Plitidepsin cellular binding and Rac1/JNK pathway activation depend on membrane cholesterol content

Molecular Pharmacology

Volumn 70, Issue 5, 2006, Pages 1654-1663

  Suárez, Yajaira ^a,b   González Santiago, Laura ^a,b   Zarich, Natasha ^c   Dávalos, Alberto ^d   Aranda, Juan F ^a   Alonso, Miguel A ^a   Lasunción, Miguel A ^d,e   Rojas, José María ^c   Muñoz, Alberto ^a,f  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b PHARMAMAR S A   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

^d HOSPITAL RAMÓN Y CAJAL   (Spain)

^e UNIVERSITY OF ALCALÁ   (Spain)

^f INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DEHYDRODIDEMNIN B; METHYL BETA CYCLODEXTRIN; PLITIDEPSIN; RAC1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CHOLESTEROL BLOOD LEVEL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION;

CELL MEMBRANE; CHOLESTEROL; DEPSIPEPTIDES; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; HELA CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN TRANSPORT; RAC1 GTP-BINDING PROTEIN; TUMOR CELLS, CULTURED;

EID: 33751175448     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.106.025569     Document Type: Article

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