Co-regulation of dopamine D1 receptor and uncoupling protein-2 expression in 3-nitropropionic acid-induced neurotoxicity: Neuroprotective role of l-carnitine

Neuroscience Letters

Volumn 410, Issue 1, 2006, Pages 62-65

  Binienda, Zbigniew K ^a   Ali, Syed F ^a   Virmani, Ashraf ^b   Amato, Antonino ^c   Salem, Nadia ^c   Przybyla, Beata D ^a,d  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b Sigma Tau SpA   (Italy)

^c Sigma Tau Pharmaceuticals Inc   (United States)

^d UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

3 Nitropropionic acid; Dopamine; l Carnitine; Rat; Striatum; Uncoupling proteins

Indexed keywords

3 NITROPROPIONIC ACID; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CARNITINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; MITOCHONDRIAL ENZYME; REACTIVE OXYGEN METABOLITE; SUCCINATE DEHYDROGENASE; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 4; UNCOUPLING PROTEIN 5; VESICULAR MONOAMINE TRANSPORTER 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN HYPOXIA; CONTROLLED STUDY; CORE TEMPERATURE; CORPUS STRIATUM; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOPAMINE METABOLISM; DOPAMINERGIC SYSTEM; ENERGY EXPENDITURE; ENZYME INACTIVATION; GENE EXPRESSION; HYPOTHERMIA; MALE; NEUROPROTECTION; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR GENE; RECTUM TEMPERATURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; TEMPERATURE MEASUREMENT;

ANIMALS; BODY TEMPERATURE; CARNITINE; DISEASE MODELS, ANIMAL; DRUG INTERACTIONS; GENE EXPRESSION REGULATION; ION CHANNELS; MALE; MITOCHONDRIAL PROTEINS; NEOSTRIATUM; NEUROPROTECTIVE AGENTS; NEUROTOXICITY SYNDROMES; NEUROTOXINS; NITRO COMPOUNDS; PROPIONIC ACIDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 33750494954     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2006.09.070     Document Type: Article

References (25)

