Basal reactive oxygen species determine the susceptibility to apoptosis in cirrhotic hepatocytes

Free Radical Biology and Medicine

Volumn 41, Issue 11, 2006, Pages 1645-1654

  Raval, Jay ^a   Lyman, Suzanne ^a   Nitta, Takashi ^b   Mohuczy, Dagmara ^b   Lemasters, John J ^c   Kim, Jae Sung ^b   Behrns, Kevin E ^b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Apoptosis; Hepatocytes; Mitochondria; Reactive oxygen species (ROS); Transforming growth factor beta (TGF )

Indexed keywords

ANTIOXIDANT; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL RESPIRATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; LIVER; LIVER CIRRHOSIS; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CASPASES; CELLS, CULTURED; DISEASE SUSCEPTIBILITY; HEPATOCYTES; HYDROGEN PEROXIDE; IMMUNOBLOTTING; LIVER CIRRHOSIS; MALE; MICE; MICE, INBRED BALB C; MITOCHONDRIA, LIVER; OXIDANTS; REACTIVE OXYGEN SPECIES; TRANSFORMING GROWTH FACTOR BETA;

ADENOVIRIDAE; MURINAE;

EID: 33750296080     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2006.07.023     Document Type: Article

References (31)

1. Black D., Bird M.A., Samson C.M., Lyman S., Lange P.A., Schrum L.W., Qian T., Lemasters J.J., Brenner D.A., Rippe R.A., and Behrns K.E. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. J. Hepatol. 40 (2004) 942-951
2. Sanchez A., Alvarez A.M., Benito M., and Fabregat I. Apoptosis induced by transforming growth factor-beta in fetal hepatocyte primary cultures: involvement of reactive oxygen intermediates. J. Biol. Chem. 271 (1996) 7416-7422
3. Herrera B., Alvarez A.M., Sanchez A., Fernandez M., Roncero C., Benito M., and Fabregat I. Reactive oxygen species (ROS) mediates the mitochondrial-dependent apoptosis induced by transforming growth factor (beta) in fetal hepatocytes. FASEB J. 15 (2001) 741-751
4. Herrera B., Murillo M.M., Alvarez-Barrientos A., Beltran J., Fernandez M., and Fabregat I. Source of early reactive oxygen species in the apoptosis induced by transforming growth factor-beta in fetal rat hepatocytes. Free Radic. Biol. Med. 36 (2004) 16-26
5. Albright C.D., Salganik R.I., Craciunescu C.N., Mar M.H., and Zeisel S.H. Mitochondrial and microsomal derived reactive oxygen species mediate apoptosis induced by transforming growth factor-beta1 in immortalized rat hepatocytes. J. Cell Biochem. 89 (2003) 254-261
6. Franklin C.C., Rosenfeld-Franklin M.E., White C., Kavanagh T.J., and Fausto N. TGFbeta1-induced suppression of glutathione antioxidant defenses in hepatocytes: caspase-dependent post-translational and caspase-independent transcriptional regulatory mechanisms. FASEB J. 17 (2003) 1535-1537
7. Cullen J.J., Hinkhouse M.M., Grady M., Gaut A.W., Liu J., Zhang Y.P., Weydert C.J., Domann F.E., and Oberley L.W. Dicumarol inhibition of NADPH:quinone oxidoreductase induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanism. Cancer Res. 63 (2003) 5513-5520
8. Weydert C., Roling B., Liu J., Hinkhouse M.M., Ritchie J.M., Oberley L.W., and Cullen J.J. Suppression of the malignant phenotype in human pancreatic cancer cells by the overexpression of manganese superoxide dismutase. Mol. Cancer Ther. 2 (2003) 361-369
9. Buckman J.F., Hernandez H., Kress G.J., Votyakova T.V., Pal S., and Reynolds I.J. MitoTracker labeling in primary neuronal and astrocytic cultures: influence of mitochondrial membrane potential and oxidants. J. Neurosci. Methods 104 (2001) 165-176
10. Elmore S.P., Nishimura Y., Qian T., Herman B., and Lemasters J.J. Discrimination of depolarized from polarized mitochondria by confocal fluorescence resonance energy transfer. Arch. Biochem. Biophys. 422 (2004) 145-152
11. Montalibet J., Skorey K.I., and Kennedy B.P. Protein tyrosine phosphatase: enzymatic assays. Methods 35 (2005) 2-8
12. Michels J., Johnson P.W., and Packham G. Mcl-1. Int. J. Biochem. Cell Biol. 37 (2005) 267-271
13. Meng T.C., Fukada T., and Tonks N.K. Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. Mol. Cell 9 (2002) 387-399
