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Volumn 60, Issue 2, 2006, Pages 99-111

Should concomitant and adjuvant treatment with temozolomide be used as standard therapy in patients with anaplastic glioma?

Author keywords

Anaplastic glioma; Astrocytoma; Chemoradiotherapy; Chemotherapy; Oligoastrocytoma; Oligodendroglioma; Radiotherapy; Temozolomide

Indexed keywords

6 O BENZYLGUANINE; AG 014699; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CARMUSTINE; CILENGITIDE; DOCETAXEL; EFLORNITHINE; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GADOLINIUM TEXAPHYRIN; GEFITINIB; GUANINE DERIVATIVE; LIVER ENZYME; LOMEGUATRIB; LOMUSTINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PROCARBAZINE; PROTEIN P53; TEMOZOLOMIDE; UNCLASSIFIED DRUG; VATALANIB; VINCRISTINE;

EID: 33750339323     PISSN: 10408428     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2006.04.005     Document Type: Review
Times cited : (31)

References (93)
  • 2
    • 33750289995 scopus 로고    scopus 로고
    • World Health Organization Classification of Tumors: pathology and genetics: tumors of the nervous system. In: Kleihues P, Cavenee WB, editors. Lyon, France: IARC Press; 2000.
  • 3
    • 0018125603 scopus 로고
    • Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial
    • Walker M.D., Alexander E., Hunt W.E., et al. Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial. J Neurosurg 49 (1978) 333-343
    • (1978) J Neurosurg , vol.49 , pp. 333-343
    • Walker, M.D.1    Alexander, E.2    Hunt, W.E.3
  • 4
    • 0037161024 scopus 로고    scopus 로고
    • Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials
    • Stewart L.A. Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials. Lancet 359 (2002) 1011-1018
    • (2002) Lancet , vol.359 , pp. 1011-1018
    • Stewart, L.A.1
  • 5
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp R., Mason W.P., van den Bent M.J., et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352 (2005) 987-996
    • (2005) N Engl J Med , vol.352 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    van den Bent, M.J.3
  • 6
    • 20244372425 scopus 로고    scopus 로고
    • Randomized phase II study of temozolomide and radiotherapy compared with radiotherapy alone in newly diagnosed glioblastoma multiforme
    • Athanassiou H., Synodinou M., Maragoudakis E., et al. Randomized phase II study of temozolomide and radiotherapy compared with radiotherapy alone in newly diagnosed glioblastoma multiforme. J Clin Oncol 23 (2005) 2372-2377
    • (2005) J Clin Oncol , vol.23 , pp. 2372-2377
    • Athanassiou, H.1    Synodinou, M.2    Maragoudakis, E.3
  • 7
    • 0025239917 scopus 로고
    • Superiority of post-radiotherapy adjuvant chemotherapy with CCNU, procarbazine, and vincristine (PCV) over BCNU for anaplastic gliomas: NCOG 6G61 final report
    • Levin V.A., Silver P., Hannigan J., et al. Superiority of post-radiotherapy adjuvant chemotherapy with CCNU, procarbazine, and vincristine (PCV) over BCNU for anaplastic gliomas: NCOG 6G61 final report. Int J Radiat Oncol Biol Phys 18 (1990) 321-324
    • (1990) Int J Radiat Oncol Biol Phys , vol.18 , pp. 321-324
    • Levin, V.A.1    Silver, P.2    Hannigan, J.3
  • 8
    • 0032729803 scopus 로고    scopus 로고
    • Procarbazine, lomustine, and vincristine (PCV) chemotherapy for anaplastic astrocytoma: a retrospective review of radiation therapy oncology group protocols comparing survival with carmustine or PCV adjuvant chemotherapy
    • Prados M.D., Scott C., Curran W.J., Nelson D.F., Leibel S., and Kramer S. Procarbazine, lomustine, and vincristine (PCV) chemotherapy for anaplastic astrocytoma: a retrospective review of radiation therapy oncology group protocols comparing survival with carmustine or PCV adjuvant chemotherapy. J Clin Oncol 17 (1999) 3389-3395
    • (1999) J Clin Oncol , vol.17 , pp. 3389-3395
    • Prados, M.D.1    Scott, C.2    Curran, W.J.3    Nelson, D.F.4    Leibel, S.5    Kramer, S.6
  • 9
    • 0035863293 scopus 로고    scopus 로고
    • Randomized trial of procarbazine, lomustine, and vincristine in the adjuvant treatment of high-grade astrocytoma: a Medical Research Council trial
    • The Medical Research Council Brain Tumor Working Party. Randomized trial of procarbazine, lomustine, and vincristine in the adjuvant treatment of high-grade astrocytoma: a Medical Research Council trial. J Clin Oncol 19 (2001) 509-518
    • (2001) J Clin Oncol , vol.19 , pp. 509-518
    • The Medical Research Council Brain Tumor Working Party1
  • 10
    • 0037342691 scopus 로고    scopus 로고
    • Phase III randomized study of postradiotherapy chemotherapy with combination a-difluoromethylornithine-PCV versus PCV for anaplastic gliomas
    • Levin V.A., Hess K.R., Choucair A., et al. Phase III randomized study of postradiotherapy chemotherapy with combination a-difluoromethylornithine-PCV versus PCV for anaplastic gliomas. Clin Can Res 9 (2003) 981-990
    • (2003) Clin Can Res , vol.9 , pp. 981-990
    • Levin, V.A.1    Hess, K.R.2    Choucair, A.3
  • 11
    • 0032855728 scopus 로고    scopus 로고
    • Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal brain tumor group
    • Yung W.K., Prados M.D., Yaya-Tur R., et al. Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal brain tumor group. J Clin Oncol 17 (1999) 2762-2771
    • (1999) J Clin Oncol , vol.17 , pp. 2762-2771
    • Yung, W.K.1    Prados, M.D.2    Yaya-Tur, R.3
  • 12
    • 0023930146 scopus 로고
    • Successful chemotherapy for recurrent malignant oligodendroglioma
    • Cairncross J.G., and Macdonald D.R. Successful chemotherapy for recurrent malignant oligodendroglioma. Ann Neurol 23 (1988) 360-364
    • (1988) Ann Neurol , vol.23 , pp. 360-364
    • Cairncross, J.G.1    Macdonald, D.R.2
  • 13
    • 0029841263 scopus 로고    scopus 로고
    • Procarbazine, lomustine, and vincristine (PCV) chemotherapy for grade III and grade IV oligoastrocytomas
    • Kim L., Hochberg F.H., Thornton A.F., et al. Procarbazine, lomustine, and vincristine (PCV) chemotherapy for grade III and grade IV oligoastrocytomas. J Neurosurg 85 (1996) 602-607
    • (1996) J Neurosurg , vol.85 , pp. 602-607
    • Kim, L.1    Hochberg, F.H.2    Thornton, A.F.3
  • 14
    • 33750339416 scopus 로고    scopus 로고
    • Cairncross G, Seiferheld W, Shaw E, et al. An intergroup randomized controlled clinical trial (RCT) of chemotherapy plus radiation (RT) versus RT alone for pure and mixed anaplastic oligodendrogliomas: initial report of RTOG 94-02. J Clin Oncol 2004 [ASCO Annual Meeting Proceedings]; 22(14S):1500.
