메뉴 건너뛰기




Volumn 453, Issue 2, 2006, Pages 147-156

AICAR inhibits the Na+/H+ exchanger in rat hearts - Possible contribution to cardioprotection

Author keywords

AICAR; Ischemic damage; NHE1; Sodium hydrogen exchange

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; 8 (4 SULFOPHENYL)THEOPHYLLINE; ADENOSINE; ADENOSINE RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; AMMONIUM CHLORIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; ISOENZYME; SODIUM; SODIUM PROTON EXCHANGE PROTEIN;

EID: 33750375176     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-006-0124-z     Document Type: Article
Times cited : (14)

References (46)
  • 1
    • 0035082451 scopus 로고    scopus 로고
    • + entry during ischemia, reperfusion and preconditioning
    • + entry during ischemia, reperfusion and preconditioning. Cardiovasc Res 50:164-166
    • (2001) Cardiovasc Res , vol.50 , pp. 164-166
    • Allen, D.G.1    Xiao, X.H.2
  • 2
    • 0035661776 scopus 로고    scopus 로고
    • Blocking Na(+)/H(+) exchange reduces [Na(+)](i) and [Ca(2+)](i) load after ischemia and improves function in intact hearts
    • An J, Varadarajan SG, Camara A, Chen Q, Novalija E, Gross GJ et al (2001) Blocking Na(+)/H(+) exchange reduces [Na(+)](i) and [Ca(2+)](i) load after ischemia and improves function in intact hearts. Am J Physiol Heart Circ Physiol 281:H2398-H2409
    • (2001) Am J Physiol Heart Circ Physiol , vol.281
    • An, J.1    Varadarajan, S.G.2    Camara, A.3    Chen, Q.4    Novalija, E.5    Gross, G.J.6
  • 3
    • 0035224346 scopus 로고    scopus 로고
    • Adenosine A(1) receptor stimulation inhibits alpha(1)-adrenergic activation of the cardiac sarcolemmal Na(+)/H(+) exchanger
    • Avkiran M, Yokoyama H (2000) Adenosine A(1) receptor stimulation inhibits alpha(1)-adrenergic activation of the cardiac sarcolemmal Na(+)/H(+) exchanger. Br J Pharmacol 131:659-662
    • (2000) Br J Pharmacol , vol.131 , pp. 659-662
    • Avkiran, M.1    Yokoyama, H.2
  • 4
    • 0032923593 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of myocardial stunning
    • Bolli R, Marban E (1999) Molecular and cellular mechanisms of myocardial stunning. Physiol Rev 79:609-634
    • (1999) Physiol Rev , vol.79 , pp. 609-634
    • Bolli, R.1    Marban, E.2
  • 5
    • 0027175961 scopus 로고
    • Changes in myoplasmic pH and calcium concentration during exposure to lactate in isolated rat ventricular myocytes
    • Cairns SP, Westerblad H, Allen DG (1993) Changes in myoplasmic pH and calcium concentration during exposure to lactate in isolated rat ventricular myocytes. J Physiol 464:561-574
    • (1993) J Physiol , vol.464 , pp. 561-574
    • Cairns, S.P.1    Westerblad, H.2    Allen, D.G.3
  • 6
    • 0027154880 scopus 로고
    • Improved functional recovery by ischaemic preconditioning is not mediated by adenosine in the globally ischaemic isolated rat heart
    • Cave AC, Collis CS, Downey JM, Hearse DJ (1993) Improved functional recovery by ischaemic preconditioning is not mediated by adenosine in the globally ischaemic isolated rat heart. Cardiovasc Res 27:663-668
    • (1993) Cardiovasc Res , vol.27 , pp. 663-668
    • Cave, A.C.1    Collis, C.S.2    Downey, J.M.3    Hearse, D.J.4
  • 7
  • 8
    • 0029681281 scopus 로고    scopus 로고
    • Cardioprotective actions of adenosine and adenosine analogs
    • Karmazyn M (ed). Birkäuser, Basel
    • Cook MA, Karmazyn M (1996) Cardioprotective actions of adenosine and adenosine analogs. In: Karmazyn M (ed) Myocardial ischemia: mechanisms, reperfusion, protection. Birkäuser, Basel, pp 325-344
    • (1996) Myocardial Ischemia: Mechanisms, Reperfusion, Protection , pp. 325-344
    • Cook, M.A.1    Karmazyn, M.2
  • 9
    • 85047689953 scopus 로고
    • 5-Aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?
