Cilostamide potentiates more the positive inotropic effects of (-)-adrenaline through β2-adrenoceptors than the effects of (-)-noradrenaline through β1-adrenoceptors in human atrial myocardium

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 374, Issue 3, 2006, Pages 249-253

  Christ, T ^a   Engel, A ^a   Ravens, U ^a   Kaumann, A J ^b  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

blocker treatment; 1 than 2 adrenoceptors; ( ) noradrenaline and ( ) adrenaline; Cilostamide and rolipram; Contractility; Human atrial trabeculae; Phosphodiesterase3

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 5 [2 [[2 HYDROXY 3 [4 (1 METHYL 4 TRIFLUOROMETHYL 2 IMIDAZOLYL)PHENOXY] PROPYL]AMINO]ETHOXY]SALICYLAMIDE; 5 [2 [[2 HYDROXY 3 [4 (1 METHYL 4 TRIFLUOROMETHYL 2 IMIDAZOLYL)PHENOXY]PROPYL]AMINO]ETHOXY]SALICYLAMIDE; ADRENALIN; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CILOSTAMIDE; CYCLIC AMP; ISOENZYME; NORADRENALIN; PHOSPHODIESTERASE III; PHOSPHODIESTERASE III INHIBITOR; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM; UNCLASSIFIED DRUG;

ADRENERGIC STIMULATION; AGED; ARTICLE; CLINICAL PATHWAY; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME MECHANISM; FEMALE; HEART ATRIUM MUSCLE; HEART MUSCLE CONTRACTILITY; HUMAN; HUMAN TISSUE; INOTROPISM; MALE; TRABECULAR BONE;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ADRENERGIC BETA-ANTAGONISTS; AGED; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; EPINEPHRINE; FEMALE; HEART ATRIA; HUMANS; HYDROLYSIS; MALE; MIDDLE AGED; MYOCARDIAL CONTRACTION; MYOCARDIUM; NOREPINEPHRINE; PHOSPHODIESTERASE INHIBITORS; QUINOLONES; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; ROLIPRAM;

EID: 33751401866     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-006-0119-5     Document Type: Article

References (25)

1. Bristow MR, Hershberger RE, Port JD, Minobe W, Rasmussen R (1989) Beta1- and beta 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium. Mol Pharmacol 35:295-303
2. s-coupled receptors are reduced by phosphodiesterase3 activity in human isolated myocardium. Biochemical Society focusing meeting. Compartmentalization of cyclic AMP signalling. King's Colledge, Cambridge, UK 29-30 March: P014
3. Crackower MA, Oudit GY, Kozieradzki I, Sarao R, Sun H, Sasaki T, Hirsch E, Suzuki A, Shioi T, Irie-Sasaki J, Sah R, Cheng H-YM, Rybin VO, Lembo G, Fratta L, Oliveira dos Santos A, Benovic JL, Kahn CR, Izumo S, Steinberg SF, Wymann M, Backx PH, Penninger JM (2002) Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signalling pathways. Cell 110:737-749
4. Francis SH, Turko IV, Corbin JD (2001) Cyclic nucleotide phosphodiesterases: relating structure and function. Prog Nucleic Acid Res Mol Biol 65:1-52
5. Gettys TW, Blackmore PF, Redmon JB, Beebe SJ, Corbin JD (1987) Short-term feedback regulation of cAMP by accelerated degradation in rat tissues. J Biol Chem 262:333-339
6. 2-adrenoceptors of human heart. Differential antagonism of the positive inotropic effects and adenylate cyclase stimulation by (-)-noradrenaline and (-)-adrenaline. Naunyn-Schmiedeberg's Arch Pharmacol 331:60-70
7. 2-adrenoceptors in human atrial myocardium. Circ Res 66:1610-1623
8. Kajimoto K, Hagiwara N, Kasanuki H, Hosoda S (1997) Contribution of phosphodiesterase isoenzymes to the regulation of the L-type calcium current in human cardiac myocytes. Br J Pharmacol 121:1549-1556
9. 2-adrenoceptor-mediated positive inotropic effects of adrenaline in human ventricular myocardium. Quantitative discrepancies with binding and adenylate stimulation. Naunyn-Schmiedeberg's Arch Pharmacol 331:60-70
10. 2-adrenoceptors in the stimulation of adenylate cyclase and contractile force. Eur Heart J 10 (Suppl B):29-37
11. 2-adrenoceptor activation by zinterol causes protein phophorylation, contractile effects and relaxant effects through a cAMP pathway in human atrium. Mol Cell Biochem 163-164:113-123
12. 2-adrenergic receptors. Proc Natl Acad Sci USA 90:10798-10802
13. Liu H, Maurice DH (1998) Expression of cyclic GMP-inhibited phosphodiesterases 3A and 3B (PDE3A and PDE3B) in rat tissues: differential subcellular localization and regulated expression by cyclic AMP. Br J Pharmacol 125:1501-1510
14. MacKenzie SJ, Baillie GS, McPhee I, Mackensie C, Seamons R, McSorley T, Millen J, Beard MB, van Heeke G, Houslay MD (2002) Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in upstream conserved region 1 (UCR1). Br J Pharmacol 136:421-433
15. Ca,L) through its positive modulation of type-3 phosphodiesterase (PDE3). J Cell Physiol 206:329-336
16. 3-adrenoceptors. Br J Pharmacol 120:165-176
17. 1-adrenoceptors in human heart. Cardiovasc Res 69:128-139
18. Mongillo M, McSorley T, Evellin S, Sood A, Lissandron V, Terrin A, Huston E, Hannawacker A, Lohse MJ, Pozzan T, Houslay MD, Zaccolo M (2004) Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases. Circ Res 95:67-75
19. Patrucco E, Notte A, Barberis L, Selvetella G, Maffei A, Brancaccio M, Marengo S, Russo G, Azzolino O, Rybalkin SD, Silengo L, Altruda F, Wetzker R, Wymann MP, Lembo G, Hirsch E (2004) PI3gamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects. Cell 118:375-387
20. Shakur Y, Holst LS, Landstrom TR, Movsesian M, Degerman E, Manganiello V (2001) Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family. Prog Nucleic Acid Res Mol Biol 66:241-277
21. Schmitz W, Eschenhagen T, Mende U, Muller FU, Neumann J, Scholz H (1992) Phosphodiesterase inhibition and positive inotropy in failing human myocardium. Basic Res Cardiol 87:Suppl 1:65-71
22. ++ current in cardiac myocytes. J Pharmacol Exp Ther 283:452-461
23. Smith CJ, Vasta V, Degerman E, Belfrage P, Manganiello VC (1991) Hormone sensitive cyclic GMP-inhibited cyclic AMP phosphodiesterases in rat adipocytes. J Biol Chem 266:13385-13390
24. Vargas ML, Hernandez J, Kaumann AJ (2006) Phosphodiesterase PDE3 blunts the positive inotropic and cyclic AMP enhancing effects of CGP12177 but not of noradrenaline in rat ventricle. Br J Pharmacol 147:158-163
25. 2 adrenoceptor subtype-specific signalling in cardiac myocytes. Proc Natl Acad Sci USA 102:909-914