Contribution of phosphodiesterase isozymes to the regulation of the L-type calcium current in human cardiac myocytes

British Journal of Pharmacology

Volumn 121, Issue 8, 1997, Pages 1549-1556

  Kajimoto, Katsuya ^a   Hagiwara, Nobuhisa ^a   Kasanuki, Hiroshi ^a   Hosoda, Saichi ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Human atrial cells; L type Ca2+ current; Phosphodiesterase inhibitor; Phosphodiesterase isozymes; Whole cell voltage clamp method

Indexed keywords

CALCIUM ION; CYCLIC AMP; ISOPRENALINE; O NORPIMOBENDAN; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; PIMOBENDAN; ROLIPRAM;

ADOLESCENT; ADULT; ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CHILD; CONTROLLED STUDY; ENZYME INHIBITION; HEART ATRIUM; HEART DEPOLARIZATION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RABBIT;

1-METHYL-3-ISOBUTYLXANTHINE; ADOLESCENT; ADULT; ANIMALS; CALCIUM CHANNELS; CALCIUM CHANNELS, L-TYPE; CHILD; CHILD, PRESCHOOL; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART; HUMANS; INFANT; ISOENZYMES; MIDDLE AGED; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PYRIDAZINES; RABBITS;

EID: 0030808325     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701297     Document Type: Article

References (35)

