Sigma sites mediate DTG-evoked hypothermia in rats

Pharmacology Biochemistry and Behavior

Volumn 73, Issue 4, 2002, Pages 779-786

  Rawls, S M ^a   Baron, David A ^a   Geller, Ellen B ^a   Adler, Martin W ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BD 1047; Body temperature; DTG; Hypothermia; Rats; Sigma receptors; Sigma sites; Thermoregulation

Indexed keywords

COCAINE; ETHYLAMINE; GUANIDINE DERIVATIVE; N [2 (2,3 DICHLOROPHENYL)ETHYL] 2 DIMETHYLAMINO N METHYLETHYLAMINE; N [2 (3,4 DICHLOROPHENYL)ETHYL] N METHYL 2 (DIMETHYLAMINO)ETHYLAMINE; OPIATE ANTAGONIST; SIGMA OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG SELECTIVITY; DYSTONIA; HYPOTHERMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THERMOREGULATION;

ANIMALS; BINDING SITES; ETHYLENEDIAMINES; GUANIDINES; HYPOTHERMIA; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SIGMA;

EID: 0036828587     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(02)00903-6     Document Type: Article

References (61)

1. Banet M., Hensel H., Liebermann H. The central control of shivering and non-shivering thermogenesis in the rat. J Physiol. 283:1978;569-584.
2. Bejanian M., Pechnick R.N., George R. Effects of acute and chronic administration of (+)-SKF 10,047 on body temperature in the rat: cross-sensitization with phencyclidine. J Pharmacol Exp Ther. 253:1990;1253-1258.
3. Bejanian M., Pechnick R.N., Bova M.P., George R. Effects of subcutaneous and intracerebroventricular administration of the sigma receptor ligand 1,3-di-o-tolylguanidine on body temperature in the rat: interactions with BMY 14802 and rimcazole. J Pharmacol Exp Ther. 258:1991;88-93.
4. Ben-Uriah Y., Yehuda S., Carasso R.L. Physiological evidence (hypothermia) for central effects of beta-blocker agents. Int J Neurosci. 14:1981;41-46.
5. 3H](+)pentazocine binding sites in the rat brain: autoradiographic visualization of the putative sigma1 and sigma2 receptor subtypes. Neuroscience. 76:1997;467-477.
6. Boulant J.A. Hypothalamic mechanisms in thermoregulation. Fed Proc. 40:1981;2843-2850.
7. 3H] (+)-pentazocine, a highly selective sigma ligand. Prog Clin Biol Res. 328:1990;117-120.
8. Brady K.T., Balster R.L., May E.L. Stereoisomers of N-allylnormetazocine: phencyclidine-like behavioral effects in squirrel monkeys and rats. Science. 215:1982;178-180.
9. Brent P.J. Similar behavioural effects of sigma agonists and PCP-like non-competitive NMDA antagonists in guinea-pigs. Psychopharmacology. 105:1991;421-427.
10. Brent P.J. Behavioural effect of pretreatment with opioid antagonists and sigma binding site ligands on the abnormal motor response produced by the kappa opioid agonist U50,488H in guinea pigs. Neuropharmacology. 32:1993;751-760.
11. Bristow L.J., Baucutt L., Thorn L., Hutson P.H., Noble A., Beer M., Middlemiss D.N., Tricklebank M.D. Behavioural and biochemical evidence of the interaction of the putative antipsychotic agent, BMY 14802 with the 5-HT1A receptor. Eur J Pharmacol. 29(204):1991;21-28.
12. Chien C.C., Pasternak G.W. Functional antagonism of morphine analgesia by (+)-pentazocine: evidence for an anti-opioid sigma 1 system. Eur J Pharmacol. 250:1993;R7-R8.
13. Chipkin R.E. Effects of D1 and D2 antagonists on basal and apomorphine decreased body temperature in mice and rats. Pharmacol, Biochem Behav. 30:1988;683-686.
14. Clark W.G., Bernardini G.L., Ponder S.W. Central injection of a sigma opioid receptor agonist alters body temperature of cats. Brain Res Bull. 7:1981;279-281.
15. Coccini T., Costa L.G., Manzo L., Candura S.M., Lapadre N., Balestra B., Tonini M. Two subtypes of enteric non-opioid sigma receptors in guinea-pig cholinergic motor neurons. Eur J Pharmacol. 198:1991;105-108.
16. Contreras P.C., Contreras M.L., O'Donohue T.L., Lair C.C. Biochemical and behavioral effects of sigma and PCP ligands. Synapse. 2:1988;240-243.
17. Cowan A., Geller E.B., Adler M.W. Classification of opioids on the basis of change in seizure threshold in rats. Science. 206:1979;465-467.
