Mouse models for gonadotropins: A 15-year Saga

Molecular and Cellular Endocrinology

Volumn 260-262, Issue , 2007, Pages 249-254

  Kumar, T Rajendra ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

FSH; Gonadotropins; Knockout mice; LH; Ovary; Testis; Transgenic

Indexed keywords

FOLLITROPIN; GONADOTROPIN; LUTEINIZING HORMONE;

COVALENT BOND; DIMERIZATION; GENE TARGETING; GENOME; LIGAND BINDING; MOLECULAR MODEL; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; REVIEW; SIGNAL TRANSDUCTION; TRANSGENICS;

ANIMALS; FOLLICLE STIMULATING HORMONE; HISTORY, 20TH CENTURY; HUMANS; LUTEINIZING HORMONE; MICE; MICE, KNOCKOUT; MODELS, ANIMAL; PHENOTYPE; TIME FACTORS;

EID: 33751249619     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2006.09.002     Document Type: Review

References (52)

1. Abel M.H., Huhtaniemi I., Pakarinen P., Kumar T.R., and Charlton H.M. Age-related uterine and ovarian hypertrophy in FSH receptor knockout and FSHbeta subunit knockout mice. Reproduction 125 (2003) 165-173
2. Abel M.H., Wootton A.N., Wilkins V., Huhtaniemi I., Knight P.G., and Charlton H.M. The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction. Endocrinology 141 (2000) 1795-1803
3. Aittomaki K., Herva R., Stenman U.H., Juntunen K., Ylostalo P., Hovatta O., and de la Chapelle A. Clinical features of primary ovarian failure caused by a point mutation in the follicle-stimulating hormone receptor gene. J. Clin. Endocrinol. Metab. 81 (1996) 3722-3726
4. Aittomaki K., Lucena J.L., Pakarinen P., Sistonen P., Tapanainen J., Gromoll J., Kaskikari R., Sankila E.M., Lehvaslaiho H., Engel A.R., et al. Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure. Cell 82 (1995) 959-968
5. Albanese C., Colin I.M., Crowley W.F., Ito M., Pestell R.G., Weiss J., and Jameson J.L. The gonadotropin genes: evolution of distinct mechanisms for hormonal control. Recent Prog. Horm. Res. 51 (1996) 23-58 (Discussion 59-61)
6. Allan C.M., Haywood M., Swaraj S., Spaliviero J., Koch A., Jimenez M., Poutanen M., Levallet J., Huhtaniemi I., Illingworth P., and Handelsman D.J. A novel transgenic model to characterize the specific effects of follicle-stimulating hormone on gonadal physiology in the absence of luteinizing hormone actions. Endocrinology 142 (2001) 2213-2220
7. Baker P.J., Pakarinen P., Huhtaniemi I.T., Abel M.H., Charlton H.M., Kumar T.R., and O'Shaughnessy P.J. Failure of normal Leydig cell development in follicle-stimulating hormone (FSH) receptor-deficient mice, but not FSHbeta-deficient mice: role for constitutive FSH receptor activity. Endocrinology 144 (2003) 138-145
8. Biesecker L.G. Coupling genomics and human genetics to delineate basic mechanisms of development. Genet. Med. 4 (2002) 39S-42S
9. Blake C.A., and Helmke S.M. Proteomics of the anterior pituitary gland as a model for studying the physiology of a heterogeneous organ. Exp. Biol. Med. (Maywood) 230 (2005) 793-799
10. Bokar J.A., Keri R.A., Farmerie T.A., Fenstermaker R.A., Andersen B., Hamernik D.L., Yun J., Wagner T., and Nilson J.H. Expression of the glycoprotein hormone alpha-subunit gene in the placenta requires a functional cyclic AMP response element, whereas a different cis-acting element mediates pituitary-specific expression. Mol. Cell Biol. 9 (1989) 5113-5122
11. Bousfield G.R., Perry W.M., and Ward D.N. Gonadotropins: chemistry and biosynthesis. In: Knobil E., and Neill J.D. (Eds). The Physiology of Reproduction (1994), Raven Press, New York 1749-1792
12. Burns K.H., Yan C., Kumar T.R., and Matzuk M.M. Analysis of ovarian gene expression in follicle-stimulating hormone beta knockout mice. Endocrinology 142 (2001) 2742-2751
13. Dierich A., Sairam M.R., Monaco L., Fimia G.M., Gansmuller A., LeMeur M., and Sassone-Corsi P. Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 13612-13617
