Intracellular levels of S-adenosylhomocysteine but not homocysteine are highly correlated to the expression of nm23-H1 and the level of 5-methyldeoxycytidine in human hepatoma cells with different invasion activities

Nutrition and Cancer

Volumn 55, Issue 2, 2006, Pages 224-231

  Yang, Tsai Hsiu ^a   Hu, Miao Lin ^b  

^a CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLDEOXYCYTIDINE; HOMOCYSTEINE; MESSENGER RNA; METHYLTRANSFERASE; S ADENOSYLHOMOCYSTEINE; TUMOR MARKER;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CANCER INVASION; CELL INVASION; CELL LEVEL; CELL STRAIN HEP 3B; CELL STRAIN HEPG2; CELL STRAIN J5; CELL STRAIN SK HEP1; CONTROLLED STUDY; CORRELATION COEFFICIENT; DNA METHYLATION; GENE; GENE EXPRESSION; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER CELL; METASTASIS; MOUSE; NM23 H1 GENE; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION;

CELL LINE, TUMOR; DEOXYCYTIDINE; DNA METHYLATION; DOWN-REGULATION; HOMOCYSTEINE; HUMANS; LIVER NEOPLASMS; NEOPLASM INVASIVENESS; S-ADENOSYLHOMOCYSTEINE;

MURINAE;

EID: 33750880062     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1207/s15327914nc5502_14     Document Type: Article

References (46)

