Biomarkers of oxidative stress in critically ill patients: What should be measured, when and how?

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 9, Issue 6, 2006, Pages 704-710

  Lemineur, Thierry ^a   Deby Dupont, Ginette ^b   Preiser, Jean Charles ^a,b  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Antioxidant; Hypoxia reoxygenation; Ischaemia reperfusion; Reactive oxygen species

Indexed keywords

ANTIOXIDANT; BIOLOGICAL MARKER; ENZYME; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANTIOXIDANT ACTIVITY; BRAIN DISEASE; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; HUMAN; KIDNEY DISEASE; OXIDATIVE STRESS; RESPIRATORY TRACT DISEASE; REVIEW;

ANTIOXIDANTS; BIOLOGICAL MARKERS; CRITICAL ILLNESS; HUMANS; LIPID PEROXIDATION; OXIDATION-REDUCTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RESPIRATORY BURST;

EID: 33750337104     PISSN: 13631950     EISSN: 15353885     Source Type: Journal    
DOI: 10.1097/01.mco.0000247467.41661.f3     Document Type: Review

References (73)

1. Dröge W. Free radicals in the physiological control of cell function. Physiol Rev 2002; 82:47-95.
2. Kohen R, Nyska A. Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicol Pathol 2002; 30:620-650.
3. Crimi E, Sica V, Williams-Ignarro S, et al. The role of oxidative stress in adult critical care. Free Radic Biol Med 2006; 40:398-406. An excellent updated and clinically oriented review.
4. Brealey D, Brand M, Hargreaves I, et al. Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 2002; 360:219-223.
5. Sheu SS, Nauduri D, Anders MW. Targeting antioxidants to mitochondria: a new therapeutic direction. Biochim Biophys Acta 2006; 1762:256-265. A good review on the role of mitochondria in ROS production.
6. Chandra J, Samali A, Orrenius S. Triggering and modulation of apopotosis by oxidative stress. Free Radic Biol Med 2000; 29:323-333.
7. Hensley K, Robinson KA, Gabbita SP, et al. Reactive oxygen species, cell signaling, and cell injury. Free Radic Biol Med 2000; 28:1456-1462.
8. Thannickal VJ, Fanburg BL. Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol 2000; 279:L1005-L1028.
9. Curtin JF, Donovan M, Cotter TG. Regulation and measurement of oxidative stress in apoptosis. J Immunol Methods 2002; 265:49-72.
10. Ushio-Fukai M. Redox signaling in angiogenesis: role of NADPH-oxidase. Cardiovascular Res 2006; 71:226-235. An excellent review underlining the important role of nicotinamide adenine dinucleotide phosphate, reduced form oxidase in ROS production by endothelial cells.
11. Kakhlon O, Cabantchik I. The labile iron pool: characterization, measurement, and participation in cellular process. Free Radic Biol Med 2002; 33:1037-1046.
12. Guetens G, De Boeck G, Highley M, et al. Oxidative DNA damage: biological significance and methods of analysis. Crit Rev Clin Lab Sci 2002; 39:331-457.
13. Landar A, Oh JY, Giles N, et al. A sensitive method for the quantification measurement of protein thiol modification in response to oxidative stress. Free Radic Biol Med 2006; 40:459-468. An article that demonstrates the difficulty of measuring thiol oxidation in proteins.
14. Leonarduzzi G, Arkan MC, Basaga H, et al. Lipid oxidation products in cell signaling. Free Radic Biol Med 2000; 28:1370-1378.
15. Winterbourn C, Kettle A. Biomarkers of myeloperoxidase-derived hypochlorous acid. Free Radic Biol Med 2000; 29:403-409.
16. Marshall HE, Merchant K, Stamler JS. Nitrosation and oxidation in the regulation of gene expression. FASEB J 2000; 14:1889-1900.
17. Rahman I, Biswas SK. Noninvasive biomarkers of oxidative stress: reproducibility and methodological issues. Redox Rep 2004; 9:125-143.