1. Binienda Z., Johnson J., Tyler-Hashemi A.A., Rountree R.L., Sapienza P.P., Ali S.F., and Kim C.S. Protective effect of l-carnitine in the neurotoxicity induced by the mitochondrial inhibitor 3-nitropropionic acid (3-NPA). Ann. N. Y. Acad. Sci. 890 (1999) 173-178
2. Binienda Z., and Kim C.S. Increase in levels of total free fatty acids in rat brain regions following 3-nitropropionic acid administration. Neurosci. Lett. 230 (1997) 199-201
3. Binienda Z., Simmons C., Hussain S., Slikker Jr. W., and Ali S.F. Effect of acute exposure to 3-nitropropionic acid on activities of endogenous antioxidants in the rat brain. Neurosci. Lett. 251 (1998) 173-176
4. Binienda Z., Virmani A., Przybyla-Zawislak B., and Schmued L. Neuroprotective effect of l-carnitine in the 3-nitropropionic acid (3-NPA)-evoked neurotoxicity in rats. Neurosci. Lett. 367 (2004) 264-267
5. Brand M.D., and Esteves T.C. Physiological functions of the mitochondrial uncoupling proteins UCP-2 and UCP-3. Cell Metab. 2 (2005) 85-93
6. Coles C.J., Edmondson D.E., and Singer T.P. Inactivation of succinate dehydrogenase by 3-nitropropionic acid. J. Biol. Chem. 254 (1979) 5161-5167
7. Di Lisa F. Biochemical and pharmacological relevance of carnitine. Riv. Ital. Nutr. Parenter. Enteral 20 (2002) 1-10
8. Duval C., Negre-Salvayre A., Doglio A., Salvayre R., Penicaud L., and Casteilla L. Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells. Biochem. Cell Biol. 80 (2002) 757-764
9. Erecińska M., and Nelson D. Effects of 3-nitropropionic acid on synaptosomal energy and transmitter metabolism: relevance to neurodegenerative brain diseases. J. Neurochem. 63 (1994) 1033-1041
10. Fornai F., Schluter O.M., Lenzi P., Gesi M., Ruffoli R., Ferrucci M., Lazzeri G., Busceti C.L., Pontarelli F., Battaglia G., Pellegrini A., Nicoletti F., Ruggieri S., paparelli A., and Sudhof T.C. Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and α-synuclein. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 3413-3418
11. Hamilton B.F., and Gould D.H. Nature and distribution of brain lesions in rats intoxicated with 3-nitropropionic acid: a type of hypoxic (energy deficient) brain damage. Acta Neuropathol. (Berl.) 72 (1987) 286-297
12. Imam S.Z., and AliF S.F. Aging increases the susceptibility to methamphetamine-induced dopaminergic neurotoxicity in rats: correlation with peroxynitrite production and hyperthermia. J. Neurochem. 78 (2001) 1-10
13. Kageyama H., Suga A., Kashiba M., Pka J., Osaka T., Kashiwa T., Hirano T., Nemoto K., Namba Y., Ricquier D., Giacobino J.-P., and Inoue S. Increased uncoupling protein-2 and -3 gene expression in skeletal muscle of STZ-induced diabetic rats. FEBS Lett. 440 (1998) 450-453
14. Kelly L.I., Vicario P.P., Thompson G.M., Candelore M.R., Doebber T.W., Ventre J., Wu M.S., Meurer R., Forrest M.J., Conner M.W., Cascieri M.A., and Moller D.E. Peroxisome proliferator-activated receptors γ and α mediate in vivo regulation of uncoupling protein (UCP1, UCP2, UCP3) gene expression. Endocrinology 139 (1998) 4920-4927
15. Lee T.F., Mora F., and Myers R.D. Dopamine and thermoregulation: an evaluation with special reference to dopaminergic pathways. Neurosci. Behav. Rev. 9 (1985) 589-598
16. Mattiasson G., Shamloo M., Gido G., Mathi K., Tomasevic G., Yi S., Warden C.H., Castilho R.F., Melchor T., Gonzalez-Zulueta M., Nikolich K., and Wieloch T. Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma. Nat. Med. 9 (2003) 1062-1068
17. Mattson M.P., and Liu D. Mitochondrial potassium channels and uncoupling proteins in synaptic plasticity and neuronal cell death. Biochem. Biophys. Res. Commun. 304 (2003) 539-549
18. Mills E.M., Xu D., Fergusson M.M., Combs C.A., Xu Y., and Finkel T. Regulation of cellular oncosis by uncoupling protein 2. J. Biol. Chem. 277 (2002) 27385-27392
19. Murray J.A., Panagia M., Hauton D., Gibbons G.F., and Clarke K. Plasma free fatty acids and peroxisome proliferators-activated receptor α in the control of myocardial uncoupling protein levels. Diabetes 54 (2005) 3496-3502
20. Nishino H., Kumazaki M., Fukuda A., Fujimoto I., Shimano Y., Hida H., Sakurai T., Deshpande S.B., Shimizu H., Morikawa S., and Inubushi T. Acute 3-nitropropionic acid intoxication induces striatal astrocytic cell death and dysfunction of the blood-brain barrier: involvement of dopamine toxicity. Neurosci. Res. 27 (1997) 343-355
21. Nony P.A., Scallet A.C., Rountree R.L., Ye X., and Binienda Z. 3-Nitropropionic acid (3-NPA) produces hypothermia and inhibits histochemical labelling of succinate dehydrogenase (SDH) in rat brain. Metab. Brain Dis. 14 (1999) 83-94
22. Pang Z., and Geddes J.W. Mechanisms of cell death induced by the mitochondrial toxin 3-nitropropionic acid: acute excitotoxic necrosis and delayed apoptosis. J. Neurosci. 17 (1997) 3064-3073
23. Przybyla-Zawislak B.D., Kim C.S., Ali S.F., Slikker Jr. W., and Binienda Z.K. The differential JunB responses to inhibition of succinate dehydrogenase in rat hippocampus and liver. Neurosci. Lett. 381 (2005) 354-357
24. Virmani M.A., Biselli R., Spadoni A., Rossi S., Corsico N., Calvani M., Fattorossi A., De Simone C., and Arrigoni-Martelli E. Protective actions of l-carnitine and acetyl-l-carnitine on the neurotoxicity evoked by mitochondrial uncoupling or inhibitors. Pharmacol. Res. 32 (1995) 383-389
25. Yamada S., Isojima Y., Yamatodani A., and Nagai K. Uncoupling protein 2 influences dopamine secretion in PC12 cells. J. Neurochem. 87 (2003) 461-469