Dexamethasone can stimulate G1-S phase transition in human airway fibroblasts in asthma

European Respiratory Journal

Volumn 27, Issue 6, 2006, Pages 1160-1167

  Fouty, B ^a   Moss, T ^b   Solodushko, V ^a   Kraft, M ^c  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^b NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Asthma; Cell cycle; Dexamethasone; Fibroblast

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CCAAT ENHANCER BINDING PROTEIN ALPHA; CORTICOSTEROID; DEXAMETHASONE; RETINOBLASTOMA PROTEIN; ANTIINFLAMMATORY AGENT;

ADULT; ARTICLE; ASTHMA; BRONCHOSCOPY; BRONCHUS BIOPSY; CELL COUNT; CELL CULTURE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL STIMULATION; CELL TRANSFORMATION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EXPOSURE; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG FIBROBLAST; MALE; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; BIOPSY; BRONCHUS; BRONCHUS HYPERREACTIVITY; CELL DIVISION; DRUG EFFECT; FIBROBLAST; IN VITRO STUDY; LUNG; PATHOLOGY; PHOSPHORYLATION; SMOOTH MUSCLE; STIMULATION; TUMOR SUPPRESSOR GENE;

ADULT; ANTI-INFLAMMATORY AGENTS; ASTHMA; BIOPSY; BRONCHI; BRONCHIAL HYPERREACTIVITY; BRONCHOSCOPY; CELL DIVISION; CELLS, CULTURED; DEXAMETHASONE; FEMALE; FIBROBLASTS; G1 PHASE; GENES, TUMOR SUPPRESSOR; HUMANS; LUNG; MALE; MUSCLE, SMOOTH; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN; S PHASE; STIMULATION, CHEMICAL;

EID: 33750728008     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.06.00078605     Document Type: Article

References (33)

