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Am J Crit Care
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Antioxidant therapy: A new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury
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Pharmacol Rev
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Antioxidants in critical illness
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Bulger EM, Maier RV: Antioxidants in critical illness. Arch Surg 2001, 136:1201-1207. A very clear and updated review of the pathogenesis of oxidative stress and of antioxidant defence mechanisms.
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Arch Surg
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Association between mitochondrial dysfunction and severity and outcome of septic shock
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Alonso de Vega JM, Diaz J, Serrano E, et al.: Oxidative stress in critically ill patients with systemic inflammatory response syndrome. Crit Care Med 2002, 30:1782-1786. A study performed on 68 patients, in which a correlation was found between the presence of SIRS and plasma concentrations of lipid peroxidation products and plasma total antioxidant capacity.
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Is the endogenous peroxyl radical scavenging capacity of plasma protective in systemic inflammatory disorders in humans?
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A.S.P.E.N. Board of Directors and the Clinical Guidelines Task Force. Guidelines for the use of parenteral and enteral nutrition in adults and pediatric patients. JPEN J Parenter Enteral Nutr 2002, 26:1SA-138S.
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Tsuchiya M, Asada A, Kasahara E, Sato EF, Shindo M, Inoue M. Antioxidant protection of propofol and its recycling in erythrocyte membranes. Am J Respir Crit Care Med 2002, 165::54-60. A nice in vitro demonstration of the antioxidant properties of propofol, which inhibited the oxidative hemolysis of erythrocyte membranes, synergistically with ascorbate.
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Am J Respir Crit Care Med
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Enteral feeding with a solution enriched with antioxidant vitamins A, C, and E enhances the resistance to oxidative stress
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Enteral Nutrition in ARDS Study Group: Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants on antioxidant status in patients with acute respiratory distress syndrome
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Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients
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Nathens AB, Neff MJ, Jurkovich GJ, et al.: Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients. Ann Surg 2002, 236:814-822. Very interesting large-scale randomized controlled trial confirming the beneficial effects of a prophylaxis with vitamin C and E in patients with trauma, in terms of both incidence of MOF and duration of mechanical ventilation.
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Caparros T, Lopez J, Grau T; Early enteral nutrition in critically ill patients with a high-protein diet enriched with arginine, fiber, and antioxidants compared with a standard high-protein diet: the effect on nosocomial infections and outcome. JPEN J Parenter Enteral Nutr 2001, 25:299-308.
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From mucolytic to antioxidant and liver protection: New aspects in the intensive care unit career of N-acetylcysteine
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Kiefer P, Vogt J, Radermacher P: From mucolytic to antioxidant and liver protection: new aspects in the intensive care unit career of N-acetylcysteine. Crit Care Med 2000, 28:3935-3936.
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Influence of intravenous vitamin E supplementation in cardiac surgery on oxidative stress: A double-blinded, randomized, controlled study
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Am J Clin Nutr
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