Acute 3-nitropropionic acid intoxication induces striatal astrocytic cell death and dysfunction of the blood-brain barrier: Involvement of dopamine toxicity

Neuroscience Research

Volumn 27, Issue 4, 1997, Pages 343-355

  Nishino, Hitoo ^a   Kumazaki, Michiko ^a   Fukuda, Atsuo ^a   Fujimoto, Ichiro ^a   Shimano, Yasunobu ^a   Hida, Hideki ^a   Sakurai, Terumi ^a   Deshpande, Shripad B ^a,c   Shimizu, Hideo ^a   Morikawa, Shigehiro ^b   Inubushi, Toshiro ^b  

^a NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^b SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^c BANARAS HINDU UNIVERSITY   (India)

Author keywords

3 nitropropionic acid; Astrocytes; Blood brain barrier; Calcium; Cell death; Dopamine; Huntington's disease; Mitochondria; Striatum

Indexed keywords

3 NITROPROPIONIC ACID; 3,4 DIHYDROXYPHENYLACETIC ACID; CALCIUM ION; DOPAMINE; DOPAMINE 2 RECEPTOR BLOCKING AGENT; DOPAMINE 2 RECEPTOR STIMULATING AGENT; IMMUNOGLOBULIN G;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN ARTERY; BRAIN EDEMA; CALCIUM CELL LEVEL; CATALEPSY; CELL DEATH; CONTROLLED STUDY; CORPUS STRIATUM; ELECTRON MICROSCOPY; FEMALE; GAIT DISORDER; HISTOLOGY; INTOXICATION; MALE; MOTOR DYSFUNCTION; NERVE CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OPISTHOTONUS; PRIORITY JOURNAL; RAT; SOMNOLENCE; TREMOR;

ANIMALS; ASTROCYTES; BEHAVIOR, ANIMAL; BLOOD-BRAIN BARRIER; CALCIUM; CELL DEATH; DOPAMINE; DOPAMINE ANTAGONISTS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; MAGNETIC RESONANCE IMAGING; MALE; MICRODIALYSIS; MICROSCOPY, ELECTRON; NEOSTRIATUM; NEUROTOXINS; NITRO COMPOUNDS; PROPIONIC ACIDS; RATS; RATS, WISTAR;

EID: 0030946777     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-0102(97)01170-X     Document Type: Article

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