7,8-methylenedioxy-4H-2,3-benzodiazepin-4-ones as novel AMPA receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 8, 1998, Pages 971-976

  De Sarro, Angela ^a   De Sarro, Giovanbattista ^b   Gitto, Rosaria ^a   Grasso, Silvana ^a   Micale, Nicola ^a   Quartarone, Silvana ^a   Zappalà, Maria ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

7,8 Methylenedioxy 4H 2,3 benzodiazepin 4 ones; AMPA receptor antagonists; Anticonvulsant activity

Indexed keywords

1 (4 AMINOPHENYL) 4 METHYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 7,8 METHYLENEDIOXY 4H 2,3 BENZODIAZEPIN 4 ONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; ANTICONVULSIVE AGENT; BENZODIAZEPINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; DOSE RESPONSE; DRUG SYNTHESIS; MOUSE; NONHUMAN; SEIZURE;

ACOUSTIC STIMULATION; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; ANTI-ANXIETY AGENTS; ANTICONVULSANTS; BENZODIAZEPINES; BENZODIAZEPINONES; EXCITATORY AMINO ACID ANTAGONISTS; INDICATORS AND REAGENTS; MICE; MICE, INBRED DBA; MOLECULAR STRUCTURE; MOTOR ACTIVITY; RECEPTORS, AMPA; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032554723     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00148-6     Document Type: Article

References (20)

1. 1. Desos, P.; Lepagnol, J. M.; Morain, P.; Lestage, P.; Cordi, A. A. J. Med. Chem. 1996, 39, 197-206.
2. 2. Cai, S. X.; Huang, J.-C.; Espitia, S. A.; Tran, M.; Ilyin, V. I.; Hawkinson, J. E.; Woodward, R. M.; Weber, E.; Keana, J. F. W. J. Med Chem. 1997, 40, 3679-3686.
3. 3. Lin, Z.; Kadaba, P. K. Med. Res. Rev. 1997, 17, 537-572.
4. 4. Sheardown, M. G.; Nielsen, E. O.; Hansen, A. J.; Jacobsen, P.; Honore, T. Science 1990, 247, 571-574.
5. 5. Buchan, A. M.; Lesiuk, H.; Barnes, K. A.; Li, H.; Huang, Z. G.; Smith, K. E.; Xue, D. Stroke 1993, 24 suppl. 1, 148-152.
6. 6. Donevan, S. D.; Rogawski, M. A. Neuron 1993, 10, 51-59.
7. 7. Rogawski, M. A. Trends Pharmacol. Sci. 1993, 14, 325-331.
8. 8. Chapman, A. G.; Smith, S. E.; Meldrum, B. S. Epilepsy Res. 1991, 9, 92-96.
9. 9. Smith, S. E.; Durmuller, N.; Meldrum, B. S. Eur. J. Pharmacol. 1991, 201, 179-183.
10. 10. Chapman, A. G.; Al-Zubaidy, Z.; Meldrum, B. S. Eur. J. Pharmacol. 1993, 231, 301-303.
11. 11. Donevan, S. D.; Yamaguchi, S. I.; Rogawski, M. A. J. Pharmac. Exp. Ther. 1994, 271, 25-29.
12. 12. Smith, S. E.; Meldrum, B. S. Stroke 1992, 23, 861-864.
13. 13. Arvin, B.; Lekieffre, D.; Graham, J. L.; Moncada, C.; Chapman, A. G.; Meldrum, B. S. J. Neurochem. 1994, 62, 1458-1467.
14. 14. De Sarro, G.; Chimirri, A.; De Sarro, A.; Gitto, R.; Grasso, S.; Giusti, P.; Chapman, A. G. Eur. J. Pharmacol. 1995, 294, 411-422.
15. 15. Chimirri, A.; De Sarro, G.; De Sarro, A.; Gitto, R.; Grasso, S.; Quartarone, S.; Zappalà, M.; Giusti, P.; Libri, V.; Constanti, A.; Chapman, A. G. J. Med. Chem. 1997, 40, 1258-1269.
16. 16. Ito, I.; Tanabe, S.; Kohda, A.; Sugiyama, H. J. Physiol. (London) 1990, 424, 533-543.
17. 17. Chiamulera, C.; Costa S.; Reggiani, A. Psychopharmacology 1990, 102, 551-552.
18. 18. Bliss, T. V. P.; Collingridge G. L. Nature 1993, 361, 31-39.
19. 19. Paternain A. V.; Morales, M.; Lerma, J. Neuron 1995, 14, 185-189.
20. 20. Litchfield, J. T.; Wilcoxon, F.. J. Pharmac. Exp. Ther. 1949, 96, 99-113.