  • 15
    • 33750338358 scopus 로고    scopus 로고
    • van den Bent MJ, Delattre J, Brandes AA, et al. First analysis of EORTC trial 26951, a randomized phase III study of adjuvant PCV chemotherapy in patients with highly anaplastic oligodendroglioma. J Clin Oncol 2005 [ASCO Annual Meeting Proceedings]; 23(16S):1503.
  • 17
    • 33750362333 scopus 로고    scopus 로고
    • Combs SE, Gutwein S, Schulz-Ertner D, et al. Temozolomide combined with radiation as first-line treatment in primary glioblastoma multiforme: phase I/II-study. J Clin Oncol 2004 [ASCO Annual Meeting Proceedings]; 22(14S):1531.
  • 18
    • 0035340512 scopus 로고    scopus 로고
    • Safety and efficacy of temozolomide in patients with recurrent anaplastic oligodendrogliomas after standard radiotherapy and chemotherapy
    • Chinot O.L., Honore S., Dufour H., et al. Safety and efficacy of temozolomide in patients with recurrent anaplastic oligodendrogliomas after standard radiotherapy and chemotherapy. J Clin Oncol 19 (2001) 2449-2455
    • (2001) J Clin Oncol , vol.19 , pp. 2449-2455
    • Chinot, O.L.1    Honore, S.2    Dufour, H.3
  • 19
    • 0038352148 scopus 로고    scopus 로고
    • Phase II study of first-line chemotherapy with temozolomide in recurrent oligodendroglial tumors: the European organization for the research and treatment of cancer brain tumor group study 26971
    • van den Bent M.J., Taphoom M.J., Brandes A.A., et al. Phase II study of first-line chemotherapy with temozolomide in recurrent oligodendroglial tumors: the European organization for the research and treatment of cancer brain tumor group study 26971. J Clin Oncol 21 (2003) 2525-2528
    • (2003) J Clin Oncol , vol.21 , pp. 2525-2528
    • van den Bent, M.J.1    Taphoom, M.J.2    Brandes, A.A.3
  • 20
    • 33750287854 scopus 로고    scopus 로고
    • Vogelbaum MA, Berkey B, Peereboom D, et al. RTOG 0131: phase II trial of pre-irradiation and concurrent temozolomide in patients with newly diagnosed anaplastic oligodendrogliomas and mixed anaplastic oligodendrogliomas. J Clin Oncol 2005 [ASCO Annual Meeting Proceedings]; 23(16S):1520.
  • 21
    • 0036136919 scopus 로고    scopus 로고
    • Histopathological-molecular genetic correlations in referral pathologist-diagnosed low grade "oligodendroglioma"
    • Sasaki H., Zlatescu M.C., Betensky R.A., et al. Histopathological-molecular genetic correlations in referral pathologist-diagnosed low grade "oligodendroglioma". J Neuropathol Exp Neurol 61 (2002) 58-63
    • (2002) J Neuropathol Exp Neurol , vol.61 , pp. 58-63
    • Sasaki, H.1    Zlatescu, M.C.2    Betensky, R.A.3
  • 22
    • 0242609174 scopus 로고    scopus 로고
    • Clinical utility of fluorescence in situ hybridization (FISH) in morphologically ambiguous gliomas with hybrid olidodendroglial/astrocytic features
    • Fuller C.E., Schmidt R.E., Roth K.A., et al. Clinical utility of fluorescence in situ hybridization (FISH) in morphologically ambiguous gliomas with hybrid olidodendroglial/astrocytic features. J Neuropathol Exp Neurol 62 (2003) 1118-1128
    • (2003) J Neuropathol Exp Neurol , vol.62 , pp. 1118-1128
    • Fuller, C.E.1    Schmidt, R.E.2    Roth, K.A.3
  • 23
    • 0032494479 scopus 로고    scopus 로고
    • Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas
    • Cairncross J.G., Ueki K., Zlatescu M.C., et al. Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. J Natl Cancer Inst 90 (1998) 1473-1479
    • (1998) J Natl Cancer Inst , vol.90 , pp. 1473-1479
    • Cairncross, J.G.1    Ueki, K.2    Zlatescu, M.C.3
  • 24
    • 0033951824 scopus 로고    scopus 로고
    • Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas
    • Smith J.S., Perry A., Borell T.J., et al. Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas. J Clin Oncol 18 (2000) 636-645
    • (2000) J Clin Oncol , vol.18 , pp. 636-645
    • Smith, J.S.1    Perry, A.2    Borell, T.J.3
  • 25
    • 0034307067 scopus 로고    scopus 로고
    • Allelic loss of chromosome 1p and radiotherapy plus chemotherapy in patients with oligodendrogliomas
    • Bauman G.S., Ino Y., Ueki K., et al. Allelic loss of chromosome 1p and radiotherapy plus chemotherapy in patients with oligodendrogliomas. Int J Radiat Oncol Biol Phys 48 (2000) 825-830
    • (2000) Int J Radiat Oncol Biol Phys , vol.48 , pp. 825-830
    • Bauman, G.S.1    Ino, Y.2    Ueki, K.3
  • 26
    • 0037298856 scopus 로고    scopus 로고
    • Impact of chromosome 1p status in response of oligodendroglioma to temozolomide: preliminary results
    • Chahlavi A., Kanner A., Peereboom D., Staugaitis S.M., Elson P., and Barnett G. Impact of chromosome 1p status in response of oligodendroglioma to temozolomide: preliminary results. J Neurooncol 61 (2003) 267-273
    • (2003) J Neurooncol , vol.61 , pp. 267-273
    • Chahlavi, A.1    Kanner, A.2    Peereboom, D.3    Staugaitis, S.M.4    Elson, P.5    Barnett, G.6
