Plasma levels of leptin and mammographic density among postmenopausal women: A cross-sectional study

Breast Cancer Research

Volumn 8, Issue 5, 2006, Pages

  Stuedal, Anne ^a   Ursin, Giske ^a,b   Veierød, Marit B ^a   Bremnes, Yngve ^c   Reseland, Janne E ^a   Drevon, Christian A ^a   Gram, Inger T ^c  

^a UNIVERSITY OF OSLO   (Norway)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF TROMSØ   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; ESTROGEN; HORMONE; LEPTIN;

ADIPOSE TISSUE; ADULT; AGED; ANTHROPOMETRIC PARAMETERS; ARTICLE; BODY FAT; BODY MASS; BREAST CANCER; CANCER RISK; COMPUTER ASSISTED DIAGNOSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG USE; FEMALE; HORMONE BLOOD LEVEL; HUMAN; HYPOTHESIS; LINEAR REGRESSION ANALYSIS; MAMMOGRAPHY; POSTMENOPAUSE; STATISTICAL SIGNIFICANCE; BLOOD; BREAST TUMOR; CROSS-SECTIONAL STUDY; METABOLISM; MIDDLE AGED; RADIOGRAPHY; RISK;

ADIPOSE TISSUE; AGED; BREAST NEOPLASMS; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; LEPTIN; MAMMOGRAPHY; MIDDLE AGED; POSTMENOPAUSE; RISK;

EID: 33750552552     PISSN: 1465542X     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr1603     Document Type: Article

References (73)

