Dynamic interactions between Pit-1 and C/EBPα in the pituitary cell nucleus

Molecular and Cellular Biology

Volumn 26, Issue 21, 2006, Pages 8087-8098

  Demarco, Ignacio A ^a   Voss, Ty C ^a,c   Booker, Cynthia F ^a   Day, Richard N ^a,b  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; HOMEODOMAIN PROTEIN; NUCLEAR PROTEIN; PROLACTIN; TRANSCRIPTION FACTOR PIT 1; TRANSCRIPTION FACTOR POU;

ALPHA HELIX; ANIMAL CELL; ARTICLE; CELL NUCLEUS; CELL TYPE; CHEMICAL ANALYSIS; CONTROLLED STUDY; DEVELOPMENT; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENE MUTATION; GENETIC CONSERVATION; HORMONE DEFICIENCY; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; HYPOPHYSIS CELL; HYPOPHYSIS HORMONE DEFICIENCY; MICROSCOPY; MOLECULAR STABILITY; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DNA BINDING; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CELL LINE; CELL NUCLEUS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; LUMINESCENT PROTEINS; MICE; MICROSCOPY, FLUORESCENCE; MULTIPROTEIN COMPLEXES; PITUITARY GLAND; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; TRANSCRIPTION FACTOR PIT-1;

EID: 33750321863     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.02410-05     Document Type: Article

References (46)

