Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: Correlation with incidence, onset and severity of disease

Human Molecular Genetics

Volumn 14, Issue 14, 2005, Pages 1977-1989

  Mazón Peláez, Ignacio ^a   Vogler, Susanne ^a   Strauss, Ulf ^a   Wernhoff, Patrik ^a   Pahnke, Jens ^a,c   Brockmann, Gudrun ^b   Moch, Holger ^c   Thiesen, Hans Juergen ^a   Rolfs, Arndt ^a   Ibrahim, Saleh M ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

MYELIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CELL INFILTRATION; CHROMOSOME 1; CHROMOSOME 10; CHROMOSOME 15; CHROMOSOME 2; CHROMOSOME 8; CONTROLLED STUDY; DEMYELINATION; DISEASE SEVERITY; EVOKED CORTICAL RESPONSE; EVOKED MUSCLE RESPONSE; FEMALE; GENETIC LINKAGE; GENETIC REGULATION; GENETIC SUSCEPTIBILITY; GENOTYPE; INCIDENCE; MALE; MICROSATELLITE MARKER; MOUSE; MOUSE STRAIN; MULTIPLE SCLEROSIS; NONHUMAN; ONSET AGE; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS MAPPING; SYNAPTIC TRANSMISSION; T LYMPHOCYTE; TISSUE MICROARRAY;

ANIMALS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EVOKED POTENTIALS, MOTOR; FEMALE; LINKAGE (GENETICS); MALE; MICE; MICE, INBRED C57BL; QUANTITATIVE TRAIT LOCI; SEVERITY OF ILLNESS INDEX;

ANIMALIA;

EID: 26444593052     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddi203     Document Type: Article

References (44)

