An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway

EMBO Journal

Volumn 25, Issue 23, 2006, Pages 5549-5559

  Nakajima, Akihito ^a   Komazawa Sakon, Sachiko ^a   Takekawa, Mutsuhiro ^b   Sasazuki, Tomonari ^a   Yeh, Wen Chen ^c   Yagita, Hideo ^a   Okumura, Ko ^a   Nakano, Hiroyasu ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

c FLIP; c Jun N terminal kinase; NF B; Reactive oxygen species; Tumor necrosis factor

Indexed keywords

APOPTOSIS INHIBITOR; APOPTOSIS SIGNAL REGULATING KINASE 1; CASPASE; ENZYME ACTIVATOR; FLICE INHIBITORY PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; C FLIP GENE; CELL DEATH; CELL LEVEL; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; FIBROBLAST; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; NULL ALLELE; OXIDATIVE STRESS; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASES; FIBROBLASTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 1; MAP KINASE KINASE 7; MAP KINASE KINASE KINASE 1; MAP KINASE KINASE KINASE 5; MAP KINASE KINASE KINASES; NF-KAPPA B; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33751558995     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7601423     Document Type: Article

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