Cholesterol is the major component of native lipoproteins activating the p38 mitogen-activated protein kinases

Biological Chemistry

Volumn 386, Issue 9, 2005, Pages 909-918

  Dobreva, Iveta ^a   Zschörnig, Olaf ^b   Waeber, Gérard ^c   James, Richard W ^d   Widmann, Christian ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^d University Hospital   (Switzerland)

Author keywords

Cholesterol; HDL; LDL; Lipoproteins; p38 MAPK; Signal transduction

Indexed keywords

HIGH DENSITY LIPOPROTEIN; LIPOSOME; LOW DENSITY LIPOPROTEIN; METHYL BETA CYCLODEXTRIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLCHOLINE; SPHINGOMYELIN;

ANIMAL CELL; ARTICLE; ATHEROSCLEROSIS; CORRELATION ANALYSIS; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ANALYSIS; FIBROBLAST; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; LIPID ANALYSIS; LIPID COMPOSITION; LIPID SOLUBILITY; LIPOPROTEIN BLOOD LEVEL; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER;

ANIMALS; CELLS, CULTURED; CHOLESTEROL; ENDOTHELIAL CELLS; ENZYME ACTIVATION; HUMANS; KINETICS; LIPOPROTEINS, LDL; LIPOSOMES; MUSCLE, SMOOTH; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; SIGNAL TRANSDUCTION;

EID: 26844460177     PISSN: 14316730     EISSN: 14316730     Source Type: Journal    
DOI: 10.1515/BC.2005.106     Document Type: Article

References (37)