18. Eaton M.J., Lookingland K.J., Moore K.E. The sigma ligand rimcazole activates noradrenergic neurons projecting to the paraventricular nucleus and increases corticosterone secretion in rats. Brain Res. 733:1996;162-166.
19. Ferris R.M., Tang F.L., Chang K.J., Russell A. Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain. Life Sci. 38:1986;2329-2337.
20. Hadfield M.G., Milio C. Rimcazole (BW 234 U) and regional monoamine concentrations in mouse brain. Life Sci. 40:1987;2087-2090.
21. Hellewell S.B., Bowen W.D. A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain. Brain Res. 527:1990;244-253.
22. Herling S., Coale E.H., Hein D.W., Winger G., Woods J.H. Similarity of the discriminative stimulus effects of ketamine, cyclazocine, and dextrorphan in the pigeon. Psychopharmacology. 73:1981;286-291.
23. Hjorth S., Clark D., Carlsson A. Lack of functional evidence for the involvement of sigma opiate receptors in the actions of the 3-PPP enantiomers on central dopaminergic systems: discrepancies between in vitro and in vivo observations. Life Sci. 37:1985;673-684.
24. Holtzman S.G. Phencyclidine-like discriminative effects of opioids in the rat. J Pharmacol Exp Ther. 214:1980;614-619.
25. Holtzman S.G. Ph encyclidine-like discriminative stimulus properties of opioids in the squirrel monkey. Psychopharmacology. 77:1982;295-300.
26. Holtzman S.G. Opioid- and phencyclidine-like discriminative effects of ditolylguanidine, a selective sigma ligand. J Pharmacol Exp Ther. 248:1989;1054-1062.
27. Husbands S.M., Izenwasser S., Loeloff R.J., Katz J.L., Bowen W.D., Vilner B.J., Newman A.H. Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole): irreversible ligands for the dopamine transporter. J Med Chem. 40:1997;4340-4346.
28. Itzhak Y. Modulation of the PCP/NMDA receptor complex and sigma binding sites by psychostimulants. Neurotoxicol Teratol. 16:1994;363-368.
29. Kest B., Mogil J.S., Sternberg W.F., Pechnick R.N., Liebeskind J.C. Antinociception following 1,3,-di-o-tolylguanidine, a selective sigma receptor ligand. Pharmacol, Biochem Behav. 50:1995;587-592.
30. King M., Pan Y.X., Mei J., Chang A., Xu J., Pasternak G.W. Enhanced kappa-opioid receptor-mediated analgesia by antisense targeting the sigma1 receptor. Eur J Pharmacol. 331:1997;R5-R6.
31. 3H]3-(3-Hydroxyphenyl)-N-(1-propyl)-piperidine binding to sigma receptors in mouse brain in vivo. Eur J Pharmacol. 161:1989;263-266.
32. Lai N.L., Bowen W.D., Matsumoto R.R., Thurkauf A., Rice K.C., Walker J.M. Anxiogenic effects of two selective sigma ligands in the rat. Proc Soc Neurosci. 15:1989;644.
33. 3H]-1-[1-(2-thienyl)cyclohexyl]piperidine. J Pharmacol Exp Ther. 238:1986;739-748.
34. Largent B.L., Wikstrom H., Snowman A.M., Snyder S.H. Novel antipsychotic drugs share high affinity for sigma receptors. Eur J Pharmacol. 155:1988;345-347.
35. Mallick B.N., Alam M.N. Different types of norepinephrinergic receptors are involved in preoptic area mediated independent modulation of sleep-wakefulness and body temperature. Brain Res. 591:1992;8-19.
36. Malone D.T., Taylor D.A. Involvement of somatodendritic 5-HT(1A) receptors in Delta(9)-tetrahydrocannabinol-induced hypothermia in the rat. Pharmacol, Biochem Behav. 69:2001;595-601.
37. Martin W.R., Eades C.G., Thompson J.A., Huppler R.E., Gilbert P.E. The effects of morphine- and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog. J Pharmacol Exp Ther. 197:1976;517-532.
38. Matsumoto R.R., Bowen W.D., Tom M.A., Vo V.N., Truong D.D., De Costa B.R. Characterization of two novel sigma receptor ligands: antidystonic effects in rats suggest sigma receptor antagonism. Eur J Pharmacol. 280:1995;301-310.
39. Matsumoto R.R., Bowen W.D., de Costa B.R., Houk J.C. Relationship between modulation of the cerebellorubrospinal system in the in vitro turtle brain and changes in motor behavior in rats: effects of novel sigma ligands. Brain Res Bull. 48:1999;497-508.
40. Matsuno K., Matsunaga K., Senda T., Mita S. Increase in extracellular acetylcholine level by sigma ligands in rat frontal cortex. J Pharmacol Exp Ther. 265:1993;851-859.