14. Fan Q.R., and Hendrickson W.A. Structure of human follicle-stimulating hormone in complex with its receptor. Nature 433 (2005) 269-277
15. Hannon G.J. RNA interference. Nature 418 (2002) 244-251
16. He L., and Hannon G.J. MicroRNAs: small RNAs with a big role in gene regulation. Nat. Rev. Genet. 5 (2004) 522-531
17. Japon M.A., Rubinstein M., and Low M.J. In situ hybridization analysis of anterior pituitary hormone gene expression during fetal mouse development. J. Histochem. Cytochem. 42 (1994) 1117-1125
18. Johnston H., Baker P.J., Abel M., Charlton H.M., Jackson G., Fleming L., Kumar T.R., and O'Shaughnessy P.J. Regulation of Sertoli cell number and activity by follicle-stimulating hormone and androgen during postnatal development in the mouse. Endocrinology 145 (2004) 318-329
19. Kendall S.K., Samuelson L.C., Saunders T.L., Wood R.I., and Camper S.A. Targeted disruption of the pituitary glycoprotein hormone alpha-subunit produces hypogonadal and hypothyroid mice. Genes Dev. 9 (1995) 2007-2019
20. Kumar T.R. Gonadotropin gene targeting and biological implications. Endocrine 26 (2005) 227-233
21. Kumar T.R., Fairchild-Huntress V., and Low M.J. Gonadotrope-specific expression of the human follicle-stimulating hormone beta-subunit gene in pituitaries of transgenic mice. Mol. Endocrinol. 6 (1992) 81-90
22. Kumar T.R., Graham K.E., Asa S.L., and Low M.J. Simian virus 40 T antigen-induced gonadotroph adenomas: a model of human null cell adenomas. Endocrinology 139 (1998) 3342-3351
23. Kumar T.R., Kelly M., Mortrud M., Low M.J., and Matzuk M.M. Cloning of the mouse gonadotropin beta-subunit-encoding genes. I. Structure of the follicle-stimulating hormone beta-subunit-encoding gene. Gene 166 (1995) 333-334
24. Kumar T.R., and Low M.J. Gonadal steroid hormone regulation of human and mouse follicle stimulating hormone beta-subunit gene expression in vivo. Mol. Endocrinol. 7 (1993) 898-906
25. Kumar T.R., and Low M.J. Hormonal regulation of human follicle-stimulating hormone-beta subunit gene expression: GnRH stimulation and GnRH-independent androgen inhibition. Neuroendocrinology 61 (1995) 628-637
26. Kumar T.R., Low M.J., and Matzuk M.M. Genetic rescue of follicle-stimulating hormone beta-deficient mice. Endocrinology 139 (1998) 3289-3295
27. Kumar T.R., and Matzuk M.M. Cloning of the mouse gonadotropin beta-subunit-encoding genes. II. Structure of the luteinizing hormone beta-subunit-encoding genes. Gene 166 (1995) 335-336
28. Kumar T.R., and Matzuk M.M. Gene knockout models to study the hypothalamus-pituitary-gonadal axis. In: Shupnik M.A. (Ed). Gene Engineering and Molecular Models in Endocrinology (2000), The Humana Press, Totowa, NJ
29. Kumar T.R., Palapattu G., Wang P., Woodruff T.K., Boime I., Byrne M.C., and Matzuk M.M. Transgenic models to study gonadotropin function: the role of follicle-stimulating hormone in gonadal growth and tumorigenesis. Mol. Endocrinol. 13 (1999) 851-865
30. Kumar T.R., Schuff K.G., Nusser K.D., and Low M.J. Gonadotroph-specific expression of the human follicle stimulating hormone beta gene in transgenic mice. Mol. Cell Endocrinol. 247 (2006) 103-115
31. Kumar T.R., Varani S., Wreford N.G., Telfer N.M., de Kretser D.M., and Matzuk M.M. Male reproductive phenotypes in double mutant mice lacking both FSHbeta and activin receptor IIA. Endocrinology 142 (2001) 3512-3518
32. Kumar T.R., Wang Y., Lu N., and Matzuk M.M. Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility. Nat. Genet. 15 (1997) 201-204
33. Lei Z.M., Mishra S., Zou W., Xu B., Foltz M., Li X., and Rao C.V. Targeted disruption of luteinizing hormone/human chorionic gonadotropin receptor gene. Mol. Endocrinol. 15 (2001) 184-200
