In-situ synthesis of a tacrine-triazole-based inhibitor of acetylcholinesterase: Configurational selection imposed by steric interactions

Journal of Medicinal Chemistry

Volumn 49, Issue 21, 2006, Pages 6222-6230

  Senapati, Sanjib ^a,b   Cheng, Yuhui ^a   McCammon, J Andrew ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b INDIAN INSTITUTE OF TECHNOLOGY MADRAS   (India)

^c San Diego   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,8 DIAMINO 6 PHENYL 5 [6 [1 [2 [(1,2,3,4 TETRAHYDRO 9 ACRIDINYL) AMINO]ETHYL] 1H 1,2,3 TRIAZOL 4 YL]HEXYL]PHENATHRIDINIUM; 3,8 DIAMINO 6 PHENYL 5 [6 [1 [2 [(1,2,3,4 TETRAHYDRO 9 ACRIDINYL) AMINO]ETHYL] 1H 1,2,3 TRIAZOL 5 YL]HEXYL]PHENANTHRIDINIUM; ACETYLENE; AZIDE; CHOLINESTERASE INHIBITOR; TACRINE DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

AB INITIO CALCULATION; ARTICLE; CYCLOADDITION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; GEOMETRY; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; QUANTUM MECHANICS;

EID: 33750139049     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm051132b     Document Type: Article

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