41. Matthews R.T., McMillen B.A., Sallis R., Blair D. Effects of BMY 14802, a potential antipsychotic drug, on rat brain dopaminergic function. J Pharmacol Exp Ther. 239:1986;124-131.
42. McCracken K.A., Bowen W.D., de Costa B.R., Matsumoto R.R. Two novel sigma receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity. Eur J Pharmacol. 370:1999;225-232.
43. Mei J., Pasternak G.W. Molecular cloning and pharmacological characterization of the rat sigma1 receptor. Biochem Pharmacol. 62:2001;349-355.
44. Mendelsohn L.G., Kerchner G.A., Kalra V., Zimmerman D.M., Leander J.D. Phencyclidine receptors in rat brain cortex. Biochem Pharmacol. 33:1984;3529-3535.
45. Nava F., Carta G., Gessa G.L. Permissive role of dopamine D(2) receptors in the hypothermia induced by delta(9)-tetrahydrocannabinol in rats. Pharmacol, Biochem Behav. 66:2000;183-187.
46. Nemmani K.V., Gullapalli S., Ramarao P. Potentiation of kappa-opioid receptor agonist-induced analgesia and hypothermia by fluoxetine. Pharmacol, Biochem Behav. 69:2001;189-193.
47. Patrick S.L., Walker J.M., Perkel J.M., Lockwood M., Patrick R.L. Increases in rat striatal extracellular dopamine and vacuous chewing produced by two sigma receptor ligands. Eur J Pharmacol. 231:1993;243-249.
48. Patterson T.A., Connor M., Appleyard S.M., Chavkin C. Oocytes from Xenopus laevis contain an intrinsic sigma 2-like binding site. Neurosci Lett. 180:1994;159-162.
49. Quirion R., Bowen W.D., Itzhak Y., Junien J.L., Musacchio J.M., Rothman R.B., Su T.P., Tam S.W., Taylor D.P. A proposal for the classification of sigma binding sites. Trends Pharmacol Sci. 13:1992;85-86.
50. Romieu P., Martin-Fardon R., Maurice T. Involvement of the sigma1 receptor in the cocaine-induced conditioned place preference. NeuroReport. 11:2000;2885-2888.
51. Ryan-Moro J., Chien C.C., Standifer K.M., Pasternak G.W. Sigma binding in a human neuroblastoma cell line. Neurochem Res. 11:1996;1309-1314.
52. Steinfels G.F., Tam S.W., Cook L. Electrophysiological effects of selective sigma-receptor agonists, antagonists, and the selective phencyclidine receptor agonist MK-801 on midbrain dopamine neurons. Neuropsychopharmacology. 2:1989;201-208.
53. Su T.P., Weissman A.D., Yeh S.Y. Endogenous ligands for sigma opioid receptors in the brain ("sigmaphin"): evidence from binding assays. Life Sci. 38:1986;2199-2210.
54. Tam S.W., Steinfels G.F., Gilligan P.J., Schmidt W.K., Cook L. DuP 734 [1-(cyclopropylmethyl)-4-(2′(4″-fluorophenyl)- 2′-oxoethyl)-piperidine HBr], a sigma and 5-hydroxytryptamine2 receptor antagonist: receptor-binding, electrophysiological and neuropharmacological profiles. J Pharmacol Exp Ther. 263:1992;1167-1174.
55. Tran T.T., de Costa B.R., Matsumoto R.R. Microinjection of sigma ligands into cranial nerve nuclei produces vacuous chewing in rats. Psychopharmacology. 137:1998;191-200.
56. Vargas H.M., Pechnick R.N. Binding affinity and antimuscarinic activity of sigma and phencyclidine receptor ligands. Eur J Pharmacol. 195:1991;151-156.
57. 3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs. Proc Natl Acad Sci U S A. 83:1986;8784-8788.
58. Woods J.H., Koek W., Weber E. Behavioral similarities of di-tolylguanidine (DTG), a selective ligand for haloperidol-sensitive sigma binding sites, to phencyclidine (PCP), in rats, pigeons, rhesus monkeys. Fed Proc. 46:1987;951.
59. Xin L., Geller E.B., Adler M.W. Body temperature and analgesic effects of selective mu and kappa opioid receptor agonists microdialyzed into rat brain. J Pharmacol Exp Ther. 281:1997;499-507.
60. Zambon A.C., De Costa B.R., Kanthasamy A.G., Nguyen B.Q., Matsumoto R.R. Subchronic administration of N-[2-(3,4-dichlorophenyl) ethyl]-N-methyl-2-(dimethylamino) ethylamine (BD1047) alters sigma 1 receptor binding. Eur J Pharmacol. 324:1997;39-47.
61. Zukin S.R., Brady K.T., Slifer B.L., Balster R.L. Behavioral and biochemical stereoselectivity of sigma opiate/PCP receptors. Brain Res. 294:1984;174-177.