18. Valgimigli L, Pedulli GF, Paolini M. Measurement of oxidative stress by EPR radical-probe technique. Free Radic Biol Med 2001; 31:708-716.
19. Svistunenko DA, Davies N, Brealey D, et al. Mitochondrial dysfunction in patients with severe sepsis: an EPR interrogation of individual respiratory chain components. Biochem Biophys Acta 2006; 1757:262-272. A highly specialized article, but very interesting to understand the difficulty of applying the EPR technique in humans.
20. Ischiropoulos H, Gow A, Thom SR, et al. Detection of reactive nitrogen species using 2,7-dichlorohydroflorescein and dihydrorhodamine 123. Methods Enzymol 1999; 301:367-373.
21. Frank J, Biesalski HK, Dominici S, Pompella A. The visualization of oxidant stress in tissues and isolated cells. Histol Histopathol 2000; 15:173-184.
22. Nicolescu AC, Li Q, Brown L, Thatcher GR. Nitroxidation, nitration, and oxidation of a BODIPY fluorophore by RNOS and ROS. Nitric Oxide 2006; 15: In press.
23. Rota C, Chignell CF, Mason RP. Evidence for free radical formation during the oxidation of 2′7′-dichlorofluorescin to the fluorescent dye 2′7′-dichlorofluorescein by horseradish peroxidase: possible implications for oxidative stress measurements. Free Radic Biol Med 1999; 27:873-881.
24. Rota C, Fann YC, Mason RP. Phenoxyl free radical formation during the oxidation of the fluorescent dye 2′7′-dichlorofluorescein by horseradish peroxidase: possible consequences for oxidative stress measurements. J Biol Chem 1999; 274:28161-28168.
25. Pratico D, Lawson JA, Fitzgerald GA. Cyclooxygenase-dependent formation of the isoprostane, 8-epi-prostaglandin F2a. J Biol Chem 1995; 270:9800-9808.
26. Ben Baouali A, Aube H, Maupoil V, et al. Plasma lipid peroxidation in critically ill patients: importance of mechanical ventilation. Free Radic Biol Med 1994; 16:223-227.
27. Quinlan GJ, Evans TW, Gutteridge JM. 4-hydroxy-2-nonenal levels increase in the plasma of patients with adult respiratory distress syndrome as linoleic acid appears to fall. Free Radic Res 1994; 21:95-106.
28. Buss H, Chan TP, Sluis KB, et al. Protein carbonyl measurement by a sensitive ELISA method. Free Radic Biol Med 1997; 23:361-366.
29. Mathy-Hartert M, Damas P, Nys M, et al. Nitrated proteins in bronchoalveolar lavage fluid of patients at risk of ventilator-associated bronchopneumonia. Eur Respir J 2000; 16:296-301.
30. Winterbourn C, Buss IH, Chan TP, et al. Protein carbonyl measurements show evidence of early oxidative stress in critically ill patients. Crit Care Med 2000; 28:275-277.
31. Sittipunt C, Steinberg KP, Ruzinski JT, et al. Nitric oxide and nitrotyrosine in the lungs of patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 2001; 163:503-510.
32. Young IS, Trimble ER. Measurement of malondialdehyde in plasma by high performance liquid chromatography with fluorimetric detection. Ann Clin Biochem 1991; 28:504-508.
33. Morrow JD, Hill KE, Burk RF, et al. A series of prostaglandin F2-like compounds are produced in vivo in humans by a noncyclooxygenase, free-radical-catalyzed mechanism. Proc Natl Acad Sci U S A 1990; 87:9383-9387.
34. Draper HH, Hadley M. Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol 1990; 186:421-431.
35. Esterbauer H, Cheeseman KH. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol 1990; 186:407-421.
36. Rahman I, Kelly F. Biomarkers in breath condensate: a promising new noninvasive technique in free radical research. Free Radic Res 2003; 37:1253-1266.
37. Goode HF, Cowley HC, Walker BE, et al. Decreased antioxidant status and increased lipid peroxidation in patients with septic shock and secondary organ dysfunction. Crit Care Med 1995; 23:646-651.
