Rational design, synthesis and in vitro evaluation of three new alkylating steroidal esters

Medicinal Chemistry

Volumn 2, Issue 6, 2006, Pages 569-576

  Fousteris, M A ^a   Koutsourea, A I ^a   Lagonikakos, N P ^a   Arsenou, E S ^a   Spyridonidou, C ^a   Mourelatos, D ^b   Nikolaropoulos, S S ^a  

^a UNIVERSITY OF PATRAS   (Greece)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

B steroidal lactam; Nitrogen mustards; Proliferation rate; SAR; SCE; Steroidal esters

Indexed keywords

3 BETA HYDROXY 7 ALPHA AZA HOMO 17 BETA ACETAMIDEANDROST 5 EN 7 ONE 4 METHYL 3 N,N BIS (2 CHLOROETHYL)AMINOBENZOIC ACID; 3 BETA HYDROXY 7 ALPHA AZA HOMO 17 BETA ACETAMIDEANDROST 5 EN 7 ONE 4 N,N BIS (2 CHLOROETHYL)AMINOPHENYLACETATE; 3 BETA HYDROXY 7 ALPHA AZA HOMO 17 BETA ACETAMIDEANDROST 5 EN 7 ONE 4 N,N BIS (2 CHLOROETHYL)AMINOPHENYLBUTYRATE; ALKYLATING AGENT; ALKYLATING STEROID ESTER; CHLORMETHINE DERIVATIVE; ESTER DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; BIOLOGICAL ACTIVITY; CELL DEATH; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DNA ADDUCT; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME INHIBITION; EXCISION REPAIR; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; INFRARED SPECTROSCOPY; LYMPHOCYTE; MELTING POINT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SISTER CHROMATID EXCHANGE; THIN LAYER CHROMATOGRAPHY;

EID: 33750979028     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/1573406410602060569     Document Type: Article

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