1. Busse W, Elias J, Sheppard D, Banks-Schlegel S. Airway remodeling and repair. Am J Respir Crit Care Med 1999; 160: 1035-1042.
2. Brewster CE, Howarth PH, Djukanovic R, Wilson J, Holgate ST, Roche WR. Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am J Respir Cell Mol Biol 1990; 3: 507-511.
3. Elias JA, Freundlich B, Kern JA, Rosenbloom J. Cytokine networks in the regulation of inflammation and fibrosis in the lung. Chest 1990; 97: 1439-1445.
4. Gauldie J, Jordana M, Cox G, Ohtoshi T, Dolovich J, Denburg J. Fibroblasts and other structural cells in airway inflammation. Am Rev Respir Dis 1992; 145: S14-S17.
5. Standards for the diagnosis and care of patients with chronic obstructive pulmonary diseaseasthma, Am Rev Respir Dis 1987; 136: 225-244.
6. Roth M, Johnson PR, Borger P, et al. Dysfunctional interaction of C/ EBPalpha and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells. N Engl J Med 2004; 351: 560-574.
7. Kraft M, Lewis C, Pham D, Chu HW. IL-4, IL-13, and dexamethasone augment fibroblast proliferation in asthma. J Allergy Clin Immunol 2001; 107: 602-606.
8. Richmond KM, Kubler AM, Martin F, Jimenez de Asua L. The stimulation of the initiation of DNA synthesis by fibroblast growth factor in Swiss 3T3 cells: interactions with hormones during the pre-replicative phase. J Cell Physiol 1980; 103: 77-85.
9. Lee LE, Bols NC. Action of cortisol on the proliferation of rainbow trout fibroblasts. Cell Tissue Kinet 1989; 22: 291-301.
10. Silvestri M, Sabatini F, Scarso L, Cordone A, Dasic G, Rossi GA. Fluticasone propionate downregulates nasal fibroblast functions involved in airway inflammation and remodeling. Int Arch Allergy Immunol 2002; 128: 51-58.
11. National Asthma Education Prevention Program, Guidelines for the diagnosis and management of asthma. Expert Panel Report 1997; 2: 1-146.
12. Kraft M, Bettinger CM, Wenzel SE, Irvin CG, Ackerman SJ, Martin RJ. Methacholine challenge does not affect bronchoalveolar fluid cell number and many indices of cell function in asthma. Eur Respir J 1995; 8: 1966-1971.
13. Krishan A. Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. J Cell Biol 1975; 66:188-193.
14. Fouty BW, Rodman DM. Mevastatin can cause G1 arrest and induce apoptosis in pulmonary artery smooth muscle cells through a p27Kip1-independent pathway. Circ Res 2003; 92: 501-509.
15. Vidal A, Koff A. Cell-cycle inhibitors: three families united by a common cause. Gene 2000; 247: 1-15.
16. Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 1999; 13: 1501-1512.
17. Gallo R, Padurean A, Jayaraman T, et al. Inhibition of intimal thickening after balloon angioplasty in porcine coronary arteries by targeting regulators of the cell cycle. Circulation 1999; 99: 2164-2170.
18. Laufs U, Marra D, Node K, Liao JK. 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1). J Biol Chem 1999; 274:21926-21931.
19. Lambert RK, Wiggs BR, Kuwano K, Hogg JC, Pare PD. Functional significance of increased airway smooth muscle in asthma and COPD. J Appl Physiol 1993; 74: 2771-2781.
20. Wiggs BR, Bosken C, Pare PD, James A, Hogg JC. A model of airway narrowing in asthma and in chronic obstructive pulmonary disease. Am Rev Respir Dis 1992; 145: 1251-1258.
21. Hoshino M, Takahashi M, Takai Y, Sim J. Inhaled corticosteroids decrease subepithelial collagen deposition by modulation of the balance between matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in asthma. J Allergy Clin Immunol 1999; 104: 356-363.
22. Lundgren R, Soderberg M, Horstedt P, Stenling R. Morphological studies of bronchial mucosal biopsies from asthmatics before and after ten years of treatment with inhaled steroids. Eur Respir J 1988; 1: 883-889.
23. Trigg CJ, Manolitsas ND, Wang J, et al. Placebo-controlled immunopathologic study of four months of inhaled corticosteroids in asthma. Am J Respir Crit Care Med 1994; 150: 17-22.
24. Sont JK, Willems LN, Bel EH, van Krieken JH, Vandenbroucke JP, Sterk PJ. Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. The AMPUL Study Group. Am J Respir Crit Care Med 1999; 159: 1043-1051.
25. Jeffery PK, Godfrey RW, Adelroth E, Nelson F, Rogers A, Johansson SA. Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma. A quantitative light and electron microscopic study. Am Rev Respir Dis 1992; 145: 890-899.
26. Warshamana GS, Martinez S, Lasky JA, Corti M, Brody AR. Dexamethasone activates expression of the PDGF-alpha receptor and induces lung fibroblast proliferation. Am J Physiol 1998; 274: L499-L507.
27. Dube J, Chakir J, Laviolette M, et al. In vitro procollagen synthesis and proliferative phenotype of bronchial fibroblasts from normal and asthmatic subjects. Lab Invest 1998; 78: 297-307.
28. Esmailpour N, Hogger P, Rabe KF, Heitmann U, Nakashima M, Rohdewald P. Distribution of inhaled fluticasone propionate between human lung tissue and serum in vivo. Eur Respir J 1997; 10: 1496-1499.
29. Ramji DP, Foka P. CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem J 2002; 365: 561-575.
30. Ossipow V, Descombes P, Schibler U. CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials. Proc Natl Acad Sci USA 1993; 90: 8219-8223.
31. Lin FT, MacDougald OA, Diehl AM, Lane MD. A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity. Proc Natl Acad Sci USA 1993; 90: 9606-9610.
32. Reil TD, Kashyap VS, Sarkar R, Freishlag J, Gelabert HA. Dexamethasone inhibits the phosphorylation of retinoblastoma protein in the suppression of human vascular smooth muscle cell proliferation. J Surg Res 2000; 92: 108-113.
33. Fernandes D, Guida E, Koutsoubos V. Glucocorticoids inhibit proliferation, cyclin D1 expression, and retinoblastoma protein phosphorylation, but not activity of the extracellular-regulated kinases in human cultured airway smooth muscle. Am J Respir Cell Mol Biol 1999; 21: 77-88.