Increase in levels of total free fatty acids in rat brain regions following 3-nitropropionic acid administration

Neuroscience Letters

Volumn 230, Issue 3, 1997, Pages 199-201

  Binienda, Zbigniew ^a   Kim, Chung S ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

3 Nitropropionic acid; Brain; Free fatty acids; Oxidative stress; Rat

Indexed keywords

3 NITROPROPIONIC ACID; FATTY ACID; FREE RADICAL; NEUROTOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CAUDATE NUCLEUS; ELECTRON TRANSPORT; FATTY ACID METABOLISM; HIPPOCAMPUS; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BRAIN; FATTY ACIDS, NONESTERIFIED; MALE; NEUROTOXINS; NITRO COMPOUNDS; OXIDATIVE STRESS; PROPIONIC ACIDS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030794563     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00514-4     Document Type: Article

References (24)

1. Alston, T.A., Mela, L. and Bright, H.J., 3-Nitropropionate, the toxic substance of indigofera, is a suicide inactivator of succinate dehydrogenase, Proc. Natl. Acad. Sci. USA, 74 (1977) 3767-3771.
2. Beal, M.F., Brouillet, E., Jenkins, B.G., Ferrante, R.J., Kowall, N.W., Miller, J.M., Storey, E., Strivastava, R., Rosen, B.R. and Hyman, B.T., Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid, J. Neurosci., 13 (1993) 4181-4192.
3. Binienda, Z., Frederick, D.L., Ferguson, S.A., Rountree, R.L., Paule, M.G., Schmued, L., Ali, S.F., Slikker, W. Jr. and Scallet, A.C., The effects of perinatal hypoxia on the behavioral, neurochemical, and neurohistological toxicity of the metabolic inhibitor 3-nitropropionic acid, Metab. Brain Dis., 10 (1995) 269-282.
4. Brouillet, E., Jenkins, B.G., Hyman, B.T., Ferrante, R.J., Kowall, N.W., Srivastava, R., Roy, D.S., Rosen, B.R. and Beal, M.F., Agedependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid, J. Neurochem., 60 (1993) 356-359.
5. Carroll, K.K., Column chromatography of neutral glycerides and fatty acids. In G.V. Marinetti (Ed.), Lipid Chromatographic Analysis, Vol. 1, Marcel Dekker, New York, NY, 1976, pp. 173-214.
6. Chan, P.H., Chen, S., Imaizumi, S., Chu, L., Kelleher, J.A., Gregory, G.A. and Chan, T., New insights into the role of oxygen radicals in cerebral ischemia. In N.G. Bazan, P. Braquet, and M.D. Ginsberg (Eds.), Neurochemical Correlates of Cerebral Ischemia, Advances in Neurochemistry, Vol. 7, Plenum Press, New York, NY, 1992, pp. 277-294.
7. Dahlen, S.E., Bjork, J., Hedquist, P., Arfors, K.E., Hammarstrom, S., Lindgren, J.A. and Samuelsson, B., Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary vessels: in vivo effects with relevance to the acute inflammatory response, Proc. Natl. Acad. Sci. USA, 78 (1981) 3887-3891.
8. Dinnauer, M., ω-3 Highly unsaturated fatty acid methyl esters on DB-23 and DB-WAX, The J and W Separation Times, 5 (1991) 10-12.
9. Fu, Y., He, F., Zhang, S. and Zhang, J., Lipid peroxidation in rats intoxicated with 3-nitropropionic acid, Toxicon, 33 (1995) 327-331.
10. Fu, Y., He, F., Zhang, S. and Jiao, X., Consistent striatal damage in rats induced by 3-nitropropionic acid and cultures of Anthrinium fungus, Neurotoxicol. Teratol., 17 (1995) 413-418.
11. 3H-dopa in various regions of the brain, J. Neurochem., 13 (1966) 655-669.
12. Gould, D.H., Wilson, M.P. and Hamar, D.W., Brain enzyme and clinical alterations induced in rats and mice by nitroaliphatic toxicants, Toxicol. Lett., 27 (1985) 83-89.
13. Hamilton, B.F. and Gould, D.H., Nature and distribution of brain lesions in rats intoxicated with 3-nitropropionic acid: a type of hypoxic (energy deficient) brain damage, Acta Neuropathol. (Berl.), 72 (1987) 286-297.
14. Hamilton, B.F. and Gould, D.H., Correlation of morphologic brain lesions with physiologic alterations and blood - brain barrier impairment in 3-nitropropionic acid toxicity in rats, Acta Neuropathol. (Berl.), 74 (1987) 67-74.
15. Hillered, L. and Chan, P.H., Role of arachidonic acid and other free fatty acids in mitochondrial dysfunction in brain ischemia, J. Neurosci. Res., 20 (1988) 451-456.
16. Kappus, H., Overview of enzyme systems involved in bioreduction of drug and in redox cycling, Biochem. Pharmacol., 35 (1986) 1-6.
17. Nishino, H., Fujimoto, I., Shimano, Y., Hida, H., Kumazaki, M. and Fukuda, A., 3-Nitropropionic acid produces striatum selective lesions accompanied by iNOS expression, J. Chem. Neuroanat., 10 (1996) 209-212.
18. Novelli, A., Reilly, J.A., Lysko, P.G. and Hennebery, R.C., Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced, Brain Res., 451 (1988) 205-212.
19. Prapurna, R.D., Rountree, R.L., Scallet, A.C., Slikker, Jr., W. and Binienda, Z., Metabolic effects of 3-nitropropionic acid (3-NPA) in the adult rat brain, Soc. Neurosci. Abstr., 22 (1996) 745.4.
20. Schulz, J.B. and Beal, M.F., Neuroprotective effects of free radical scavengers and energy repletion in animal models of neurodegenerative disease, Ann. N. Y. Acad. Sci., 765 (1995) 100-110.
21. Virmani, M.A., Biselli, R., Spadoni, A., Rossi, S., Corsico, N., Calvani, M., Fattorossi, A., De Simone, C. and Arrigoni-Martelli, E., Protective actions of L-carnitine and acetyl-L-carnitine on the neurotoxicity evoked by mitochondrial uncoupling or inhibitors, Pharmacol. Res., 32 (1995) 383-389.
22. Wilson, D.F., Oxygen dependence of neuronal metabolism. In N.G. Bazan, P. Braquet, and M.D. Ginsberg (Eds.), Neurochemical Correlates of Cerebral Ischemia, Advances in Neurochemistry, Vol. 7, Plenum Press, New York, NY, 1992, pp. 98-99.
23. Wüllner, U., Young, A.B., Penney, J.B. and Beal, M.F., 3-Nitropropionic acid toxicity in the striatum, J. Neurochem., 63 (1994) 1772-1781.
24. Yosida, S., Inoh, S., Asan, T., Sano, K., Kubota, J., Shimazaki, H. and Meta, N., Effect of transient ischemia on free fatty acids and phospholipids in the gerbil brain, J. Neurosurg., 53 (1980) 323-331.