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Volumn 1, Issue 10, 2006, Pages 1142-1148

Optimized synthesis of AMPA receptor antagonist ZK 187638 and neurobehavioral activity in a mouse model of neuronal ceroid lipofuscinosis

(10) Elger, Bernd a Schneider, Matthias a Winter, Eric b Carvelli, Lucia c Bonomi, Marco c Fracasso, Claudia c Guiso, Giovanna c Colovic, Milena c Caccia, Silvio c Mennini, Tiziana c

a BAYER PHARMA AG (Germany)

b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG (Germany)

c MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH (Italy)

Author keywords

Blood brain barrier; mnd mouse neurochemistry; Receptors; ZK 187638

Indexed keywords

1,3 DIOXOLANE DERIVATIVE; 2,3 DIMETHYL 6 PHENYL 12H (1,3)DIOXOLO(4,5 H)IMIDAZO(1,2 C)(2,3)BENZODIAZEPINE; 2,3-DIMETHYL-6-PHENYL-12H-(1,3)DIOXOLO(4,5-H)IMIDAZO(1,2-C)(2,3)BENZODIAZEPINE; AMPA RECEPTOR; BENZODIAZEPINE DERIVATIVE;

AGE; ANIMAL; ANIMAL BEHAVIOR; ARTICLE; CENTRAL NERVOUS SYSTEM; CHEMICAL STRUCTURE; DISEASE MODEL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; MALE; MOTOR PERFORMANCE; MOUSE; MOUSE MUTANT; NEURONAL CEROID LIPOFUSCINOSIS; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; SYNTHESIS;

ADMINISTRATION, ORAL; AGE FACTORS; ANIMALS; BEHAVIOR, ANIMAL; BENZODIAZEPINES; CENTRAL NERVOUS SYSTEM; DIOXOLES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; MALE; MICE; MICE, NEUROLOGIC MUTANTS; MOLECULAR STRUCTURE; MOTOR SKILLS; NEURONAL CEROID-LIPOFUSCINOSES; RECEPTORS, AMPA;

EID: 33750354018 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.200600144 Document Type: Article

Times cited : (22)

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