-
1
-
-
0023754423
-
Discovery, biochemistry and biology of lovastatin
-
Alberts, A. W. 1988. Discovery, biochemistry and biology of lovastatin. Am. J. Cardiol. 62:10J-15J.
-
(1988)
Am. J. Cardiol.
, vol.62
-
-
Alberts, A.W.1
-
2
-
-
0025180855
-
Effect of HMG CoA rcductase inhibitors on cholesterol synthesis
-
Alberts, A. W. 1990. Effect of HMG CoA rcductase inhibitors on cholesterol synthesis. Drug Invest. 2:9-12.
-
(1990)
Drug Invest.
, vol.2
, pp. 9-12
-
-
Alberts, A.W.1
-
3
-
-
0018939225
-
Mevinolin: A highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme a reductase and a cholesterol-lowering agent
-
Alberts, A. W., J. Kuron, V. Hunt, J. Huff, J. Hoffman, J. Rothrock, M. Lopez, H. Joshua, E. Harris, A. Patchett, R. Monaghan, S. Currie, E. Stapley, G. Albers-Schonberg, O. Hensens, J. Hirshfield, K. Hoogsteen, J. Liesch, and J. Springer. 1980. Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc. Natl. Acad. Sci. USA 77:3957-3961.
-
(1980)
Proc. Natl. Acad. Sci. USA
, vol.77
, pp. 3957-3961
-
-
Alberts, A.W.1
Kuron, J.2
Hunt, V.3
Huff, J.4
Hoffman, J.5
Rothrock, J.6
Lopez, M.7
Joshua, H.8
Harris, E.9
Patchett, A.10
Monaghan, R.11
Currie, S.12
Stapley, E.13
Albers-Schonberg, G.14
Hensens, O.15
Hirshfield, J.16
Hoogsteen, K.17
Liesch, J.18
Springer, J.19
-
4
-
-
0000610543
-
Synthesis of synvinolin: Extremely hich conversion alkylation of an ester enolate
-
Askin, D., T. R. Verhoeven, T. M.-H. Liu, and I. Shinkai. 1991. Synthesis of synvinolin: extremely hich conversion alkylation of an ester enolate. J. Org. Chem. 56:4929-4932.
-
(1991)
J. Org. Chem.
, vol.56
, pp. 4929-4932
-
-
Askin, D.1
Verhoeven, T.R.2
Liu, T.M.-H.3
Shinkai, I.4
-
5
-
-
0027488722
-
Coronary angiographic changes with lovastatin therapy
-
Blankenhorn, D. H., S. P. Azen, D. M. Kramsch, W. J. Mack, L. Cashin-Hemphill, H. N. Hodis, L. W. V. DeBoer, P. R. Mahrer, M. J. Masteller, L. I. Vailas, P. Alaupovic, L. J. Hirsch, and the MARS Research Group. 1993. Coronary angiographic changes with lovastatin therapy. Ann. Intern. Med. 119:969-976.
-
(1993)
Ann. Intern. Med.
, vol.119
, pp. 969-976
-
-
Blankenhorn, D.H.1
Azen, S.P.2
Kramsch, D.M.3
Mack, W.J.4
Cashin-Hemphill, L.5
Hodis, H.N.6
Deboer, L.W.V.7
Mahrer, P.R.8
Masteller, M.J.9
Vailas, L.I.10
Alaupovic, P.11
Hirsch, L.J.12
Group, T.M.R.13
-
6
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
-
(1976)
Anal. Biochem.
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
7
-
-
0343712903
-
Industrial enzymes in drug development
-
J. M. Tabor (ed.), Marcel Dekker, Inc., New York, N.Y.
-
Burnett, W. V., and T. G. Heckler. 1989. Industrial enzymes in drug development, p. 133-154. In J. M. Tabor (ed.), Genetic engineering technology in industrial pharmacy. Marcel Dekker, Inc., New York, N.Y.
-
(1989)
Genetic Engineering Technology in Industrial Pharmacy
, pp. 133-154
-
-
Burnett, W.V.1
Heckler, T.G.2
-
8
-
-
0028292593
-
8-Hydroxypenillic acid - NMR characteristics and facile formation from 6-aminopenicillanic acid
-
Casy, A. F., and A. Lipczynski. 1994. 8-Hydroxypenillic acid - NMR characteristics and facile formation from 6-aminopenicillanic acid. J. Pharm. Pharmacol. 46:533-534.
