Exhaustive genotyping of the interferon alpha receptor 1 (IFNAR1) gene and association of an IFNAR1 protein variant with AIDS progression or susceptibility to HIV-1 infection in a French AIDS cohort

Biomedicine and Pharmacotherapy

Volumn 60, Issue 9, 2006, Pages 569-577

  Diop, G ^a,b   Hirtzig, T ^a,b   Do, H ^a,b   Coulonges, C ^a   Vasilescu, A ^a,b   Labib, T ^a   Spadoni, J L ^c   Therwath, A ^a   Lathrop, M ^b   Matsuda, F ^b   Zagury, J F ^a,c  

^a INSERM   (France)

^b CENTRE NATIONAL DE GÉNOTYPAGE   (France)

^c Bioinformatique et Chimie Moléculaire   (France)

Author keywords

AIDS progression; Gene; Genotyping; GRIV cohort; Haplotype; IFN alpha receptor 1; Single nucleotide polymorphism

Indexed keywords

ALPHA BETA INTERFERON RECEPTOR; ALPHA INTERFERON;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; COHORT ANALYSIS; DISEASE COURSE; GENE LINKAGE DISEQUILIBRIUM; GENETICS; GENOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; PHYSIOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

ACQUIRED IMMUNODEFICIENCY SYNDROME; COHORT STUDIES; DISEASE PROGRESSION; GENOTYPE; HIV-1; HUMANS; INTERFERON-ALPHA; LINKAGE DISEQUILIBRIUM; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, INTERFERON ALPHA-BETA;

EID: 33750336653     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopha.2006.08.002     Document Type: Article

References (47)

