Prevalence of dopamine and 5HT2C receptor polymorphisms in Amerindians and in an urban population from Argentina

American Journal of Human Biology

Volumn 18, Issue 6, 2006, Pages 822-828

  Martínez Marignac, Verónica L ^a   Bianchi, Néstor O ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b Instituto Multidisciplinario de Biologia Celular   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR A1; DOPAMINE 3 RECEPTOR; DOPAMINE 3 RECEPTOR A1; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR; MITOCHONDRIAL DNA; SEROTONIN 2C RECEPTOR; SEROTONIN 2C RECEPTOR A1; SEROTONIN RECEPTOR; UNCLASSIFIED DRUG;

AMERICAN INDIAN; ARGENTINA; ARTICLE; CHILE; DISEASE ASSOCIATION; DNA EXTRACTION; ETHNIC DIFFERENCE; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; HUMAN EXPERIMENT; MALE; MENTAL DISEASE; MOOD DISORDER; NEUROPSYCHIATRY; NORMAL HUMAN; PARAGUAY; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; URBAN POPULATION;

ARGENTINA; CHILE; CONFOUNDING FACTORS (EPIDEMIOLOGY); EPIDEMIOLOGY, MOLECULAR; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; HUMANS; INDIANS, SOUTH AMERICAN; MALE; MENTAL DISORDERS; PARAGUAY; POLYMORPHISM, GENETIC; PREVALENCE; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, DOPAMINE;

EID: 33750887081     PISSN: 10420533     EISSN: 15206300     Source Type: Journal    
DOI: 10.1002/ajhb.20565     Document Type: Article

References (41)