-
(1994)
J. Pharm. Pharmacol.
, vol.46
, pp. 533-534
-
-
Casy, A.F.1
Lipczynski, A.2
-
9
-
-
36949069667
-
Formation of 6-aminopenicillanic acid from penicillin by enzymatic hydrolysis
-
Claridge, C. A., A. Gourevitch, and J. Lein. 1960. Formation of 6-aminopenicillanic acid from penicillin by enzymatic hydrolysis. Nature 187:236-238.
-
(1960)
Nature
, vol.187
, pp. 236-238
-
-
Claridge, C.A.1
Gourevitch, A.2
Lein, J.3
-
10
-
-
0342517582
-
-
October U.S. patent 5250435
-
Cover, W. H., R. L. Dabora. A. Hong, C. Reeves, R. W. Stieber, and V. A. Vinci. October 1993. Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8A(R)-hexa-hydro-2(S), 6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R)-dihydroxyheptanoic acid (triol acid). U.S. patent 5250435.
-
(1993)
Mutant Strains of Aspergillus Terreus for Producing 7-[1,2,6,7,8,8A(R)-hexa-hydro-2(S), 6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R)-dihydroxyheptanoic Acid (Triol Acid)
-
-
Cover, W.H.1
Dabora, R.L.2
Hong, A.3
Reeves, C.4
Stieber, R.W.5
Vinci, V.A.6
-
11
-
-
0017055252
-
ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinum
-
Endo, A., M. Kuroda, and Y. Tsujita. 1976. ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinum. J. Antibiot. 29:1346-1348.
-
(1976)
J. Antibiot.
, vol.29
, pp. 1346-1348
-
-
Endo, A.1
Kuroda, M.2
Tsujita, Y.3
-
12
-
-
0018592266
-
Monacolin K, a new hypocholesterolemic agent produced by a Monsacus species
-
Endo, A. 1979. Monacolin K, a new hypocholesterolemic agent produced by a Monsacus species. J. Antibiot. 32:852-854.
-
(1979)
J. Antibiot.
, vol.32
, pp. 852-854
-
-
Endo, A.1
-
13
-
-
84982044713
-
Ferulic acid esterase from Aspergillus niger - Purification and partial characterization of two forms from a commercial source of pectinase
-
Faulds, C. B., and G. Williamson. 1993. Ferulic acid esterase from Aspergillus niger - purification and partial characterization of two forms from a commercial source of pectinase. Biotechnol. Appl. Biochem. 17:349-359.
-
(1993)
Biotechnol. Appl. Biochem.
, vol.17
, pp. 349-359
-
-
Faulds, C.B.1
Williamson, G.2
-
14
-
-
0029981745
-
A simple preparative method for tert-butyl protection of aminocephalosporanic acid
-
Grigan, N., D. Musel, G. A. Veinberg, and E. Lukevics. 1996. A simple preparative method for tert-butyl protection of aminocephalosporanic acid. Synth. Commun. 26:1183-1185.
-
(1996)
Synth. Commun.
, vol.26
, pp. 1183-1185
-
-
Grigan, N.1
Musel, D.2
Veinberg, G.A.3
Lukevics, E.4
-
15
-
-
0027332512
-
Pleurotus fungi produce mevinolin, an inhibitor of HMG-CoA reductase
-
Gunde-Cimerman, N., A. Plenenitas, and A. Cimerman. 1993. Pleurotus fungi produce mevinolin, an inhibitor of HMG-CoA reductase. FEMS Microbiol. Lett. 113:333-337.
-
(1993)
FEMS Microbiol. Lett.
, vol.113
, pp. 333-337
-
-
Gunde-Cimerman, N.1
Plenenitas, A.2
Cimerman, A.3
-
16
-
-
0022486908
-
3-Hydroxy-3-methylglularyl-coenzyme a reductase inhibitors. 4. Side chain ester derivatives of mevinolin
-
Hoffman, W. F., A. W. Alberts, P. S. Anderson, J. S. Chen, R. L. Smith, and A. K. Willard. 1986. 3-Hydroxy-3-methylglularyl-coenzyme A reductase inhibitors. 4. Side chain ester derivatives of mevinolin. J. Med. Chem. 29:849-852.