1. van den Brandt PA, Spiegelman D, Yaun SS, Adami HO, Beeson L, Folsom AR, Fraser G, Goldbohm RA, Graham S, Kushi L, et al.: Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. Am J Epidemiol 2000, 152:514-527.
2. Key TJ, Appleby PN, Reeves GK, Roddam A, Dorgan JF, Longcope C, Stanczyk FZ, Stephenson HE Jr, Falk RT, Miller R, et al.: Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. J Natl Cancer Inst 2003, 95:1218-1226.
3. Lahmann PH, Hoffmann K, Allen N, Van Gils CH, Khaw KT, Tehard B, Berrino F, Tjonneland A, Bigaard J, Olsen A, et al.: Body size and breast cancer risk: findings from the European prospective investigation into cancer and nutrition (EPIC). Int J Cancer 2004, 111:762-771.
4. Purohit A, Reed MJ: Regulation of estrogen synthesis in postmenopausal women. Steroids 2002, 67:979-983.
5. Boyd NF, Stone J, Martin LJ, Jong R, Fishell E, Yaffe M, Hammond G, Minkin S: The association of breast mitogens with mammographic densities. Br J Cancer 2002, 87:876-882.
6. Ahima RS, Flier JS: Adipose tissue as an endocrine organ. Trends Endocrinol Metab 2000, 11:327-332.
7. Rose DP, Komninou D, Stephenson GD: Obesity, adipocytokines, and insulin resistance in breast cancer. Obes Rev 2004, 5:153-165.
8. van Rossum EF, Nicklas BJ, Dennis KE, Berman DM, Goldberg AP: Leptin responses to weight loss in postmenopausal women: relationship to sex-hormone binding globulin and visceral obesity. Obes Res 2000, 8:29-35.
9. Van Harmelen V, Reynisdottir S, Eriksson P, Thorne A, Hoffstedt J, Lonnqvist F, Arner P: Leptin secretion from subcutaneous and visceral adipose tissue in women. Diabetes 1998, 47:913-917.
10. Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, Moizo L, Lehy T, Guerre-Millo M, Marchand-Brustel Y, et al.: The stomach is a source of leptin. Nature 1998, 394:790-793.
11. Masuzaki H, Ogawa Y, Sagawa N, Hosoda K, Matsumoto T, Mise H, Nishimura H, Yoshimasa Y, Tanaka I, Mori T, et al.: Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med 1997, 3:1029-1033.
12. Reseland JE, Syversen U, Bakke I, Qvigstad G, Eide LG, Hjertner O, Gordeladze JO, Drevon CA: Leptin is expressed in and secreted from primary cultures of human osteoblasts and promotes bone mineralization. J Bone Miner Res 2001, 16:1426-1433.
13. Solberg R, Aas V, Thoresen GH, Kase ET, Drevon CA, Rustan AC, Reseland JE: Leptin expression in human primary skeletal muscle cells is reduced during differentiation. J Cell Biochem 2005, 96:89-96.
14. Smith-Kirwin SM, O'Connor DM, De Johnston J, Lancey ED, Hassink SG, Funanage VL: Leptin expression in human mammary epithelial cells and breast milk. J Clin Endocrinol Metab 1998, 83:1810-1813.
15. Friedman JM, Halaas JL: Leptin and the regulation of body weight in mammals. Nature 1998, 395:763-770.
16. Ahima RS, Flier JS: Leptin. Annu Rev Physiol 2000, 62:413-437.
17. Otero M, Lago R, Lago F, Casanueva FF, Dieguez C, Gomez-Reino JJ, Gualillo O: Leptin, from fat to inflammation: old questions and new insights. FEBS Lett 2005, 579:295-301.
18. Markowska A, Malendowicz K, Drews K: The role of leptin in breast cancer. Eur J Gynaecol Oncol 2004, 25:192-194.
19. Somasundar P, McFadden DW, Hileman SM, Vona-Davis L: Leptin is a growth factor in cancer. J Surg Res 2004, 116:337-349.
20. Sierra-Honigmann MR, Nath AK, Murakami C, Garcia-Cardena G, Papapetropoulos A, Sessa WC, Madge LA, Schechner JS, Schwabb MB, Polverini PJ, et al.: Biological action of leptin as an angiogenic factor. Science 1998, 281:1683-1686.
21. Bouloumie A, Drexler HC, Lafontan M, Busse R: Leptin, the product of Ob gene, promotes angiogenesis. Circ Res 1998, 83:1059-1066.
22. Iversen PO, Drevon CA, Reseland JE: Prevention of leptin binding to its receptor suppresses rat leukemic cell growth by inhibiting angiogenesis. Blood 2002, 100:4123-4128.
23. Hu X, Juneja SC, Maihle NJ, Cleary MP: Leptin - a growth factor in normal and malignant breast cells and for normal mammary gland development. J Natl Cancer Inst 2002, 94:1704-1711.
24. Johns PC, Yaffe MJ: X-ray characterisation of normal and neoplastic breast tissues. Phys Med Biol 1987, 32:675-695.
25. Boyd NF, Lockwood GA, Byng JW, Tritchler DL, Yaffe MJ: Mammographic densities and breast cancer risk. Cancer Epidemiol Biomarkers Prev 1998, 7:1133-1144.
26. Byrne C, Schairer C, Wolfe J, Parekh N, Salane M, Brinton LA, Hoover R, Haile R: Mammographic features and breast cancer risk: effects with time, age, and menopause status. J Natl Cancer Inst 1995, 87:1622-1629.