1. Abdolmaleky HM, Thiagalingam S, Wilcox M. 2005. Genetics and epigenetics in major psychiatric disorders: dilemmas, achievements, applications, and future scope. Am J Pharmacogenom 5:149-160.
2. Bailliet G, Rothhammer F, Carnese FR, Bravi CM, Bianchi NO. 1994. Founder mitochondrial haplotypes in Amerindian. Am J Hum Genet 55:27-33.
3. Barba FE. 1983. Tiempo: el momento histörico, de la fundación de La Plata. In: Terán F, editor. La Plata ciudad nueva, ciudad antigua: historia, forma y estructura de un espacio urbano singular. La Plata: Universidad Nacional de La Plata, Instituto de Estudios de Administración Local. p 16-27.
4. Barr CL, Kidd KK. 1993. Population frecuencies of the A1 allele at the dopamine D2 receptor locus. Biol Psychiatry 34:204-209.
5. Bejarano M. 1967. Inmigración y estructura demográfica de La Plata: 1884-1914. In: Ministerio, de Educación y Subsecretaría de Cultura, editors. Bolletín 6, Dirección de Museos, Monumentos y Lugares Históricos. La Plata: Provincia de Buenos Aires, Ministerio de Educación y Subsecretaría de Cultura. p 13-35.
6. Berry N, Jobanputra V, Pal H. 2003. Molecular genetics of schizophrenia: a critical review. J Psychiatry Neurosci 28:415-429.
7. Bianchi NO, Catanesi CI, Bailliet G, Martinez-Marignac VL, Bravi CM, Vidal-Rioja LB, Herrera RJ, Lopez-Camelo JS. 1998. Characterization of ancestral and derive Y-chromosome haplotypes of New World Natives. Am J Hum Genet 63:1862-1871.
8. Chakraborty R, Jin L. 1992. Heterozygote deficiency, population substructure and their implications in DNA finger-printing. Hum Genet 88:267-272.
9. Chang FM, Kidd JR, Pakstis AJ, Kidd KK. 1996. The worldwide distribution of allele frequencies at the human dopamine D4 receptor locus. Hum Genet 98:91-101.
10. Comings DE. 1997. Why different rules are required for polygenic inheritance: lessons from studies of the DRD2 gene. Alcohol 16:61-70.
11. Ebstein RP, Segman R, Benjamin J, Osher Y, Nemanov L, Belmaker RH. 1997. 5.HT 2C (HTR2C) serotonin receptor gene polymorphism associated with the human personality trait of reward dependence: interaction with dopamine D4 receptor (DRD4) and dopamine D3 receptor (D3DR) polymorphisms. Am J Med Genet 74:65-72.
12. Ewens WJ, Spielman RS. 1995. The transmission/disequilibrium test: history, subdivision, and admixture. Am J Hum Genet 57:455-464.
13. Frisch A, Postilnick D, Rockah R, Michaelovsky E, Postilnick S, Birman E, Laor N, Rauchverger B, Kreinin A, Poyurovsky M, Schneidman M, Modai I, Weizman R. 1999. Association of unipolar major depressive disorder with genes of the serotonergic and dopaminergic pathways. Mol Psychiatry 4:389-392.
14. Goldman D, Brown GL, Albaugh B, Robin R, Goodson S, Trunzo M, Akhtar L, Lucas-Derse S, Long J, Linnoila M, et al. 1993. DRD2 dopamine receptor genotype, linkage disequilibrium, and alcoholism in American Indians and other. Alcohol Clin Exp Res 17:199-204.
15. Grandy DK, Zhang Y, Civelli O. 1993. PCR detection of the TaqA RFLP at the DRD2 locus. Hum Mol Genet 2:2197.
16. Gutierrez B, Fananas L, Arranz MJ, Valles V, Guillamat R, van Os J, Collier D. 1996. Allelic association analysis of the 5-HT2C receptor gene in bipolar affective disorder. Neurosci Lett 212:65-67.
17. Hegalson A, Yngvadóttir B, Hrafnkelsson B, Gulcher J, Stefásson K. 2005. An Icelandic example of impact of population structure on association studies. Nat Genet 37:90-95.
18. Hutz MH, Almeida S, Coimbra C, Santos R, Salzano FM. 2000. Haplotype and allele frequencies for three genes of the dopaminergic system in South American Indians. Am J Hum Biol 12:638-645.
19. Jin L, Chakraborty R. 1995. Population structure, stepwise mutations, heterozygote deficiency and their implications in DNA forensics. Heredity 74:274-285.
20. Jönsson EG, Flyckt L, Burgert E, Crocq M, Forslund K, Mattila-Evenden M, Rylander G, Asberga M, Nimgaonkare V, Edmanf G, Bjerkenstedt L, Wieselg F, Sedvalla G. 2003. Dopamine D3 receptor gene Ser9Gly variant and schizophrenia: association study and meta-analysis. Psychiatr Genet 13:1-12.
21. Jönsson EG, Kaiserb R, Brockmoller J, Nimgaonkarc V, Crocq MA. 2004. Meta-analysis of the dopamine D3 receptor gene (DRD3) Ser9Gly variant and schizophrenia. Psychiatr Genet 14:9-12.
