Antileukemic and cytogenetic effects of modified and non-modified Esteric steroidal derivatives of 4-Methyl-3-bis(2-chloroethyl) amino benzoic acid (4-Me-CABA)

Anticancer Research

Volumn 22, Issue 4, 2002, Pages 2293-2299

  Fousteris, Manolis A ^a   Koutsourea, Anna I ^a   Arsenou, Evagelia S ^a   Papageorgiou, Athanasios ^a   Mourelatos, Dionisis ^a   Nikolaropoulos, Sotiris S ^a  

^a UNIVERSITY OF PATRAS   (Greece)

Author keywords

Antileukemic activity; Antitumor steroidal derivatives; Cytogenetic effects; Nitrogen mustards

Indexed keywords

4 METHYL 3 BIS(2 CHLOROETHYL)AMINOBENZOIC ACID; CHLORMETHINE; STEROID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOGENETICS; DNA SEQUENCE; DRUG STRUCTURE; FEMALE; MALE; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SISTER CHROMATID EXCHANGE; STRUCTURE ACTIVITY RELATION;

4-AMINOBENZOIC ACID; ANIMALS; ANTINEOPLASTIC AGENTS; HUMANS; LEUKEMIA L1210; LEUKEMIA P388; LYMPHOCYTES; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MOLECULAR STRUCTURE; SISTER CHROMATID EXCHANGE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036336963     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Formation and removal of DNA cross-links induced by melphalan and nitrogen mustard in relation to drug-induced cytotoxicity in human melanoma cells
2. Mechanisms of DNA sequence selective alkylation of guanine N7 positions by nitrogen mustards
3. Mechlorethamine cross-links deoxyguanoside residues at 5′-GNC sequences in duplex DNA fragments
4. Interstrand cross-linking of DNA by 1,3-bis(2-chloroethyl)-1-nitrosourea and other 1-(2-haloethyl)-1 -nitrosoureas
5. DNA-protein and DNA-interstrand crosslinking by cis- and trans-platinum(II) diamminedichloride in L1210 mouse leukemia cells and relation to cytotoxicity
6. DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells
7. Relationships between functionality and genetic toxicology of selected DNA-damaging agents
8. Synthesis, DNA interactions and biological activity of DNA minor groove targeted polybenzamide-linked nitrogen mustards
9. Hormones, vitamins and growth factors in cancer treatment and prevention
10. Antitumor activity of steroidal lactone esters of N,N-bis(2-chloroethyl)aminophenylacetic acid
11. Effects of homo-aza-steroidal ester of p-bis(2chloroethyl)aminophenylacetic acid on lymphocytes stimulated with PHA in vitro
12. Chromosome damage and SCE induced by the cytostatic factor homo-aza-steroidal ester of p-bis(2-chloroethyl) aminophenyl acetic acid in CHO cells in culture
13. Antitumor and cytogenetic effects of esteric (ASE) and amidic (ASA) steroidal derivatives of pbis(2-chloroethyl) amino phenylacetic acid (CAPA). A comparative study
14. On the formation of homo-aza-steroidal esters of N,N-bis(2-chloroethyl)aminobenzoic acid isomers and their antitumor activity
15. Monofunctional adenine N3 adducts of melphalan: Occurrence at a mutational hotspot sequence and resistance to removal by AlkA protein
16. 17- and 17α-aza-D-homo steroids
17. Steroids. XVI. Beckmann rearrangement of 17ketosteroid oximes
18. Steroids and steroidases. Studies on some potentially antitumor active androstane compounds containing C-17 nitrogen mustard functions
19. Potential anticancer agents. IV. Nitrogen mustards of methylbenzoic acid
20. Potential anticancer agents. V. New aromatic nitrogen mustards related to 3-[N,N-bis(2chloroethyl)amino]-4-methylbenzoic acid
21. Factors involved in differential Giesma staining of sister chromatids
22. Experimental evaluation of antitumor drugs in the USA and USSR and clinical correlations
23. A new steroidal alkylating agent with improved activity in advanced murine leukaemias
24. Antitumor activity of homo-aza-steroidal esters of p-bis(2-chloroethyl) amino phenylacetic acid
25. Antileukemic effect of homo-aza-steroidal ester of p-bis(2-chloroethyl) amino phenylacetic acid
26. An agarose gel method for the determination of DNA interstrand crosslinking applicable to the measurement of the rate of total and "second-arm" crosslink reactions
27. Prediction of in vivo tumor response to chemotherapeutic agents by the in vitro SCE assay
28. Enhancement of cytogenetic damage and of antineoplastic effect by caffeine in Ehrlich ascites tumour cells treated with cyclophosphamide in vivo
29. Prediction of human tumour cell chemosensitivity using the SCE assay
30. A comparison of the toxic and SCE-inducing effects of inhibitors of ADP-ribosyl transferase in CHO cells
31. Chromosomes study as predictor of chemoresponse of tumours