    • Corton JM, Gillespie JG, Hawley SA, Hardie DG (1995) 5-aminoimidazole-4- carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? Eur J Biochem 229:558-565
    • (1995) Eur J Biochem , vol.229 , pp. 558-565
    • Corton, J.M.1    Gillespie, J.G.2    Hawley, S.A.3    Hardie, D.G.4
  • 10
    • 33645319245 scopus 로고    scopus 로고
    • Extracellular nucleotides and adenosine independently activate AMP-activated protein kinase in endothelial cells: Involvement of P2 receptors and adenosine transporters
    • da Silva CG, Jarzyna R, Specht A, Kaczmarek E (2006) Extracellular nucleotides and adenosine independently activate AMP-activated protein kinase in endothelial cells: involvement of P2 receptors and adenosine transporters. Circ Res 98:e39-e47
    • (2006) Circ Res , vol.98
    • Da Silva, C.G.1    Jarzyna, R.2    Specht, A.3    Kaczmarek, E.4
  • 11
    • 0026663138 scopus 로고
    • Metabolic changes during ischaemia and their role in contractile failure in isolated ferret hearts
    • Elliott AC, Smith GL, Eisner DA, Allen DG (1992) Metabolic changes during ischaemia and their role in contractile failure in isolated ferret hearts. J Physiol 454:467-490
    • (1992) J Physiol , vol.454 , pp. 467-490
    • Elliott, A.C.1    Smith, G.L.2    Eisner, D.A.3    Allen, D.G.4
  • 12
    • 0027523272 scopus 로고
    • Protective effects of adenosine in the perfused rat heart: Changes in metabolism and intracellular ion homeostasis
    • Fralix TA, Murphy E, London RE, Steenbergen C (1993) Protective effects of adenosine in the perfused rat heart: changes in metabolism and intracellular ion homeostasis. Am J Physiol 264:C986-C994
    • (1993) Am J Physiol , vol.264
    • Fralix, T.A.1    Murphy, E.2    London, R.E.3    Steenbergen, C.4
  • 13
    • 0026668252 scopus 로고
    • Sustained protection by acadesine against ischemia- and reperfusion-induced injury. Studies in the transplanted rat heart
    • Galinanes M, Bullough D, Mullane KM, Hearse DJ (1992) Sustained protection by acadesine against ischemia- and reperfusion-induced injury. Studies in the transplanted rat heart. Circulation 86:589-597
    • (1992) Circulation , vol.86 , pp. 589-597
    • Galinanes, M.1    Bullough, D.2    Mullane, K.M.3    Hearse, D.J.4
  • 14
    • 0026661329 scopus 로고
    • Acadesine and myocardial protection. Studies of time of administration and dose-response relations in the rat
    • Galinanes M, Mullane KM, Bullough D, Hearse DJ (1992) Acadesine and myocardial protection. Studies of time of administration and dose-response relations in the rat. Circulation 86:598-608
    • (1992) Circulation , vol.86 , pp. 598-608
    • Galinanes, M.1    Mullane, K.M.2    Bullough, D.3    Hearse, D.J.4
  • 15
    • 0033990674 scopus 로고    scopus 로고
    • Adenosine and preconditioning in the rat heart
    • Ganote CE, Armstrong SC (2000) Adenosine and preconditioning in the rat heart. Cardiovasc Res 45:134-140
    • (2000) Cardiovasc Res , vol.45 , pp. 134-140
    • Ganote, C.E.1    Armstrong, S.C.2
  • 16
    • 0024454449 scopus 로고
    • Increased adenosine concentration in blood from ischemic myocardium by AICA riboside. Effects on flow, granulocytes, and injury
    • Gruber HE, Hoffer ME, McAllister DR, Laikind PK, Lane TA, Schmid-Schoenbein GW et al (1989) Increased adenosine concentration in blood from ischemic myocardium by AICA riboside. Effects on flow, granulocytes, and injury. Circulation 80:1400-1411
    • (1989) Circulation , vol.80 , pp. 1400-1411
    • Gruber, H.E.1    Hoffer, M.E.2    McAllister, D.R.3    Laikind, P.K.4    Lane, T.A.5    Schmid-Schoenbein, G.W.6
  • 17