-
(1986)
J. Med. Chem.
, vol.29
, pp. 849-852
-
-
Hoffman, W.F.1
Alberts, A.W.2
Anderson, P.S.3
Chen, J.S.4
Smith, R.L.5
Willard, A.K.6
-
17
-
-
0028002015
-
Production of penicillin acylase from Bacillus megaterium in complex and defined media
-
Illanes, A., F. Acevedo, J. C. Gentina, I. Reyes, R. Torres, O. Caragena, A. Ruiz, and M. Vasquez. 1994. Production of penicillin acylase from Bacillus megaterium in complex and defined media. Process Biochem. 29:263-270.
-
(1994)
Process Biochem.
, vol.29
, pp. 263-270
-
-
Illanes, A.1
Acevedo, F.2
Gentina, J.C.3
Reyes, I.4
Torres, R.5
Caragena, O.6
Ruiz, A.7
Vasquez, M.8
-
18
-
-
0024205325
-
Engineering biocatalytic systems in organic media with low water content
-
Khmelnitsky, Y. L., A. V. Levashov, N. L. Klyachko, and K. Martinek. 1988. Engineering biocatalytic systems in organic media with low water content. Enzyme Microb. Technol. 10:710-715.
-
(1988)
Enzyme Microb. Technol.
, vol.10
, pp. 710-715
-
-
Khmelnitsky, Y.L.1
Levashov, A.V.2
Klyachko, N.L.3
Martinek, K.4
-
19
-
-
0030568517
-
Penicillin acylase-catalyzed synthesis of pivampicillin - Effect of reaction variables and organic cosolvents
-
Kim, M. G., and S. B. Lee. 1996. Penicillin acylase-catalyzed synthesis of pivampicillin - effect of reaction variables and organic cosolvents. J. Mol. Catal. B Enzymatic 1:71-80.
-
(1996)
J. Mol. Catal. B Enzymatic
, vol.1
, pp. 71-80
-
-
Kim, M.G.1
Lee, S.B.2
-
20
-
-
0022969753
-
Microbial conversion of compactin (ML-236B) to ML-236A
-
Komagata, D., H. Yamashita, and A. Endo. 1986. Microbial conversion of compactin (ML-236B) to ML-236A. J. Antibiot. 39:1574-1577.
-
(1986)
J. Antibiot.
, vol.39
, pp. 1574-1577
-
-
Komagata, D.1
Yamashita, H.2
Endo, A.3
-
21
-
-
0027938951
-
Heterogeneity of plasma low-density lipoproteins and atherosclerosis risk
-
Krauss, R. M. 1994. Heterogeneity of plasma low-density lipoproteins and atherosclerosis risk. Curr. Opin. Lipidol. 5:339-349.
-
(1994)
Curr. Opin. Lipidol.
, vol.5
, pp. 339-349
-
-
Krauss, R.M.1
-
22
-
-
0014949207
-
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
-
Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
-
(1970)
Nature
, vol.227
, pp. 680-685
-
-
Laemmli, U.K.1
-
23
-
-
0028394355
-
Purification and characterization of an acetyl esterase from Aspergillus niger
-
Linden, J., M. Samara, S. Decker, E. Johnson, M. Boyer, M. Pecs, W. Adney, and M. Himmel. 1994. Purification and characterization of an acetyl esterase from Aspergillus niger. Appl. Biochem. Biotechnol. 45-46:383-93.
-
(1994)
Appl. Biochem. Biotechnol.
, vol.45-46
, pp. 383-393
-
-
Linden, J.1
Samara, M.2
Decker, S.3
Johnson, E.4
Boyer, M.5
Pecs, M.6
Adney, W.7
Himmel, M.8
-
24
-
-
0028842521
-
Enzymatic synthesis of hydrophobic penicillins
-
Luengo, J. M. 1995. Enzymatic synthesis of hydrophobic penicillins. J. Antibiot. 48:1195-1212.
-
(1995)
J. Antibiot.
, vol.48
, pp. 1195-1212
-
-
Luengo, J.M.1
-
25
-
-
0029092064
-
Simvastatin: A reappraisal of its pharmacology and therapeutic efficacy in hypercholesterolaemia
-
Plosker, G. L., and D. McTavish. 1995. Simvastatin: a reappraisal of its pharmacology and therapeutic efficacy in hypercholesterolaemia. Drugs 50: 334-363.