1. Ebers, G.C., Sadovnick, A.D. and Risch, N.J. (1995) A genetic basis for familial aggregation in multiple sclerosis. Canadian Collaborative Study Group. Nature, 377, 150-151.
2. Dyment, D.A., Sadovnick, A.D., Ebers, G.C. and Sadnovich, A.D. (1997) Genetics of multiple sclerosis. Hum. Mol. Genet., 6, 1693-1698.
3. Teuscher, C., Hickey, W.F., Grafer, C.M. and Tung, K.S. (1998) A common immunoregulatory locus controls susceptibility to actively induced experimental allergic encephalomyelitis and experimental allergic orchitis in BALB/c mice. J. Immunol., 160, 2751-2756.
4. Kurtzke, J.F. (1993) Epidemiologic evidence for multiple sclerosis as an infection. Clin. Microbiol. Rev., 6, 382-427.
5. Serrano-Fernández, P., Ibrahim, S.M., Zettl, U.K., Thiesen, H.J., Gödde, R., Epplen, J.T. and Möller, S. (2004) Intergenomic consensus in multifactorial inheritance loci: The case of multiple sclerosis. Genes Immun., 5, 615-620.
6. Wandstrat, A. and Wakeland, E. (2001) The genetics of complex autoimmune diseases: Non-MHC susceptibility genes. Nat. Immunol., 2, 802-809.
7. Encinas, J.A., Lees, M.B., Sobel, R.A., Symonowicz, C., Greer, J.M., Shovlin, C.L., Weiner, H.L., Seidman, C.E., Seidman, J.G. and Kuchroo, V.K. (1996) Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice. J. Immunol., 157, 2186-2192.
8. Bergsteinsdottir, K., Yang, H.T., Pettersson, U. and Holmdahl, R. (2000) Evidence for common autoimmune disease genes controlling onset, severity, and chronicity based on experimental models for multiple sclerosis and rheumatoid arthritis. J. Immunol., 164, 1564-1568.
9. Butterfield, R.J., Blankenhorn, E.P., Roper, R.J., Zachary, J.F., Doerge, R.W. and Teuscher, C. (2000) Identification of genetic loci controlling the characteristics and severity of brain and spinal cord lesions in experimental allergic encephalomyelitis. Am. J. Pathol. 157, 637-645.
10. Butterfield, R.J., Sudweeks, J.D., Blankenhorn, E.P., Korngold, R., Marini, J.C., Todd, J.A., Roper, R.J. and Teuscher, C. (1998) New genetic loci that control susceptibility and symptoms of experimental allergic encephalomyelitis in inbred mice. J. Immunol., 161, 1860-1867.
11. Klein, J., Figueroa, F. and David, C.S. (1983) H-2 haplotypes, genes and antigens: Second listing. II. The H-2 complex. Immunogenetics, 17, 553-596.
12. Ituliano, B.A., Schmelzer, J.D., Thiemann, R.L., Low, P.A. and Rodriguez, M. (1994) Motor and somatosensory evoked potentials in mice infected with Theiler's murine encephalomyelitis virus. J. Neurol. Sci., 123, 186-194.
13. McGavern, D.B., Murray, P.D., Rivera-Quinones, C., Schmelzer, J.D., Low, P.A. and Rodriguez, M. (2000) Axonal loss results in spinal cord atrophy, electrophysiological abnormalities and neurological deficits following demyelination in a chronic inflammatory model of multiple sclerosis. Brain, 123, 519-531.
14. Butterfield, R.J., Roper, R.J., Rhein, D.M., Melvold, R.W., Haynes. L., Ma, R.Z., Doerge, R.W. and Teuscher, C. (2003) Sex-specific quantitative trait loci govern susceptibility to Theiler's murine encephalomyelitis virus-induced demyelination. Genetics, 163, 1041-1046.
15. Wicker, L.S., Chamberlain, G., Hunter, K., Rainbow, D., Howlett, S., Tiffen, P., Clark, J., Gonzalez-Munoz, A., Cumiskey. A.M., Rosa, R.L. et al. (2004) Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse. J. Immunol., 173, 164-173.
16. Greve, B., Vijayakrishnan, L., Kubal, A., Sobel, R.A., Peterson, L.B., Wicker, L.S. and Kuchroo, V.K. (2004) The diabetes susceptibility locus Idd5.1 on mouse chromosome 1 regulates ICOS expression and modulates murine experimental autoimmune encephalomyelitis. J. Immunol., 173, 157-163.
17. Blankenhorn, E.P., Butterfield, R.J., Rigby, R., Cort, L., Giambrone, D., McDermott, P., McEntee, K., Solowski, N., Meeker, N.D., Zachary, J.F. et al. (2000) Genetic analysis of the influence of pertussis toxin on experimental allergic encephalomyelitis susceptibility: An environmental agent can override genetic checkpoints. J. Immunol., 164, 3420-3425.
18. Doyle, J., Ren, X., Lennon, G. and Stubbs, L. (1997) Mutations in the Cacnl1a4 calcium channel gene are associated with seizures, cerebellar degeneration, and ataxia in tottering and leaner mutant mice. Mamm. Genome, 8, 113-120.
19. Burgess, D.L. and Noebels, J.L. (1999) Single gene defects in mice: The role of voltage-dependent calcium channels in absence models. Epilepsy Res., 36, 111-122.
20. Lee, Y.C., Chen, J.T., Liao, K.K., Wu, Z.A. and Soong, B.W. (2003) Prolonged cortical relay time of long latency reflex and central motor conduction in patients with spinocerebellar ataxia type 6. Clin. Neurophysiol., 114, 458-462.
21. Carmody, R.J., Hilliard, B., Maguschak, K., Chodosh, L.A. and Chen, Y.H. (2002) Genomic scale profiling of autoimmune inflammation in the central nervous system: The nervous response to inflammation. J. Neuroimmunol., 133, 95-107.