14. Greenwel P., Hu W., Kohanski R.A., and Ramirez F. Tyrosine dephosphorylation of nuclear proteins mimics transforming growth factor beta 1 stimulation of alpha 2(I) collagen gene expression. Mol. Cell. Biol. 15 (1995) 6813-6819
15. Dypbukt J.M., Ankarcrona M., Burkitt M., Sjoholm A., Strom K., Orrenius S., and Nicotera P. Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. The role of intracellular polyamines. J. Biol. Chem. 269 (1994) 30553-30560
16. Ribeiro A., Bronk S.F., Roberts P.J., Urrutia R., and Gores G.J. The transforming growth factor beta(1)-inducible transcription factor TIEG1, mediates apoptosis through oxidative stress. Hepatology 30 (1999) 1490-1497
17. Tsukada S., Westwick J.K., Ikejima K., Sato N., and Rippe R.A. SMAD and p38 MAPK signaling pathways independently regulate alpha1(I) collagen gene expression in unstimulated and transforming growth factor-beta-stimulated hepatic stellate cells. J. Biol. Chem. 280 (2005) 10055-10064
18. Pani G., Fusco S., Colavitti R., Borrello S., Maggiano N., Cravero A.A., Farre S.M., Galeotti T., and Koch O.R. Abrogation of hepatocyte apoptosis and early appearance of liver dysplasia in ethanol-fed p53-deficient mice. Biochem. Biophys. Res. Commun. 325 (2004) 97-100
19. O'Byrne K.J., and Dalgleish A.G. Chronic immune activation and inflammation as the cause of malignancy. Br. J. Cancer 85 (2001) 473-483
20. Yoon- D.Y., Cho Y.S., Park J.W., Kim S.H., and Kim J.W. Up-regulation of reactive oxygen species (ROS) and resistance to Fas-mediated apoptosis in the C33A cervical cancer cell line transfected with IL-18 receptor. Clin. Chem. Lab. Med. 42 (2004) 499-506
21. Liu J., Hinkhouse M.M., Sun W., Weydert C.J., Ritchie J.M., Oberley L.W., and Cullen J.J. Redox regulation of pancreatic cancer cell growth: role of glutathione peroxidase in the suppression of the malignant phenotype. Hum. Gene Ther. 15 (2004) 239-250
22. Horimoto M., Fulop P., Derdak Z., Wands J.R., and Baffy G. Uncoupling protein-2 deficiency promotes oxidant stress and delays liver regeneration in mice. Hepatology 39 (2004) 386-392
23. Herrera B., Fernandez M., Alvarez A.M., Roncero C., Benito M., Gil J., and Fabregat I. Activation of caspases occurs downstream from radical oxygen species production, Bcl-xL down-regulation, and early cytochrome C release in apoptosis induced by transforming growth factor beta in rat fetal hepatocytes. Hepatology 34 (2001) 548-556
24. Herrera B., Fernandez M., Roncero C., Ventura J.J., Porras A., Valladares A., Benito M., and Fabregat I. Activation of p38MAPK by TGF-beta in fetal rat hepatocytes requires radical oxygen production, but is dispensable for cell death. FEBS Lett. 499 (2001) 225-229
25. Fromenty B., Robin M.A., Igoudjil A., Mansouri A., and Pessayre D. The ins and outs of mitochondrial dysfunction in NASH. Diabetes Metab. 30 (2004) 121-138
26. Kroemer G., and Reed J.C. Mitochondrial control of cell death. Nat. Med. 6 (2000) 513-519
27. Ding W.X., Ni H.M., DiFrancesca D., Stolz D.B., and Yin X.M. Bid-dependent generation of oxygen radicals promotes death receptor activation-induced apoptosis in murine hepatocytes. Hepatology 40 (2004) 403-413
28. Adachi M., Higuchi H., Miura S., Azuma T., Inokuchi S., Saito H., Kato S., and Ishii H. Bax interacts with the voltage-dependent anion channel and mediates ethanol-induced apoptosis in rat hepatocytes. Am. J. Physiol. Gastrointest. Liver Physiol. 287 (2004) G695-G705
29. Tejima K., Arai M., Ikeda H., Tomiya T., Yanase M., Inoue Y., Nagashima K., Nishikawa T., Watanabe N., Omata M., and Fujiwara K. Ischemic preconditioning protects hepatocytes via reactive oxygen species derived from Kupffer cells in rats. Gastroenterology 127 (2004) 1488-1496
30. Czaja M.J., Liu H., and Wang Y. Oxidant-induced hepatocyte injury from menadione is regulated by ERK and AP-1 signaling. Hepatology 37 (2003) 1405-1413
31. Katoh I., Tomimori Y., Ikawa Y., and Kurata S. Dimerization and processing of procaspase-9 by redox stress in mitochondria. J. Biol. Chem. 279 (2004) 15515-15523