-
(1995)
Drugs
, vol.50
, pp. 334-363
-
-
Plosker, G.L.1
McTavish, D.2
-
26
-
-
0343822805
-
-
April U.S. patent 4,582,915
-
Sleteinger, M., T. Verhoeven, and R. Volante. April 1986. One step process for C-methylation of 2-methylbutyrates. U.S. patent 4,582,915.
-
(1986)
One Step Process for C-methylation of 2-methylbutyrates
-
-
Sleteinger, M.1
Verhoeven, T.2
Volante, R.3
-
27
-
-
0022512448
-
3-Hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors. 5. 6-(Fluoren-9-yl)- And 6-(fluoren-9-ylidenyl)-3,5-dihydroxyhexanoic acids and their lactone derivatives
-
Stokker, G. E., A. W. Alberts, J. L. Gilfillan, J. W. Huff, and R. L. Smith. 1986. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 5. 6-(Fluoren-9-yl)-and 6-(fluoren-9-ylidenyl)-3,5-dihydroxyhexanoic acids and their lactone derivatives. J. Med. Chem. 29:852-855.
-
(1986)
J. Med. Chem.
, vol.29
, pp. 852-855
-
-
Stokker, G.E.1
Alberts, A.W.2
Gilfillan, J.L.3
Huff, J.W.4
Smith, R.L.5
-
28
-
-
0000071495
-
Molecular aspects of penicillin and cephalosporin acylases
-
Sudhakaran, V. K., B. S. Deshpande, S. S. Ambedkar, and J. G. Shewale. 1992. Molecular aspects of penicillin and cephalosporin acylases. Process Biochem. 27:131-143.
-
(1992)
Process Biochem.
, vol.27
, pp. 131-143
-
-
Sudhakaran, V.K.1
Deshpande, B.S.2
Ambedkar, S.S.3
Shewale, J.G.4
-
29
-
-
0023217436
-
New developments in lipid-lowering therapy: The role of inhibitors of hydroxymethylglutaryl-coenzyme a reductase
-
Tobert, J. A. 1987. New developments in lipid-lowering therapy: the role of inhibitors of hydroxymethylglutaryl-coenzyme A reductase. Circulation 76: 534-538.
-
(1987)
Circulation
, vol.76
, pp. 534-538
-
-
Tobert, J.A.1
-
30
-
-
0027983554
-
Synthesis of new sulfonylamido-penicillanic acid sulfones
-
VanWetswinkel, S., J. Fastrez, and J. Marchandbrynaert. 1994. Synthesis of new sulfonylamido-penicillanic acid sulfones. J. Antibiot. 47:1041-1051.
-
(1994)
J. Antibiot.
, vol.47
, pp. 1041-1051
-
-
VanWetswinkel, S.1
Fastrez, J.2
Marchandbrynaert, J.3
-
31
-
-
0023199520
-
The clinical efficacy and safety of lovastatin and MK-733 - An overview
-
Walker, J. F., and J. A. Tobert. 1988. The clinical efficacy and safety of lovastatin and MK-733 - an overview. Eur. Heart J. 8(Suppl. E):93-96.
-
(1988)
Eur. Heart J.
, vol.8
, Issue.SUPPL. E
, pp. 93-96
-
-
Walker, J.F.1
Tobert, J.A.2
-
32
-
-
0028267313
-
Effects of monotherapy with an HMG-CoA reductase inhibitor on the progression of coronary atherosclerosis as assessed by serial quantitative arteriography - The Canadian coronary atherosclerosis intervention trial
-
Waters, D., L. Higginson, P. Gladstone, B. Kimball, M. LeMay, S. J. Boccuzzi, J. Lesperance, and the CCAIT Study Group. 1994. Effects of monotherapy with an HMG-CoA reductase inhibitor on the progression of coronary atherosclerosis as assessed by serial quantitative arteriography - the Canadian coronary atherosclerosis intervention trial. Circulation 89:959-968.
-
(1994)
Circulation
, vol.89
, pp. 959-968
-
-
Waters, D.1
Higginson, L.2
Gladstone, P.3
Kimball, B.4
Lemay, M.5
Boccuzzi, S.J.6
Lesperance, J.7
|