Induction of cyclin D1 by submicromolar concentrations of arsenite in human epidermal keratinocytes

Toxicology and Applied Pharmacology

Volumn 217, Issue 2, 2006, Pages 161-167

  Hwang, Bor Jang ^a   Utti, Charles ^a   Steinberg, Mark ^a  

^a CITY COLLEGE OF NEW YORK   (United States)

Author keywords

Arsenite; Cell cycle; D type cyclins; Microarrays

Indexed keywords

ARSENATE SODIUM; ARSENIC TRIOXIDE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIN D1; TRANSCRIPTION FACTOR;

ARTICLE; BINDING AFFINITY; CARCINOGENESIS; CELL CULTURE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL GROWTH; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EPIDERMIS CELL; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; GROWTH RATE; GROWTH STIMULATION; HUMAN; HUMAN CELL; KERATINOCYTE; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; UPREGULATION; WESTERN BLOTTING;

ARSENITES; CARCINOGENS; CELL CYCLE; CELL PROLIFERATION; CELL SEPARATION; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CREB-BINDING PROTEIN; CYCLINS; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EPIDERMIS; FLOW CYTOMETRY; HUMANS; KERATINOCYTES; POLYMERASE CHAIN REACTION; PROTEIN BINDING; RNA, MESSENGER; SODIUM COMPOUNDS; TIME FACTORS; TRANSCRIPTION FACTOR AP-1; UP-REGULATION;

EID: 33750806047     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2006.08.006     Document Type: Article

References (39)

