Dissociation of tolerance and dependence for opioid peripheral antinociception in rats

Journal of Neuroscience

Volumn 17, Issue 10, 1997, Pages 3907-3912

  Aley, K O ^a   Levine, J D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

nitric oxide; pain; protein kinase C; second messenger systems; withdrawal; opioids

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; ARGININE; CHELERYTHRINE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; MU OPIATE RECEPTOR AGONIST; N(G) METHYLARGININE; NALOXONE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; OPIATE ANTAGONIST; PROSTAGLANDIN E2; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR; PROTEIN KINASE C INHIBITOR;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; DRUG MECHANISM; DRUG TOLERANCE; DRUG WITHDRAWAL; ENZYME INHIBITION; ETIOLOGY; HYPERALGESIA; INTRADERMAL DRUG ADMINISTRATION; MALE; NONHUMAN; PAIN; PREVENTION; PRIORITY JOURNAL; RAT; SECOND MESSENGER;

EID: 0030993179     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-10-03907.1997     Document Type: Article

References (8)

1. Aley KO, Green PG, Levine JD (1995) Opioid and adenosine peripheral antinociception are subject to tolerance and withdrawal. J Neurosci 15:8031-8038.
2. Bhargava HN (1995) Attenuation of tolerance to, and physical dependence on, morphine in the rat by inhibition of nitric oxide synthase. Gen Pharmacol 26:1049-1053.
3. Bhargava HN, Zhao GM (1996) Effect of nitric oxide synthase inhibition on tolerance to the analgesic action of D-Pen2,D-Pen5,enkephalin and morphine in the mouse. Neuropeptides 30:219-223.
4. Bilsky EJ, Bernstein RN, Wang Z, Sadee W, Porreca (1996) Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice. J Pharmacol Exp Ther 277:484-490.
5. David C, Davis N, Mason R, Wilson VG (1993) Evidence for functional dissociation of dependence and tolerance in guinea-pig isolated ileal segments following 20 hr exposure to morphine in vitro. Br J Pharmacol 110:1522-1526.
6. Dunbar S, Yaksh TL (1996) Effect of spinal infusion of L-NAME, a nitric oxide synthase inhibitor, on spinal tolerance and dependence induced by chronic intrathecal morphine in the rat. Neurosci Lett 207:33-36.
7. Elliott K, Minami N, Kolesnikov YA, Pasternak GW, Inturrisi CE (1994) The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids. Pain 56:69-75.
8. Elliott K, Kest B, Man A, Kao B, Inturrisi CE (1995) N-methyl-D-aspartate (NMDA) receptors, mu and kappa opioid tolerance, and perspectives on new analgesic drug development. Neuropsychopharmacology 13:347-356.