    • 0029883316 scopus 로고    scopus 로고
    • Stimulation of rat liver AMP-activated protein kinase by AMP analogues
    • Henin N, Vincent MF, Van den Berghe G (1996) Stimulation of rat liver AMP-activated protein kinase by AMP analogues. Biochim Biophys Acta 1290:197-203
    • (1996) Biochim Biophys Acta , vol.1290 , pp. 197-203
    • Henin, N.1    Vincent, M.F.2    Van Den Berghe, G.3
  • 18
    • 0028967272 scopus 로고
    • Cell-type specificity of inhibition of glycolysis by 5-amino-4- imidazolecarboxamide riboside. Lack of effect in rabbit cardiomyocytes and human erythrocytes, and inhibition in FTO-2B rat hepatoma cells
    • Javaux F, Vincent MF, Wagner DR, Van den Berghe G (1995) Cell-type specificity of inhibition of glycolysis by 5-amino-4-imidazolecarboxamide riboside. Lack of effect in rabbit cardiomyocytes and human erythrocytes, and inhibition in FTO-2B rat hepatoma cells. Biochem J 305(Pt 3):913-919
    • (1995) Biochem J , vol.305 , Issue.PART 3 , pp. 913-919
    • Javaux, F.1    Vincent, M.F.2    Wagner, D.R.3    Van Den Berghe, G.4
  • 21
    • 0032771552 scopus 로고    scopus 로고
    • Improvement by 5-amino-4-imidazole carboxamide riboside of the contractile dysfunction that follows brief periods of ischemia through increases in ecto-5-nucleotidase activity and adenosine release in canine hearts
    • Kitakaze M, Takashima S, Minamino T, Node K, Shinozaki Y, Mori H et al (1999) Improvement by 5-amino-4-imidazole carboxamide riboside of the contractile dysfunction that follows brief periods of ischemia through increases in ecto-5-nucleotidase activity and adenosine release in canine hearts. Jpn Circ J 63:542-553
    • (1999) Jpn Circ J , vol.63 , pp. 542-553
    • Kitakaze, M.1    Takashima, S.2    Minamino, T.3    Node, K.4    Shinozaki, Y.5    Mori, H.6
  • 22
    • 0023807201 scopus 로고
    • Amiloride and its analogs as tools in the study of ion transport
    • Kleyman TR, Cragoe EJ (1988) Amiloride and its analogs as tools in the study of ion transport. J Membr Biol 105:1-21
    • (1988) J Membr Biol , vol.105 , pp. 1-21
    • Kleyman, T.R.1    Cragoe, E.J.2
  • 23
    • 18844478970 scopus 로고    scopus 로고
    • Comparison of interstitial fluid and coronary venous adenosine levels in in vivo porcine myocardium
    • Lasley RD, Hegge JO, Noble MA, Mentzer RM Jr (1998) Comparison of interstitial fluid and coronary venous adenosine levels in in vivo porcine myocardium. J Mol Cell Cardiol 30:1137-1147
    • (1998) J Mol Cell Cardiol , vol.30 , pp. 1137-1147
    • Lasley, R.D.1    Hegge, J.O.2    Noble, M.A.3    Mentzer Jr., R.M.4
  • 24
    • 0033563037 scopus 로고    scopus 로고
    • Characterization of intracellular pH regulation in the guinea-pig ventricular myocyte
    • Leem CH, Lagadic-Gossmann D, Vaughan-Jones RD (1999) Characterization of intracellular pH regulation in the guinea-pig ventricular myocyte. J Physiol 517:159-180
    • (1999) J Physiol , vol.517 , pp. 159-180
    • Leem, C.H.1    Lagadic-Gossmann, D.2    Vaughan-Jones, R.D.3
  • 25
    • 0027247547 scopus 로고
    • The cardioprotective effects of ischemic 'preconditioning' are not mediated by adenosine receptors in rat hearts
    • Li Y, Kloner RA (1993) The cardioprotective effects of ischemic 'preconditioning' are not mediated by adenosine receptors in rat hearts. Circulation 87:1642-1648
    • (1993) Circulation , vol.87 , pp. 1642-1648
    • Li, Y.1    Kloner, R.A.2
  • 26
    • 13944276378 scopus 로고    scopus 로고
    • Myocardium tolerant to an adenosine-dependent ischemic preconditioning stimulus can still be protected by stimuli that employ alternative signaling pathways