27. Ursin G, Ma H, Wu AH, Bernstein L, Salane M, Parisky YR, Astrahan M, Siozon CC, Pike MC: Mammographic density and breast cancer in three ethnic groups. Cancer Epidemiol Biomarkers Prev 2003, 12:332-338.
28. Ursin G, Hovanessian-Larsen L, Parisky YR, Pike MC, Wu AH: Greatly increased occurrence of breast cancers in areas of mammographically dense tissue. Breast Cancer Res 2005, 7:R605-R608.
29. Boyd NF, Lockwood GA, Martin LJ, Byng JW, Yaffe MJ, Tritchler DL: Mammographic density as a marker of susceptibility to breast cancer: a hypothesis. IARC Sci Publ 2001, 154:163-169.
30. Gram IT, Bremnes Y, Ursin G, Maskarinec G, Bjurstam N, Lund E: Percentage density, Wolfe's and Tabar's mammographic patterns: agreement and association with risk factors for breast cancer. Breast Cancer Res 2005, 7:R854-R861.
31. Ma Z, Gingerich RL, Santiago JV, Klein S, Smith CH, Landt M: Radioimmunoassay of leptin in human plasma. Clin Chem 1996, 42:942-946.
32. Ursin G, Astrahan MA, Salane M, Parisky YR, Pearce JG, Daniels JR, Pike MC, Spicer DV: The detection of changes in mammographic densities. Cancer Epidemiol Biomarkers Prev 1998, 7:43-47.
33. Willett W, Stampfer MJ: Total energy intake: implications for epidemiologic analyses. Am J Epidemiol 1986, 124:17-27.
34. Petridou E, Papadiamantis Y, Markopoulos C, Spanos E, Dessypris N, Trichopoulos D: Leptin and insulin growth factor I in relation to breast cancer (Greece). Cancer Causes Control 2000, 11:383-388.
35. Mantzoros CS, Bolhke K, Moschos S, Cramer DW: Leptin in relation to carcinoma in situ of the breast: a study of pre-menopausal cases and controls. Int J Cancer 1999, 80:523-526.
36. Stattin P, Soderberg S, Biessy C, Lenner P, Hallmans G, Kaaks R, Olsson T: Plasma leptin and breast cancer risk: a prospective study in northern sweden. Breast Cancer Res Treat 2004, 86:191-196.
37. Furberg AS, Jasienska G, Bjurstam N, Torjesen PA, Emaus A, Lipson SF, Ellison PT, Thune I: Metabolic and hormonal profiles: HDL cholesterol as a plausible biomarker of breast cancer risk. The Norwegian EBBA Study. Cancer Epidemiol Biomarkers Prev 2005, 14:33-40.
38. Lam PB, Vacek PM, Geller BM, Muss HB: The association of increased weight, body mass index, and tissue density with the risk of breast carcinoma in Vermont. Cancer 2000, 89:369-375.
39. Salminen TM, Saarenmaa IE, Heikkila MM, Hakama M: Unfavourable change in mammographic patterns and the breast cancer risk factors. Breast Cancer Res Treat 1999, 57:165-173.
40. Gram IT, Funkhouser E, Tabar L: Anthropometric indices in relation to mammographic patterns among peri-menopausal women. Int J Cancer 1997, 73:323-326.
41. Boyd NF, Rommens JM, Vogt K, Lee V, Hopper JL, Yaffe MJ, Paterson AD: Mammographic breast density as an intermediate phenotype for breast cancer. Lancet Oncol 2005, 6:798-808.
42. Capuco AV, Smith JJ, Waldo DR, Rexroad CE Jr: Influence of prepubertal dietary regimen on mammary growth of Holstein heifers. J Dairy Sci 1995, 78:2709-2725.
43. Silva LF, VandeHaar MJ, Weber Nielsen MS, Smith GW: Evidence for a local effect of leptin in bovine mammary gland. J Dairy Sci 2002, 85:3277-3286.
44. Maskarinec G, Meng L: A case-control study of mammographic densities in Hawaii. Breast Cancer Res Treat 2000, 63:153-161.
45. Chen Z, Wu AH, Gauderman WJ, Bernstein L, Ma H, Pike MC, Ursin G: Does mammographic density reflect ethnic differences in breast cancer incidence rates? Am J Epidemiol 2004, 159:140-147.
46. Maskarinec G, Meng L: An investigation of soy intake and mammographic characteristics in Hawaii. Breast Cancer Res 2001, 3:134-141.
47. Maskarinec G, Takata Y, Franke AA, Williams AE, Murphy SP: A 2- year soy intervention in premenopausal women does not change mammographic densities. J Nutr 2004, 134:3089-3094.
48. Boyd NF, Greenberg C, Lockwood G, Little L, Martin L, Byng J, Yaffe M, Tritchler D: Effects at two years of a low-fat, high-carbohydrate diet on radiologic features of the breast: results from a randomized trial. Canadian Diet and Breast Cancer Prevention Study Group. J Natl Cancer Inst 1997, 89:488-496.
49. O'Brien SN, Welter BH, Price TM: Presence of leptin in breast cell lines and breast tumors. Biochem Biophys Res Commun 1999, 259:695-698.
50. Laud K, Gourdou I, Pessemesse L, Peyrat JP, Djiane J: Identification of leptin receptors in human breast cancer: functional activity in the T47-D breast cancer cell line. Mol Cell Endocrinol 2002, 188:219-226.
51. Okumura M, Yamamoto M, Sakuma H, Kojima T, Maruyama T, Jamali M, Cooper D, Yasuda K: Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: reciprocal involvement of PKC-α and PPAR expression. Biochim Biophys Acta 2002, 1592:107-116.
