In silico identification and biochemical characterization of novel inhibitors of NQO1

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 24, 2006, Pages 6246-6254

  Nolan, Karen A ^a   Timson, David J ^b   Stratford, Ian J ^a   Bryce, Richard A ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Docking; Inhibitors; NQO1; Rational drug design; Scoring functions; Virtual screening

Indexed keywords

ENZYME INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

ARTICLE; BINDING AFFINITY; COMPUTER MODEL; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; ENZYME BINDING; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50;

AMINO ACID SEQUENCE; BINDING SITES; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; NAD(P)H DEHYDROGENASE (QUINONE); PROTEIN CONFORMATION;

EID: 33750694243     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.09.015     Document Type: Article

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