1. AKITA, T., JOYNER, R.W., LU, C., KUMAR, R. & HARTZELL, H.C. (1994). Developmental changes in modulation of calcium currents of rabbit ventricular cells by phosphodiesterase inhibitors. Circulation, 90, 469-478.
2. BEAVO, J.A. & REIFSNYDER, D.H. (1990). Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors. Trends Pharmacol. Sci., 11, 150-155.
3. BETHKE, T., KLIMKIEWICZ, A., KOHL, C., VON DER LEYEN, H., MEHL, H., MENDE, U., MEYER, W., NEUMANN, J., SCHMITZ, W. & SHOLZ, H. (1991). Effects of isomazole on force of contraction and phosphodiesterase isoenzymes I-IV in non-failing and failing human hearts. J. Cardiovasc. Pharmacol., 18, 386-397.
4. BETHKE, T., MEYER, W., SCHMITZ, W., SCHOLZ, H., STEIN, B., THOMAS, K. & WENZLAFF, H. (1992). Phosphodiesterase inhibition in ventricular cardiomyocytes from guinea-pig hearts. Br. J. Pharmacol., 107, 127-133.
5. BÖHM, M., MORANO, I., PIESKE, B. & RÜEGG, J.C. (1991). Contribution of cAMP-phosphodiesterase inhibition and sensitization of the contractile proteins for calcium to the inotropic effect of pimobendan in the failing human myocardium. Circ. Res., 68, 689-701.
6. BRUNKHORST, D., VON DER LEYEN, H., MEYER, W., NIGBUR, R., SCHMIDT-SCHUMACHER, C. & SCHOLZ, H. (1989). Relation of positive inotropic and chronotropic effects of pimobendan, UD-CG 212, milrinone and other phosphodiesterase inhibitors to phosphodiesterase III inhibition in guinea-pig heart. Naunyn-Schmiedeberg's Arch. Pharmacol., 339, 575-583.
7. CHEFFOY, D.D., LOORE, D.K., FREYNE, E. & JANSSEN, P.A.J. (1992). Inhibition of human cardiac cyclic AMP-phosphodiesterase by R80122, a new selective cyclic AMP-phosphodiesterase III inhibitor: a comparison with other cardiotonic compounds. J. Pharmacol. Exp. Ther., 263, 6-14.
8. DIBANCO, R., SHABETAI, R., KOSTUK, W., MORAN, J., SCHLANT, R.C. & WRIGHT, R.A. (1989). Comparison of oral milrinone, digoxin and their combination in the treatment of patients with chronic heart failure. N. Engl. J. Med., 320, 677-683.
9. ESCANDE, D., COULOMBE, A., FAIVRE, J.-F., DEROUBAIX, E. & CORABOEUF, E. (1987). Two types of transient outward currents in adult human atrial cells. Am. J. Physiol., 252, H142-H148.
10. 2+ current regulation in cardiac cells. Life Sci., 48, 2365-2376.
11. HAGIWARA, N., IRISAWA, H., KASANUKI, H. & HOSODA, S. (1992a). Background current in the sino-atrial node cells of the rabbit heart. J. Physiol., 448, 53-72.
12. HAGIWARA, N., MASUDA, H., SHODA, M. & IRISAWA, H. (1992b). Stretch-activated anion currents of rabbit cardiac myocytes. J. Physiol., 456, 285-302.
13. HAMILL, O.P., MARTY, A., NEHER, E., SAKMANN, B. & SIGWORTH, F.J. (1981). Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers. Arch., 391, 85-100.
14. ISENBERG, G. & KLÖCKNER, U. (1982). Calcium tolerant ventricular myocytes prepared by preincubation in a 'KB-medium'. Pflügers. Arch., 395, 6-18.
15. KAMEYAMA, M., HESCHELER, J., HOFMANN, F. & TRAUTWEIN, W. (1986). Modulation of Ca current during the phosphorylation cycle in the guinea pig heart. Pflügers. Arch., 407, 123-128.
16. KUBO, S.H., GOLLUB, S., BOURGE, R., RAHKO, P., COBB, F., JESSUP, M., BROZENA, S., BRODSKY, M., KIRLIN, P., SHANES, J., KONSTAM, M., GRADMAN, A., MORLEDGE, J., CINQUEGRANI, M., SINGH, S., LEJEMTEL, T., NICKLAS, J., TROHA, J. & COHN, J.N. (for the Pimobendan Multicenter Research Group). (1992). Beneficial effects of pimobendan on exercise tolerance and quality of life in patients with heart failure. Circulation, 85, 942-949.
17. LEE, J.A., RUEGG, J.C. & ALLEN, D.G. (1989). Effects of pimobendan, a novel inotropic agent, on intracellular calcium and tension in isolated ferret ventricular muscle. Clin. Sci., 76, 609-618.
18. LEGRAND, B., HATEM, S., DEROUBAIX, E., COUTEIL, J.P. & CORABOEUF, E. (1991). Calcium current depression in isolated human atrial myocytes after cessation of chronic treatment with calcium antagonists. Circ. Res., 69, 292-300.
19. LI, Q., HIMMEL, H.M. & RAVENS, U. (1994). Effects of the new phosphodiesterase-III inhibitor R80122 on contractility and calcium current in human cardiac tissue. J. Cardiovasc. Pharmacol., 24, 133-143.
20. MASUOKA, H., ITO, M., NAKANO, T., NAKA, M. & TANAKA, T. (1990). Effect of amrinone and enoximone on the subclasses of cyclic AMP phosphodiesterase from human heart and kidney. J. Cardiovasc. Pharmacol., 15, 302-307.
21. 2+ current by mechanical stimulation in single rabbit cardiac myocytes. Circ. Res., 78, 650-659.
22. MULLER, B., LUGNIER, C. & STOCLET, J.M. (1990). Involvement of rolipram-sensitive cyclic AMP phosphodiesterase in the regulation of cardiac contraction. J. Cardiovasc. Pharmacol., 16, 796-803.
23. MULLER, B., STOCLET, J.M. & LUGNIER, C. (1992). Cytosolic and membrane-bound cyclic nucleotide phosphodiesterases from guinea-pig cardiac ventricles. Eur. J. Pharmacol. Mol. Pharmacol., 225, 263-272.
24. OUADID, H., SEGUIN, J., RICHARD, S., CHAPTAL, P.A. & NARGEOT, J. (1991). Properties and modulation of Ca channels in adult human atrial cells. J. Mol. Cell. Cardiol., 23, 41-54.
25. PIOT, C., LEMAIRE, S., ALBAT, B. SEGUIN, J., NARGEOT, J. & RICHARD, S. (1996). High frequency-induced upregulation of human cardiac calcium currents. Circulation, 93, 120-128.
26. RAPUNDALO, S.T., SOLARO, J. & KRANIAS, E.G. (1989). Inotropic responses to isoproterenol and phosphodiesterase inhibitors in intact guinea-pig hearts. Comparison of cyclic AMP levels and phosphorylation of sarcoplasmic reticulum and myofibrillar proteins. Circ. Res., 64, 104-111.
27. REEVES, M.L., LEIGH, B.K. & ENGLAND, P.J. (1987). The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle: implication for the mechanisms of action of selective phosphodiesterase inhibitors. Biochem. J., 241, 535-541.
28. SAKAI, R., HAGIWARA, N., KASANUKI, H. & HOSODA, S. (1995). Chloride conductance in human atrial cells. J. Mol. Cell. Cardiol., 27, 2403-2408.
29. SAKAI, R., HAGIWARA, N., MATSUDA, N., KASANUKI, H. & HOSODA, S. (1996). Sodium-potassium pump current in rabbit sino-atrial node cells. J. Physiol., 490, 51-62.
30. SHAHID, M. & NICHOLSON, C.D. (1990). Comparison of cyclic nucleotide phosphodiesterase isozymes in rat and rabbit ventricular myocardium: positive inotropic and phosphodiesterase inhibitory effects of Org 30029, milrinone and rolipram. Naunyn-Schmiedeberg's Arch. Pharmacol., 342, 698-705.
31. SCHOLTZ, H. & MEYER, W. (1987). Phosphodiesterase-inhibiting properties of newer inotropic agents. Circulation, 73 (Suppl III), III 99-108.
32. VON DER LEYEN, H., MENDE, U., NEUMANN, J., NOSE, M., SCHMITZ, W., SCHOLTZ, H., STARBARRY, J., STEIN, B., WENZLAFF, H., DORING, P., KALMAR, P. & HARVERICH, A. (1991). Mechanism underlying the positive inotropic effects of the phosphodiesterase III inhibitors pimobendan, adibendan and saterinone in failing as compared to non failing human cardiac muscle preparations. Naunyn-Schmiedeberg's Arch. Pharmacol., 344, 90-100.
33. WEISHAAR, R.E., KOBYLARZ-SINGER, D.C., STEFFEN, R. & KLAPLAN, H.R. (1987a). Subclasses of cyclic AMP-specific phosphodiesterase in left ventricular muscle and their involvement in regulating myocardial contractility. Circ. Res., 61, 539-547.
34. WIESHAAR, R.E., KOBYLARZ-SINGER, D.C. & KAPLAN, H.R. (1987b). Subclasses of cyclic AMP phosphodiesterase in cardiac muscle. J. Mol. Cell. Cardiol., 19, 1025-1036.
35. WESTFALL, M.V., WAHLER, G.M., FUJINO, K. & SOLARO, R.J. (1992). Electrophysiological actions of the pimobendan metabolite, UD-CG 212, in guinea pig myocardium. J. Pharmacol. Exp. Ther., 260, 58-630.