1. Andrewes P., Kitchin K.T., and Wallace K. Dimethylarsine and trimethylarsine are potent genotoxins in vitro. Chem. Res. Toxicol. 16 8 (2003) 994-1003
2. Boyce S.T., and Ham R.G. Cultivation, frozen storage, and clonal growth of normal human epidermal keratinocytes in serum-free media. J. Tissue Cult. Methods 9 (1985) 83-93
3. Burns F.J., Uddin A.N., Wu F., Nádas A., and Rossman T.G. Arsenic-induced enhancement of ultraviolet radiation carcinogenesis in mouse skin: a dose-response study. Environ. Health Perspect. 112 (2004) 599-603
4. Chen C.-J., Chen C.W., Wu M.-M., and Kuo T.-L. Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water. Br. J. Cancer 66 (1992) 888-892
5. Chen H., Liu J., Zhao C.Q., Diwan B.A., Merrick B.A., and Waalkes M.P. Association of c-myc overexpression and hyperproliferation with arsenite-induced malignant transformation. Toxicol. Appl. Pharmacol. 175 3 (2001) 260-268
6. Corsini E., Asti, L., Viviani B., Marinovich M., and Galli C.L. Sodium arsenite induces overproduction of interleukin-1α in murine keratinocytes: role of mitochondira. J. Invest. Dermatol. 113 5 (1999) 760-765
7. Edelman B., Steinberg M.L., and Defendi V. Changes in fibronectin synthesis and binding distribution in SV40-transformed human keratinocytes. Int. J. Cancer 35 2 (1985) 219-225
8. Edmead C., Kanthou C., and Benzakour1 O. Thrombin activates transcription factors Sp1, NF-kB, and CREB: importance of the use of phosphatase inhibitors during nuclear protein extraction for the assessment of transcription factor DNA-binding activities. Anal. Biochem. 275 (1999) 180-186
9. Felix K., Manna S.K., Wise K., Barr J., and Ramesh G.T. Low levels of arsenite activates nuclear factor-κB and activator-1 in immortalized mesencephalic cells. J. Biochem. Mol. Toxicol. 19 2 (2005) 67-77
10. Gebel T.W. Genotoxicity of arsenical compounds. Int. J. Hyg. Environ. Health 203 (2001) 249-262
11. Germolec D.R., Spalding J., Boorman G.A., Wilmer J.L., Yoshida T., Simeonova P.P., Bruccoleri A., Kayama F., Gaido K., Tennant R., Burleson F., Dong W., Lang R.W., and Luster M.I. Arsenic can mediate skin neoplasia by chronic stimulation of keratinocyte-derived growth factors. Mutat. Res. 386 (1997) 209-218
12. Gomez-Caminero A., Howe P., Hughes M., Kenyon E., Lewis D.R., Moore M., Ng J., Aitio A., and Becking G. Environmental health criteria for arsenic and arsenic compounds. The International Programme on Chemical Safety (IPCS). 224: Chapter 1: Summary, Section 4 (2001), The World Health Organization Press, Geneva
13. Hamadeh H.K., Trouba K.J., Amin R.P., Afshari C.A., and Germolec D. Coordination of altered DNA repair and damage pathways in arsenite-exposed keratinocytes. Toxicol. Sci. 69 (2002) 306-316
14. Hei T.K., Liu S.X., and Waldren C. Mutagenicity of arsenic in mammalian cells: role of reactive oxygen species. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 8103-8107
15. Hernandez-Zavala A., Cordova E., Del Razo L.M., Cebrian M.E., and Garrido E. Effects of arsenite on cell cycle progression in a human bladder cancer cell line. Toxicology 207 1 (2005) 49-57
16. Hopenhayn-Rich C., Biggs M.L., and Smith A.L. Lung and kidney cancer mortality associated with arsenic in drinking water in Cordoba Argentina. Int. Epidemiol. Assoc. 27 (1998) 561-569
17. Hu J., Fang J., Dong Y., Chen S.J., and Chen Z. Arsenic in cancer therapy. Anti-Cancer Drugs 16 2 (2005) 119-127
18. Hyun Park W., Hee Cho Y., Won Jung C., Oh Park J., Kim K., Hyuck Im Y., Lee M.H., Ki Kang W., and Park K. Arsenic trioxide inhibits the growth of A498 renal cell carcinoma cells via cell cycle arrest or apoptosis. Biochem. Biophys. Res. Commun. 300 1 (2003) 230-235
19. Kligerman A.D., Doerr C.L., Tennant A.H., Harrington-Brock K., Allen J.W., Winkfield E., Poorman-Allen P., Kundu B., Funasaka K., Roop B.C., Mass M.J., and DeMarini D.M. Methylated trivalent arsenicals as candidate ultimate genotoxic forms of arsenic: induction of chromosomal mutations but not gene mutations. Environ. Mol. Mutagen 42 3 (2003) 192-205
20. Lau A.T.Y., Li M., Xie R., He Q.-Y., and Chiu J.-F. Opposed arsenite-induced signaling pathways promote cell proliferation or apoptosis in cultured lung cells. Carcinogenesis 25 1 (2004) 21-28
21. Li J.-H., and Rossman T.G. Mechanism of comutagenesis of sodium arsenite with N-methyl-N-nitrosourea. Biol. Trace Element Res. 21 (1989) 373-381
22. Li J.-H., and Rossman T.G. Inhibition of DNA ligase activity by arsenite: a possible mechanism of its comutagenesis. Mol. Toxicol. 2 (1989) 1-9
23. Li J.-H., and Rossman T.G. Comutagenesis of sodium arsenite with ultraviolet radiation in Chinese hamster V79 cells. Biol. Met. 4 (1991) 197-200
24. Li X., Ding X., and Adrian T.E. Arsenic trioxide induces apoptosis in pancreatic cancer cells via changes in cell cycle, caspase activation, and GADD expression. Pancreas 27 2 (2003) 174-179
25. Liao W.T., Chang K.L., Yu C.L., Chen G.S., Chang L.W., and Yu H.S. Arsenic induces human keratinocyte apoptosis by the FAS/FAS ligand pathway, which correlates with alterations in nuclear factor-kappa B and activator protein-1 activity. J. Invest. Dermatol. 122 1 (2004) 125-129
26. Moore M.M., Harrington-Brock K., and Doerr C.L. Relative genotoxic potency of arsenic and its methylated metabolites. Mutat. Res. 386 (1997) 279-290
27. Mori J., Takahashi-Yanaga F., Miwa Y., Watanabe Y., Hirata M., Morimoto S., Shirasuna K., and Sasaguri T. Differentiation-inducing factor-1 induces cyclin D1 degradation through the phosphorylation of Thr286 in squamous cell carcinoma. Exp. Cell Res. 310 (2005) 426-433
28. Nagata D., Suzuki E., Nishimatsui H., Satonaka H., Goto A., Omata M., and Hirata Y. Transcriptional activation of the cyclin D1 gene is mediated by multiple cis-elements, including SP1 sites and a cAMP-responsive element in vascular endothelial cells. J. Biol Chem. 276 (2001) 662-669
29. Noda Y., Suzuki T., Kohara A., Hasegawa A., Yotsuyanagi T., Hayashi M., Sofuni T., Yamanaka K., and Okada S. In vivo genotoxicity evaluation of dimethylarsinic acid in MutaMouse. Mutat. Res. 513 1-2 (2002) 205-212
30. Rosenwald I.B., lazaris-Karatzas A., Sonenberg N., and Schmidt E.V. Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E. Mol. Cell. Biol. 13 12 (1993) 7358-7363
31. Rossman T.G. Mechanism of arsenic carcinogenesis: an integrated approach. Mutat. Res. 533 (2003) 37-65
32. Sahu G.R., and Jena R.K. Significance of intracellular arsenic trioxide for therapeutic response in acute promyelocytic leukemia. Am. J. Hematol. 78 2 (2005) 113-116
33. Simeonova P.P., Wang S., Toriuma W., Kommineni V., Matheson J., Unimye N., Kayama F., Harki D., Ding M., Vallyathan V., and Luster M.I. Arsenic mediates cell proliferation and gene expression in the bladder epithelium: association with activating protein-1 transactivation. Cancer Res. 60 13 (2000) 3445-3453
34. Smith A.H., Hopenhayn-Rich C., Bates M.N., Goeden H.M., Hertz-Picciotto I.H., Duggan I., Wood R., Kosnett M., and Smith M.T. Cancer risk from arsenic in drinking water. Environ. Health Perspect. 97 (1992) 259-267
35. Steinberg M.L., and Defendi V. Fusion induced differentiation of SV40 transformed human keratinocytes. Exp. Cell Res. 139 (1982) 369-375
36. Tseng W.P. Effects and dose response relationships of skin cancer and blackfoot disease with arsenic. Environ. Health Perspect. 19 (1977) 109-119
37. Tseng W.P., Chu H.M., How S.W., Fong J.M., Lin C.S., and Yeh S. Prevalence of skin cancer in an endemic area of chronic arsenicism in Taiwan. J. Natl. Cancer Inst. 40 (1968) 453-463
38. Vogt B.L., and Rossman T.G. Effects of arsenite on p53, p21 and cyclin D expression in normal human fibroblasts-A possible mechanism for arsenite's comutagenicity. Mutat. Res. 478 1-2 (2001) 159-168
39. Zhao S., Tsuchida T., Kawakami K., Shi C., and Kawamoto K. Effect of As2O3 on cell cycle progression and cyclins D1 and B1 expression in two glioblastoma cell lines differing in p53 status. Int. J. Oncol. 21 1 (2002) 49-55