Roads to dysfunction: Argininase II contributes to oxidized low-density lipoprotein-induced attenuation of endothelial NO production

Circulation Research

Volumn 99, Issue 9, 2006, Pages 918-920

  Brandes, Ralf P ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Arginase; Atherosclerosis; Endothelial dysfunction; GTPases; Hyperlipidemia; Statins

Indexed keywords

ARGINASE; ARGINASE II; EPOTHILONE B; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; METHYLTRANSFERASE; MITOGEN ACTIVATED PROTEIN KINASE; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PROTEIN KINASE B; PROTEIN KINASE C; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ATHEROGENESIS; CELL ACTIVATION; CELL INTERACTION; CYTOSKELETON; EDITORIAL; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM; ENZYME ACTIVITY; FOAM CELL; HYPERCHOLESTEROLEMIA; MICROTUBULE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN BINDING;

ARGINASE; ARGININE; ATHEROSCLEROSIS; ENDOTHELIUM, VASCULAR; HUMANS; LIPOPROTEINS, LDL; MODELS, BIOLOGICAL; NITRIC OXIDE; RHO GTP-BINDING PROTEINS;

EID: 33750469730     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000249617.15456.4c     Document Type: Editorial

References (25)

1. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med. 1999;340:115-126.
2. Mehta JL, Chen J, Hermonat PL, Romeo F, Novelli G. Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): a critical player in the development of atherosclerosis and related disorders. Cardiovasc Res. 2006;69:36-45.
3. Bickel PE, Freeman MW. Rabbit aortic smooth muscle cells express inducible macrophage scavenger receptor messenger RNA that is absent from endothelial cells. J Clin Invest. 1992;90:1450-1457.
4. Sawamura T, Kume N, Aoyama T, Moriwaki H, Hoshikawa H, Aiba Y, Tanaka T, Miwa S, Katsura Y, Kita T, Masaki T. An endothelial receptor for oxidized low-density lipoprotein. Nature. 1997;386:73-77.
5. Mehta JL, Chen J, Yu F, Li DY. Aspirin inhibits ox-LDL-mediated LOX-1 expression and metalloproteinase-1 in human coronary endothelial cells. Cardiovasc Res. 2004;64:243-249.
6. Li D, Singh RM, Liu L, Chen H, Singh BM, Kazzaz N, Mehta JL. Oxidized-LDL through LOX-1 increases the expression of angiotensin converting enzyme in human coronary artery endothelial cells. Cardiovasc Res. 2003;57:238-243.
7. Ohgushi M, Kugiyama K, Fukunaga K, Murohara T, Sugiyama S, Miyamoto E, Yasue H. Protein kinase C inhibitors prevent impairment of endothelium-dependent relaxation by oxidatively modified LDL. Arterioscler Thromb Vasc Biol. 1993;13:1525-1532.
8. Sugiyama S, Kugiayama K, Ohgushi M, Hujimoto K, Yasue H. Lysophosphatidylcholin in oxidized low-density lipoprotein increases endothelial susceptibility to polymorphonuclear leukocyte-induced endothelial dysfunction in procine coronary arteries: Role of protein kinase C. Circ Res. 1994;74:565-575.
9. Nihei S, Yamashita K, Tasaki H, Ozumi K, Nakashima Y. Oxidized low-density lipoprotein-induced apoptosis is attenuated by insulin-activated phosphatidylinositol 3-kinase/Akt through p38 mitogen-activated protein kinase. Clin Exp Pharmacol Physiol. 2005;32:224-229.
10. Everson WV, Smart EJ. Influence of caveolin, cholesterol, and lipoproteins on nitric oxide synthase: implications for vascular disease. Trends Cardiovasc Med. 2001;11:246-250.
11. Fleming I, Mohamed A, Galle J, Turchanowa L, Brandes RP, Fisslthaler B, Busse R. Oxidized low-density lipoprotein increases superoxide production by endothelial nitric oxide synthase by inhibiting PKCalpha. Cardiovasc Res. 2005;65:897-906.
12. Girerd XJ, Hirsch AT, Cooke JP, Dzau VJ, Creager MA. L-arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits. Circ Res. 1990;67:1301-1308.
13. Drexler H, Zeiher AM, Meinzer K, Just H. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine. Lancet. 1991;338:1546-1550.
14. Böger RH, Bode-Böger SM, Brandes RP, Phivthong-ngam L, Böhme M, Nafe R, Mügge A, Frölich JC. Dietary L-arginine reduces the progression, but does not induce regression of atherosclerosis in cholesterol-fed rabbits - comparison with lovastatin. Circulation. 1997;96:1282-1290.
15. Brandes RP, Brandes S, Boger RH, Bode-Boger SM, Mugge A. L-arginine supplementation in hypercholesterolemic rabbits normalizes leukocyte adhesion to non-endothelial matrix. Life Sci. 2000;66:1519-1524.
16. Boger RH, Sydow K, Borlak J, Thum T, Lenzen H, Schubert B, Tsikas D, Bode-Boger SM. LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S- adenosylmethionine-dependent methyltransferases. Circ Res. 2000;87:99-105.
17. Ito A, Tsao PS, Adimoolam S, Kimoto M, Ogawa T, Cooke JP. Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation. 1999;99:3092-3095.
18. Ryoo S, Lemmon C, Soucy K, Gupta G, White A, Nyhan D, Shoukas A, Romer L, Berkowitz D OxLDL-dependent endothelial arginase II activation contributes to imaired NO signaling. Circ Res. 2006;99:951-960.
19. Morris SM, Jr. Arginine metabolism in vascular biology and disease. Vasc Med. 2005;10 Suppl 1:S83-S87.
20. Gundersen GG, Cook TA. Microtubules and signal transduction. Curr Opin Cell Biol. 1999;11:81-94.
21. Ming XF, Barandier C, Viswambharan H, Kwak BR, Mach F, Mazzolai L, Hayoz D, Ruffieux J, Rusconi S, Montani JP, Yang Z. Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction. Circulation. 2004;110:3708-3714.
22. Galle J, Mameghani A, Bolz SS, Gambaryan S, Gorg M, Quaschning T, Raff U, Barth H, Seibold S, Wanner C, Pohl U. Oxidized LDL and its compound lysophosphatidylcholine potentiate AngII-induced vasoconstriction by stimulation of RhoA. J Am Soc Nephrol. 2003;14:1471-1479.
23. Laufs U, LaFata V, Plutzky J, Liao JK. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation. 1998;97:1129-1135.
24. Wagner AH, Kohler T, Ruckschloss U, Just I, Hecker M. Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation. Arterioscler Thromb Vasc Biol. 2000;20:61-69.
25. Laufs U, Liao JK. Targeting Rho in cardiovascular disease. Circ Res. 2000;87:526-528.