1. Zagury D., Bernard J., Leonard R., et al. Long-term cultures of HTLV-III-infected T cells: a model of cytopathology of T-cell depletion in AIDS. Science 231 (1986) 850-853
2. Kollmann T.R., Pettoello-Mantovani M., Katopodis N.F., et al. Inhibition of acute in vivo human immunodeficiency virus infection by human interleukin 10 treatment of SCID mice implanted with human fetal thymus and liver. Proc. Natl. Acad. Sci. USA 93 (1996) 3126-3131
3. Naif H.M., Li S., Ho-Shon M., et al. The state of maturation of monocytes into macrophages determines the effects of IL-4 and IL-13 on HIV replication. J. Immunol. 158 (1997) 501-511
4. Han X., Becker K., Degen H.J., et al. Synergistic stimulatory effects of tumour necrosis factor alpha and interferon gamma on replication of human immunodeficiency virus type 1 and on apoptosis of HIV-1-infected host cells. Eur. J. Clin. Invest. 26 (1996) 286-292
5. Samuel C.E. Antiviral actions of interferons. Clin. Microbiol. Rev. 14 (2001) 778-809 [table of contents]
6. Baca-Regen L., Heinzinger N., Stevenson M., and Gendelman H.E. Alpha interferon-induced antiretroviral activities: restriction of viral nucleic acid synthesis and progeny virion production in human immunodeficiency virus type 1-infected monocytes. J. Virol. 68 (1994) 7559-7565
7. Bogdan C. The function of type I interferons in antimicrobial immunity. Curr. Opin. Immunol. 12 (2000) 419-424
8. Sen G.C. Viruses and interferons. Annu. Rev. Microbiol. 55 (2001) 255-281
9. Shirazi Y., and Pitha P.M. Alpha interferon inhibits early stages of the human immunodeficiency virus type 1 replication cycle. J. Virol. 66 (1992) 1321-1328
10. Chen K., Huang J., Zhang C., et al. Alpha interferon potently enhances the anti-human immunodeficiency virus type 1 activity of APOBEC3G in resting primary CD4 T cells. J. Virol. 80 (2006) 7645-7657
11. Lapenta C., Santini S.M., Proietti E., et al. Type I interferon is a powerful inhibitor of in vivo HIV-1 infection and preserves human CD4(+) T cells from virus-induced depletion in SCID mice transplanted with human cells. Virology 263 (1999) 78-88
12. Zagury D., Lachgar A., Chams V., et al. Interferon alpha and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS. Proc. Natl. Acad. Sci. USA 95 (1998) 3851-3856
13. Gringeri A., Musicco M., Hermans P., et al. Active anti-interferon-alpha immunization: a European-Israeli, randomized, double-blind, placebo-controlled clinical trial in 242 HIV-1-infected patients (the EURIS study). J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 20 (1999) 358-370
14. Shin H.D., Winkler C., Stephens J.C., et al. Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10. Proc. Natl. Acad. Sci. USA 97 (2000) 14467-14472
15. Nakayama E.E., Meyer L., Iwamoto A., et al. Protective effect of interleukin-4-589T polymorphism on human immunodeficiency virus type 1 disease progression: relationship with virus load. J. Infect. Dis. 185 (2002) 1183-1186
16. Vasilescu A., Heath S.C., Ivanova R., et al. Genomic analysis of Th1-Th2 cytokine genes in an AIDS cohort: identification of IL4 and IL10 haplotypes associated with the disease progression. Genes Immun. 4 (2003) 441-449
17. Do H., Vasilescu A., Diop G., et al. Associations of the IL2Ralpha, IL4Ralpha, IL10Ralpha, and IFN (gamma) R1 cytokine receptor genes with AIDS progression in a French AIDS cohort. Immunogenetics 58 (2006) 89-98
18. Do H., Vasilescu A., Carpentier W., Meyer L., Diop G., Hirtzig H., et al. Exhaustive genotyping of the IL-1 family genes and associations with AIDS progression in a French cohort. J. Infect. Dis. (2006) [in press]
19. Marie I., Durbin J.E., and Levy D.E. Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7. EMBO J. 17 (1998) 6660-6669
20. Kim S.H., Cohen B., Novick D., and Rubinstein M. Mammalian type I interferon receptors consists of two subunits: IFNaR1 and IFNaR2. Gene 196 (1997) 279-286
21. Mogensen K.E., Lewerenz M., Reboul J., et al. The type I interferon receptor: structure, function, and evolution of a family business. J. Interferon Cytokine Res. 19 (1999) 1069-1098
22. Prejean C., and Colamonici O.R. Role of the cytoplasmic domains of the type I interferon receptor subunits in signaling. Semin. Cancer Biol. 10 (2000) 83-92
23. Langer J.A., Rashidbaigi A., Lai L.W., et al. Sublocalization on chromosome 21 of human interferon-alpha receptor gene and the gene for an interferon-gamma response protein. Somat. Cell Mol. Genet. 16 (1990) 231-240
24. Domanski P., and Colamonici O.R. The type-I interferon receptor. The long and short of it. Cytokine Growth Factor Rev. 7 (1996) 143-151
25. Huber C., Pons O., Hendel H., et al. Genomic studies in AIDS: problems and answers. Development of a statistical model integrating both longitudinal cohort studies and transversal observations of extreme cases. Biomed. Pharmacother. 57 (2003) 25-33
26. Rappaport J., Cho Y.Y., Hendel H., et al. 32 bp CCR-5 gene deletion and resistance to fast progression in HIV-1 infected heterozygotes. Lancet 349 (1997) 922-923
27. Hendel H., Henon N., Lebuanec H., et al. Distinctive effects of CCR5, CCR2, and SDF1 genetic polymorphisms in AIDS progression. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 19 (1998) 381-386
28. Winkler C.A., Hendel H., Carrington M., et al. Dominant effects of CCR2-CCR5 haplotypes in HIV-1 disease progression. J. Acquir. Immune Defic. Syndr. 37 (2004) 1534-1538
29. Flores-Villanueva P.O., Hendel H., Caillat-Zucman S., et al. Associations of MHC ancestral haplotypes with resistance/susceptibility to AIDS disease development. J. Immunol. 170 (2003) 1925-1929
30. Hendel H., Caillat-Zucman S., Lebuanec H., et al. New class I and II HLA alleles strongly associated with opposite patterns of progression to AIDS. J. Immunol. 162 (1999) 6942-6946
31. Takahashi M., Matsuda F., Margetic N., and Lathrop M. Automated identification of single nucleotide polymorphisms from sequencing data. J. Bio-inform. Comput. Biol. 1 (2003) 253-265
32. Gomes I., Collins A., Lonjou C., et al. Hardy-Weinberg quality control. Ann. Hum. Genet. 63 (1999) 535-538
33. Salanti G., Amountza G., Ntzani E.E., and Ioannidis J.P. Hardy-Weinberg equilibrium in genetic association studies: an empirical evaluation of reporting, deviations, and power. Eur. J. Hum. Genet. 13 (2005) 840-848
34. Stephens M., Smith N.J., and Donnelly P. A new statistical method for haplotype reconstruction from population data. Am. J. Hum. Genet. 68 (2001) 978-989
35. Stephens M., and Donnelly P. A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am. J. Hum. Genet. 73 (2003) 1162-1169
36. Hill W.G., and Weir B.S. Maximum-likelihood estimation of gene location by linkage disequilibrium. Am. J. Hum. Genet. 54 (1994) 705-714
37. Devlin B., and Risch N. A comparison of linkage disequilibrium measures for fine-scale mapping. Genomics 29 (1995) 311-322
38. Gabriel S.B., Schaffner S.F., Nguyen H., et al. The structure of haplotype blocks in the human genome. Science 296 (2002) 2225-2229
39. Barrett J.C., Fry B., Maller J., and Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21 (2005) 263-265
40. de Bakker P.I., Yelensky R., Pe'er I., et al. Efficiency and power in genetic association studies. Nat. Genet. 37 (2005) 1217-1223
41. Novick D., Cohen B., and Rubinstein M. The human interferon alpha/beta receptor: characterization and molecular cloning. Cell 77 (1994) 391-400
42. Muldoon J., Uriel A., Khoo S., et al. Novel IFN-alpha receptor promoter polymorphisms. Genes Immun. 2 (2001) 159-160
43. Wingender E., Chen X., Hehl R., et al. TRANSFAC: an integrated system for gene expression regulation. Nucleic Acids Res. 28 (2000) 316-319
44. The International HapMap Project. Nature 426 (2003) 789-796 (according to Hap Map Project: www.hapmap.org/publications.html.en)
45. Leyva L., Fernandez O., Fedetz M., et al. IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response. J. Neuroimmunol. 163 (2005) 165-171
46. Cajean-Feroldi C., Nosal F., Nardeux P.C., et al. Identification of residues of the IFNAR1 chain of the type I human interferon receptor critical for ligand binding and biological activity. Biochemistry 43 (2004) 12498-12512
47. Aucan C., Walley A.J., Hennig B.J., et al. Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia. Genes Immun. 4 (2003) 275-282