Ketorolac prevents recurrent withdrawal induced hyperalgesia but does not inhibit tolerance to spinal morphine in the rat

European Journal of Pain

Volumn 11, Issue 1, 2007, Pages 1-

  Dunbar, Stuart A ^a   Karamian, Ivan ^a   Zhang, Jiahui ^a  

^a BAYSTATE MEDICAL CENTER   (United States)

Author keywords

Hyperalgesia; Ketorolac; Morphine; Recurrent withdrawal; Tolerance

Indexed keywords

KETOROLAC; MORPHINE; NALOXONE; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG INHIBITION; DRUG TOLERABILITY; DRUG WITHDRAWAL; HYPERALGESIA; LATENT PERIOD; MALE; NONHUMAN; OPIATE ADDICTION; PRIORITY JOURNAL; RAT; SPINAL CORD; STATISTICAL SIGNIFICANCE; WITHDRAWAL SYNDROME;

EID: 33750324293     PISSN: 10903801     EISSN: 15322149     Source Type: Journal    
DOI: 10.1016/j.ejpain.2005.12.007     Document Type: Article

References (28)

1. Aley K.O., and Levine J.D. Different mechanisms mediate development and expression of tolerance and dependence for peripheral mu-opioid antinociception in rat. J Neurosci 17 (1997) 8018-8023
2. Aley K.O., and Levine J.D. Dissociation of tolerance and dependence for opioid peripheral antinociception in rats. J Neurosci 17 (1997) 3907-3912
3. Bailey C.P., and Connor M. Opioids: cellular mechanisms of tolerance and physical dependence. Curr Opin Pharmacol 5 (2005) 60-68
4. David C., Davis N., Mason R., and Wilson V.G. Evidence for functional dissociation of dependence and tolerance in guinea-pig isolated ileal segments following 20 h exposure to morphine in vitro. Br J Pharmacol 110 (1993) 1522-1526
5. Dunbar S.A., and Karamian I.G. Periodic abstinence enhances nociception without significantly altering the antinociceptive efficacy of spinal morphine in the rat. Neurosci Lett 344 (2003) 145-148
6. Dunbar S.A., Karamov I.G., and Buerkle H. The effect of spinal ibuprofen on opioid withdrawal in the rat. Anesth Analg 91 (2000) 417-422
7. Dunbar S.A., and Pulai I.J. Repetitive opioid abstinence causes progressive hyperalgesia sensitive to N-methyl-d-aspartate receptor blockade in the rat. J Pharmacol Exp Ther 284 (1998) 678-686
8. Dunbar S.A., and Yaksh T.L. Concurrent spinal infusion of MK801 blocks spinal tolerance and dependence induced by chronic intrathecal morphine in the rat. Anesthesiology 84 (1996) 1177-1188
9. Dunbar S.A., and Yaksh T.L. Spinal infusion of N-methyl-d-aspartate antagonist MK801 induces hypersensitivity to the spinal alpha-2 agonist ST91 in the rat. J Pharmacol Exp Ther 281 (1997) 1219-1225
10. Ibuki T., Marsala M., Masuyama T., and Yaksh T.L. Spinal amino acid release and repeated withdrawal in spinal morphine tolerant rats. Br J Pharmacol 138 (2003) 689-697
11. Ito S., Okuda-Ashitaka E., and Minami T. Central and peripheral roles of prostaglandins in pain and their interactions with novel neuropeptides nociceptin and nocistatin. Neurosci Res 41 4 (2001) 299-332
12. Kang Y.J., Vincler M., Li X., Conklin D., and Eisenach J.C. Intrathecal ketorolac reverses hypersensitivity following acute fentanyl exposure. Anesthesiology 97 6 (2002) 1641-1644
13. Malmberg A.B., and Yaksh T.L. Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science 257 (1992) 1276-1279
14. Mandyam C.D., Thakker D.R., and Standifer K.M. micro-opioid-induced desensitization of opioid receptor-like 1 and micro-opioid receptors: differential intracellular signaling determines receptor sensitivity. J Pharmacol Exp Ther 306 (2003) 965-972
15. Mao J. Opioid-induced abnormal pain sensitivity: implications in clinical opioid therapy. Pain 100 3 (2002) 213-217
16. Marret E., Kurdi O., Zufferey P., and Bonnet F. Effects of nonsteroidal antiinflammatory drugs on patient-controlled analgesia morphine side effects: meta-analysis of randomized controlled trials. Anesthesiology 102 6 (2005) 1249-1260
17. Mayer D.J., Mao J., Holt J., and Price D.D. Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions. Proc Natl Acad Sci USA 96 (1999) 7731-7736
18. McNicol E., Strassels S., Goudas L., Lau J., and Carr D. Nonsteroidal anti-inflammatory drugs, alone or combined with opioids, for cancer pain: a systematic review. J Clin Oncol 22 10 (2004) 1975-1992
19. Ossipov M.H., Lai J., King T., Vanderah T.W., and Porreca F. Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure. Biopolymers 80 2-3 (2005) 319-324
20. Petrenko A.B., Yamakura T., Baba H., and Shimoji K. The role of N-methyl-D-aspartate (NMDA) receptors in pain: a review. Anesth Analg 97 (2003) 1108-1116
21. Powell K.J., Hosokawa A., Bell A., Sutak M., Milne B., Quirion R., et al. Comparative effects of cyclo-oxygenase and nitric oxide synthase inhibition on the development and reversal of spinal opioid tolerance. Br J Pharmacol 127 (1999) 631-644
22. Reznikov I., Pud D., and Eisenberg E. Oral opioid administration and hyperalgesia in patients with cancer or chronic nonmalignant pain. Br J Clin Pharmacol 60 3 (2005) 311-318
23. Ruscheweyh R., and Sandkuhler J. Opioids and central sensitisation: II. Induction and reversal of hyperalgesia. Eur J Pain 9 2 (2005) 149-152
24. Tallarida R.J., and Murray R.B. Manual of pharmacologic calculations and computer programs (1981), Springer, New York
25. Terman G.W., Jin W., Cheong Y.P., Lowe J., Caron M.G., Lefkowitz R.J., et al. G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal. Br J Pharmacol 141 (2004) 55-64
26. Trujillo K.A., and Akil H. Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801. Science 251 (1991) 85-87
27. Vanderah T.W., Gardell L.R., Burgess S.E., Ibrahim M., Dogrul A., Zhong C.M., et al. Dynorphin promotes abnormal pain and spinal opioid antinociceptive tolerance. J Neurosci 20 (2000) 7074-7079
28. Wong C.S., Hsu M.M., Chou R., Chou Y.Y., and Tung C.S. Intrathecal cyclooxygenase inhibitor administration attenuates morphine antinociceptive tolerance in rats. Br J Anaesth 85 (2000) 747-751