  • 27
    • 0034667383 scopus 로고    scopus 로고
    • Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and capase-9/3 regulated and Fas/capse-8 independent
    • Ochs K., and Kaina B. Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and capase-9/3 regulated and Fas/capse-8 independent. Cancer Res 60 (2000) 5815-5824
    • (2000) Cancer Res , vol.60 , pp. 5815-5824
    • Ochs, K.1    Kaina, B.2
  • 28
    • 0028133013 scopus 로고
    • NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA
    • Denny B.J., Wheelhouse R.T., Stevens M.F., Tsang L.L., and Slack J.A. NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA. Biochemistry 33 (1994) 9045-9051
    • (1994) Biochemistry , vol.33 , pp. 9045-9051
    • Denny, B.J.1    Wheelhouse, R.T.2    Stevens, M.F.3    Tsang, L.L.4    Slack, J.A.5
  • 29
    • 0028986307 scopus 로고
    • Chemosensitivity to triazene compounds and O6-alkylguanine-DNA alkyltransferase levels: studies with blasts of leukaemic patients
    • D'Atri S., Piccioni D., and Castellano A. Chemosensitivity to triazene compounds and O6-alkylguanine-DNA alkyltransferase levels: studies with blasts of leukaemic patients. Ann Oncol 6 (1995) 389-393
    • (1995) Ann Oncol , vol.6 , pp. 389-393
    • D'Atri, S.1    Piccioni, D.2    Castellano, A.3
  • 30
    • 0029662166 scopus 로고    scopus 로고
    • 3-Aminobenzamide and/or O6-benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment in cell lines of variable mismatch repair status and O6-alkylguanine-DNA alkyltransferase activity
    • Wedge S.R., Porteous J.K., and Newlands E.S. 3-Aminobenzamide and/or O6-benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment in cell lines of variable mismatch repair status and O6-alkylguanine-DNA alkyltransferase activity. Br J Cancer 74 (1996) 1030-1036
    • (1996) Br J Cancer , vol.74 , pp. 1030-1036
    • Wedge, S.R.1    Porteous, J.K.2    Newlands, E.S.3
  • 31
    • 0025116511 scopus 로고
    • DNA alkylation by the haloethylnitrosoureas: nature of modifications produced and their enzymatic repair or removal
    • Ludlum D.B. DNA alkylation by the haloethylnitrosoureas: nature of modifications produced and their enzymatic repair or removal. Mutat Res 233 (1990) 117-126
    • (1990) Mutat Res , vol.233 , pp. 117-126
    • Ludlum, D.B.1
  • 32
    • 0021111679 scopus 로고
    • Purification and properties of O6-methylguanine-DNA transmethylase from rat liver
    • Pegg A.E., Wiest L., Foote R.S., Mitra S., and Perry W. Purification and properties of O6-methylguanine-DNA transmethylase from rat liver. J Biol Chem 258 (1983) 2327-2333
    • (1983) J Biol Chem , vol.258 , pp. 2327-2333
    • Pegg, A.E.1    Wiest, L.2    Foote, R.S.3    Mitra, S.4    Perry, W.5
  • 33
    • 0030611736 scopus 로고    scopus 로고
    • Understanding and manipulating O6-methylguanine-DNA methyltransferase expression
    • Pieper R.O. Understanding and manipulating O6-methylguanine-DNA methyltransferase expression. Pharmacol Ther 74 (1997) 285-297
    • (1997) Pharmacol Ther , vol.74 , pp. 285-297
    • Pieper, R.O.1
  • 34
    • 0942279488 scopus 로고    scopus 로고
    • Generating mutations but providing chemosensitivity: the role of O6-methylgauanine DNA methyltransferase in human cancer
    • Esteller M., and Herman J.G. Generating mutations but providing chemosensitivity: the role of O6-methylgauanine DNA methyltransferase in human cancer. Oncogene 23 (2004) 1-8
    • (2004) Oncogene , vol.23 , pp. 1-8
    • Esteller, M.1    Herman, J.G.2
  • 35
    • 0032588748 scopus 로고    scopus 로고
    • O6-methylguanine-DNA methyltransferase-deficient phenotype in human gliomas: frequency and time to tumor progression after alkylating agent-based chemotherapy
    • Silber J.R., Blank A., Bobola M.S., Ghatan S., Kolstoe D.D., and Berger M.S. O6-methylguanine-DNA methyltransferase-deficient phenotype in human gliomas: frequency and time to tumor progression after alkylating agent-based chemotherapy. Clin Cancer Res 5 (1999) 807-814
    • (1999) Clin Cancer Res , vol.5 , pp. 807-814
    • Silber, J.R.1    Blank, A.2    Bobola, M.S.3    Ghatan, S.4    Kolstoe, D.D.5    Berger, M.S.6
  • 36
    • 0031595389 scopus 로고    scopus 로고
    • Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a southwest oncology group study
    • Jaeckle K.A., Eyre H.J., Townsend J.J., et al. Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a southwest oncology group study. J Clin Oncol 16 (1998) 3310-3315
    • (1998) J Clin Oncol , vol.16 , pp. 3310-3315
    • Jaeckle, K.A.1    Eyre, H.J.2    Townsend, J.J.3
  • 37
    • 0030823671 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase gene
    • 6-methylguanine-DNA methyltransferase gene. Cancer Res 57 (1997) 3672-3677
    • (1997) Cancer Res , vol.57 , pp. 3672-3677
    • Qian, X.C.1    Brent, T.P.2