    • Liem DA, te Lintel HM, Manintveld OC, Boomsma F, Verdouw PD, Duncker DJ (2005) Myocardium tolerant to an adenosine-dependent ischemic preconditioning stimulus can still be protected by stimuli that employ alternative signaling pathways. Am J Physiol Heart Circ Physiol 288:H1165-H1172
    • (2005) Am J Physiol Heart Circ Physiol , vol.288
    • Liem, D.A.1    Te Lintel, H.M.2    Manintveld, O.C.3    Boomsma, F.4    Verdouw, P.D.5    Duncker, D.J.6
  • 28
    • 0031021506 scopus 로고    scopus 로고
    • Effects of acadesine on myocardial infarction, stroke, and death following surgery. A meta-analysis of the 5 international randomized trials
    • The Multicenter Study of Perioperative Ischemia (McSPI) Research Group
    • Mangano DT (1997) Effects of acadesine on myocardial infarction, stroke, and death following surgery. A meta-analysis of the 5 international randomized trials. The Multicenter Study of Perioperative Ischemia (McSPI) Research Group. JAMA 277:325-332
    • (1997) JAMA , vol.277 , pp. 325-332
    • Mangano, D.T.1
  • 29
    • 0034687210 scopus 로고    scopus 로고
    • Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia
    • Marsin AS, Bertrand L, Rider MH, Deprez J, Beauloye C, Vincent MF et al (2000) Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. Curr Biol 10:1247-1255
    • (2000) Curr Biol , vol.10 , pp. 1247-1255
    • Marsin, A.S.1    Bertrand, L.2    Rider, M.H.3    Deprez, J.4    Beauloye, C.5    Vincent, M.F.6
  • 30
    • 0021911272 scopus 로고
    • Influence of ribose, adenosine, and "AICAR" on the rate of myocardial adenosine triphosphate synthesis during reperfusion after coronary artery occlusion in the dog
    • Mauser M, Hoffmeister HM, Nienaber C, Schaper W (1985) Influence of ribose, adenosine, and "AICAR" on the rate of myocardial adenosine triphosphate synthesis during reperfusion after coronary artery occlusion in the dog. Circ Res 56:220-230
    • (1985) Circ Res , vol.56 , pp. 220-230
    • Mauser, M.1    Hoffmeister, H.M.2    Nienaber, C.3    Schaper, W.4
  • 31
    • 0028862741 scopus 로고
    • Acadesine: A new drug that may improve myocardial protection in coronary artery bypass grafting. Results of the first international multicenter study
    • Multinational Acadesine Study Group
    • Menasche P, Jamieson WR, Flameng W, Davies MK (1995) Acadesine: a new drug that may improve myocardial protection in coronary artery bypass grafting. Results of the first international multicenter study. Multinational Acadesine Study Group. J Thorac Cardiovasc Surg 110:1096-1106
    • (1995) J Thorac Cardiovasc Surg , vol.110 , pp. 1096-1106
    • Menasche, P.1    Jamieson, W.R.2    Flameng, W.3    Davies, M.K.4
  • 32
    • 0026002814 scopus 로고
    • Influence of perfusate pH on the postischemic recovery of cardiac contractile function: Involvement of sodium-hydrogen exchange
    • Meng HP, Lonsberry BB, Pierce GN (1991) Influence of perfusate pH on the postischemic recovery of cardiac contractile function: involvement of sodium-hydrogen exchange. J Pharmacol Exp Ther 258:772-777
    • (1991) J Pharmacol Exp Ther , vol.258 , pp. 772-777
    • Meng, H.P.1    Lonsberry, B.B.2    Pierce, G.N.3
  • 33
    • 85047676330 scopus 로고
    • Acadesine: The prototype adenosine regulating agent for reducing myocardial ischaemic injury
    • Mullane K (1993) Acadesine: the prototype adenosine regulating agent for reducing myocardial ischaemic injury. Cardiovasc Res 27:43-47
    • (1993) Cardiovasc Res , vol.27 , pp. 43-47
    • Mullane, K.1
  • 34
    • 0029743378 scopus 로고    scopus 로고
