-
PPAR-alpha activation required for decreased glucose uptake and increased susceptibility to injury during ischemia
-
Panagia M, Gibbons GF, Radda GK, Clarke K: PPAR-alpha activation required for decreased glucose uptake and increased susceptibility to injury during ischemia. Am J Physiol Heart Circ Physiol 2005, 288:H2677-H2683.
-
(2005)
Am J Physiol Heart Circ Physiol
, vol.288
-
-
Panagia, M.1
Gibbons, G.F.2
Radda, G.K.3
Clarke, K.4
-
27
-
-
0036143320
-
The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus
-
Finck BN, Lehman JJ, Leone TC, et al.: The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. J Clin Invest 2002, 109:121-130.
-
(2002)
J Clin Invest
, vol.109
, pp. 121-130
-
-
Finck, B.N.1
Lehman, J.J.2
Leone, T.C.3
-
28
-
-
33644662725
-
Chronic activation of PPARalpha is detrimental to cardiac recovery after ischemia
-
Sambandam N, Morabito D, Wagg C, et al.: Chronic activation of PPARalpha is detrimental to cardiac recovery after ischemia. Am J Physiol Heart Circ Physiol 2006,290:H87-H95.
-
(2006)
Am J Physiol Heart Circ Physiol
, vol.290
-
-
Sambandam, N.1
Morabito, D.2
Wagg, C.3
-
29
-
-
0036670222
-
Stimulation of peroxisome-proliferator-activated receptor alpha (PPAR alpha) attenuates cardiac fibrosis and endothelin-1 production in pressure-overloaded rat hearts
-
Ogata T, Miyauchi T, Sakai S, et al.: Stimulation of peroxisome-proliferator-activated receptor alpha (PPAR alpha) attenuates cardiac fibrosis and endothelin-1 production in pressure-overloaded rat hearts. Clin Sci (Lond) 2002, 103(suppl 48):284S-288S
-
(2002)
Clin Sci (Lond)
, vol.103
, Issue.SUPPL. 48
-
-
Ogata, T.1
Miyauchi, T.2
Sakai, S.3
-
30
-
-
26844561663
-
Decreased contractile and metabolic reserve in peroxisome proliferator-activated receptor-alpha-null hearts can be rescued by increasing glucose transport and utilization
-
Luptak I, Balschi JA, Xing Y, et al.: Decreased contractile and metabolic reserve in peroxisome proliferator-activated receptor-alpha-null hearts can be rescued by increasing glucose transport and utilization. Circulation 2005, 112:2339-2346.
-
(2005)
Circulation
, vol.112
, pp. 2339-2346
-
-
Luptak, I.1
Balschi, J.A.2
Xing, Y.3
-
31
-
-
33745712686
-
Deletion of peroxisome proliferators-activated receptor-alpha induces an alteration of cardiac functions
-
Loichot C, Jesel L, Tesse A, et al.: Deletion of peroxisome proliferators-activated receptor-alpha induces an alteration of cardiac functions. Am J Physiol Heart Circ Physiol 2006, 291:H161-166.
-
(2006)
Am J Physiol Heart Circ Physiol
, vol.291
-
-
Loichot, C.1
Jesel, L.2
Tesse, A.3
-
32
-
-
0242525729
-
Activation of peroxisome proliferator-activated receptor-alpha protects the heart from ischemia/reperfusion injury
-
Yue TL, Bao W, Jucker BM, et al.: Activation of peroxisome proliferator-activated receptor-alpha protects the heart from ischemia/ reperfusion injury. Circulation 2003, 108:2393-2399.
-
(2003)
Circulation
, vol.108
, pp. 2393-2399
-
-
Yue, T.L.1
Bao, W.2
Jucker, B.M.3
-
33
-
-
2642581745
-
Activation of the peroxisome proliferator-activated receptor alpha protects against myocardial ischaemic injury and improves endothelial vasodilatation
-
Tabernero A, Schoonjans K, Jesel L, et al.: Activation of the peroxisome proliferator-activated receptor alpha protects against myocardial ischaemic injury and improves endothelial vasodilatation. BMC Pharmacol 2002, 2:10.
-
(2002)
BMC Pharmacol
, vol.2
, pp. 10
-
-
Tabernero, A.1
Schoonjans, K.2
Jesel, L.3
-
34
-
-
33645048176
-
Do PPARs play a role in cardiac hypertrophy and heart failure?
-
Tian Q, Barger PM: Do PPARs play a role in cardiac hypertrophy and heart failure? Drug Discov Today: Disease Mechanism 2005, 2:109-114.
-
(2005)
Drug Discov Today: Disease Mechanism
, vol.2
, pp. 109-114
-
-
Tian, Q.1
Barger, P.M.2
-
35
-
-
0345735302
-
Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes
-
Cheng L, Ding G, Qin J, et al.: Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes. Biochem Biophys Res Commun 2004, 313:277-286.