1. Finkelstein JD: Homocysteine: a history in progress. Nutr Rev 58, 193-204, 2000.
2. Finkelstein JD and Martin JJ: Homocysteine. Int J Biochem Cell Biol 32, 385-389, 2000.
3. Mudd SH, Finkelstein JD, Refsum H, Ueland PM, et al.: Homocysteine and its disulfide derivatives: a suggested consensus terminology. Arterioscler Thromb Vasc Biol 20, 1704-1706, 2000.
4. De Cabo SF, Santos J, and Fernandez-Piqueras J: Molecular and cytological evidence of s-adenosyl-1-homocysteine as an innocuous undermethylating agent in vivo. Cytogenet Cell Genet 71, 187-192, 1995.
5. Duthie SJ, Narayanan S, Blum S, Pirie L, and Brand GM: Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells. Nutr Cancer 37, 245-251, 2000.
6. Fu W, Dudman NPB, Perry MA, Young K, and Wang XI: Interrelations between plasma homocysteine and intracellular S-adenosylhomocysteine. Biochem Biophys Res Commun 271, 47-53, 2000.
7. Kennedy BP, Bottiglieri T, Hansen A, and Masliah E: Elevated S-adenosylhomocysteine in Alzheimer rain: influence on methyltransferases and cognitive function. J Neural Transm 111, 547-567, 2004.
8. Castro R, Rivera I, Struys EA, Jansen EE, Ravasco P, et al.: Tavares de Almeida I: increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease. Clin Chem 49, 1292-1296, 2003.
9. Melnyk S, Pogribna M, Pogribny IP, Yi P, and James SJ: Measurement of plasma and intracellular S-adenosylmethionine and S-adenosylhomocysteine utilizing coulometric electrochemical detection: alterations with plasma homocysteine and pyridoxal 5-phosphate concentrations. Clin Chem 46, 265-272, 2000.
10. Perna AF, Ingrosso D, De Santo NG, Galletti P, Brunone M, et al.: Metabolic consequences of folate-induced reduction of hyperhomocysteinemia in uremia. J Am Soc Nephrol 8, 1899-1905, 1997.
11. Perna AF, Castaldo P, De Santo NG, di Carlo E, Cimmino A, et al.: Plasma proteins containing damaged L-aspartyl residues are increased in uremia: implications for mechanism. Kidney Int 59, 2299-2308, 2001.
12. Hoffman DR, Marion DW, Cornatzer WE, and Duerre JA: S-Adenosylmethionine and S-adenosylhomocysteine metabolism in isolated liver. J Biol Chem 22, 10822-10827, 1980.
13. Razin A and Riggs AD: DNA methylation and gene function. Science 210, 604-610, 1980.
14. James SJ, Melnyk S, Pogribny M, Pogribny IP, and Caudill MA: Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. J Nutr 132, 2361S-2366S, 2002.
15. Domagala TB, Undas A, Libura M, and Szczeklik A: Pathogenesis of vascular disease in hyperhomocysteinaemic. J Cardiovasc Risk 5, 239-247, 1998.
16. Dong C, Yoon W, and Coldschmidt-Clermont PJ: DNA methylation and atherosclerosis. J Nutr 132, 2406S-2409S, 2002.
17. Esfandiari F, Green R, Cotterman RF, Pogribny IP, James SJ, et al.: Methyl deficiency causes reduction of the methyl-CpG-binding protein, MeCP2, in rat liver. Carcinogen 24, 1935-1940, 2003.
18. Hiltunen MO and Yla-Herttuala S: DNA methylation, smooth muscle cells, and atherogenesis. Arterioscler Thromb Vasc Biol 23, 1750-1753, 2003.
19. Ehrlich M and Wang RY: 5-Methylcytosine in eukaryotic DNA. Science. 212, 1350-1357, 1981.
20. Sibani S, Melnyk S, Pogribny IP, Wang W, Hiou-Tim F, et al.: Studies of methionine cycle intermediates (SAM, SAH), DNA methylation and the impact of folate deficiency on tumor numbers in Min mice. Carcinogen 23, 61-65, 2002.
21. Yang TH, Yang NC, and Hu ML: S-Adenosylhomocysteine enhances hydrogen peroxide-induced DNA damage by inhibition of DNA repair in two cell lines. Nutr Cancer 47, 70-75, 2003.
22. Sun CF, Haven TR, Wu TL, Tsao KC, and Wu JT: Serum total homocysteine increases with the rapid proliferation rate of tumor cells and decline upon cell death: a potential new tumor marker. Clinica Chimica Acta 321, 55-62, 2002.
23. Harlozinska A: Progress in molecular mechanisms of tumor metastasis and angiogenesis. Anticancer Res 25, 3327-3333, 2005.
24. Lin KH, Lin YW, Lee HF, Liu WL, Chen ST, et al.: Increased invasive activity of human hepatocellular carcinoma cells is associated with an overexpression of thyroid hormone b1 nuclear receptor and low expression of the anti-metastatic nm23 gene. Cancer Lett 98, 89-95, 1995.
25. MacDonald NJ, De La Rosa A, and Steeg PS; The potential roles of nm23 in cancer metastasis and cellular differentiation. Eur J Cancer 31, 1096-1100, 1995.
26. Lai WW, Wu MH, Yan JJ, and Chen FF: Immunohistochemical analysis of nm23-H1 in stage 1 non-small cell lung cancer: a useful marker in prediction of metastases. Ann Thorac Surg 62, 1500-1504, 1996.
27. Kapitanovic S, Spaventi R, Vujsic S, Petrovic Z, Kurjak A, et al.: Nm23-H1 gene expression in ovarian tumors-a potential tumor marker. Anticancer Res 15, 587-590, 1995.
28. Nakayama T, Ohtsuru A, Nakao K, Shima M, Nakata K, et al.: Expression in hepatocellular carcinoma of nucleotide diphosphate kinase, a homologue of the nm23 gene product. J Natl Cancer Inst 84, 1349-1354, 1992.
29. Joshi SS, Kuszynski CA, Bagchi M, and Bagchi D: Chemopreventive effects of grape seed proanthocyanidin extract on Chang Liver cells. Toxicolo 155, 83-90, 2000.
30. Wang YJ, Ho YS, Jeng JH, Su HJ, and Lee CC: Different cell death mechanisms and gene expression in human cells induced by pentachlorophenol and its major metabolite, tetrachlorohydroquinone. Chem Biol Interact 128, 173-188, 2000.
31. Lin LI, Lee PH, Wu CM, and Lin JK: Significance of nm23 mRNA expression in human hepatocellular carcinoma. Anticancer Res 18, 541-546, 1998.
32. Wise Ck, Conney CA, Ali SF, and Poirier LA: Measuring S-adenosylmethionine in whole blood, red blood cells and cultured cells using a fast preparation method and high-performance liquid chromatography. J Chromatogr B 696, 145-152, 1997.
33. Fermo I, Arcelloni C, Mazzola G, and D'Angelo A: High-performance liqid chromatographic method for measuring total plasma homocysteine levels. J Chromatogr B 719, 31-36, 1998.
34. Accinni R, Campolo J, Bartesaghi S, De Leo G, Lucarelli C, et al.: High-performance liquid chromatographic determination of total plasma homocysteine with or without internal standards. J Chromatogr 828, 397-400, 1998.
35. Cooney CA, Wise CK, and Poirier LA: An improved sample preparation method for the quantitative HPLC determination of 5-methyldeoxycytidine in animal tissue DNA. J Liq Chrom & Rel Technol 20, 1279-1293, 1997.
36. Gupta RC: Nonrandom binding of the carcinogen N-hydroxy-2-Acetyl- aminofluorene to repetitive sequences of rat liver DNA in vivo. Proc Natl Acad Sci USA 81, 6943-6947, 1984.
37. Villar-Garea A, Fraga MF, Espada J, and Esteller M: Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. Cancer Res 63, 4984-4989, 2003.
38. Fraga MF, Herranz M, Espada J, Ballestar E, Paz MF, et al.: A mouse multistage carcinogenesis model reflects the abrrant DNA methylation patterns of human tumors. Cancer Res 64, 5527-5534, 2004.
39. Yi P, Melnyk S, Pogribna M, Pogribna IP, Hine RJ, et al.: Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem 275, 29318-29323, 2000.
40. Caudill MA, Wang JC, Melnyk S, Pogribny IP, Jernigan S, et al.: Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine β-synthase heterozygous mice. J Nutr 131, 2811-2818, 2001.
41. Capdevila A, Decha-Umphai W, Song KH, Borchardt RT, and Wagner C: Pancreatic exocrine secretion is blocked by inhibitors of methylation. Arch Biochem Biophys 345, 47-55, 1997.
42. Chiang PK: Biological effects of inhibitors of S-adenosylhomocysteine hydrolase. Pharmacol Ther 77, 115-134, 1998.
43. Brown TC and Jiricny J: A specific mismatch repair event protects mammalian cells from loss of 5-methylcytosine. Cell 50, 945-950, 1987.
44. Shen L, Qui D, and Fang J: Correlation between hypomethylation of c-myc and c-N-ras oncogenes and pathological changes in human hepatocellular carcinoma. Chung-Hua Chnng Liu Tsa Chih 19, 173-176, 1997.
45. Hartsough MT, Clare SE, Mair M, Elkahloun AG, Sgroi D, et al.: Elevation of breast carcinoma nm23-H 1 metastasis suppressor gene expression and reduced motility by DNA methylation inhibition. Cancer Res 61, 2320-2327, 2001.
46. Dayal S, Bottiglieri T, Arning E, Maeda N, Malinow MR, et al.: Endothelial dysfunction elevation S-adenosylhomocysteine cystathionine Beta-synthase-deficient mice. Circ Res 88, 1203-1209, 2001.