Influence of short-term octreotide administration on chronic tissue injury, transforming growth factor β (TGF-β) overexpression, and collagen accumulation in irradiated rat intestine

Journal of Pharmacology and Experimental Therapeutics

Volumn 297, Issue 1, 2001, Pages 35-42

  Wang, J ^a   Zheng, H ^a   Hauer Jensen, M ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS ANTIGEN; COLLAGEN; MESSENGER RNA; OCTREOTIDE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL HYPERPLASIA; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; EPITHELIUM CELL; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTESTINE INJURY; MALE; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; RADIATION INJURY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER;

ANIMALS; CELL DIVISION; COLLAGEN; DOSE-RESPONSE RELATIONSHIP, DRUG; INTESTINES; MALE; OCTREOTIDE; PANCREAS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA; TRYPSIN;

EID: 0035078667     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. The effect of octreotide on wound healing: An in vitro and in vivo experimental study
2. Estimation of surface area from vertical sections
3. Angiopeptin inhibits oncogene induction in rabbit aorta after balloon denudation
4. Pancreatic proteases and oxygen-derived free radicals in acute ischemic enteropathy
5. Expression of somatostatin receptor subtypes on guinea pig gastric and colonic smooth muscle cells
6. Protective effect of hypoxia against radiation-induced fibrosis in the rat gut
7. Mucosal protection during irradiation of exteriorized rat ileum: Effect of hypoxia induced by starch microspheres
8. Influence of exocrine pancreatic secretion on mucosal morphology and crypt cell proliferation in rat small intestine
9. Effects of accelerated fractionation on radiation injury of the small intestine: A new rat model
10. Changes in transforming growth factor β1 (TGF-β1) gene expression and immunoreactivity levels during development of chronic radiation enteropathy
11. Influence of pancreatic secretion on late radiation enteropathy in the rat
12. Late changes following single dose roentgen irradiation of rat small intestine
13. Blockade of growth factor synthesis and growth factor action: Two possible sites of interference in allograft vessel disease and coronary bypass or balloon injury
14. Detrimental effects of octreotide on intestinal microcirculation
15. Modulation of transforming growth factor betal gene expression in the mammary gland by insulin-like growth factor 1 and octreotide
16. Tolerance of rat small intestine to localized single dose and fractionated irradiation
17. Relationship between intestinal fibrosis and histopathologic and merphometric changes in consequential and late radiation enteropathy
18. The effect of intestinal permeability on pancreatic enzyme-induced enteropathy in the rat
19. Hypoxic radioprotection by temporary intestinal ischemia: Degradable starch microsphere embelization in the cat
20. Mast cell heterogeneity in various oral mucosal sites in the rat
21. Injurious effect of pancreatic secretions on postradiation enteropathy
22. Prolongation of survival in lethally irradiated dogs
23. The role of luminal contents in radiation enteritis
24. Postreceptor signal transduction mechanisms involved in octreotide-induced inhibition of angiogenesis
25. Small intestinal microcirculatory effects of octreotide
26. cDNA cloning by PCR of rat transforming growth factor β-1
27. The nature of intestinal radiation death
28. Objective measurement of the different collagen types in the corpus cavernosum of potent and impotent men: An immunohistochemical staining with computerized-image analysis
29. Increased transforming growth factor β (TGF-β) immunoreactivity is independently associated with chronic injury in both consequential and primary radiation enteropathy
30. The somatostatin analog, octreotide, inhibits in vitro outgrowth of smooth muscle cells from canine coronary and carotid atherosclerotic plaque tissues
31. Recombinant growth hormone's effects on the strength and thickness of radiation-injured ileal anastomoses: A rat model
32. Structures of ascending colon in cystic fibrosis and high-strength pancreatic enzymes
33. Somatostatin analogue inhibits intestinal regeneration
34. The adverse effects of octreotide on the healing of colonic anastomoses in rats
35. Upregulation and spatial shift in protease activated receptor-2 in irradiated rat intestine
36. The synthetic somatostatin analogue, octreotide, ameliorates acute and delayed intestinal radiation injury
37. Cellular sources of transforming growth factor β (TGF-β) isoforms in early and chronic radiation enteropathy
38. Antiproliferative effects of the somatostatin analogue octreotide (SMS 201-995) on ZR-75-1 human breast cancer cells in vivo and in vitro
39. Role of mast cells in early and delayed radiation injury in rat intestine
40. Recombinant soluble transforming growth factor-β type II receptor ameliorates radiation enteropathy in the mouse