52. Cleary MP, Phillips FC, Getzin SC, Jacobson TL, Jacobson MK, Christensen TA, Juneja SC, Grande JP, Maihle NJ: Genetically obese MMTV-TGF-α/ Lep(ob)Lep(ob) female mice do not develop mammary tumors. Breast Cancer Res Treat 2003, 77:205-215.
53. Cleary MP, Juneja SC, Phillips FC, Hu X, Grande JP, Maihle NJ: Leptin receptor-deficient MMTV-TGF-α/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors. Exp Biol Med (Maywood) 2004, 229:182-193.
54. Ishikawa M, Kitayama J, Nagawa H: Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer. Clin Cancer Res 2004, 10:4325-4331.
55. Caldefie-Chezet F, Damez M, de Latour M, Konska G, Mishellani F, Fusillier C, Guerry M, Penault-Llorca F, Guillot J, Vasson MP: Leptin: a proliferative factor for breast cancer? Study on human ductal carcinoma. Biochem Biophys Res Commun 2005, 334:737-741.
56. Glasow A, Kiess W, Anderegg U, Berthold A, Bottner A, Kratzsch J: Expression of leptin (Ob) and leptin receptor (Ob-R) in human fibroblasts: regulation of leptin secretion by insulin. J Clin Endocrinol Metab 2001, 86:4472-4479.
57. Alowami S, Troup S, Al Haddad S, Kirkpatrick I, Watson PH: Mammographic density is related to stroma and stromal proteoglycan expression. Breast Cancer Res 2003, 5:R129-R135.
58. Casabiell X, Pineiro V, Peino R, Lage M, Camina J, Gallego R, Vallejo LG, Dieguez C, Casanueva FF: Gender differences in both spontaneous and stimulated leptin secretion by human omental adipose tissue in vitro: dexamethasone and estradiol stimulate leptin release in women, but not in men. J Clin Endocrinol Metab 1998, 83:2149-2155.
59. Kristensen K, Pedersen SB, Richelsen B: Interactions between sex steroid hormones and leptin in women. Studies in vivo and in vitro. Int J Obes Relat Metab Disord 2000, 24:1438-1444.
60. Thomas T, Burguera B, Melton LJ 3rd, Atkinson EJ, O'Fallon WM, Riggs BL, Khosla S: Relationship of serum leptin levels with body composition and sex steroid and insulin levels in men and women. Metabolism 2000, 49:1278-1284.
61. Castracane VD, Kraemer GR, Ogden BW, Kraemer RR: Interrelationships of serum estradiol, estrone, and estrone sulfate, adiposity, biochemical bone markers, and leptin in postmenopausal women. Maturitas 2006, 53:217-225.
62. Di Carlo C, Tommaselli GA, Nappi C: Effects of sex steroid hormones and menopause on serum leptin concentrations. Gynecol Endocrinol 2002, 16:479-491.
63. Cauley JA, Gutai JP, Kuller LH, LeDonne D, Powell JG: The epidemiology of serum sex hormones in postmenopausal women. Am J Epidemiol 1989, 129:1120-1131.
64. Magoffin DA, Weitsman SR, Aagarwal SK, Jakimiuk AJ: Leptin regulation of aromatase activity in adipose stromal cells from regularly cycling women. Ginekol Pol 1999, 70:1-7.
65. Fogteloo AJ, Pijl H, Roelfsema F, Frolich M, Meinders AE: Impact of meal timing and frequency on the twenty-four-hour leptin rhythm. Horm Res 2004, 62:71-78.
66. Licinio J, Negrao AB, Mantzoros C, Kaklamani V, Wong ML, Bongiorno PB, Negro PP, Mulla A, Veldhuis JD, Cearnal L, et al.: Sex differences in circulating human leptin pulse amplitude: clinical implications. J Clin Endocrinol Metab 1998, 83:4140-4147.
67. Widjaja A, Levy JC, Morris RJ, Frayn KN, Humphreys SM, Horn R, von Zur MA, Turner RC, Brabant G: Determinants of within-subject variation of fasting serum leptin concentrations in healthy subjects. Exp Clin Endocrinol Diabetes 2000, 108:208-213.
68. Chu NF, Spiegelman D, Hotamisligil GS, Rifai N, Stampfer M, Rimm EB: Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men. Atherosclerosis 2001, 157:495-503.
69. Fors H, Matsuoka H, Bosaeus I, Rosberg S, Wikland KA, Bjarnason R: Serum leptin levels correlate with growth hormone secretion and body fat in children. J Clin Endocrinol Metab 1999, 84:3586-3590.
70. Lee NA, Rusinek H, Weinreb J, Chandra R, Toth H, Singer C, Newstead G: Fatty and fibroglandular tissue volumes in the breasts of women 20-83 years old: comparison of X-ray mammography and computer-assisted MR imaging. AJR 1997, 168:501-506.
71. Mantzoros C, Petridou E, Dessypris N, Chavelas C, Dalamaga M, Alexe DM, Papadiamantis Y, Markopoulos C, Spanos E, Chrousos G, et al.: Adiponectin and breast cancer risk. J Clin Endocrinol Metab 2004, 89:1102-1107.
72. Rahimi N, Saulnier R, Nakamura T, Park M, Elliott B: Role of hepatocyte growth factor in breast cancer: a novel mitogenic factor secreted by adipocytes. DNA Cell Biol 1994, 13:1189-1197.
73. Lorincz AM, Sukumar S: Molecular links between obesity and breast cancer. Endocr Relat Cancer 2006, 13:279-292.