  • 38
    • 0030874380 scopus 로고    scopus 로고
    • Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene
    • Watts G.S., Pieper R.O., Costello J.F., Peng Y.M., Dalton W.S., and Futscher B.W. Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene. Mol Cell Biol 17 (1997) 5612-5619
    • (1997) Mol Cell Biol , vol.17 , pp. 5612-5619
    • Watts, G.S.1    Pieper, R.O.2    Costello, J.F.3    Peng, Y.M.4    Dalton, W.S.5    Futscher, B.W.6
  • 39
    • 0033557903 scopus 로고    scopus 로고
    • Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia
    • Estellar M., Hamilton S.R., Burger P.C., Baylin S.B., and Herman J.G. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res 59 (1999) 793-797
    • (1999) Cancer Res , vol.59 , pp. 793-797
    • Estellar, M.1    Hamilton, S.R.2    Burger, P.C.3    Baylin, S.B.4    Herman, J.G.5
  • 40
    • 0034626988 scopus 로고    scopus 로고
    • Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
    • Esteller M., Garcia-Foncillas J., Andion E., et al. Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med 343 (2000) 1350-1354
    • (2000) N Engl J Med , vol.343 , pp. 1350-1354
    • Esteller, M.1    Garcia-Foncillas, J.2    Andion, E.3
  • 41
    • 12144291692 scopus 로고    scopus 로고
    • Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide
    • Hegi M.E., Diserens A.C., Godard S., et al. Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide. Clin Cancer Res 10 (2004) 1871-1874
    • (2004) Clin Cancer Res , vol.10 , pp. 1871-1874
    • Hegi, M.E.1    Diserens, A.C.2    Godard, S.3
  • 42
    • 4143084896 scopus 로고    scopus 로고
    • CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas
    • Paz M.F., Yaya-Tur R., Rojas-Marcos I., et al. CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas. Clin Cancer Res 10 (2004) 4933-4938
    • (2004) Clin Cancer Res , vol.10 , pp. 4933-4938
    • Paz, M.F.1    Yaya-Tur, R.2    Rojas-Marcos, I.3
  • 43
    • 20044372154 scopus 로고    scopus 로고
    • MGMT gene silencing and benefit from temozolomide in glioblastoma
    • Hegi M.E., Diserens A.C., Gorlia T., et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352 (2005) 997-1003
    • (2005) N Engl J Med , vol.352 , pp. 997-1003
    • Hegi, M.E.1    Diserens, A.C.2    Gorlia, T.3
  • 44
    • 11144349554 scopus 로고    scopus 로고
    • Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors
    • Mollemann M., Wolter M., Felsberg J., Collins V.P., and Reifenberger G. Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors. Int J Cancer 113 (2005) 379-385
    • (2005) Int J Cancer , vol.113 , pp. 379-385
    • Mollemann, M.1    Wolter, M.2    Felsberg, J.3    Collins, V.P.4    Reifenberger, G.5
  • 45
    • 0024834599 scopus 로고
    • Radiation therapy oncology group (RTOG) survival data on anaplastic astrocytomas of the brain: does a more aggressive form of treatment adversely impact survival?
    • Laramore G.E., Martz K.L., Nelson J.S., Griffin T.W., Chang C.H., and Horton J. Radiation therapy oncology group (RTOG) survival data on anaplastic astrocytomas of the brain: does a more aggressive form of treatment adversely impact survival?. Int J Radiat Oncol Biol Phys 17 (1989) 1351-1356
    • (1989) Int J Radiat Oncol Biol Phys , vol.17 , pp. 1351-1356
    • Laramore, G.E.1    Martz, K.L.2    Nelson, J.S.3    Griffin, T.W.4    Chang, C.H.5    Horton, J.6
  • 46
    • 16444368462 scopus 로고    scopus 로고
    • Genetic pathways to glioblastomas
    • Ohgaki H. Genetic pathways to glioblastomas. Neuropathology 25 (2005) 1-7
    • (2005) Neuropathology , vol.25 , pp. 1-7
    • Ohgaki, H.1
  • 47
    • 0020332947 scopus 로고
    • Mismatch correction at O6-methylguanine residues in E. Coli DNA
    • Karran P., and Marinus M.G. Mismatch correction at O6-methylguanine residues in E. Coli DNA. Nature 296 (1982) 868-869
    • (1982) Nature , vol.296 , pp. 868-869
    • Karran, P.1    Marinus, M.G.2
  • 48
    • 0030479125 scopus 로고    scopus 로고
    • Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea
    • Liu L., Markowitz S., and Gerson S.L. Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea. Cancer Res 56 (1996) 5375-5379
    • (1996) Cancer Res , vol.56 , pp. 5375-5379
    • Liu, L.1    Markowitz, S.2    Gerson, S.L.3
  • 49
    • 0842286751 scopus 로고    scopus 로고
    • Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is medicated by p53 and Fas/CD95/Apo-1
    • Roos W., Baumgartner M., and Kaina B. Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is medicated by p53 and Fas/CD95/Apo-1. Oncogene 23 (2004) 359-367
    • (2004) Oncogene , vol.23 , pp. 359-367
    • Roos, W.1    Baumgartner, M.2    Kaina, B.3
  • 50
    • 0032435612 scopus 로고    scopus 로고
    • DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma
    • Friedman H.S., McLendon R.E., Kerby T., et al. DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma. J Clin Oncol 16 (1998) 3851-3857