    • Effects of adenine nucleotide analogues on myocardial dysfunction during reperfusion after ischemia in dogs
    • Nakai T, Kano S, Satoh K, Hoshi K, Ichihara K (1996) Effects of adenine nucleotide analogues on myocardial dysfunction during reperfusion after ischemia in dogs. J Cardiovasc Pharmacol 28:264-270
    • (1996) J Cardiovasc Pharmacol , vol.28 , pp. 264-270
    • Nakai, T.1    Kano, S.2    Satoh, K.3    Hoshi, K.4    Ichihara, K.5
  • 36
    • 0034839395 scopus 로고    scopus 로고
    • Cardioprotection with adenosine metabolism inhibitors in ischemic-reperfused mouse heart
    • Peart J, Matherne GP, Cerniway RJ, Headrick JP (2001) Cardioprotection with adenosine metabolism inhibitors in ischemic-reperfused mouse heart. Cardiovasc Res 52:120-129
    • (2001) Cardiovasc Res , vol.52 , pp. 120-129
    • Peart, J.1    Matherne, G.P.2    Cerniway, R.J.3    Headrick, J.P.4
  • 37
    • 0032881635 scopus 로고    scopus 로고
    • Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR
    • Russell RR III, Bergeron R, Shulman GI, Young LH (1999) Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR. Am J Physiol 277:H643-H649
    • (1999) Am J Physiol , vol.277
    • Russell III, R.R.1    Bergeron, R.2    Shulman, G.I.3    Young, L.H.4
  • 38
    • 0028851256 scopus 로고
    • Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion
    • Scholz W, Albus U, Counillon L, Gogelein H, Lang HJ, Linz Wet al (1995) Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. Cardiovasc Res 29:260-268
    • (1995) Cardiovasc Res , vol.29 , pp. 260-268
    • Scholz, W.1    Albus, U.2    Counillon, L.3    Gogelein, H.4    Lang, H.J.5    Al, L.W.6
  • 40
    • 0019976785 scopus 로고
    • Accelerated repletion of ATP and GTP pools in postischemic canine myocardium using a precursor of purine de novo synthesis
    • Swain JL, Hines JJ, Sabina RL, Holmes EW (1982) Accelerated repletion of ATP and GTP pools in postischemic canine myocardium using a precursor of purine de novo synthesis. Circ Res 51:102-105
    • (1982) Circ Res , vol.51 , pp. 102-105
    • Swain, J.L.1    Hines, J.J.2    Sabina, R.L.3    Holmes, E.W.4
  • 42
    • 0033569864 scopus 로고    scopus 로고
    • + exchanger during ischemia and preconditioning in the isolated rat heart
    • + exchanger during ischemia and preconditioning in the isolated rat heart. Circ Res 85:723-730
    • (1999) Circ Res , vol.85 , pp. 723-730
    • Xiao, X.H.1    Allen, D.G.2
  • 43
    • 0033770196 scopus 로고    scopus 로고
    • + exchanger is critical to reperfusion damage and preconditioning in the isolated rat heart
    • + exchanger is critical to reperfusion damage and preconditioning in the isolated rat heart. Cardiovasc Res 48:244-253
    • (2000) Cardiovasc Res , vol.48 , pp. 244-253
    • Xiao, X.1    Allen, D.G.2
  • 44
    • 0037353993 scopus 로고    scopus 로고
    • The role of endogenous angiotensin II in ischemia, reperfusion and preconditioning of the isolated rat heart
    • Xiao XH, Allen DG (2002) The role of endogenous angiotensin II in ischemia, reperfusion and preconditioning of the isolated rat heart. Pflügers Arch 445:643-650
    • (2002) Pflügers Arch , vol.445 , pp. 643-650
    • Xiao, X.H.1    Allen, D.G.2
  • 45
    • 0442292061 scopus 로고    scopus 로고
    • + exchange inhibition and mitochondrial KATP channel activation are additive in the isolated rat heart
    • + exchange inhibition and mitochondrial KATP channel activation are additive in the isolated rat heart. Pflugers Arch 447:272-279
    • (2003) Pflugers Arch , vol.447 , pp. 272-279
    • Xiao, X.H.1    Allen, D.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.