Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in The Gambia

Genes and Immunity

Volumn 4, Issue 4, 2003, Pages 275-282

  Aucan, C ^a   Walley, A J ^a   Hennig, B J W ^a   Fitness, J ^a   Frodsham, A ^a   Zhang, L ^a   Kwiatkowski, D ^a,b   Hill, A V S ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

Author keywords

Case control; Cerebral malaria; Diplotype; Genetic association; Interferon alpha receptor 1

Indexed keywords

ALPHA INTERFERON RECEPTOR; ALPHA INTERFERON RECEPTOR 1; BETA INTERFERON; CYTOKINE RECEPTOR; GAMMA INTERFERON RECEPTOR; INTERLEUKIN 10 RECEPTOR; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG; ALPHA BETA INTERFERON RECEPTOR; IFNAR1 PROTEIN, HUMAN; INTERFERON RECEPTOR; MEMBRANE PROTEIN;

ARTICLE; BRAIN MALARIA; CHILD; CHROMOSOME 21Q; COMPUTER PROGRAM; CONTROLLED STUDY; DISEASE SEVERITY; GAMBIA; GENE CLUSTER; GENE CONSTRUCT; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; INFECTION RESISTANCE; INFECTION RISK; MAJOR CLINICAL STUDY; MARKER GENE; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; RISK REDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; CASE CONTROL STUDY; CHI SQUARE DISTRIBUTION; COMPARATIVE STUDY; GENETIC MARKER; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; INFANT; INNATE IMMUNITY; MALARIA; PRESCHOOL CHILD;

CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CHILD; CHILD, PRESCHOOL; GAMBIA; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; IMMUNITY, NATURAL; INFANT; MALARIA, CEREBRAL; MEMBRANE PROTEINS; RECEPTOR, INTERFERON ALPHA-BETA; RECEPTORS, INTERFERON; VARIATION (GENETICS);

EID: 1342319661     PISSN: 14664879     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gene.6363962     Document Type: Article

References (34)

