Cardioprotection with adenosine metabolism inhibitors in ischemic-reperfused mouse heart

Cardiovascular Research

Volumn 52, Issue 1, 2001, Pages 120-129

  Peart, Jason ^a   Paul Matherne, G ^b   Cerniway, Rachael J ^b   Headrick, John P ^a  

^a GRIFFITH UNIVERSITY   (Australia)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Adenosine; Contractile function; Ischemia; Reperfusion; Stunning

Indexed keywords

8 (4 SULFOPHENYL)THEOPHYLLINE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE DEAMINASE INHIBITOR; ADENOSINE KINASE INHIBITOR; ERYTHRO 2 (2 HYDROXY 3 NONYL)ADENINE; HYPOXANTHINE; INOSINE; IODOTUBERCIDIN; LACTATE DEHYDROGENASE; UNCLASSIFIED DRUG; XANTHINE OXIDASE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG MECHANISM; FEMALE; HEART FUNCTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE LEVEL; VOLKMANN CONTRACTURE;

ADENINE; ADENOSINE; ADENOSINE DEAMINASE; ADENOSINE KINASE; ANIMALS; ENZYME INHIBITORS; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PERFUSION; RECEPTORS, PURINERGIC P1; THEOPHYLLINE; TUBERCIDIN;

EID: 0034839395     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(01)00360-1     Document Type: Article

References (47)

1. Protective effects of adenosine in myocardial ischemia
2. Adenosine and adenosine receptors in the cardiovascular system: Biochemistry, physiology, and pharmacology
3. Antioxidant defences in rat, pig, guinea pig, and human hearts: Comparison with xanthine oxidoreductase activity
4. Kinetics of adenylate metabolism in human and rat myocardium
5. Improved functional recovery of ischemic myocardium by suppression of adenosine catabolism
6. 31P-nuclear magnetic resonance
7. Myocardial reperfusion injury. Role of myocardial hypoxanthine and xanthine in free radical-mediated reperfusion injury
8. Augmenting intracellular adenosine improves myocardial recovery
9. Protective effects of adenosine deaminase inhibitor on ischemia-reperfusion injury in isolated perfused rat heart
10. Enhanced interstitial fluid adenosine attenuates myocardial stunning
11. Augmentation of endogenous adenosine attenuates myocardial stunning independently of coronary flow or hemodynamic effects
12. Regulation of adenosine concentration and cytoprotective effects of novel reversible adenosine deaminase inhibitors
13. Differential cardioprotection with selective inhibitors of adenosine metabolism and transport: Role of purine release in ischemic and reperfusion injury
14. Adenosine deaminase inhibition prevents free radical-mediated injury in the post-ischemic heart
15. Modulation of adenosine effects in attenuation of ischemia and reperfusion injury in rat heart
16. Adenosine kinase inhibition protects brain against focal ischemia in rats
17. Adenosine kinase inhibitors
18. The adenosine kinase inhibitor, 5-iodotubercidin, is not protective against cerebral ischemic injury in the gerbil
19. Adenylate degradation products release from the human myocardium during open heart surgery
20. Xanthine oxidoreductase activity in perfused hearts of various species, including humans
21. Nucleotide and adenosine metabolism in different cell types of human and rat heart
22. Protective effects of adenosine in the reversibly injured heart
23. Effects of ischemia, preconditioning, and adenosine deaminase inhibition on interstitial adenosine levels and infarct size
24. Xanthine oxidase is not responsible for reoxygenation injury in isolated-perfused rat heart
25. AMP degradation in the perfused rat heart during 2-deoxy-D glucose perfusion and anoxia. Part II: The determination of the degradation pathways using an adenosine deaminase inhibitor
26. 1 adenosine receptor overexpression improves myocardial energy state during ischemia reperfusion
27. 1 adenosine receptors
28. Rapid turnover of the AMP-adenosine metabolic cycle in the guinea pig heart
29. Inhibition of adenosine metabolism increases myocardial interstitial adenosine concentrations and coronary flow
30. Ischemic preconditioning: Bioenergetic and metabolic changes, and the role of endogenous adenosine
31. Inhibitors of adenosine catabolism improve recovery of dog myocardium after ischemia
32. Adenosine deaminase inhibitors attenuate ischemic injury and preserve energy balance in isolated guinea pig hearts
33. Pentostatin-augmented interstitial adenosine prevents postcardioplegia injury in damaged hearts
34. Adenosine and the stunned heart
35. Inhibition of adenosine kinase during oxygen-glucose deprivation in rat cortical neuronal cultures
36. 1 receptor activation attenuates cardiac injury produced by hydrogen peroxide
37. 1 receptor activation
38. Adenosine acts as an endogenous activator of the cellular antioxidant defense system
39. Adenine/ribose supply increases adenosine production and protects ATP pool in adenosine kinase-inhibited cardiac cells
40. 1 adenosine receptors during ischemia and reperfusion improves ischemic tolerance
41. Cardiac microdialysis in isolated rat hearts: Interstitial purine metabolites during ischemia
42. Substrate control of free radical generation from xanthine oxidase in the post-ischemic heart
43. Oxygen radicals released during ischemic preconditioning contribute to cardioprotection in the rabbit myocardium
44. 1 receptor activation reduces reactive oxygen species and attenuates stunning in ventricular myocytes
45. 1 adenosine receptors mimics ischemic preconditioning
46. Is a high glycogen content beneficial or detrimental to the ischemic rat heart? A controversy resolved
47. 1 receptors in ischemic rat hearts