Variability of naked DNA expression after direct local injection: The influence of the injection speed

Gene Therapy

Volumn 13, Issue 23, 2006, Pages 1619-1627

  Andre F M ^a   Cournil Henrionnet, C ^a,b   Vernerey, D ^a   Opolon, P ^a   Mir, Luis M ^a  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b UNIVERSITÉ DE LORRAINE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HEPARIN; NAKED DNA; PLASMID DNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PERMEABILIZATION; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; GENE EXPRESSION; HYDRODYNAMICS; INJECTION; LIVER; MOUSE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; SKELETAL MUSCLE; STRESS;

ANIMALS; DNA; FEMALE; GENE EXPRESSION; GENE THERAPY; GREEN FLUORESCENT PROTEINS; HEPARIN; HINDLIMB; HSP70 HEAT-SHOCK PROTEINS; INFLAMMATION; INJECTIONS, INTRAVENOUS; LIVER; LUCIFERASES; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; TIME FACTORS; TRANSFECTION;

EID: 33751171960     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/sj.gt.3302827     Document Type: Article

References (32)

1. Wolff JA, Malone RW, Williams P, Chong W, Acsadi G, Jani A et al. Direct gene transfer into mouse muscle in vivo. Science 1990; 247: 1465-1468.
2. Dileo J, Miller Jr TE, Chesnoy S, Huang L. Gene transfer to subdermal tissues via a new gene gun design. Hum Gene Ther 2003; 14: 79-87.
3. Li T, Tachibana K, Kuroki M. Gene transfer with echo-enhanced contrast agents: Comparison between Albunex, Optison, and Levovist in mice - initial results. Radiology 2003; 229: 423-428.
4. Miller DL, Song J. Tumor growth reduction and DNA transfer by cavitation-enhanced high-intensity focused ultrasound in vivo. Ultrasound Med Biol 2003; 29: 887-893.
5. Cemazar M, Grosel A, Glavac D, Kotnik V, Skobrne M, Kranjc S et al. Effects of electrogenetherapy with p53wt combined with cisplatin on survival of human tumor cell lines with different p53 status. DNA Cell Biol 2003; 22: 765-775.
6. Trochon-Joseph V, Martel-Renoir D, Mir LM, Thomaidis A, Opolon P, Connault E et al. Evidence of antiangiogenic and antimetastatic activities of the recombinant disintegrin domain of metargidin. Cancer Res 2004; 64: 2062-2069.
7. Zhang G, Budker V, Wolff JA. High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther 1999; 10: 1735-1737.
8. Liu F, Song Y, Liu D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Therapy 1999; 6: 1258-1266.
9. Alino SF, Crespo A, Dasi F. Long-term therapeutic levels of human alpha-1 antitrypsin in plasma after hydrodynamic injection of nonviral DNA. Gene Therapy 2003; 10: 1672-1679.
10. Dagnaes-Hansen F, Holst HU, Sondergaard M, Vorup-Jensen T, Flyvbjerg A, Jensen UB et al. Physiological effects of human growth hormone produced after hydrodynamic gene transfer of a plasmid vector containing the human ubiquitin promotor. J Mol Med 2002; 80: 665-670.
11. He CX, Shi D, Wu WJ, Ding YF, Feng DM, Lu B et al. Insulin expression in livers of diabetic mice mediated by hydro-dynamics-based administration. World J Gastroenterol 2004; 10: 567-572.
12. Manthorpe M, Cornefert-Jensen F, Hartikka J, Felgner J, Rundell A, Margalith M et al. Gene therapy by intramuscular injection of plasmid DNA: Studies on firefly luciferase gene expression in mice. Hum Gene Ther 1993; 4: 419-431.
13. Wolff JA, Williams P, Acsadi G, Jiao S, Jani A, Chong W. Conditions affecting direct gene transfer into rodent muscle in vivo. Biotechniques 1991; 11: 474-485.