1. Butler D, Maurice J, O'Brien C. Time to put malaria control on the global agenda [news] [see comments]. Nature 1997; 386: 535-536.
2. Rihet P, Traoré Y, Abel L, Aucan C, Traoré-Leroux T, Fumoux F. Malaria in humans: Plasmodium falciparum blood infection levels are linked to chromosome 5q31-q33. Am J Hum Genet 1998; 63: 498-505.
3. Jepson A, Sisay JF, Banya W et al. Genetic linkage of mild malaria to the major histocompatibility complex in Gambian children: study of affected sibling pairs. BMJ 1997; 315: 96-97.
4. Hill AV. The genomics and genetics of human infectious disease susceptibility. Annu Rev Genomics Hum Genet 2001; 2: 373-400.
5. Kwiatkowski D, Hill AV, Sambou I et al. TNF concentration in fatal cerebral, non-fatal cerebral and uncomplicated Plasmodium falciparum malaria. Lancet 1990; 336: 1201-1204.
6. Grau GE, Taylor TE, Molyneux ME et al. Tumor necrosis factor and disease severity in children with falciparum malaria. N Engl J Med 1989; 320: 1586-1591.
7. Lucas R, Lou J, Morel DR, Ricou B, Suter PM, Grau GE. TNF receptors in the microvascular pathology of acute respiratory distress syndrome and cerebral malaria. J Leukoc Biol 1997; 61: 551-558.
8. Koch O, Awomoyi A, Usen S et al. IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria. J Infect Dis 2002; 185: 1684-1687.
9. Langer JA, Rashidbaigi A, Lai LW, Patterson D, Jones C. Sublocalization on chromosome 21 of human interferon-alpha receptor gene and the gene for an interferon-gamma response protein. Somat Cell Mol Genet 1990; 16: 231-240.
10. Lutfalla G, Holland SJ, Cinato E et al. Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. EMBO J 1995; 14: 5100-5108.
11. Reboul J, Gardiner K, Monneron D, Uze G, Lutfalla G. Comparative genomic analysis of the interferon/interleukin-10 receptor gene cluster. Genome Res 1999; 9: 242-250.
12. Luty AJ, Lell B, Schmidt OR et al. Interferon-gamma responses are associated with resistance to reinfection with Plasmodium falciparum in young African children. J Infect Dis 1999; 179: 980-988.
13. Ferreira A, Schofield L, Enea V et al. Inhibition of development of exoerythrocytic forms of malaria parasites by gamma-interferon. Science 1986; 232: 881-884.
14. Herrera MA, Rosero F, Herrera S et al. Protection against malaria in Aotus monkeys immunized with a recombinant blood-stage antigen fused to a universal T-cell epitope: correlation of serum gamma interferon levels with protection. Infect Immun 1992; 60: 154-158.
15. Kurtis JD, Lanar DE, Opollo M, Duffy PE. Interleukin-10 responses to liver-stage antigen 1 predict human resistance to Plasmodium falciparum. Infect Immun 1999; 67: 3424-3429.
16. Othoro C, Lal AA, Nahlen B, Koech D, Orago AS, Udhayakumar V. A low interleukin-10 tumor necrosis factor-alpha ratio is associated with malaria anemia in children residing in a holoendemic malaria region in western Kenya [see comments]. J Infect Dis 1999; 179: 279-2821.
17. May J, Lell B, Luty AJ, Meyer CG, Kremsner PG. Plasma interleukin-10:tumor necrosis factor (TNF)-alpha ratio is associated with TNF promoter variants and predicts malarial complications. J Infect Dis 2000; 182: 1570-1573.
18. Riley EM, Olerup O, Troye-Blomberg M. The immune recognition of Malaria antigens. Parasitol Today 1991; 7: 5-11.
19. Bogdan C. The function of type I interferons in antimicrobial immunity. Curr Opin Immunol 2000; 12: 419-424.
20. Vigario AM, Belnoue E, Cumano A et al. Inhibition of Plasmodium yoelii blood-stage malaria by interferon alpha through the inhibition of the production of its target cell, the reticulocyte. Blood 2001; 97: 3966-3971.
21. Sturchler D, Berger R, Etlinger H et al. Effects of interferons on immune response to a synthetic peptide malaria sporozoite vaccine in non-immune adults. Vaccine 1989; 7: 457-461.
22. Luty AJ, Perkins DJ, Lell B et al. Low interleukin-12 activity in severe Plasmodium falciparum malaria. Infect Immun 2000; 68: 3909-3915.
23. Malaguarnera L, Musumeci S. The immune response to Plasmodiurn falciparum malaria. Lancet Infect Dis 2002; 2: 472-478.
24. Modiano D, Petrarca V, Sirima BS et al. Different response to Plasmodium falciparum malaria in west African sympatric ethnic groups. Proc Natl Acad Sci USA 1996; 93: 13206-13211.
25. Hill AV, Allsopp CE, Kwiatkowski D et al. Common west African HLA antigens are associated with protection from severe malaria. Nature 1991; 352: 595-600.
26. Aucan C, Walley AJ, Greenwood BM, Hill AV. Haptoglobin genotypes are not associated with resistance to severe malaria in The Gambia. Trans Roy Soc Trop Med Hyg 2002; 96: 327-328.
27. Aitman TJ, Cooper LD, Norsworthy PJ et al. Malaria susceptibility and CD36 mutation. Nature 2000; 405: 1015-1016.
28. Modiano D, Luoni G, Sirima BS et al. Haemoglobin C protects against clinical Plasmodium falciparum malaria. Nature 2001; 414: 305-308.
29. Yan H, Krishnan K, Greenlund AC et al. Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J 1996; 15: 1064-1074.
30. Colamonici O, Yan H, Domanski P et al. Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase. Mol Cell Biol 1994; 14: 8133-8142.
31. Day DJ, Speiser PW, Schulze E et al. Identification of non-amplifying CYP21 genes when using PCR-based diagnosis of 21-hydroxylase deficiency in congenital adrenal hyperplasia (CAH) affected pedigrees. Hum Mol Genet 1996; 5: 2039-2048.
32. Hosmer DW, Lemeshow S. Applied Logistic Regression. Wiley, New York, 1989.
33. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001; 68: 978-989.
34. Abecasis GR, Cookson WO. GOLD - graphical overview of linkage disequilibrium. Bioinformatics 2000; 16: 182-183.