22. Keramaris, E., Stefanis, L., MacLaurin, J., Harada, N., Takaku, K., Ishikawa, T., Taketo, M.M., Robertson, G.S., Nicholson, D.W., Slack, R.S. et al. (2000) Involvement of caspase 3 in apoptotic death of cortical neurons evoked by DNA damage. Mol. Cell. Neurosci., 15 368-379.
23. Cid, C., Alvarez-Cermeno, J.C., Regidor, I., Plaza, J., Salinas, M. and Alcazar, A. (2003) Caspase inhibitors protect against neuronal apoptosis induced by cerebrospinal fluid from multiple sclerosis patients. J. Neuroimmunol., 136, 119-124.
24. Neumar, R.W., Xu, Y.A., Gada, H., Guttmann, R.P. and Siman, R. (2003) Cross-talk between calpain and caspase proteolytic systems during neuronal apoptosis. J. Biol. Chem., 278, 14162-14167.
25. Howe, C.L., Bieber, A.J., Warrington, A.E., Pease, L.R. and Rodriguez, M. (2004) Antiapoptotic signaling by a remyelination-promoting human antimyelin antibody. Neurobiol. Dis., 15, 120-131.
26. Ibrahim, S.M., Mix, E., Bottcher, T., Koczan, D., Gold, R., Rolfs, A. and Thiesen, H.J. (2001) Gene expression profiling of the nervous system in murine experimental autoimmune encephalomyelitis. Brain, 124 1927-1938.
27. Chen, H., Jawahar, S., Qian, Y., Duong, Q., Chan, G., Parker, A., Meyer, J.M., Moore, K.J., Chayen, S., Gross, D.J. et al. (2001) Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity. Hum. Mutat., 18, 120-131.
28. Utsunomiya, N., Ohagi, S., Sanke, T., Tatsuta, H., Hanabusa, T. and Nanjo, K. (1998) Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity. Diabetologia, 41, 701-705.
29. Haegeman, A., Williams, J.L., Law, A., van Zeveren, A. and Peelman, L.J. (2003) Mapping and SNP analysis of bovine candidate genes for meat and carcass quality. Anim. Genet., 34, 349-353.
30. Schumacher, R.F., Mella, P., Badolato, R., Fiorini, M., Savoldi, G., Giliani, S., Villa, A., Candotti, F., Tampalini, A., O'Shea, J.J. et al. (2000) Complete genomic organization of the human JAK3 gene and mutation analysis in severe combined immunodeficiency by single-strand conformation polymorphism. Hum. Genet., 106, 73-79.
31. Cool, D.R., Normant, E., Shen, F., Chen, H.C., Pannell, L., Zhang. Y. and Loh, Y.P. (1997) Carboxypeptidase E is a regulated secretory pathway sorting receptor: Genetic obliteration leads to endocrine disorders in Cpe(fat) mice. Cell, 88, 73-83.
32. Witthuhn, B.A., Silvennoinen, O., Miura, O., Lai, K.S., Cwik, C., Liu, E.T. and Ihle, J.N. (1994) Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature, 370, 153-157.
33. Letts, V.A., Felix, R., Biddlecome, G.H., Arikkath, J., Mahaffey, C.L., Valenzuela. A., Bartlett, F.S., II, Mori, Y., Campbell, K.P. and Frankel, W.N. (1998) The mouse stargazer gene encodes a neuronal Ca2 +-channel gamma subunit. Nat. Genet., 19, 340-347.
34. Beaulieu, J.M., Nguyen, M.D. and Julien, J.P. (1999) Late onset of motor neurons in mice overexpressing wild-type peripherin. J. Cell. Biol. 147, 531-544.
35. McIndoe, R.A., Bohlman, B., Chi, E., Schuster, E., Lindhardt, M. and Hood, L. (1999) Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBA/1j mice. Proc. Natl Acad. Sci. USA, 96, 2210-2214.
36. Olsson, T. (1992) Cytokines in neuroinflammatory disease: Role of myelin autoreactive T cell production of interferon-gamma. J. Neuroimmunol. 40, 211-218.
37. Milner. R. and Campbell, I.L. (2003) The extracellular matrix and cytokines regulate microglial integrin expression and activation. J. Immunol., 170, 3850-3858.
38. Venstrom, K.A. and Reichardt, L.F. (1993) Extracellular matrix. 2: Role of extracellular matrix molecules and their receptors in the nervous system. FASEB J., 7, 996-1003.
39. Duckers, H.J., van Dokkum, R.P., Verhaagen, J., Lopes da Silva, F.H. and Gispen, W.H. (1996) Functional and neurophysiological evidence of the efficacy of trophic pharmacotherapy using an adrenocorticotrophic hormone 4-9 analog in experimental allergic encephalomyelitis, an animal model of multiple sclerosis. Neuroscience, 71, 507-521.
40. Onofrj, M., Gambi, D., Bazzano, S., Colamartino, P., Fulgente, T., Malatesta, G. and Ferracci, F. (1992) Evoked potentials (EPs) in experimental allergic encephalomyelitis: A study of EP modifications during the course of a controlled disease. Electromyogr. Clin. Neurophysiol., 32, 125-135.
41. Laird, P.W., Zijderveld, A., Linders, K., Rudnicki, M.A., Jaenisch, R. and Berns, A. (1991) Simplified mammalian DNA isolation procedure. Nucleic. Acids Res., 19, 4293.
42. Moch, H., Schraml, P., Bubendorf, L., Mirlacher, M., Kononen, J., Gasser, T., Mihatsch, M.J., Kallioniemi, O.P. and Sauter, G. (1999) High-throughput tissue microarray analysis to evaluate genes uncovered by cDNA microarray screening in renal cell carcinoma. Am. J. Pathol. 154, 981-986.
43. Sen, S. and Churchill, G.A. (2001) A statistical framework for quantitative trait mapping. Genetics, 159, 371-387.
44. Broman, K.W., Wu, H., Sen, S. and Churchill, G.A. (2003) R/qtl: QTL mapping in experimental crosses. Bioinformatics, 19, 889-890.