    • (1998) J Clin Oncol , vol.16 , pp. 3851-3857
    • Friedman, H.S.1    McLendon, R.E.2    Kerby, T.3
  • 51
    • 0035849785 scopus 로고    scopus 로고
    • CCNU-dependent potentiation of TRAIL/Apo2L-induced apoptosis in human glioma cells is p53-independent but may involve enhanced cytochrome c release
    • Rohn T.A., Wagenknecht B., Roth W., et al. CCNU-dependent potentiation of TRAIL/Apo2L-induced apoptosis in human glioma cells is p53-independent but may involve enhanced cytochrome c release. Oncogene 20 (2001) 4128-4137
    • (2001) Oncogene , vol.20 , pp. 4128-4137
    • Rohn, T.A.1    Wagenknecht, B.2    Roth, W.3
  • 52
    • 0035009692 scopus 로고    scopus 로고
    • Combined effects of adenovirus-mediated wild-type p53 transduction, temozolomide and poly(ADP-ribose)polymerase inhibitor in mismatch repair deficient and non-proliferating tumor cells
    • Tentori L., Portarena I., Bonmassar E., and Graziani G. Combined effects of adenovirus-mediated wild-type p53 transduction, temozolomide and poly(ADP-ribose)polymerase inhibitor in mismatch repair deficient and non-proliferating tumor cells. Cell Death Differ 8 (2001) 457-469
    • (2001) Cell Death Differ , vol.8 , pp. 457-469
    • Tentori, L.1    Portarena, I.2    Bonmassar, E.3    Graziani, G.4
  • 53
    • 0034901404 scopus 로고    scopus 로고
    • Enforced expression of wild-type p53 curtails the transcription of the O(6)-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents
    • Srivenugopal K.S., Shou J., Mullapudi S.R., Lang Jr. F.F., Rao J.S., and Ali-Osman F. Enforced expression of wild-type p53 curtails the transcription of the O(6)-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents. Clin Cancer Res 7 (2001) 1398-1409
    • (2001) Clin Cancer Res , vol.7 , pp. 1398-1409
    • Srivenugopal, K.S.1    Shou, J.2    Mullapudi, S.R.3    Lang Jr., F.F.4    Rao, J.S.5    Ali-Osman, F.6
  • 54
    • 0037692954 scopus 로고    scopus 로고
    • Marked inactivation of O6-alkylguanineDNA alkyltransferase activity with protracted temozolomide schedules
    • Tolcher A.W., Gerson S.L., Denis, et al. Marked inactivation of O6-alkylguanineDNA alkyltransferase activity with protracted temozolomide schedules. Br J Cancer 88 (2003) 1004-1011
    • (2003) Br J Cancer , vol.88 , pp. 1004-1011
    • Tolcher, A.W.1    Gerson, S.L.2    Denis3
  • 55
    • 0032188739 scopus 로고    scopus 로고
    • Phase I trial of temozolomide using an extended continuous oral schedule
    • Brock C.S., Newlands E.S., Wedge S.R., et al. Phase I trial of temozolomide using an extended continuous oral schedule. Cancer Res 58 (1998) 4363-4367
    • (1998) Cancer Res , vol.58 , pp. 4363-4367
    • Brock, C.S.1    Newlands, E.S.2    Wedge, S.R.3
  • 56
    • 0942266264 scopus 로고    scopus 로고
    • O6-benzylguanine suppression of O6-alkylguanine-DNA alkyltransferase in anaplastic gliomas
    • Schold Jr. S.C., Kokkinakis D.M., Chang S.M., et al. O6-benzylguanine suppression of O6-alkylguanine-DNA alkyltransferase in anaplastic gliomas. Neuro-oncology 6 (2004) 28-32
    • (2004) Neuro-oncology , vol.6 , pp. 28-32
    • Schold Jr., S.C.1    Kokkinakis, D.M.2    Chang, S.M.3
  • 57
    • 0025571828 scopus 로고
    • Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
    • Dolan M.E., Stine L., Mitchell R.B., Moschel R.C., and Pegg A.E. Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea. Cancer Commun 2 (1990) 371-377
    • (1990) Cancer Commun , vol.2 , pp. 371-377
    • Dolan, M.E.1    Stine, L.2    Mitchell, R.B.3    Moschel, R.C.4    Pegg, A.E.5
  • 58
    • 0030608633 scopus 로고    scopus 로고
    • O6-benzylguanine and its role in chemotherapy
    • Dolan M.E., and Pegg A.E. O6-benzylguanine and its role in chemotherapy. Clin Cancer Res 3 (1997) 837-847
    • (1997) Clin Cancer Res , vol.3 , pp. 837-847
    • Dolan, M.E.1    Pegg, A.E.2
  • 59
    • 0030022069 scopus 로고    scopus 로고
    • Potentiation of temozolomide and BCNU cytotoxicity by O(6)-benzylguanine: a comparative study in vitro
    • Wedge S.R., Porteus J.K., May B.L., and Newlands E.S. Potentiation of temozolomide and BCNU cytotoxicity by O(6)-benzylguanine: a comparative study in vitro. Br J Cancer 73 (1996) 482-490
    • (1996) Br J Cancer , vol.73 , pp. 482-490
    • Wedge, S.R.1    Porteus, J.K.2    May, B.L.3    Newlands, E.S.4
  • 60
    • 0034668064 scopus 로고    scopus 로고
    • 6-benzylguanine for patients with recurrent or progressive malignant glioma
    • 6-benzylguanine for patients with recurrent or progressive malignant glioma. J Clin Oncol 18 (2000) 3522-3528
    • (2000) J Clin Oncol , vol.18 , pp. 3522-3528
    • Friedman, H.S.1    Pluda, J.2    Quinn, J.A.3
  • 61
    • 0036570292 scopus 로고    scopus 로고
    • Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma
    • Quinn J.A., Pluda J., Dolan M.E., et al. Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma. J Clin Oncol 20 (2002) 2277-2283
    • (2002) J Clin Oncol , vol.20 , pp. 2277-2283
    • Quinn, J.A.1    Pluda, J.2    Dolan, M.E.3
  • 62
    • 0027339636 scopus 로고
    • Synergistic efficacy of O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in human colon cancer xenografts completely resistant to BCNU alone
    • Gerson S.L., Zborowska E., Norton K., Gordon N.H., and Willson J.K. Synergistic efficacy of O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in human colon cancer xenografts completely resistant to BCNU alone. Biochem Pharmacol 45 (1993) 483-491
    • (1993) Biochem Pharmacol , vol.45 , pp. 483-491
    • Gerson, S.L.1    Zborowska, E.2    Norton, K.3    Gordon, N.H.4    Willson, J.K.5
  • 63
    • 0027335963 scopus 로고
    • Effect of O6-benzylguanine on the response to 1,3-bis(2-chloroethyl)-1-nitrosourea in the Dunning R3327G model of prostatic cancer
    • Dolan M.E., Pegg A.E., Biser N.D., Moschel R.C., and English H.F. Effect of O6-benzylguanine on the response to 1,3-bis(2-chloroethyl)-1-nitrosourea in the Dunning R3327G model of prostatic cancer. Cancer Chemother Pharmacol 32 (1993) 221-225
    • (1993) Cancer Chemother Pharmacol , vol.32 , pp. 221-225
    • Dolan, M.E.1    Pegg, A.E.2    Biser, N.D.3    Moschel, R.C.4    English, H.F.5
  • 64
    • 0030614974 scopus 로고    scopus 로고
    • O6-benzylguanine potentiates the in vivo toxicity and clastogenicity of temozolomide and BCNU in mouse bone marrow
    • Chinnasamy N., Rafferty J.A., Hickson I., et al. O6-benzylguanine potentiates the in vivo toxicity and clastogenicity of temozolomide and BCNU in mouse bone marrow. Blood 89 (1997) 1566-1573
    • (1997) Blood , vol.89 , pp. 1566-1573
    • Chinnasamy, N.1    Rafferty, J.A.2    Hickson, I.3
  • 65
    • 0032542080 scopus 로고    scopus 로고
    • Inactivation of O6-alkylguanine-DNA alkyltransferase. 1. Novel O6-(hetarylmethyl)guanines having basic rings in the side chain
    • McElhinney R.S., Donnelly D.J., McCormick J.E., et al. Inactivation of O6-alkylguanine-DNA alkyltransferase. 1. Novel O6-(hetarylmethyl)guanines having basic rings in the side chain. J Med Chem 41 (1998) 5265-5271
    • (1998) J Med Chem , vol.41 , pp. 5265-5271
    • McElhinney, R.S.1    Donnelly, D.J.2    McCormick, J.E.3
  • 66
    • 7444261398 scopus 로고    scopus 로고
    • Sensitization of a human ovarian cancer cell line to temozolomide by simultaneous attenuation of the Bcl-2 antiapoptotic protein and DNA repair by O6-alkylguanine-DNA alkyltransferase
    • Barvaux V.A., Lorigan P., Ranson M., et al. Sensitization of a human ovarian cancer cell line to temozolomide by simultaneous attenuation of the Bcl-2 antiapoptotic protein and DNA repair by O6-alkylguanine-DNA alkyltransferase. Mol Cancer Ther 3 (2004) 1215-1220
    • (2004) Mol Cancer Ther , vol.3 , pp. 1215-1220
    • Barvaux, V.A.1    Lorigan, P.2    Ranson, M.3
  • 67
    • 0036447366 scopus 로고    scopus 로고
    • Potential clinical applications of poly(ADP-ribose)polymerase (PARP) inhibitors
    • Tentori L., Portarena I., and Graziani G. Potential clinical applications of poly(ADP-ribose)polymerase (PARP) inhibitors. Pharmacol Res 45 (2002) 73-85
    • (2002) Pharmacol Res , vol.45 , pp. 73-85
    • Tentori, L.1    Portarena, I.2    Graziani, G.3
  • 68
    • 10744233628 scopus 로고    scopus 로고
    • Novel poly(ADP-ribose)polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells
    • Curtin N.J., Wang L.-Z., Yiakouvaki A., et al. Novel poly(ADP-ribose)polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells. Clin Cancer Res 10 (2004) 881-889
    • (2004) Clin Cancer Res , vol.10 , pp. 881-889
    • Curtin, N.J.1    Wang, L.-Z.2    Yiakouvaki, A.3
  • 69
    • 33750298737 scopus 로고    scopus 로고
    • Lapidus RG, Tentori L, Graziani G, et al. Oral administration of PARP inhibitor GPI 18180 increases the anti-tumor activity of temozolomide against intracranial melanoma n mice. J Clin Oncol 2005 [ASCO Annual Meeting Proceedings]; 23(16S):3136.
  • 70
    • 10744226451 scopus 로고    scopus 로고
    • Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose)polymerase-1 inhibitor AG14361
    • Calabrese C.R., Almassy R., Barton S., et al. Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose)polymerase-1 inhibitor AG14361. J Natl Cancer Inst 96 (2004) 56-67
    • (2004) J Natl Cancer Inst , vol.96 , pp. 56-67
    • Calabrese, C.R.1    Almassy, R.2    Barton, S.3
  • 71
    • 33750332761 scopus 로고    scopus 로고
    • Plummer R, Middleton M, Wilson R, et al. First in human phase I trial of the PARP inhibitory AG-014699 with temozolomide (TMZ) in patients (pts) with advanced solid tumors. J Clin Oncol 2005 [ASCO Annual Meeting Proceedings]; 23(16S):3065.