38. Cowley HC, Bacon PJ, Goode HF, et al. Plasma antioxidant potential in severe sepsis: a comparison of survivors and nonsurvivors. Crit Care Med 1996; 24:1179-1183.
39. Geoghegan M, McAuley D, Eaton S, Powell-Tuck J. Selenium in critical illness. Curr Opin Crit Care 2006; 12:136-141. A good summary of actual knowledge on selenium's role in critical patients.
40. Chuang CC, Shiesh SC, Chi CH, et al. Serum total antioxidant capacity reflects severity of illness in patients with severe sepsis. Crit Care 2006; 10:R36. An interesting article that should be read to learn to examine critically the data obtained with the 'total antioxidant capacity' method.
41. Lovat R, Preiser JC. Antioxidant therapy in intensive care. Curr Opin Crit Care 2003; 9:266-270.
42. Magder S. Reactive oxygen species: toxic molecules or spark of life? Crit Care 2006; 10:208. An outstanding article, gathering clinical data and sound physiopathological hypotheses.
43. Mishra V, Baines M, Wenstone R, Shenkin A. Markers of oxidative damage, antioxidant status and clinical outcome in critically ill patients. Ann Clin Biochem 2005; 42:269-276. A nicely performed medium-scale clinical study.
44. Alonso de Vega JM, Diaz J, Serrano E, Carbonell LF. Oxidative stress in critically ill patients with systemic inflammatory response syndrome. Crit Care Med 2002; 30:1782-1786.
45. Selmeci L, Seres L, Antal M, et al. Advanced oxidation protein products (AOPP) for monitoring oxidative stress in critically ill patients: a simple, fast and inexpensive automated technique. Clin Chem Lab Med 2005; 43:294-297. Good implications for everyday clinical practice.
46. Ritter C, Andrades M, Frota Junior ML, et al. Oxidative parameters and mortality in sepsis induced by cecal ligation and perforation. Intens Care Med 2003; 29:1782-1789.
47. Preiser JC, Devos P, Van den Berghe G. Tight control of glycaemia in critically ill patients. Curr Opin Clin Nutr Metab Care 2002; 5:533-537.
48. Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes 2005; 54:1615-1625. A superb and comprehensive review on the potential mechanisms underlying the toxicity of hyperglycaemia.
49. Monnier L, Mas E, Ginet C, et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA 2006; 295:1707-1708. A very careful and mechanistically sound clinical study in diabetic patients.
50. Rahman I, Biswas SK, Kode A. Oxidant and antioxidant balance in the airways and airway diseases. Eur J Pharmacol 2006; 533:222-239. A good review on the biochemistry of oxidative stress in airway diseases.
51. Bowler RP. Oxidative stress in the pathogenesis of asthma. Curr Allergy Asthma Rep 2004; 4:116-122.
52. Rahman I. The role of oxidative stress in the pathogenesis of COPD: implications for therapy. Treat Respir Med 2005; 4:175-200. A good review with therapeutic implications.
53. MacNee W. Pulmonary and systemic oxidant/antioxidant imbalance in chronic obstructive pulmonary disease. Am Thorac Soc 2005; 2:50-60. A good review on oxidative stress in COPD physiopathology and its systemic manifestation.
54. Fink M. Role of reactive oxygen and nitrogen species in acute respiratory distress syndrome. Curr Opin Crit Care 2002; 8:6-11.
55. Lang JD, McArdle PJ, O'Reilly PJ, Matalon S. Oxidant-antioxidant balance in acute lung injury. Chest 2002; 122:314-320.
56. Bowler RP, Crapo JD. Oxidative stress in airways. Am J Respir Crit Care Med 2002; 166:S35-S43.