22. Kidd KK, Morar B, Castiglione CM, Zhao H, Pakstis AJ, Speed WC, Bonne-Tamir B, Lu RB, Goldman D, Lee C, Nam YS, Grandy DK, Jenkins T, Kidd JR. 1998. A global survey haplotype frequencies and linkage disequilibrium at the DRD2 locus. Hum Genet 103:211-227.
23. Lannfelt L, Sokoloff P, Martres MP, et al. 1992. Amino acid substitution in the dopamine D3 receptor as a useful polymorphism for investigating psychiatric disorders. Psychiatr Genet 2:249-256.
24. Lappalainen J, Zhang L, Dean M, Oz M, Ozaki N, Yu DH, Virkkunen M, Weight F, Linnoila M, Goldman D. 1995. Identification, expression, and pharmacology of a Cys23-Ser 23 substitution in the human 5-HT2C receptor gene (HTR2C). Genomics 27:274-279.
25. Lerer B, Macciardi F, Segman RH, Adolfsson R, Blackwood D, Blairy S, Del Favero J, Dikeos DG, Kaneva R, Lilli R, Massat I, Milanova V, Muir W, Noethen M, Oruc L, Petrova T, Papadimitriou GN, Rietschel M, Serretti A, Souery D, Van Gestel S, Van Broeckhoven C, Mendlewicz J. 2001. Variability of 5 HT2C receptor cys23ser polymorphism among European and vulnerability to affective disorder. Mol Psychiatry 6:579-585.
26. Martinez Marignac VL, Bertoni B, Parra EJ, Bianchi NO. 2004. Characterization of admixture in an urban sample from Buenos Aires, Argentina, using uniparentally and biparentally inherited genetic markers. Hum Biol 76:543-557.
27. Masellis M, Basile V, Meltzer HY, Lieberman JA, Sevy S, Macciardi FM, Cola P, Howard A, Badri F, Nothen MM, Kalow W, Kennedy JL. 1998. Serotonin subtype 2 receptor genes and clinical response to clozapine in schizophrenia patients. Neuropsychopharmacology 19:123-132.
28. Matteo VD, Esposito E. 2003. Serotonin control of dopaminergic neurotransmission: focus on 5-HT2 receptors. Curr Neuropharmacol 1:153-164.
29. Noble EP. 1998. The D2 dopamine receptor gene: a review of association studies in alcoholism and phenotypes. Alcohol 16:33-45.
30. Noble EP, 2003. D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. Am J Med Genet 116:103-125.
31. Oruc L, Verheyen GR, Furac I, Jakovljevic M, Ivezic S, Raeymaekers P, Van Broeckhoven C. 1997. Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorder. Am J Med Genet 74:504-506.
32. Prasad S, Semwal P, Deshpande S, Bhatia T, Nimgaonkar VL, Thelma BK. 2002. Molecular genetics of schizophrenia: past, present and future. J Biosci [Suppl] 27:35-52.
33. Risch N. 2001. Implications of multilocus inheritance for gene-disease association studies. Theor Popul Biol 60:215-220.
34. Sander T, Harms H, Podschus J, Finckh U, Nickel B, Rolfs A, Rommelspacher H, Schmidt LG. 1995. Dopamine D1, D2 and D3 receptor genes in alcohol dependence. Psychiatr Genet 5:171-176.
35. Schurr TG, Sherry ST 2004. Mitochondrial DNA and Y chromosome diversity and the peopling of the Americas: evolutionary and demographic evidence. Am J Hum Biol 16:420-439.
36. Tarazi Frank I. 2001. Neuropharmacology of dopamine receptors: implications in neuropsychiatric diseases. SQU J Sci Res Med Sci 3:87-104.
37. Turner E, Ewing J, Shilling P, Smith T, Irwin M, Schuckit M, Kelsoe J. 1992. Lack of association between an RFLP near the D2 dopamine receptor gene and severe alcoholism. Biol Psychiatry 31:285-290.
38. Underhill PA, Jin L, Zeman R, Oefner PJ, Cavalli-Sforza LL. 1996. A pre-Columbian Y chromosome specific transition and its implications for human evolutionary history. Proc Natl Aced Sci USA 93:196-200.
39. Vieyra G, Moraga M, Henriquez H, Aboitiz F, Rothhammer F. 2003. Distribution of DRD4 and DAT1 alleles from dopaminergic system in a mixed Chilean population. Rev Med Chil 131:135-143 [review in Spanish].
40. Williams J, Spurlock G, Holmans P, Mant R, Murphy K, Jones L, Cardno A, Asherson P, Blackwood D, Muir W, Meszaros Y, Aschauer H, Mallet J, Laurent C, Pekkarinen P, Seppala J, Stefanis C, Papadimitriou G, Macciardi F, Verge M, Pato C, Azevedo H, Crocq M, Gurling H, Kalsi G, Curtis D, McGuffin P, Owen M, 1998. A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia. Mol Psychiatry 3:141-149.
41. Wong AHC, Buckle CE, Van Tol HHM. 2000. Polymorphisms in dopamine receptors: what do they tell us? Eur J Pharmacol 410:183-203.