  • 72
    • 12144286887 scopus 로고    scopus 로고
    • Phase III randomized study of radiotherapy plus procarbazine, lomustine, and vincristine with or withough BUdR for treatment of anaplastic astrocytoma: final report of RTOG 9404
    • Prados M.D., Seiferheld W., Sandler H.M., et al. Phase III randomized study of radiotherapy plus procarbazine, lomustine, and vincristine with or withough BUdR for treatment of anaplastic astrocytoma: final report of RTOG 9404. In J Radiat Oncol Biol Phys 58 (2004) 1147-1152
    • (2004) In J Radiat Oncol Biol Phys , vol.58 , pp. 1147-1152
    • Prados, M.D.1    Seiferheld, W.2    Sandler, H.M.3
  • 73
    • 21244436279 scopus 로고    scopus 로고
    • Effects of motexafin gadolinium on DNA damage and X-ray-induced DNA damage repair, as assessed by the Comet assay
    • Donnelly E.T., Liu Y., Paul T.K., and Rockwell S. Effects of motexafin gadolinium on DNA damage and X-ray-induced DNA damage repair, as assessed by the Comet assay. Int J Radiat Oncol Biol Phys 62 (2005) 1176-1186
    • (2005) Int J Radiat Oncol Biol Phys , vol.62 , pp. 1176-1186
    • Donnelly, E.T.1    Liu, Y.2    Paul, T.K.3    Rockwell, S.4
  • 74
    • 0034797931 scopus 로고    scopus 로고
    • Motexafin gadolinium: a redox active drug that enhances the efficacy of bleomycin and doxorubicin
    • Miller R.A., Woodburn K.W., Fan Q., et al. Motexafin gadolinium: a redox active drug that enhances the efficacy of bleomycin and doxorubicin. Clin Cancer Res 7 (2001) 3215-3221
    • (2001) Clin Cancer Res , vol.7 , pp. 3215-3221
    • Miller, R.A.1    Woodburn, K.W.2    Fan, Q.3
  • 75
    • 25144489184 scopus 로고    scopus 로고
    • The redox mediator motexafin gadolinium (MGd) enhances the activity of several chemotherapy drugs
    • Magda D., Lepp C., Fan Q., Lecane P., and Miller R.A. The redox mediator motexafin gadolinium (MGd) enhances the activity of several chemotherapy drugs. Proc Am Soc Clin Oncol 22 (2003) 229
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 229
    • Magda, D.1    Lepp, C.2    Fan, Q.3    Lecane, P.4    Miller, R.A.5
  • 76
    • 10644260910 scopus 로고    scopus 로고
    • Comparison of survival of patients in the phase I study of motexafin gadolinium (MGd) with radiation therapy (RT) for glioblastoma multiforme (GBM), with a matched cohort of patients from the RTOG RPA glioma database
    • Ford J.M., Seiferheld W., Mehta M., Phan S., and Curran W. Comparison of survival of patients in the phase I study of motexafin gadolinium (MGd) with radiation therapy (RT) for glioblastoma multiforme (GBM), with a matched cohort of patients from the RTOG RPA glioma database. Proc Am Soc Clin Oncol 22 (2003) 106
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 106
    • Ford, J.M.1    Seiferheld, W.2    Mehta, M.3    Phan, S.4    Curran, W.5
  • 77
    • 33750325907 scopus 로고    scopus 로고
    • Cumulative dose of motexafin gadolinium and survival in newly diagnosed glioblastoma multiforme
    • Mehta M., Ford J.M., Suh J., and Phan S. Cumulative dose of motexafin gadolinium and survival in newly diagnosed glioblastoma multiforme. Neuro-oncology 6 (2004) 378
    • (2004) Neuro-oncology , vol.6 , pp. 378
    • Mehta, M.1    Ford, J.M.2    Suh, J.3    Phan, S.4
  • 78
    • 0028955388 scopus 로고
    • Epidermal growth factor-related peptides and their receptors in human malignancies
    • Salomon D.S., Brandt R., Ciardiello F., and Normanno N. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 19 (1995) 183-232
    • (1995) Crit Rev Oncol Hematol , vol.19 , pp. 183-232
    • Salomon, D.S.1    Brandt, R.2    Ciardiello, F.3    Normanno, N.4
  • 79
    • 1842500007 scopus 로고    scopus 로고
    • Phase II trial of gefitinib in recurrent glioblastoma
    • Rich J.N., Reardon D.A., Peery T., et al. Phase II trial of gefitinib in recurrent glioblastoma. J Clin Oncol 22 (2004) 133-142
    • (2004) J Clin Oncol , vol.22 , pp. 133-142
    • Rich, J.N.1    Reardon, D.A.2    Peery, T.3
  • 80
    • 1542382083 scopus 로고    scopus 로고
    • Phase I study of OSI-774 alone or with temozolomide in patients with malignant glioma
    • Prados M., Chang S., Burton E., et al. Phase I study of OSI-774 alone or with temozolomide in patients with malignant glioma. Eur J Cancer Suppl 1 5 (2003) S14
    • (2003) Eur J Cancer Suppl , vol.1 , Issue.5
    • Prados, M.1    Chang, S.2    Burton, E.3
  • 81
    • 33750343310 scopus 로고    scopus 로고
    • Phase II study of single agent therapy with the EGFR tyrosine kinase inhibitor erlotinib in recurrent glioblastoma multiforme
    • Vogelbaum M.A., Peereboom D., Stevens G.H., Barnett G.H., and Brewer C. Phase II study of single agent therapy with the EGFR tyrosine kinase inhibitor erlotinib in recurrent glioblastoma multiforme. Ann Oncol 15 (2004) iii206
    • (2004) Ann Oncol , vol.15
    • Vogelbaum, M.A.1    Peereboom, D.2    Stevens, G.H.3    Barnett, G.H.4    Brewer, C.5
  • 82
    • 33750287853 scopus 로고    scopus 로고
    • Uhm JH, Ballman KV, Giannini C, et al. Phase II study of ZD1839 in patients with newly diagnosed grade 4 astrocytoma. J Clin Oncol 2004 [ASCO Annual Meeting Proceedings]; 22(14S):1505.
