Bioconversion of compactin into pravastatin by Streptomyces sp.

Biotechnology Letters

Volumn 25, Issue 21, 2003, Pages 1827-1831

  Park, Joo Woong ^a   Lee, Joo Kyung ^a   Kwon, Tae Jong ^b   Yi, Dong Hee ^b   Kim, Young Jun ^d   Moon, Seong Hoon ^d   Suh, Hyun Hyo ^c   Kang, Sang Mo ^b   Park, Yong Il ^d  

^a Yungjin Pharm Co Ltd   (South Korea)

^b Konkuk University   (South Korea)

^c Chinju National University   (South Korea)

^d The Catholic University of Korea   (South Korea)

Author keywords

Bioconversion; Compactin; Cytochrome P 450; Pavastatin; Streptomyces sp.

Indexed keywords

COMPACTIN; CYTOCHROME P450; DRUG DERIVATIVE; MEVINOLIN; PRAVASTATIN;

ARTICLE; BIOREACTOR; BIOSYNTHESIS; BIOTRANSFORMATION; CELL DIVISION; CULTURE TECHNIQUE; CYTOLOGY; EVALUATION; GROWTH, DEVELOPMENT AND AGING; METABOLISM; METHODOLOGY; MICROBIOLOGY; PHYSIOLOGY; STREPTOMYCES;

BIOREACTORS; BIOTRANSFORMATION; CELL CULTURE TECHNIQUES; CELL DIVISION; CYTOCHROME P-450 ENZYME SYSTEM; LOVASTATIN; PRAVASTATIN; STREPTOMYCES;

STREPTOMYCES; STREPTOMYCES SP.;

EID: 0344961885     PISSN: 01415492     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026281914301     Document Type: Article

References (11)

1. Haruyuki Y, Tsubokawa S, Endo A (1985) Microbial hydroxylation of compactin (ML-236B) and monacolin K. J. Antibiotics 38: 605-609.
2. Holt JG (1994) Bergey's Manual of Determinative Bacteriology, 9th edn. Baltmore: Williams and Wilkins Co.
3. Masahiko H, Ogawa K, Yoshikawa H (1993) Application of computer to monitoring and control of fermentation process: microbial conversion of ML-236B Na to pravastatin. Biotechnol. Bioeng. 42: 815-820.
4. Omura T, Sato R (1964) The carbon monooxide-binding pigment of liver microsomes. J. Biol. Chem. 239: 2370-2378.
5. Park JW, Lee JK, Kwon TJ, YI DH, Park YI, Kang SM (2001) Purification and characterization of a cytochrome P-450 from pravatstatin-producing Streptomyses sp. Y-110. J. Microbiol. Biotechnol. 11: 1011-1017.
6. Shepherd J, Cobbe SM, Ford I, Isles CG, Lorimer AR, Macferlane PW, Mckillop JH, Packard CJ (1995) Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. New Engl. J. Med. 333: 1301-1309.
7. Shirling EB, Gottlieb D (1966) Methods for characterization of Streptomyces species. Int. J. Syst. Bacteriol. 16: 313-340.
8. Willcox WB, Vapage SP, Bascomb S, Curtis MA (1973) Identification of bacteria by computer: theory and programming. J. Gen. Microbiol. 77: 317-310.
9. Williams ST, Goodfellow M, Alderson G, Wellington EMH, Sneath PHA, Sackin M (1983) Numerical classification of Streptomyces and related genera. J. Gen. Microbiol. 129: 1743-1813.
10. Williams ST, Sharpe ME, Holt JG, Murray RG, Brener DJ, Krieg NR, Mouldar JW, Pfenning N, Sneath PHA, Staley JT (1989) Bergey's Mannual of Systematic Bacteriology, Vol. 4. Baltimore: William & Willkins Co.
11. Yulin P, Yashphe J, Demain AL (1997) Biotransformation of compactin to pravastatin by Actinomadura sp. 2966. J. Antibiotics 50: 1032-1035.