14. Aufricht C. Heat-shock protein 70: Molecular supertool? Pediatr Nephrol 2005; 20: 707-713.
15. Andrews JM, Newbound GC, Lairmore MD. Transcriptional modulation of viral reporter gene constructs following induction of the cellular stress response. Nucleic Acids Res 1997; 25: 1082-1084.
16. Budker V, Budker T, Zhang G, Subbotin V, Loomis A, Wolff JA. Hypothesis: naked plasmid DNA is taken up by cells in vivo by a receptor-mediated process. J Gene Med 2000; 2: 76-88.
17. Satkauskas S, Bureau MF, Mahfoudi A, Mir LM. Slow accumulation of plasmid in muscle cells: Supporting evidence for a mechanism of DNA uptake by receptor-mediated endocytosis. Mol Ther 2001; 4: 317-323.
18. Siess DC, Vedder CT, Merkens LS, Tanaka T, Freed AC, McCoy SL et al. A human gene coding for a membrane-associated nucleic acid-binding protein. J Biol Chem 2000; 275: 33655-33662.
19. Levy MY, Barron LG, Meyer KB, Szoka Jr FC. Characterization of plasmid DNA transfer into mouse skeletal muscle: Evaluation of uptake mechanism, expression and secretion of gene products into blood. Gene Therapy 1996; 3: 201-211.
20. Crespo A, Peydro A, Dasi F, Benet M, Calvete JJ, Revert F et al. Hydrodynamic liver gene transfer mechanism involves transient sinusoidal blood stasis and massive hepatocyte endocytic vesicles. Gene Therapy 2005; 12: 927-935.
21. Takakura Y, Takagi T, Hashiguchi M, Nishikawa M, Yamashita F, Doi T et al. Characterization of plasmid DNA binding and uptake by peritoneal macrophages from class A scavenger receptor knockout mice. Pharm Res 1999; 16: 503-508.
22. Benimetskaya L, Loike JD, Khaled Z, Loike G, Silverstein SC, Cao L et al. Mac-1 (CD11b/CD18) is an oligodeoxynucleotide-binding protein. Nat Med 1997; 3: 414-420.
23. Satkauskas S, Bureau MF, Puc M, Mahfoudi A, Scherman D, Miklavcic D et al. Mechanisms of in vivo DNA electrotransfer: Respective contributions of cell electropermeabilization and DNA electrophoresis. Mol Ther 2002; 5: 133-140.
24. Kobayashi N, Nishikawa M, Hirata K, Takakura Y. Hydro-dynamics-based procedure involves transient hyperpermeability in the hepatic cellular membrane: Implication of a nonspecific process in efficient intracellular gene delivery. J Gene Med 2004; 6: 584-592.
25. Liu F, Huang L. Noninvasive gene delivery to the liver by mechanical massage. Hepatology 2002; 35: 1314-1319.
26. Liu F, Lei J, Vollmer R, Huang L. Mechanism of liver gene transfer by mechanical massage. Mol Ther 2004; 9: 452-457.
27. Dupuis M, Denis-Mize K, Woo C, Goldbeck C, Selby MJ, Chen M et al. Distribution of DNA vaccines determines their immunogenicity after intramuscular injection in mice. J Immunol 2000; 165: 2850-2858.
28. Davis HL, Whalen RG, Demeneix BA. Direct gene transfer into skeletal muscle in vivo: Factors affecting efficiency of transfer and stability of expression. Hum Gene Ther 1993; 4: 151-159.
29. Hartikka J, Sukhu L, Buchner C, Hazard D, Bozoukova V, Margalith M et al. Electroporation-facilitated delivery of plasmid DNA in skeletal muscle: Plasmid dependence of muscle damage and effect of poloxamer 188. Mol Ther 2001; 4: 407-415.
30. Mir LM, Bureau MF, Gehl J, Rangara R, Rouy D, Caillaud JM et al. High-efficiency gene transfer into skeletal muscle mediated by electric pulses. Proc Natl Acad Sci USA 1999; 96: 4262-4267.
31. United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR). Guidelines for the welfare of animals in experimental neoplasia (second edition). Br J Cancer 1998; 77: 1-10.
32. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156-159.