  • 83
    • 18944393158 scopus 로고    scopus 로고
    • Immunohistochemically determined total epidermal growth factor levels not of prognostic value in newly diagnosed glioblastoma multiforme: report from the radiation therapy oncology group
    • Chakravarti A., Seiferheld W., Tu X., et al. Immunohistochemically determined total epidermal growth factor levels not of prognostic value in newly diagnosed glioblastoma multiforme: report from the radiation therapy oncology group. Int J Radiat Oncol Biol Phys 62 (2005) 318-327
    • (2005) Int J Radiat Oncol Biol Phys , vol.62 , pp. 318-327
    • Chakravarti, A.1    Seiferheld, W.2    Tu, X.3
  • 84
    • 27744606737 scopus 로고    scopus 로고
    • Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
    • Mellinghoff I.K., Wang M.Y., Vivanco I., et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N Engl J Med 353 (2005) 2012-2024
    • (2005) N Engl J Med , vol.353 , pp. 2012-2024
    • Mellinghoff, I.K.1    Wang, M.Y.2    Vivanco, I.3
  • 85
    • 0036141447 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor I (IGFRI) mediates resistance to anti-epidermal growth factor receptor (EGFR) therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling
    • Chakravarti A., Loeffler J.S., and Dyson N.J. Insulin-like growth factor receptor I (IGFRI) mediates resistance to anti-epidermal growth factor receptor (EGFR) therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling. Cancer Res 62 1 (2002) 200-207
    • (2002) Cancer Res , vol.62 , Issue.1 , pp. 200-207
    • Chakravarti, A.1    Loeffler, J.S.2    Dyson, N.J.3
  • 86
    • 0036681993 scopus 로고    scopus 로고
    • The epidermal growth factor receptor pathway mediates resistance to sequential administration of radiation and chemotherapy in primary human glioblastoma cells in a RAS-dependent manner
    • Chakravarti A., Chakladar A., Delaney M.A., Latham D.E., and Loeffler J.S. The epidermal growth factor receptor pathway mediates resistance to sequential administration of radiation and chemotherapy in primary human glioblastoma cells in a RAS-dependent manner. Cancer Res 62 15 (2002) 4307-4315
    • (2002) Cancer Res , vol.62 , Issue.15 , pp. 4307-4315
    • Chakravarti, A.1    Chakladar, A.2    Delaney, M.A.3    Latham, D.E.4    Loeffler, J.S.5
  • 87
    • 21444450373 scopus 로고    scopus 로고
    • Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib
    • Haas-Kogan D.A., Prados M.D., Tihan T., et al. Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib. J Natl Cancer Inst 97 (2005) 880-887
    • (2005) J Natl Cancer Inst , vol.97 , pp. 880-887
    • Haas-Kogan, D.A.1    Prados, M.D.2    Tihan, T.3
  • 88
    • 33750332232 scopus 로고    scopus 로고
    • Chakravarti A, Seiferheld W, Robins HI, et al. An update of phase I data from RTOG 0211: a phase I/II clinical study of gefitinib + radiation for newly-diagnosed glioblastoma (GBM) patients. J Clin Oncol 2004 [ASCO Annual Meeting Proceedings]; 22(14S):1571.
  • 89
    • 3042823868 scopus 로고    scopus 로고
    • The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas
    • Chakravarti A., Zhai G., Suzuki Y., et al. The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas. J Clin Oncol 22 10 (2004) 1926-1933
    • (2004) J Clin Oncol , vol.22 , Issue.10 , pp. 1926-1933
    • Chakravarti, A.1    Zhai, G.2    Suzuki, Y.3
  • 90
    • 33750354630 scopus 로고    scopus 로고
    • Conrad C, Friedman H, Reardon D, et al. A phase I/II trial of single-agent PTK 787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in patients with recurrent glioblastoma multiforme (GBM). J Clin Oncol 2004 [ASCO Annual Meeting Proceedings]; 22(14S):1512.
  • 91
    • 0033549864 scopus 로고    scopus 로고
    • N-methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists
    • Dechantsreiter M.S., Planker E., Matha B., et al. N-methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists. J Med Chem 42 (1999) 3033-3040
    • (1999) J Med Chem , vol.42 , pp. 3033-3040
    • Dechantsreiter, M.S.1    Planker, E.2    Matha, B.3
  • 92
    • 0035866813 scopus 로고    scopus 로고
    • Sublethal irradiation promotes migration and invasiveness of glioma cells: implications for radiotherapy of human glioblastoma
    • Wilde-Bode C., Weller M., Rimner A., et al. Sublethal irradiation promotes migration and invasiveness of glioma cells: implications for radiotherapy of human glioblastoma. Cancer Res 61 (2001) 2744-2750
    • (2001) Cancer Res , vol.61 , pp. 2744-2750
    • Wilde-Bode, C.1    Weller, M.2    Rimner, A.3
  • 93
    • 21244435398 scopus 로고    scopus 로고
    • NABTT 9911: a phase I trial of EMD 121974 for treatment of patients with recurrent malignant gliomas
    • Nabors L.B., Rosenfeld S.S., Mikkelsen T., et al. NABTT 9911: a phase I trial of EMD 121974 for treatment of patients with recurrent malignant gliomas. Neuro-oncology 6 (2004) 379
    • (2004) Neuro-oncology , vol.6 , pp. 379
    • Nabors, L.B.1    Rosenfeld, S.S.2    Mikkelsen, T.3


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