34. Lukas-Croisier C., Lasala C., Nicaud J., Bedecarras P., Kumar T.R., Dutertre M., Matzuk M.M., Picard J.Y., Josso N., and Rey R. FSH increases testicular anti-mullerian hormone (AMH) production through Sertoli cell proliferation and a non-classical cyclic AMP-mediated activation of the AMH gene. Mol. Endocrinol. 17 (2003) 550-561
35. Ma X., Dong Y., Matzuk M.M., and Kumar T.R. Targeted disruption of luteinizing hormone beta-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 17294-17299
36. Matzuk M.M., DeMayo F.J., Hadsell L.A., and Kumar T.R. Overexpression of human chorionic gonadotropin causes multiple reproductive defects in transgenic mice. Biol. Reprod. 69 (2003) 338-346
37. Matzuk M.M., and Kumar T.R. Mouse models to study pituitary hormone gene expression and function. In: Beck-Peccoz P. (Ed). Regulation of Pituitary Hormone Secretion (1999), HypoCCS Series, Bristol, UK 197-217
38. Moudgal N.R., Jagannadha Rao A., Maneckjee R., Muralidhar K., Mukku V., and Sheela Rani C.S. Gonadotropins and their antibodies. Recent Prog. Horm. Res. 30 (1974) 47-77
39. Moudgal N.R., Jeyakumar M., Krishnamurthy H.N., Sridhar S., Krishnamurthy H., and Martin F. Development of male contraceptive vaccine-a perspective. Hum. Reprod. Update 3 (1997) 335-346
40. Moudgal N.R., and Li C.H. Beta subunits of human choriogonadotropin and ovine lutropin are biologically active. Proc Natl. Acad. Sci. U.S.A. 79 (1982) 2500-2503
41. Moudgal N.R., and Sairam M.R. Is there a true requirement for follicle stimulating hormone in promoting spermatogenesis and fertility in primates?. Hum. Reprod. 13 (1998) 916-919
42. Narayan P., Gray J., and Puett D. Yoked complexes of human choriogonadotropin and the lutropin receptor: evidence that monomeric individual subunits are inactive. Mol. Endocrinol. 16 (2002) 2733-2745
43. Pierce J.G., and Parsons T.F. Glycoprotein hormones: structure and function. Annu. Rev. Biochem. 50 (1981) 465-495
44. Risma K.A., Clay C.M., Nett T.M., Wagner T., Yun J., and Nilson J.H. Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 1322-1326
45. Risma K.A., Hirshfield A.N., and Nilson J.H. Elevated luteinizing hormone in prepubertal transgenic mice causes hyperandrogenemia, precocious puberty, and substantial ovarian pathology. Endocrinology 138 (1997) 3540-3547
46. Rulli S.B., Ahtiainen P., Makela S., Toppari J., Poutanen M., and Huhtaniemi I. Elevated steroidogenesis, defective reproductive organs, and infertility in transgenic male mice overexpressing human chorionic gonadotropin. Endocrinology 144 (2003) 4980-4990
47. Rulli S.B., Kuorelahti A., Karaer O., Pelliniemi L.J., Poutanen M., and Huhtaniemi I. Reproductive disturbances, pituitary lactotrope adenomas, and mammary gland tumors in transgenic female mice producing high levels of human chorionic gonadotropin. Endocrinology 143 (2002) 4084-4095
48. Sairam M.R., Danilovich N., and Lussier-Cacan S. The FORKO mouse as a genetic model for exploring estrogen replacement therapy. J. Reprod. Med. 47 (2002) 412-418
49. Silva J., Chang K., Hannon G.J., and Rivas F.V. RNA-interference-based functional genomics in mammalian cells: reverse genetics coming of age. Oncogene 23 (2004) 8401-8409
50. Warner G.J., Adeleye Y.A., and Ideker T. Interactome networks: the state of the science. Genome Biol. 7 (2006) 301
51. Zhang F.P., Pakarainen T., Zhu F., Poutanen M., and Huhtaniemi I. Molecular characterization of postnatal development of testicular steroidogenesis in luteinizing hormone receptor knockout mice. Endocrinology 145 (2004) 1453-1463
52. Zhang F.P., Poutanen M., Wilbertz J., and Huhtaniemi I. Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice. Mol. Endocrinol. 15 (2001) 172-183