57. Nys M, Preiser JC, Deby-Dupont G, et al. Nitric oxide-related products and myeloperoxidase in bronchoalveolar lavage fluids from patients with ALI activate NF-kappa B in alveolar cells and monocytes. Vascul Pharmacol 2005; 43:425-433. A detailed clinical study designed to describe the specific effects of infection superimposed on lung inflammation.
58. Schmidt R, Luboeinski T, Markart P, et al. Alveolar antioxidant status in patients with acute respiratory distress syndrome. Eur Respir J 2004; 24:994-999.
59. Pawlak K, Pawlak D, Mysliwiec M. Cu/Zn superoxide dismutase plasma levels as a new useful clinical biomarker of oxidative stress in patients with end-stage renal disease. Clin Biochem 2005; 38:700-705. Good study on oxidative stress new markers in renal disease.
60. Terawaki H, Yoshimura K, Hasegawa T, et al. Oxidative stress is enhanced in correlation with renal dysfunction: examination with the redox state of albumin. Kidney Int 2004; 66:1988-1993.
61. Agarwal R. Chronic kidney disease is associated with oxidative stress independent of hypertension. Clin Nephrol 2004; 61:377-383.
62. Morena M, Delbosc S, Dupuy AM, et al. Overproduction of reactive oxygen species in end-stage renal disease patients: a potential component of hemodialysis associated inflammation. Hemodialysis Int 2005; 9:37-46. A very complete and comprehensive article on oxidative stress in end stage renal disease.
63. Balakrishnan VS, Blumberg J, Pereira BJ, Jaber BL. Antioxidant and oxidative stress indices in dialysis-dependent acute renal failure. Blood Purif 2003; 21:213-219.
64. Morena M, Cristol JP, Bosc JY, et al. Convective and diffuse losses of vitamin C during haemodiafiltration session: a contributive factor to oxidative stress in haemodialysis patients. Nephrol Dial Transplant 2002; 17:422-427.
65. Wooley JA, Btaiche IF, Good KL. Metabolic and nutritional aspects of acute renal failure in critically ill patients requiring continuous renal replacement therapy. Nutr Clin Pract 2005; 20:176-191. A good study with therapeutic explanations and clinical examples.
66. Klein CJ, Moser-Veillon PB, Schweitzer A, et al. Magnesium, calcium, zinc, and nitrogen loss in trauma patients during continuous renal replacement therapy. Parenter Enter Nutr 2002; 26:77-92.
67. Paolin A, Nardin L, Gaetani P, et al. Oxidative damage after severe head injury and its relationship to neurological outcome. Neurosurgery 2002; 51:949-954.
68. Chang CY, Chen JY, Ke D, Hu ML. Plasma levels of lipophilic antioxidant vitamins in acute ischemic stroke patients: correlation to inflammation markers and neurological deficits. Nutrition 2005; 21:987-993. A good study on the indirect measurement of oxidative stress.
69. Liu H, Uno M, Kitazato KT, et al. Peripheral oxidative biomarkers constitute a valuable indicator of the severity of oxidative brain damage in acute cerebral infarction. Brain Res 2004; 1025:43-50.
70. Varma S, Janesko KL, Wisniewski SR, et al. F2-isoprostane and neuronspecific enolase in cerebrospinal fluid after severe traumatic brain injury in infants and children. J Neurotrauma 2003; 20:781-786.
71. Wagner AK, Bayir H, Ren D, et al. Relationships between cerebrospinal fluid markers of excitotoxicity, ischemia, and oxidative damage after severe TBI: the impact of gender, age, and hypothermia. J Neurotrauma 2004; 21:125-136.
72. Sanchez-Moreno C, Dashe JF, Scott T, et al. Decreased levels of plasma vitamin C and increased concentrations of inflammatory and oxidative stress markers after stroke. Stroke 2004; 35:163-168.
73. Cherubini A, Ruggiero C, Polidori MC, Mecocci P. Potential markers of oxidative stress in stroke. Free Radic Biol Med 2005; 39:841-852. A comprehensive and exhaustive review on the physiopathology of oxidative stress in stroke and associated biomarkers.