-
(2004)
Biochem Biophys Res Commun
, vol.313
, pp. 277-286
-
-
Cheng, L.1
Ding, G.2
Qin, J.3
-
36
-
-
9144262378
-
Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy
-
Cheng L, Ding G, Qin Q, et al.: Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat Med 2004, 10:1245-1250.
-
(2004)
Nat Med
, vol.10
, pp. 1245-1250
-
-
Cheng, L.1
Ding, G.2
Qin, Q.3
-
37
-
-
20444450632
-
Thiazolidinediones, peripheral oedema and congestive heart failure: What is the evidence?
-
Patel C, Wyne KL, McGuire DK: Thiazolidinediones, peripheral oedema and congestive heart failure: what is the evidence? Diab Vasc Dis Res 2005, 2:61-66.
-
(2005)
Diab Vasc Dis Res
, vol.2
, pp. 61-66
-
-
Patel, C.1
Wyne, K.L.2
McGuire, D.K.3
-
38
-
-
4444358440
-
Beneficial and deleterious effects of rosiglitazone on hypertension development in spontaneously hypertensive rats
-
Wu L, Wang R, De Champlain J, Wilson TW: Beneficial and deleterious effects of rosiglitazone on hypertension development in spontaneously hypertensive rats. Am J Hypertens 2004, 17:749-756.
-
(2004)
Am J Hypertens
, vol.17
, pp. 749-756
-
-
Wu, L.1
Wang, R.2
De Champlain, J.3
Wilson, T.W.4
-
39
-
-
10744221479
-
Quantitative analysis of peroxisome proliferator-activated receptor gamma (PPARgamma) expression in arteries and hearts of patients with ischaemic or dilated cardiomyopathy
-
Mehrabi MR, Haslmayer P, Humpeler S, et al.: Quantitative analysis of peroxisome proliferator-activated receptor gamma (PPARgamma) expression in arteries and hearts of patients with ischaemic or dilated cardiomyopathy. Eur J Heart Fail 2003, 5:733-739.
-
(2003)
Eur J Heart Fail
, vol.5
, pp. 733-739
-
-
Mehrabi, M.R.1
Haslmayer, P.2
Humpeler, S.3
-
40
-
-
0035797865
-
Peroxisome proliferator-activated receptor gamma activators inhibit cardiac hypertrophy in cardiac myocytes
-
Yamamoto K, Ohki R, Lee RT, et al.: Peroxisome proliferator-activated receptor gamma activators inhibit cardiac hypertrophy in cardiac myocytes. Circulation 2001, 104:1670-1675.
-
(2001)
Circulation
, vol.104
, pp. 1670-1675
-
-
Yamamoto, K.1
Ohki, R.2
Lee, R.T.3
-
41
-
-
0037066014
-
Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo
-
Asakawa M, Takano H, Nagai T, et al.: Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo. Circulation 2002, 105:1240-1246.
-
(2002)
Circulation
, vol.105
, pp. 1240-1246
-
-
Asakawa, M.1
Takano, H.2
Nagai, T.3
-
42
-
-
24044476859
-
Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice
-
Duan SZ, Ivashchenko CY, Russell MW, et al.: Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice. Circ Res 2005, 97:372-379.
-
(2005)
Circ Res
, vol.97
, pp. 372-379
-
-
Duan, S.Z.1
Ivashchenko, C.Y.2
Russell, M.W.3
-
43
-
-
7744234747
-
Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart
-
Sharma S, Adrogue JV, Golfman L, et al.: Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart. FASEB J 2004, 18:1692-1700.
-
(2004)
FASEB J
, vol.18
, pp. 1692-1700
-
-
Sharma, S.1
Adrogue, J.V.2
Golfman, L.3
-
44
-
-
0037453056
-
Triglyceride accumulation protects against fatty acid-induced lipotoxicity
-
Listenberger LL, Han X, Lewis SE, et al.: Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci U S A 2003, 100:3077-3082.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 3077-3082
-
-
Listenberger, L.L.1
Han, X.2
Lewis, S.E.3
-
45
-
-
0032478314
-
Fatty acid-induced beta cell apoptosis: A link between obesity and diabetes
-
Shimabukuro M, Zhou YT, Levi M, Unger RH: Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci U S A 1998, 95:2498-2502.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 2498-2502
-
-
Shimabukuro, M.1
Zhou, Y.T.2
Levi, M.3
Unger, R.H.4
-
46
-
-
0036092239
-
Banting lecture 2001: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
-
McGarry JD: Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 2002,51:7-18.
-
(2002)
Diabetes
, vol.51
, pp. 7-18
-
-
McGarry, J.D.1
-
47
-
-
0033594980
-
A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: The PPARalpha-null mouse as a model of fatty acid oxidation disorders
-
Leone TC, Weinheimer CJ, Kelly DP: A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci USA 1999, 96:7473-7478.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 7473-7478
-
-
Leone, T.C.1
Weinheimer, C.J.2
Kelly, D.P.3
|