GABAA receptor function and pharmacology in epilepsy and status epilepticus

Current Opinion in Pharmacology

Volumn 3, Issue 1, 2003, Pages 12-18

  Jones Davis, Dorothy M ^a   Macdonald, Robert L ^b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4,5,6,7 TETRAHYDROISOXAZOLO[4,5 C]PYRIDIN 3 OL; ANTICONVULSIVE AGENT; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE; BICUCULLINE; NEUROSTEROID; NICOTINIC RECEPTOR; PICROTOXIN; PILOCARPINE; POTASSIUM CHANNEL; RECEPTOR SUBTYPE; SODIUM CHANNEL; TIAGABINE; VIGABATRIN; ZINC;

EPILEPSY; EPILEPTIC STATE; EPILEPTOGENESIS; GENE MUTATION; GENERALIZED EPILEPSY; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; SEIZURE;

ANIMALS; ANTICONVULSANTS; EPILEPSY; HUMANS; RECEPTORS, GABA-A; STATUS EPILEPTICUS;

EID: 0037302051     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4892(02)00015-2     Document Type: Review

References (40)

1. A receptor. J Neurosci 1996, 16:5415-5424.
2. A receptors. Neurochem Int 19919, 34:379-385.
3. A receptor channels. Annu Rev Neurosci 1994 , 17:569-602.
4. Macdonald RL, Kapar J: Acute cellular alterations in the hippocampus after status epilepticus. Epilepsia 1999, 40(Suppl 1):S9-S20.
5. Ben Menachem E, Eadie MJ, Vajda FJE: Antiepieleptic drugs. In Pharmacology and Therapeutic. Berlin: Springer, 1999.
6. A receptors. J Neurosci 1997, 17:7532-7540.
7. Kapur J, Coulter DA: Experimental status epilepticus alters gamma-aminobutyric acid type A receptor function in CA1 pyramidal neurons. Ann Neurol 1995, 38:893-900.
8. Lowenstein DH, Alldredge BK: Status epilepticus at an urban public hospital in the 1980s. Neurology 1993, 43:483-488.
9. Jones D, Esmaeil N, Maren S, Macdonald R: Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus. Epilepsy Res 2002, 50:301-312.
10. A receptor subunits in the rat hippocampus I: immunocytochemical distribution of 13 subunits. Neuroscience 1997, 80:987-1000.
11. A receptor subunits in the rat hippocampus II: altered distribution in kainic acid-induced temporal lobe epilepsy. Neuroscience 1997, 80:1001-1017.
12. A receptor subunits in the rat hippocampus III: altered messenger RNA expression in kainic acid-induced epilepsy. Neuroscience 1997, 80: 1019-1032.
13. A receptor subunit expression and function in temporal lobe epilepsy. Nat Med 1998, 4:1166-1172.
14. A-receptors in temporl lobe epilepsy. Neurochem Int 1999, 34:435-445.
15. Ben Ari Y: Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Neurosci 1985, 14:375-403.
16. Mello LE, Cavalheiro EA, Tan Am, Kupfer WR, Pretorius JK, Babb TL, Finch D: Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: cell loss and mossy fiber sprouting. Epilepsia 1993, 34: 985-995.
17. A receptor subtypes in human temporal lobe epilepsy. J Neurosci 2000, 20:5401-5419.
18. A receptor function in dentate granule and CA1 neurons. J Neurophysiol 1997, 77:1924-1938.
19. Holland KD, McKeon AC, Canney DJ, Covey DF, Ferrendelli JA: Relative anticonvulsant effects of GABAmimetic and GABA modulatory agents. Epilepsia 1992, 33:981-986.
20. Macdonald RL: Antiepileptic drug actions. Epilepsia 1989, 30(Suppl 1):S19-S28.
21. Alldredge BK, Lowenstein DH: Status epilepticus related to alcohol abuse. Epilepsia 1993, 34:1033-1037.
22. Fisher RS: Animal models of the epilepsies. Brain Res Brain Res Rev 1989, 14:245-278.
23. Macdonald RL, Greenfield LJ Jr: Mechanisms of action of new antiepileptic drugs. Curr Opin Neurol 1997, 10:121-128.
24. A receptor dysfunction in epilepsy: a mutation in the gamma2-subunit gene. Nat Genet 2001, 28:46-48.
25. A receptor gamma2-subunit in childhood absence epilepsy and febrile seizures. Nat Genet 2001, 28:49-52.
26. A receptor mutations linked to epilepsy in humans. J Neurosci 2002, 22:5321-5327.
27. Kananura C, Haug K, Sander T, Runge U, Gu W, Hallmann K, Rebstock J, Heils A, Steintein OK: A splice-site mutation in GABRG2 associated with childhood absence epilepsy and fabrile convulsions. Arch Neurol 2002, 59:1137-1141.
28. Engel J: Epilepsy: a Comprehensive Textbook. Philadelphia: Lippincott-Raven; 1998.
29. +-channel beta1 subunit gene SCN1B. Nat Genet 1998, 19:366-370.
30. Escayg A, MacDonald BT, Meisier MH, Baulac S, Huberfeld G, An-Gourfinkel I, Brice A, LeGuern E, Moulard B, Chaigne D et al.: Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS + 2. Nat Genet 2000, 24:343-345.
31. Claes L, Del Favero J, Ceulemans B, Lagae L, Van Broeckhoven C, De Jonghe P: De novo mutations in the sodium-channel gene SCNA1 cause severe myoclonic epilepsy of infancy. Am J Hum Genet 2001, 68:1327-1332.
32. Sugawara T, Mazaki-Miyazaki E, Ito M, Nagafuji H, Fukuma G, Mitsudome A, Wada K, Kaneko S, Hirose S, Yamakawa K: Nav1.1 mutations cause febrile seizures associated with afebrile partial seizures. Neurology 2001, 57:703-705.
33. Bievert C, Schroader BC, Kubisch C, Berkovic SF, Propping P, Jentsch TJ, Steinlein OK: A potassium channel mutation in neonatal human epilepsy. Science 1998, 279:403-406.
34. Charlier C, Singh NA, Ryan SG, Lewis TB, Reus BE, Leach RJ, Leppert M: A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family. Nat Genet 1998, 18:53-55.
35. Singh NA, Charlier C, Stauffer D, DuPont BR, Leach RJ, Melis R, Ronan GM, Bjerre I, Quattlebaum T, Murphy JV et al.: A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns. Nat Genet 1998, 18:25-29.
36. A receptors. Trends Pharmacol Sci 1997, 18:425-429.
37. A-receptor gamma2 subunit in a family with generalized epilepsy with febrile seizures plus. Am J Hum Genet 2002, 70:530-536.
38. A receptor have the epilepsy phenotypes and many of the behavioral characteristics of Angelman syndrome. J Neurosci 1998, 18:8505-8514.
39. A receptor beta3 subunit to the Angelman/Prader-Will region of human chromosome 15. Am J Hum Genet 1991, 49:330-337.
40. Cossette P, Liu L, Brisebois K, Dong H, Lortie A, Vanasse M, Saint-Hilaire JM, Carmant L, Verner A, Lu WY et al.: Mutation of GABRA1 In an autosomal dominant form of juvenille myoclonic epilepsy. Net Genet 2002, 31:184-189.