1. Bennett, B.L., Sasaki, D.T., Murray, B.W., O'Leary, E.C., Sakata, S.T., Xu, W., Leisten, J.C., Motiwala, A., Pierce, S., Satoh, Y. et al. (2001). SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc. Natl. Acad. Sci. USA 98, 13681-13686.
2. Brown, D.A. and London, E. (2000). Structure and function of sphingolipid- and cholesterol-rich membrane rafts. J. Biol. Chem. 275, 17221-17224.
3. Chen Jr., P.S., Toribara, T.Y., and Warner, H. (1956). Microdetermination of phosphorus. Anal. Chem. 28, 1756-1758.
4. Cherradi, N., Bideau, M., Arnaudeau, S., Demaurex, N., James, R.W., Azhar, S., and Capponi, A.M. (2001). Angiotensin II promotes selective uptake of high density lipoprotein cholesterol esters in bovine adrenal glomerulosa and human adrenocortical carcinoma cells through induction of scavenger receptor class B type I. Endocrinology 142, 4540-4549.
5. Davies, S.P., Reddy, H., Caivano, M., and Cohen, P. (2000). Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351, 95-105.
6. Dietschy, J.M. and Turley, S.D. (2002). Control of cholesterol turnover in the mouse. J. Biol. Chem. 277, 3801-3804.
7. Dobreva, I., Waeber, G., Mooser, V., James, R.W., and Widmann, C. (2003). LDLs induce fibroblast spreading independently of the LDL receptor via activation of the p38 MAPK pathway. J. Lipid Res. 44, 2382-2390.
8. Eckhardt, E.R., Cai, L., Sun, B., Webb, N.R., and Van Der Westhuyzen, D.R. (2004). High density lipoprotein uptake by scavenger receptor SR-BII. J. Biol. Chem. 279, 14372-14381.
9. Eyers, P.A., Craxton, M., Morrice, N., Cohen, P., and Goedert, M. (1998). Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution. Chem. Biol. 5, 321-328.
10. Fidge, N.H. (1999). High density lipoprotein receptors, binding proteins, and ligands. J. Lipid Res. 40, 187-201.
11. Furuchi, T. and Anderson, R.G. (1998). Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK). J. Biol. Chem. 273, 21099-21104.
12. Ge, B., Gram, H., Di Padova, F., Huang, B., New, L., Ulevitch, R.J., Luo, Y., and Han, J. (2002). MAPKK-independent activation of p38a mediated by TAB1-dependent autophosphorylation of p38a. Science 295, 1291-1294.
13. Ginsberg, H.N. and Goldberg, I.J. (1998). Disorders of lipoprotein metabolism. In: Harrison's Principles of Internal Medicine (Berkshire, UK: McGraw Hill).
14. Glass, C.K. and Witztum, J.L. (2001). Atherosclerosis. The road ahead. Cell 104, 503-516.
15. Gouni-Berthold, I., Berthold, H.K., Weber, A.A., Seul, C., Vetter, H., and Sachinidis, A. (2001). Troglitazone and rosiglitazone inhibit the low density lipoprotein-induced vascular smooth muscle cell growth. Exp. Clin. Endocrinol. Diabetes 109, 203-209.
16. Gouni-Berthold, I. and Sachinidis, A. (2002). Does the coronary risk factor low density lipoprotein alter growth and signaling in vascular smooth muscle cells? FASEB J. 16, 1477-1487.
17. Granot, E., Deckelbaum, R.J., Eisenberg, S., Oschry, Y., and Bengtsson-Olivecrona, G. (1985). Core modification of human low-density lipoprotein by artificial triacylglycerol emulsion. Biochim. Biophys. Acta 833, 308-315.
18. Havel, R.J., Eder, H.A., and Bragton, J.H. (1955). The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J. Clin. Invest. 34, 1345-1353.
19. Hayashi, K., Takahashi, M., Nishida, W., Yoshida, K., Ohkawa, Y., Kitabatake, A., Aoki, J., Arai, H., and Sobue, K. (2001). Phenotypic modulation of vascular smooth muscle cells induced by unsaturated lysophosphatidic acids. Circ. Res. 89, 251-258.
20. Hevonoja, T., Pentikainen, M.O., Hyvonen, M.T., Kovanen, P.T., and Ala-Korpela, M. (2000). Structure of low density lipoprotein (LDL) particles: basis for understanding molecular changes in modified LDL. Biochim. Biophys. Acta 1488, 189-210.
21. Incardona, J.P. and Eaton, S. (2000). Cholesterol in signal transduction. Curr. Opin. Cell Biol. 12, 193-203.
22. James, R.W. and Pometta, D. (1990). Immunofractionation of high density lipoprotein subclasses 2 and 3. Similarities and differences of fractions isolated from male and female populations. Atherosclerosis 83, 35-45.
23. Jans, R., Atanasova, G., Jadot, M., and Poumay, Y. (2004). Cholesterol depletion upregulates involucrin expression in epidermal keratinocytes through activation of p38. J. Invest. Dermatol. 123, 564-573.
24. Jing, Q., Xin, S.M., Zhang, W.B., Wang, P., Qin, Y.W., and Pei, G. (2000). Lysophosphatidylcholine activates p38 and p42/44 mitogen-activated protein kinases in monocytic THP-1 cells, but only p38 activation is involved in its stimulated chemotaxis. Circ. Res. 87, 52-59.
25. Kritchevsky, D. (1986). Atherosclerosis and nutrition. Nutr. Int. 2, 290-297.
26. LaBelle, E.F. and Tulenko, T.N. (2004). LDL, IGF-1, and VSMC apoptosis: linking atherogenesis to plaque rupture in vulnerable lesions. Cardiovasc. Res. 61, 204-205.
27. Legler, D.F., Micheau, O., Doucey, M.A., Tschopp, J., and Bron, C. (2003). Recruitment of TNF receptor 1 to lipid rafts is essential for TNFα-mediated NF-κB activation. Immunity 18, 655-664.
28. Okajima, F. (2002). Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator? Biochim. Biophys. Acta 1582, 132-137.
29. Olofsson, S.O., Bostrom, K., Svanberg, U., and Bondjers, G. (1980). Isolation and partial characterization of a polypeptide belonging to apolipoprotein B from low-density lipoproteins of human plasma. Biochemistry 19, 1059-1064.
30. Pike, L.J. and Miller, J.M. (1998). Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover. J. Biol. Chem. 273, 22298-22304.
31. Robert, P., Tsui, P., Laville, M.P., Livi, G.P., Sarau, H.M., Bril, A., and Berrebi-Bertrand, I. (2001). EDG1 receptor stimulation leads to cardiac hypertrophy in rat neonatal myocytes. J. Mol. Cell Cardiol. 33, 1589-1606.
32. Sheets, E.D., Holowka, D., and Baird, B. (1999). Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of FcepsilonRI and their association with detergent-resistant membranes. J. Cell Biol. 145, 877-887.
33. Takahashi, M., Okazaki, H., Ogata, Y., Takeuchi, K., Ikeda, U., and Shimada, K. (2002). Lysophosphatidylcholine induces apoptosis in human endothelial cells through a p38-mitogen-activated protein kinase-dependent mechanism. Atherosclerosis 161, 387-394.
34. Widmann, C., Dolci, W., and Thorens, B. (1995). Agonist-induced internalization and recycling of the glucagon-like peptide-1 receptor in transfected fibroblasts and in insulinomas. Biochem. J. 310, 203-214.
35. Xavier, R., Brennan, T., Li, Q., McCormack, C., and Seed, B. (1998). Membrane compartmentation is required for efficient T cell activation. Immunity 8, 723-732.
36. Yang, J.-Y. and Widmann, C. (2001). Antiapoptotic signaling generated by caspase-induced cleavage of RasGAP. Mol. Cell. Biol. 21, 5346-5358.
37. Zhu, Y., Liao, H., Wang, N., Ma, K.S., Verna, L.K., Shyy, J.Y., Chien, S., and Stemerman, M.B. (2001). LDL-activated p38 in endothelial cells is mediated by Ras. Arterioscler. Thromb. Vasc. Biol. 21, 1159-1164.