Detection of topoisomerase inhibitor-induced DNA strand breaks and apoptosis by the alkaline comet assay

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 520, Issue 1-2, 2002, Pages 47-56

  Godard, Thierry ^a,b   Deslandes, Edwige ^a   Sichel, François ^a   Poul, Jean Michel ^b   Gauduchon, Pascal ^a  

^a UNIVERSITÉ DE CAEN   (France)

^b Healthy Pigs Production and Experimentation Section   (France)

Author keywords

Apoptosis; Cleavable complexes; Comet assay; DNA strand breaks; Topoisomerase inhibitors

Indexed keywords

CAMPTOTHECIN; CELL DNA; DNA FRAGMENT; DNA TOPOISOMERASE INHIBITOR; ELLIPTICINE; ETOPOSIDE; GYRASE INHIBITOR; TOPOTECAN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BIOCHEMISTRY; CELL CYCLE; CHO CELL; COMET ASSAY; CONTROLLED STUDY; DNA CLEAVAGE; DNA DAMAGE; DNA STRAND BREAKAGE; KINETICS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CAMPTOTHECIN; CELL SURVIVAL; CHO CELLS; COMET ASSAY; CRICETINAE; DNA DAMAGE; DNA FRAGMENTATION; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; ELLIPTICINES; ENZYME INHIBITORS; ETOPOSIDE; FORMAZANS; TOPOTECAN;

CRICETINAE; CRICETULUS GRISEUS;

EID: 0037179495     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(02)00174-2     Document Type: Article

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