1. Agresti, A., P. Scaffidi, A. Riva, V. R. Caiolfa, and M. E. Bianchi. 2005. GR and HMGB1 interact only within chromatin and influence each other's residence time. Mol. Cell 18:109-121.
2. Bradford, A. P., C. Wasylyk, B. Wasylyk, and A. Gutierrez-Hartmann. 1997. Interaction of Ets-1 and the POU-homeodomain protein GHF-1/Pit-1 reconstitutes pituitary specific gene expression. Mol. Cell. Biol. 17:1065-1074.
3. Brown, K. E., S. Amoils, J. M. Horn, V. J. Buckle, D. R. Higgs, M. Merken-Schlager, and A. G. Fisher. 2001. Expression of alpha- and beta-globin genes occurs within different nuclear domains in haemopoietic cells. Nat. Cell Biol. 3:602-606.
4. Catez, F., H. Yang, K. J. Tracey, R. Reeves, T. Misteli, and M. Bustin. 2004. Network of dynamic interactions between histone H1 and high-mobility-group proteins in chromatin. Mol. Cell. Biol. 24:4321-4328.
5. Chi, Y. I. 2005. Homeodomain revisited: a lesson from disease-causing mutations. Hum. Genet. 116:433-444.
6. Cohen, L. E., and S. Radovick. 2002. Molecular basis of combined pituitary hormone deficiencies. Endocr. Rev. 23:431-442.
7. Cohen, R. N., T. Brue, K. Naik, C. A. Houlihan, F. E. Wondisford, and S. Radovick. 2005. The role of CBP/p300 interactions and Pit-1 dimerization in the pathophysiological mechanism of combined pituitary hormone deficiency. J. Clin. Endocrinol. Metab. 91:239-247.
8. Cosma, M. P. 2002. Ordered recruitment: gene-specific mechanism of transcription activation. Mol. Cell 10:227-236.
9. Dasen, J. S., and M. G. Rosenfeld. 1999. Combinatorial codes in signaling and synergy: lessons from pituitary development. Curr. Opin. Genet. Dev. 9:566-574.
10. Day, R. N., S. Koike, M. Sakai, M. Muramatsu, and R. A. Maurer, R. A. 1990. Both Pit-1 and the estrogen receptor are required for estrogen responsiveness of the rat PRL gene. Mol. Endocrinol. 4:1964-1971.
11. Day, R. N., J. Liu, V. Sundmark, M. Kawecki, D. Berry, and H. P. Elsholtz. 1998. Selective inhibition of prolactin gene transcription by the ETS-2 repressor factor. J. Biol. Chem. 273:31909-31915.
12. Day, R. N., A. Periasamy, and F. Schaufele. 2001. Fluorescence resonance energy transfer microscopy of localized protein interactions in the living cell nucleus. Methods 25:4-18.
13. Day, R. N., T. C. Voss, J. F. Enwright III, C. F. Booker, A. Periasamy, and F. Schaufele. 2003. Imaging the localized protein interactions between Pit-1 and the CCAAT/enhancer binding protein alpha in the living pituitary cell nucleus. Mol. Endocrinol. 17:333-345.
14. Diamond, S. E., M. Chiono, and A. Gutierrez-Hartmann. 1999. Reconstitution of the protein kinase A response of the rat prolactin promoter: differential effects of distinct Pit-1 isoforms and functional interaction with Oct-1. Mol. Endocrinol. 13:228-238.
15. Diamond, S. E., and A. Gutierrez-Hartmann. 2000. The Pit-1β domain dictates active repression and alteration of histone acetylation of the proximal prolactin promoter. J. Biol. Chem. 275:30977-30986.
16. Dollé, P., J. L. Castrillo, L. E. Theil, T. Deernick, M. Ellisman, and M. Karin. 1990. Expression of GHF-1 protein in mouse pituitaries correlates both temporally and spatially with the onset of growth hormone gene activity. Cell 60:809-820.
17. Dundr, M., U. Hoffmann-Rohrer, Q. Hu, I. Grummt, L. I. Rothblum, R. D. Phair, and T. Misteli. 2002. A kinetic framework for a mammalian RNA polymerase in vivo. Science 298:1623-1626.
18. Enwright, J. F., III, M. A. Kawecki-Crook, T. C. Voss, F. Schaufele, and R. N. Day. 2003. A PIT-1 homeodomain mutant blocks the intranuclear recruitment of the CCAAT/enhancer binding protein alpha required for prolactin gene transcription. Mol. Endocrinol. 17:209-222.
19. Fischberg, D. J., X-H. Chen, and C. Bancroft. 1994. A Pit-1 phosphorylation mutant can mediate both basal and induced prolactin and growth hormone promoter activity. Mol. Endocrinol. 8:1566-1573.
20. Francastel, C., W. Magis, and M. Groudine. 2001. Nuclear relocation of a transactivator subunit precedes target gene activation. Proc. Natl. Acad. Sci. USA 98:12120-12125.
21. Gaiddon, C., M. de Tapia, and L. P. Loeffler. 1999. The tissue-specific transcription factor Pit-1/GHF-1 binds to the c-fos serum response element and activates c-fos transcription. Mol. Endocrinol. 13:742-751.
22. Ingraham, H. A., S. E. Flynn, J. W. Voss, V. R. Albert, M. S. Kapiloff, L. Wilson, and M. G. Rosenfeld. 1990. The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1-Pit-1 interactions. Cell 61:1021-1033.
23. Jacobson, E. M., P. Li, A. Leon-del-Rio, M. G. Rosenfeld, and A. K. Aggarwal. 1997. Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility. Genes Dev. 11:198-212.
24. Johnson, P. F. 2005. Molecular stop signs: regulation of cell-cycle arrest by C/EBP transcription factors. J. Cell Sci. 118:2545-2555.
