Low-density lipoprotein modified by macrophage-derived lysosomal hydrolases induces expression and secretion of IL-8 via p38 MAPK and NF-κB by human monocyte-derived macrophages

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 26, Issue 11, 2006, Pages 2504-2509

  Hakala, Jukka K ^a   Lindstedt, Ken A ^a   Kovanen, Petri T ^a   Pentikäinen, Markku O ^a  

^a WIHURI RESEARCH INSTITUTE   (Finland)

Author keywords

Atherosclerosis; Cytokines; Inflammation; LDL

Indexed keywords

COMPLEMENTARY DNA; CYTOKINE; HYDROLASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 8; LOW DENSITY LIPOPROTEIN; LYSOSOME ENZYME; MITOGEN ACTIVATED PROTEIN KINASE P38; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; AUTOCRINE EFFECT; BIOLOGICAL ACTIVITY; CELL NUCLEUS; CONTROLLED STUDY; CYTOKINE RELEASE; DNA DETERMINATION; ENZYME INHIBITION; ENZYME MECHANISM; HUMAN; HUMAN CELL; INFLAMMATION; MACROPHAGE; MONOCYTE; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION;

BIOLOGICAL TRANSPORT; CELL NUCLEUS; CELLS, CULTURED; ENZYME ACTIVATION; HUMANS; HYDROLASES; INFLAMMATION; INTERLEUKIN-8; LIPOPROTEINS, LDL; LYSOSOMES; MACROPHAGES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; TIME FACTORS; TRANSCRIPTION FACTOR AP-1;

EID: 33750216378     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000245796.97133.ad     Document Type: Article

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