Aplidin® induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation

Cell Death and Differentiation

Volumn 13, Issue 11, 2006, Pages 1968-1981

  Gonzalez Santiago L ^a,b   Suarez Y ^a,b   Zarich, N ^c   Munoz Alonso M J ^a,b   Cuadrado, A ^a,b   Martinez T ^a   Goya, L ^d   Iradi, A ^e   Saez Tormo G ^e   Maier, J V ^f   Moorthy, A ^f   Cato, A C B ^f   Rojas, J M ^c   Munoz A ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b PHARMAMAR S A   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

^d INSTITUTO DEL FRÍO CSIC   (Spain)

^e UNIVERSITY OF VALENCIA   (Spain)

^f KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BUTHIONINE SULFOXIMINE; DEHYDRODIDEMNIN B; GLUTATHIONE; GLUTATHIONE DISULFIDE; GUANOSINE TRIPHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE 1; RAC1 GUANOSINE TRIPHOSPHATASE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; 3CH134 PROTEIN; ANTINEOPLASTIC AGENT; CALCIUM; CELL CYCLE PROTEIN; COPPER; DEPSIPEPTIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; IMMEDIATE EARLY PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE; RAC1 PROTEIN; RAC1 PROTEIN, HUMAN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL DEATH; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG MECHANISM; EMBRYO; ENZYME ACTIVATION; GENETIC TRANSFECTION; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; ANIMAL; BREAST TUMOR; CELL MEMBRANE POTENTIAL; DRUG EFFECT; ENZYMOLOGY; GENETICS; HELA CELL; HOMEOSTASIS; METABOLISM; PATHOLOGY;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CALCIUM; CELL CYCLE PROTEINS; COPPER; DEPSIPEPTIDES; DOWN-REGULATION; ENZYME ACTIVATION; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HELA CELLS; HOMEOSTASIS; HUMANS; IMMEDIATE-EARLY PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MEMBRANE POTENTIALS; MICE; MITOCHONDRIAL MEMBRANES; OXIDATIVE STRESS; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN-TYROSINE-PHOSPHATASE; RAC1 GTP-BINDING PROTEIN; REACTIVE OXYGEN SPECIES;

EID: 33749609031     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401898     Document Type: Article

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