25. Kadonaga, J. T. 2004. Regulation of RNA polymerase II transcription by sequence-specific DNA binding factors. Cell 116:247-257.
26. Kenworthy, A. K. 2001. Imaging protein-protein interactions using fluorescence resonance energy transfer microscopy. Methods 24:289-296.
27. Lew, D., H. Brady, K. Klausing, K. Yaginuma, L. E. Theill, C. Stauber, M. Karin, and P. L. Mellon. 1993. GHF-1-promoter-targeted immortalization of a somatotropic progenitor cell results in dwarfism in transgenic mice. Genes Dev. 7:683-693.
28. Li, S., E. B. Crenshaw III, E. J. Rawson, D. M. Simmons, L. W. Swanson, and M. G. Rosenfeld. 1990. Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Nature 347:528-533.
29. Liu, W., J. F. Enwright III, W. Hyun, R. N. Day, and F. Schaufele. 2002. CCAAT/enhancer binding protein alpha uses distinct domains to prolong pituitary cells in the growth 1 and DNA synthesis phases of the cell cycle. BMC Cell Biol. 21:6.
30. Okimura, Y., P. W. Howard, and R. A. Maurer. 1994. Pit-1 binding sites mediate transcriptional responses to cyclic adenosine 3′,5′- monophosphate through a mechanism that does not require inducible phosphorylation of Pit-1. Mol. Endocrinol. 8:1559-1565.
31. Parks, J. S., M. R. Brown, D. L. Hurley, C. J. Phelps, and M. P. Wajnrajch. 1999. Heritable disorders of pituitary development. J. Clin. Endocrinol. Metab. 84:4362-4370.
32. Perrod, S., and S. M. Gasser. 2003. Long-range silencing and position effects at telomeres and centromeres: parallels and differences. Cell Mol. Life Sci. 60:2303-2318.
33. Phair, R. D., P. Scaffidi, C. Elbi, J. Vecerova, A. Dey, K. Ozato, D. T. Brown, G. Hager, M. Bustin, and T. Misteli. 2004. Global nature of dynamic protein-chromatin interactions in vivo: three dimensional genome scanning and dynamic interaction networks of chromatin proteins. Mol. Cell. Biol. 24:6393-6402.
34. Piwien Pilipuk, G., M. D. Galigniana, and J. Schwartz. 2003. Subnuclear localization of C/EBP beta is regulated by growth hormone and dependent on MAPK. J. Biol. Chem. 278:35668-35677.
35. Reményi, A., H. R. Schöler, and M. Wilmanns. 2004. Combinatorial control of gene expression. Nat. Struct. Mol. Biol. 11:812-815.
36. Rhodes, S. J., R. Chen, G. E. DiMattia, K. M. Scully, K. A. Kalla, S. C. Lin, V. C. Yu, and M. G. Rosenfeld. 1993. A tissue-specific enhancer confers Pit-1-dependent morphogen inducibility and autoregulation on the pit-1 gene. Genes Dev. 7:913-932.
37. Schaufele, F., J. F. Enwright III, X. Wang, C. Teoh, R. Srihari, R. Erickson, O. A. MacDougald, and R. N. Day. 2001. CCAAT/enhancer binding protein alpha assembles essential cooperating factors in common subnuclear domains. Mol. Endocrinol. 15:1665-1676.
38. Scully, K. M., E. M. Jacobson, K. Jepsen, V. Lunyak, H. Viadiu, C. Carriere, D. W. Rose, F. Hooshmand, A. K. Aggarwal, and M. G. Rosenfeld. 2000. Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specification. Science 290:1127-1131.
39. Sharp, Z. D., D. L. Stenoien, M. G. Mancini, I. I. Ouspenski, and M. A. Mancini. 2004. Inactivating Pit-1 mutations alter subnuclear dynamics suggesting a protein misfolding and nuclear stress response. J. Cell Biochem. 92:664-678.
40. Tang, Q. Q., and M. D. Lane. 1999. Activation and centromeric localization of CCAAT/enhancer-binding proteins during the mitotic clonal expansion of adipocyte differentiation. Genes Dev. 13:2231-2241.
41. Vallette-Kasic, S., I. Pellegrini-Bouiller, F. Sampieri, G. Gunz, A. Diaz, S. Radovick, A. Enjalbert, and T. Brue. 2001. Combined pituitary hormone deficiency due to the F135C human Pit-1 (pituitary-specific factor 1) gene mutation: functional and structural correlates. Mol. Endocrinol. 15:411-420.
42. Voss, T. C., I. A. Demarco, C. F. Booker, and R. N. Day. 2005. Functional interactions with Pit-1 reorganize co-repressor complexes in the living cell nucleus. J. Cell Sci. 118:3277-3288.
43. Xu, L., R. M. Lavinsky, J. S. Dasen, S. E. Flynn, E. M. McInerney, T. M. Mullen, T. Heinzel, D. Szeto, E. Korzus, R. Kurokawa, A. K. Aggarwal, D. W. Rose, C. K. Glass, and M. G. Rosenfeld. 1998. Signal-specific co-activator domain requirements for Pit-1 activation. Nature 395:301-306.
44. Zacharias, D. A., J. D. Violin, A. C. Newton, and R. Y. Tsien. 2002. Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science 296:913-916.
45. Zanger, K., L. E. Cohen, K. Hashimoto, S. Radovick, and F. E. Wondisford. 1999. A novel mechanism for cyclic adenosine 3′,5′-monophosphate regulation of gene expression by CREB-binding protein. Mol. Endocrinol. 13:268-275.
46. Zhang, J. W., Q. Q. Tang, C. Vinson, and M. D. Lane. 2004. Dominant-negative C/EBP disrupts mitotic clonal expansion and differentiation of 3T3-L1 preadipocytes. Proc. Natl. Acad. Sci. USA 101:43-47.